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Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis

Kucia, Magda, Reca, Ryan, Miekus, Katarzyna, Wanzeck, Jens, Wojakowski, Wojtek, Janowska‐Wieczorek, Anna, Ratajczak, Janina, Ratajczak, Mariusz Z.·2005·STEM CELLS

DOI 10.1634/stemcells.2004-0342

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Abstract

The alpha-chemokine stromal-derived factor (SDF)-1 and the G-protein-coupled seven-span transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this review, we present the concept that the SDF-1-CXCR4 axis is a master regulator of trafficking of both normal and cancer stem cells. Supporting this is growing evidence that SDF-1 plays a pivotal role in the regulation of trafficking of normal hematopoietic stem cells (HSCs) and their homing/retention in bone marrow. Moreover, functional CXCR4 is also expressed on nonhematopoietic tissue-committed stem/progenitor cells (TCSCs); hence, the SDF-1-CXCR4 axis emerges as a pivotal regulator of trafficking of various types of stem cells in the body. Furthermore, because most if not all malignancies originate in the stem/progenitor cell compartment, cancer stem cells also express CXCR4 on their surface and, as a result, the SDF-1-CXCR4 axis is also involved in directing their trafficking/metastasis to organs that highly express SDF-1 (e.g., lymph nodes, lungs, liver, and bones). Hence, we postulate that the metastasis of cancer stem cells and trafficking of normal stem cells involve similar mechanisms, and we discuss here the common molecular mechanisms involved in these processes. Finally, the responsiveness of CXCR4+ normal and malignant stem cells to an SDF-1 gradient may be regulated positively/primed by several small molecules related to inflammation which enhance incorporation of CXCR4 into membrane lipid rafts, or may be inhibited/blocked by small CXCR4 antagonist peptides. Consequently, strategies aimed at modulating the SDF-1-CXCR4 axis could have important clinical applications both in regenerative medicine to deliver normal stem cells to the tissues/organs and in clinical hematology/oncology to inhibit metastasis of cancer stem cells.

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Stromal Cell-Derived Factor 1, a Novel Target of Estrogen Receptor Action, Mediates the Mitogenic Effects of Estradiol in Ovarian and Breast Cancer Cells
Hall, J. M., & Korach, K. S. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0438 · Cited by 293
Regulation of Human Chemokine Receptors CXCR4
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Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes
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Role of the α‐chemokine stromal cell‐derived factor (SDF‐1) in the developing and mature central nervous system
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Expression of Functional CXCR4 by Muscle Satellite Cells and Secretion of SDF-1 by Muscle-Derived Fibroblasts is Associated with the Presence of Both Muscle Progenitors in Bone Marrow and Hematopoietic Stem/Progenitor Cells in Muscles
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Stromal cell–derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism
Lataillade, J.-J., Clay, D., Bourin, P., Hérodin, F., Dupuy, C., Jasmin, C., & Le Bousse-Kerdilès, M.-C. (2002) · Blood · doi:10.1182/blood.v99.4.1117 · Cited by 277
Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells
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SDF-1 is both necessary and sufficient to promote proliferative retinopathy
Butler, J. M., Guthrie, S. M., Koc, M., Afzal, A., Caballero, S., Brooks, H. L., Mames, R. N., Segal, M. S., Grant, M. B., & Scott, E. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522869 · Cited by 263
Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C
Wang, J.-F., Park, I.-W., & Groopman, J. E. (2000) · Blood · doi:10.1182/blood.v95.8.2505 · Cited by 254
CXCR4/CXCL12 expression and signalling in kidney cancer
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Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
Wysoczynski, M., Reca, R., Ratajczak, J., Kucia, M., Shirvaikar, N., Honczarenko, M., Mills, M., Wanzeck, J., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2005) · Blood · doi:10.1182/blood-2004-04-1430 · Cited by 252
