Early Development of the Gut Microbiome and Immune-Mediated Childhood Disorders
Open accessAbstract
The human gastrointestinal tract inhabits a complex microbial ecosystem that plays a vital role in host health through its contributions to nutrient synthesis and digestion, protection from pathogens, and promoting maturation of host innate and adapt immune systems. The development of gut microbiota primarily occurs during infancy and is influenced by multiple factors, including prenatal exposure; gestational age; mode of delivery; feeding type; pre-, pro-, and antibiotic use; and host genetics. In genetically susceptible individuals, changes in the gut microbiota induced by environmental factors may contribute to the development of immune-related disorders in childhood, including atopic diseases, inflammatory bowel disease, irritable bowel syndrome, and necrotizing enterocolitis. Pre- and probiotics may be useful in the prevention and treatment of some immune-related diseases by modulating gut microbiota and regulating host mucosal immune function. The review will discuss recent findings on the environmental factors that influence development of gut microbiota during infancy and its potential impact on some immune-related diseases in childhood. The use of pre- and probiotics for prevention and intervention of several important diseases in early life will also be reviewed.
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While the inflammation characteristics of gingivitis are mostly reversible, periodontitis results in long-term, irreversible damage to the periodontal tissues and alveolar bone that manifests as tissue detachment from the tooth, formation of a pocket wherein pathogenic bacteria can proliferate further, and eventual tooth loss in advanced stages of the disease.
“While the inflammation characteristics of gingivitis are mostly reversible, periodontitis results in long‐term, irreversible damage to the periodontal tissues and alveolar bone that manifests as tissue detachment from the tooth, formation of a pocket wherein pathogenic bacteria can proliferate further, and eventual tooth loss in advanced stages of the disease.192, 193, 194, 195”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [193]
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Renz, H., Holt, P. G., Inouye, M., Logan, A. C., Prescott, S. L., & Sly, P. D. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.015 · Cited by 226 · see citing works
The complex link and disease between the gut microbiome and the immune system in infants
Zhang, H., Zhang, Z., Liao, Y., Zhang, W., & Tang, D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.924119 · Cited by 45 · see citing works
- Authors
- Li, M., Wang, M., & Donovan, S.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Donovan, Sharon
- Venue
- Seminars in Reproductive Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2014-01-03
- Volume
- 32
- Issue
- 01
- Pages
- 074-086
- ISSN
- 1526-4564 (ISSN-L)
- 1526-8004
- OpenAlex
- W2084661426
- Cited by
- 131
- References
- 180
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 12 · 2020: 18 · 2019: 13 · 2018: 9 · 2017: 7 · 2016: 13 · 2015: 19 · 2014: 4
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Seminars in Reproductive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD061929, R01HD061929)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, atopic diseases, inflammatory bowel disease, irritable bowel syndrome, necrotizing enterocolitis, prebiotics, probiotics, mode of delivery, infant feeding, antibiotic use, prenatal exposure, mucosal immunity, host genetics
- MeSH terms
- Anti-Bacterial Agents, Child, Diet, Female, Gestational Age, Humans, Immune System Diseases, Infant, Newborn, Pregnancy, Probiotics, Delivery, Obstetric, Gastrointestinal Tract, Microbiota
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