Cited by 385Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging

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Davatzikos, Christos, Fan, Yong, Wu, Xiaoying, Shen, Dinggang, Resnick, Susan M.·2008·Neurobiology of Aging

Abstract

We report evidence that computer-based high-dimensional pattern classification of magnetic resonance imaging (MRI) detects patterns of brain structure characterizing mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD). Ninety percent diagnostic accuracy was achieved, using cross-validation, for 30 participants in the Baltimore Longitudinal Study of Aging. Retrospective evaluation of serial scans obtained during prior years revealed gradual increases in structural abnormality for the MCI group, often before clinical symptoms, but slower increase for individuals remaining cognitively normal. Detecting complex patterns of brain abnormality in very early stages of cognitive impairment has pivotal importance for the detection and management of AD.

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Crossref · 10.1016/j.neurobiolaging.2006.11.010

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Authors
Davatzikos, C., Fan, Y., Wu, X., Shen, D., & Resnick, S. M.
Affiliations
  • University of Pennsylvania (US)
  • National Institutes of Health (US)
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2008-04
Volume
29
Issue
4
Pages
514-523
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2120111102
Cited by
385
References
52
Citations by year
2026: 9 · 2025: 6 · 2024: 11 · 2023: 7 · 2022: 13 · 2021: 15 · 2020: 20 · 2019: 15 · 2018: 26 · 2017: 25 · 2016: 19 · 2015: 27 · 2014: 23 · 2013: 34 · 2012: 33
FWCI
9.56
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Johns Hopkins University
  • National Institutes of Health (n01ag032124-003)
  • National Institute on Aging (N01-AG-32124, Z01AG000191, R01 AG 14971, N01 AG032124, R01AG014971)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
prodromal Alzheimer's disease, mild cognitive impairment, structural brain abnormalities, magnetic resonance imaging, early detection of cognitive impairment, longitudinal MRI, Baltimore Longitudinal Study of Aging, diagnostic accuracy
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Prospective Studies, Retrospective Studies

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