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A Point Mutation That Confers Constitutive Activity to CXCR4 Reveals That T140 Is an Inverse Agonist and That AMD3100 and ALX40-4C Are Weak Partial Agonists
Zhang, W.-B., Navenot, J.-M., Haribabu, B., Tamamura, H., Hiramatu, K., Omagari, A., Pei, G., Manfredi, J. P., Fujii, N., Broach, J. R., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200889200 · Cited by 247
The presence of FGF2 signaling determines whether β-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells
Israsena, N., Hu, M., Fu, W., Kan, L., & Kessler, J. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.12.024 · Cited by 240
Cell Surface Peptidase CD26/Dipeptidylpeptidase IV Regulates CXCL12/Stromal Cell-Derived Factor-1α-Mediated Chemotaxis of Human Cord Blood CD34+ Progenitor Cells
Christopherson, K. W., Hangoc, G., & Broxmeyer, H. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.7000 · Cited by 240
Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury
Kucia, M., Ratajczak, J., Reca, R., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2004) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2003.09.025 · Cited by 239
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Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling
Walmsley, M. J., Ooi, S. K. T., Reynolds, L. F., Smith, S. H., Ruf, S., Mathiot, A., Vanes, L., Williams, D. A., Cancro, M. P., & Tybulewicz, V. L. J. (2003) · Science · doi:10.1126/science.1089709 · Cited by 238
The CXC Chemokine Stromal Cell-Derived Factor Activates a Gi-Coupled Phosphoinositide 3-Kinase in T Lymphocytes
Sotsios, Y., Whittaker, G. C., Westwick, J., & Ward, S. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.5954 · Cited by 237
The SDF‐1‐CXCR4 Axis Stimulates VEGF Secretion and Activates Integrins but does not Affect Proliferation and Survival in Lymphohematopoietic Cells
Kijowski, J., Baj‐Krzyworzeka, M., Majka, M., Reca, R., Marquez, L. A., Christofidou‐Solomidou, M., Janowska‐Wieczorek, A., & Ratajczak, M. Z. (2001) · STEM CELLS · doi:10.1634/stemcells.19-5-453 · Cited by 224
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SDF-1 α /CXCR4: A Mechanism for Hepatic Oval Cell Activation and Bone Marrow Stem Cell Recruitment to the Injured Liver of Rats
Hatch, H. M., Zheng, D., Jorgensen, M. L., & Petersen, B. E. (2002) · Cloning and Stem Cells · doi:10.1089/153623002321025014 · Cited by 222
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1
Reca, R., Mastellos, D., Majka, M., Marquez, L., Ratajczak, J., Franchini, S., Glodek, A., Honczarenko, M., Spruce, L. A., Janowska-Wieczorek, A., et al. (2003) · Blood · doi:10.1182/blood-2002-10-3233 · Cited by 220
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β-Arrestin Differentially Regulates the Chemokine Receptor CXCR4-mediated Signaling and Receptor Internalization, and This Implicates Multiple Interaction Sites between β-Arrestin and CXCR4
Cheng, Z.-J., Zhao, J., Sun, Y., Hu, W., Wu, Y.-L., Cen, B., Wu, G.-X., & Pei, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2479 · Cited by 219
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Damås, J. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00142-5 · Cited by 216
Signal Transduction by Cxc Chemokine Receptor 4
Tilton, B., Ho, L., Oberlin, E., Loetscher, P., Baleux, F., Clark-Lewis, I., & Thelen, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.313 · Cited by 215
Leukocyte Elastase Negatively Regulates Stromal Cell-derived Factor-1 (SDF-1)/CXCR4 Binding and Functions by Amino-terminal Processing of SDF-1 and CXCR4
Valenzuela-Fernaéndez, A., Planchenault, T., Baleux, F., Staropoli, I., Le-Barillec, K., Leduc, D., Delaunay, T., Lazarini, F., Virelizier, J.-L., Chignard, M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111388200 · Cited by 210
The Role of Post-translational Modifications of the CXCR4 Amino Terminus in Stromal-derived Factor 1α Association and HIV-1 Entry
Farzan, M., Babcock, G. J., Vasilieva, N., Wright, P. L., Kiprilov, E., Mirzabekov, T., & Choe, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203361200 · Cited by 204
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
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VEGF is a chemoattractant for FGF-2–stimulated neural progenitors
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Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro.
Chen, Y., Stamatoyannopoulos, G., & Song, C.-Z. (2003) · PubMed · Cited by 195
Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy.
