Cited by 131Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

Early Development of the Gut Microbiome and Immune-Mediated Childhood Disorders

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Li, Min, Wang, Mei, Donovan, Sharon·2014·Seminars in Reproductive Medicine

Abstract

The human gastrointestinal tract inhabits a complex microbial ecosystem that plays a vital role in host health through its contributions to nutrient synthesis and digestion, protection from pathogens, and promoting maturation of host innate and adapt immune systems. The development of gut microbiota primarily occurs during infancy and is influenced by multiple factors, including prenatal exposure; gestational age; mode of delivery; feeding type; pre-, pro-, and antibiotic use; and host genetics. In genetically susceptible individuals, changes in the gut microbiota induced by environmental factors may contribute to the development of immune-related disorders in childhood, including atopic diseases, inflammatory bowel disease, irritable bowel syndrome, and necrotizing enterocolitis. Pre- and probiotics may be useful in the prevention and treatment of some immune-related diseases by modulating gut microbiota and regulating host mucosal immune function. The review will discuss recent findings on the environmental factors that influence development of gut microbiota during infancy and its potential impact on some immune-related diseases in childhood. The use of pre- and probiotics for prevention and intervention of several important diseases in early life will also be reviewed.

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  • While the inflammation characteristics of gingivitis are mostly reversible, periodontitis results in long-term, irreversible damage to the periodontal tissues and alveolar bone that manifests as tissue detachment from the tooth, formation of a pocket wherein pathogenic bacteria can proliferate further, and eventual tooth loss in advanced stages of the disease.

    “While the inflammation characteristics of gingivitis are mostly reversible, periodontitis results in long‐term, irreversible damage to the periodontal tissues and alveolar bone that manifests as tissue detachment from the tooth, formation of a pocket wherein pathogenic bacteria can proliferate further, and eventual tooth loss in advanced stages of the disease.192, 193, 194, 195”

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  1. Mannino DM, Homa DM, Pertowski CA, et al. Surveillance for asthma-United States, 1960-1995. MMWR CDC Surveill Summ 1998;47(1):1-27 66
  2. Fölster-Holst R, Müller F, Schnopp N, et al. Prospective, random- ized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis. Br J Dermatol 2006;155(6): 1256-1261 142
  3. Fallon EM, Nehra D, Potemkin AK, et al; American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A. S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for necrotizing enterocolitis. JPEN J Parenter Enteral Nutr 2012;36(5):506-523 166

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Authors
Li, M., Wang, M., & Donovan, S.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Donovan, Sharon
Venue
Seminars in Reproductive Medicine
Published
2014-01-03
Volume
32
Issue
01
Pages
074-086
ISSN
  • 1526-4564 (ISSN-L)
  • 1526-8004
OpenAlex
W2084661426
Cited by
131
References
180
Citations by year
2026: 4 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 12 · 2020: 18 · 2019: 13 · 2018: 9 · 2017: 7 · 2016: 13 · 2015: 19 · 2014: 4
FWCI
1.35
Type
journal article
Language
en
Open access
Locations
  • Seminars in Reproductive Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD061929, R01HD061929)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, atopic diseases, inflammatory bowel disease, irritable bowel syndrome, necrotizing enterocolitis, prebiotics, probiotics, mode of delivery, infant feeding, antibiotic use, prenatal exposure, mucosal immunity, host genetics
MeSH terms
Anti-Bacterial Agents, Child, Diet, Female, Gestational Age, Humans, Immune System Diseases, Infant, Newborn, Pregnancy, Probiotics, Delivery, Obstetric, Gastrointestinal Tract, Microbiota

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