Jankowski, K., Kucia, M., Wysoczynski, M., Reca, R., Zhao, D., Trzyna, E., Trent, J. O., Peiper, S. C., Zembala, M., Ratajczak, J., et al. (2003) · PubMed · Cited by 195
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Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues
Corti, S., Locatelli, F., Donadoni, C., Guglieri, M., Papadimitriou, D., Strazzer, S., Del Bo, R., & Comi, G. P. (2004) · Brain · doi:10.1093/brain/awh273 · Cited by 195
Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia
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G Protein-Coupled Chemokine Receptors Induce Both Survival and Apoptotic Signaling Pathways
Vlahakis, S. R., Villasis-Keever, A., Gomez, T., Vanegas, M., Vlahakis, N., & Paya, C. V. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5546 · Cited by 188
Bone marrow as a source of circulating CXCR4+ tissue‐committed stem cells
Kucia, M., Ratajczak, J., & Ratajczak, M. Z. (2005) · Biology of the Cell · doi:10.1042/bc20040069 · Cited by 173
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Janus kinase 2 is involved in stromal cell–derived factor-1α–induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells
Zhang, X.-F., Wang, J.-F., Matczak, E., Proper, J., & Groopman, J. E. (2001) · Blood · doi:10.1182/blood.v97.11.3342 · Cited by 173
Differential MMP and TIMP production by human marrow and peripheral blood CD34+ cells in response to chemokines
Janowska-Wieczorek, A., Marquez, L. A., Dobrowsky, A., Ratajczak, M. Z., & Cabuhat, M. L. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00532-4 · Cited by 173
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Role of the intracellular domains of CXCR4 in SDF-1–mediated signaling
Roland, J., Murphy, B. J., Ahr, B., Robert-Hebmann, V., Delauzun, V., Nye, K. E., Devaux, C., & Biard-Piechaczyk, M. (2003) · Blood · doi:10.1182/blood-2002-03-0978 · Cited by 171
Statin effects on cholesterol micro-domains in brain plasma membranes
Kirsch, C., Eckert, G. P., & Mueller, W. E. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01654-4 · Cited by 167
Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo
Broxmeyer, H. E., Cooper, S., Kohli, L., Hangoc, G., Lee, Y., Mantel, C., Clapp, D. W., & Kim, C. H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.421 · Cited by 165
HIF-1: master and commander of the hypoxic world
Mazure, N. M., Brahimi-Horn, M. C., Berta, M., Benizri, E. I., Bilton, R. L., Dayan, F., Ginouvès, A., Berra, E., & Pouysségur, J. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.04.022 · Cited by 163
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells
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Atypical PKC-ζ regulates SDF-1–mediated migration and development of human CD34+ progenitor cells
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Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis
Majka, M., Janowska‐Wieczorek, A., Ratajczak, J., Kowalska, M. A., Vilaire, G., Pan, Z. K., Honczarenko, M., Marquez‐Curtis, L. A., Poncz, M., & Ratajczak, M. Z. (2000) · Blood · doi:10.1182/blood.v96.13.4142 · Cited by 148
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The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells
Kimura, T., Boehmler, A. M., Seitz, G., Kuçi, S., Wiesner, T., Brinkmann, V., Kanz, L., & Möhle, R. (2004) · Blood · doi:10.1182/blood-2003-03-0875 · Cited by 143
Unique SDF-1–induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling
Spiegel, A., Kollet, Ó., Peled, A., Abel, L., Nagler, A., Bielorai, B., Rechavi, G., Vormoor, J. H., & Lapidot, T. (2003) · Blood · doi:10.1182/blood-2003-06-1891 · Cited by 139
Stromal Cell-Derived Factor-1α Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities
Bartolomé, R. A., Gálvez, B. G., Longo, N., Baleux, F., van Muijen, G. N. P., Sánchez‐Mateos, P., Arroyo, A. G., & Teixidó, J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3398 · Cited by 137
Transplanted human bone marrow contributes to vascular endothelium
Jiang, S., Walker, L., Afentoulis, M. E., Anderson, D. A., Jauron-Mills, L., Corless, C. L., & Fleming, W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404398101 · Cited by 136
Participation of Adult Mouse Bone Marrow Cells in Reconstitution of Skin
Kataoka, K., Medina, R. J., Kageyama, T., Miyazaki, M., Yoshino, T., Makino, T., & Huh, N.-H. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63482-7 · Cited by 133
Thymocyte emigration is mediated by active movement away from stroma-derived factors
Poznansky, M. C., Olszak, I. T., Evans, R. H., Wang, Z., Foxall, R. B., Olson, D. P., Weibrecht, K. W., Luster, A. D., & Scadden, D. T. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13853 · Cited by 123
Natural Alpha Interferon-Producing Cells Respond to Human Immunodeficiency Virus Type 1 with Alpha Interferon Production and Maturation into Dendritic Cells
Yonezawa, A., Morita, R., Takaori‐Kondo, A., Kadowaki, N., Kitawaki, T., Hori, T., & Uchiyama, T. (2003) · Journal of Virology · doi:10.1128/jvi.77.6.3777-3784.2003 · Cited by 122
Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells
Hidalgo, A., Sanz-Rodríguez, F., Rodríguez‐Fernández, J. L., Albella, B., Blaya, C., Wright, N., Cabañas, C., Prósper, F., Gutierrez‐Ramos, J. C., & Teixidó, J. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(00)00668-8 · Cited by 121
Cytokines and Cell Surface Molecules Independently Induce CXCR4 Expression on CD4+ CCR7+ Human Memory T Cells
Jourdan, P., Vendrell, J.-P., Huguet, M., Segondy, M., Bousquet, J. J., Pène, J., & Yssel, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.716 · Cited by 120
The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression
Rosu‐Myles, M., Gallacher, L. M., Murdoch, B., Hess, D. A., Keeney, M., Kelvin, D. J., Dale, L., Ferguson, S. S. G., Wu, D., Fellows, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14626 · Cited by 119
The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion–mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase
Schmidmaier, R., Baumann, P., Şimşek, M., Dayyani, F., Emmerich, B., & Meinhardt, G. (2004) · Blood · doi:10.1182/blood-2003-12-4218 · Cited by 119
L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration
Ding, Z., Issekutz, T. B., Downey, G. P., & Waddell, T. K. (2003) · Blood · doi:10.1182/blood-2002-06-1782 · Cited by 103
Chemokines and their receptors in the CNS: expression of CXCL12/SDF-1 and CXCR4 and their role in astrocyte proliferation
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CXCR4-mediated adhesion and MMP-9 secretion in head and neck squamous cell carcinoma
Samara, G. J., Lawrence, D. M., Chiarelli, C., Valentino, M. D., Lyubsky, S. L., Zucker, S., & Vaday, G. G. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.04.035 · Cited by 102
Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells
Ratajczak, M. Z., Reca, R., Wysoczynski, M., Kucia, M., Baran, J., Allendorf, D. J., Ratajczak, J., & Ross, G. D. (2004) · Leukemia · doi:10.1038/sj.leu.2403446 · Cited by 99
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Stem cell factor is a chemoattractant and a survival factor for CNS stem cells
Erlandsson, A., Larsson, J., & Forsberg‐Nilsson, K. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.08.009 · Cited by 98
Transforming growth factor-β1 down-regulates expression of chemokine stromal cell–derived factor-1: functional consequences in cell migration and adhesion
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Chemokine receptors in human basophils: inducible expression of functional CXCR4
Iikura, M., Miyamasu, M., Yamaguchi, M., et al. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.1.113 · Cited by 96
A Novel Role for Vascular Endothelial Growth Factor as an Autocrine Survival Factor for Embryonic Stem Cells during Hypoxia
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Differential Regulation of CXCR4-mediated T-cell Chemotaxis and Mitogen-activated Protein Kinase Activation by the Membrane Tyrosine Phosphatase, CD45
Fernandis, A. Z., Cherla, R. P., & Ganju, R. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211803200 · Cited by 95
CXCR4 Activation Induces Epidermal Growth Factor Receptor Transactivation in an Ovarian Cancer Cell Line
Porcile, C., Bajetto, A., Barbero, S., PIRANI, P., & Schettini, G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.021 · Cited by 92
SHP2 and cbl participate in α-chemokine receptor CXCR4–mediated signaling pathways
Chernock, R. D., Cherla, R. P., & Ganju, R. K. (2001) · Blood · doi:10.1182/blood.v97.3.608 · Cited by 90
Bone Marrow as a Source of Endothelial Cells for Natural and Iatrogenic Vascular Repair
Isner, J. M., Kalka, C., Kawamoto, A., & Asahara, T. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb02075.x · Cited by 90
LIF receptor signaling modulates neural stem cell renewal
Pitman, M. C., Emery, B., Binder, M. D., Wang, S., Butzkueven, H., & Kilpatrick, T. J. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.07.004 · Cited by 87
Heterogeneous populations of bone marrow stem cells--are we spotting on the same cells from the different angles?
Ratajczak, M. Z., Kucia, M., Majka, M., Reca, R., & Ratajczak, J. (2004) · PubMed · doi:10.5603/4649 · Cited by 86
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CXCR4 Receptor Expression on Human Retinal Pigment Epithelial Cells from the Blood-Retina Barrier Leads to Chemokine Secretion and Migration in Response to Stromal Cell-Derived Factor 1α
Crane, I. J., Wallace, C. A., McKillop‐Smith, S., & Forrester, J. V. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4372 · Cited by 80
Stromal cell‐derived factor 1α (SDF‐1α) induces gene‐expression of early growth response‐1 (Egr‐1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation
Neuhaus, T., Stier, S., Totzke, G., Grünewald, E., Fronhoffs, S., Sachinidis, A., Vetter, H., & Ko, Y. D. (2003) · Cell Proliferation · doi:10.1046/j.1365-2184.2003.00262.x · Cited by 79
TGF-β1 enhances SDF-1α-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules
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Binding of stromal derived factor‐1α(SDF‐1α) to CXCR4 chemokine receptorin normal human megakaryoblasts butnot in platelets induces phosphorylationof mitogen‐activated protein kinase p42/44 (MAPK), ELK‐1 transcription factor and serine/threonine kinase AKT
Majka, M., Ratajczak, J., Kowalska, M. A., & Ratajczak, M. Z. (2000) · European Journal Of Haematology · doi:10.1034/j.1600-0609.2000.90112.x · Cited by 77
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Distinct Role of ZAP-70 and Src Homology 2 Domain-Containing Leukocyte Protein of 76 kDa in the Prolonged Activation of Extracellular Signal-Regulated Protein Kinase by the Stromal Cell-Derived Factor-1α/CXCL12 Chemokine
Kremer, K. N., Humphreys, T. D., Kumar, A., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.360 · Cited by 72
Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression
Tomescu, O. A., Xia, S. J., Strezlecki, D., Bennicelli, J. L., Ginsberg, J. P., Pawel, B., & Barr, F. G. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700125 · Cited by 70
CCR5-binding chemokines modulate CXCL12 (SDF-1)–induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor
Honczarenko, M., Le, Y., Glodek, A. M., Majka, M., Campbell, J. J., Ratajczak, M. Z., & Silberstein, L. E. (2002) · Blood · doi:10.1182/blood-2002-01-0248 · Cited by 70
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Stromal cell–derived factor-1α/CXCL12–induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1
Okabe, S., Fukuda, S., Kim, Y., Niki, M., Pelus, L. M., Ohyashiki, K., Pandolfi, P. P., & Broxmeyer, H. E. (2004) · Blood · doi:10.1182/blood-2004-03-0843 · Cited by 69
Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity.
Pituch‐Noworolska, A., Majka, M., Janowska‐Wieczorek, A., Baj‐Krzyworzeka, M., Urbanowicz, B., Malec, E. J., & Ratajczak, M. Z. (2003) · PubMed · Cited by 68
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Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells
Han, K. H., Hong, K. H., Ko, J., Rhee, K. S., Hong, M., Kim, J., Kim, Y. H., & Park, S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103563 · Cited by 53
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Fang, B., Shi, M., Liao, L., Yang, S., Liu, Y., & Zhao, R. C. (2003) · Stem Cells and Development · doi:10.1089/15258160360732632 · Cited by 50
Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization
Velders, G. A., van Os, R. P., Hagoort, H., Verzaal, P., Guiot, H. F. L., Lindley, I. J. D., Willemze, R., Opdenakker, G., & Fibbe, W. E. (2003) · Blood · doi:10.1182/blood-2002-07-2270 · Cited by 49
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See all 759

Authors: Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska‐Wieczorek, A., Ratajczak, J., & Ratajczak, M. Z.
Venue: STEM CELLS
Publisher: Oxford University Press (OUP)
Published: 2005-08
Volume: 23
Issue: 7
Pages: 879-894
ISSN: 1066-5099 (ISSN-L)
1549-4918
DOI: 10.1634/stemcells.2004-0342
OpenAlex: W2058554403
Cited by: 759
References: 160
FWCI: 23.46
Type: journal article
Language: en
Open access: closed

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Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis

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