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Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal.

Yousef, Hanadie, Conboy, Michael J., Morgenthaler, Adam, Schlesinger, Christina, Bugaj, Lukasz, Paliwal, Preeti, Greer, Christopher, Conboy, Irina M., Schaffer, David·2015·Oncotarget
DOI 10.18632/oncotarget.3851PMC PMC4494916
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Crossref · 10.18632/oncotarget.3851

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  • YY mice had ~10-fold higher numbers of Ki67+ SGZ cells than old mice.

    “YY mice had ~10-fold higher numbers of Ki67+ SGZ cells than old, as expected [9, 15, 26]”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [15]

    The Results section ('TGF-β1/pSmad signaling increases in aged neural and muscle stem cell niches'; page unavailable) reports that proliferating hippocampal neural stem and progenitor cells decline with age. It measures Sox2+BrdU+ cells, however, and does not report a YY-mouse comparison, Ki67+ SGZ cell counts, or a roughly tenfold difference. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Mouse primary myoblasts can be used for determining the effects of proteins secreted by human cells on myogenic cell proliferation and differentiation.

    “We previously established that mouse primary myoblasts can be used for determining the effects of the proteins that are secreted by human cells on myogenic cell proliferation and differentiation [15, 19, 20].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [15]

    The Experimental Procedures (Cell culture; page not available) describe isolating and culturing primary mouse myoblasts, and the Results (Rejuvenation of myogenesis and neurogenesis by genetic attenuation of TGF-β signaling; page not available) measure proliferation of mouse myogenic precursors. These passages do not establish their use to test proteins secreted by human cells or effects on myogenic differentiation. (LLM, conf=0.81)

    Experimental — accuracy not yet measured

  • The increase in hippocampal neurogenesis after NBE was larger than observed after heterochronic parabiosis or through defined pharmacology of modulating TGF-beta and oxytocin pathways.

    “This increase was larger than what was observed after heterochronic parabiosis or through defined pharmacology of modulating the TGF-beta and oxytocin pathways [15].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [15]

    The Results section ('Simultaneous systemic enhancement of hippocampal neurogenesis and myogenesis in old mice'; page unavailable) reports a two-fold increase in proliferating hippocampal neural stem and progenitor cells after TGF-β pathway inhibition. It does not establish that the increase after NBE was larger, or provide comparable hippocampal neurogenesis results for heterochronic parabiosis or oxytocin-pathway modulation. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Attenuation of TGF-beta signaling in old animals has effects similar to those of NBE.

    “and the fact that attenuation of TGF-beta signaling in old animals has effects that are similar to those of NBE [7, 14, 15, 28, 44].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [15]

    The Introduction (page not available) reports that attenuating TGF-β signaling in old animals rejuvenated hippocampal neurogenesis and skeletal myogenesis. Our copy does not compare those effects with NBE, so it supports the reported effects but not the asserted similarity. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • YY muscles regenerated much better than OO.

    “YY muscles regenerated much better than OO, as expected [1, 9, 14, 15].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [15]

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Research works printed but not linked: 57

  1. Rando, 2012, Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches, Cell cycle (Georgetown, Tex), 11, 2260, 10.4161/cc.20437 · DOI · Paper page
  2. Gilliland, 2008, Aging and stem cell renewal, StemBook: The Stem Cell Research Community
  3. Bartlett, 2012, Microglia modulate hippocampal neural precursor activity in response to exercise and aging, J Neurosci, 32, 6435, 10.1523/JNEUROSCI.5925-11.2012 · DOI · Paper page
  4. Conboy, 2009, Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses, Aging cell, 8, 676, 10.1111/j.1474-9726.2009.00517.x · DOI · Paper page
  5. Gage, 2009, Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain, J Neurosci, 29, 13532, 10.1523/JNEUROSCI.3362-09.2009 · DOI · Paper page
  6. Peretto, 2009, Integration and sensory experience-dependent survival of newly-generated neurons in the accessory olfactory bulb of female mice, The European journal of neuroscience, 29, 679, 10.1111/j.1460-9568.2009.06614.x · DOI
  7. Pruitt, 2004, Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice, J Neurosci, 24, 1726, 10.1523/JNEUROSCI.4608-03.2004 · DOI
  8. Cameron, 2007, Decreased neurogenesis in aged rats results from loss of granule cell precursors without lengthening of the cell cycle, The Journal of comparative neurology, 501, 659, 10.1002/cne.21268 · DOI
  9. Redecker, 2011, Age-related effects on hippocampal precursor cell subpopulations and neurogenesis, Neurobiology of aging, 32, 1906, 10.1016/j.neurobiolaging.2009.11.011 · DOI
  10. Gage, 1998, Neurogenesis in the adult human hippocampus, Nature medicine, 4, 1313, 10.1038/3305 · DOI · Paper page
  11. Frisen, 2013, Dynamics of hippocampal neurogenesis in adult humans, Cell, 153, 1219, 10.1016/j.cell.2013.05.002 · DOI · Paper page
  12. Frisen, 2012, The age of olfactory bulb neurons in humans, Neuron, 74, 634, 10.1016/j.neuron.2012.03.030 · DOI
  13. Rando, 2002, The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis, DevCell, 3, 397
  14. Walston, 2012, Sarcopenia in older adults, Current opinion in rheumatology, 24, 623, 10.1097/BOR.0b013e328358d59b · DOI
  15. Levin, 1998, Plasma oxytocin levels in autistic children, Biological psychiatry, 43, 270, 10.1016/S0006-3223(97)00439-3 · DOI · Paper page
  16. Persico, 2014, Biomarkers in autism spectrum disorder: the old and the new, Psychopharmacology, 231, 1201, 10.1007/s00213-013-3290-7 · DOI
  17. Buckwalter, 2010, TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke, Journal of neuroinflammation, 7, 62, 10.1186/1742-2094-7-62 · DOI
  18. Boxhorn, 1989, Regulation of skeletal muscle satellite cell proliferation and differentiation by transforming growth factor-beta, insulin-like growth factor I, and fibroblast growth factor, Journal of cellular physiology, 138, 311, 10.1002/jcp.1041380213 · DOI
  19. Wyss-Coray, 2006, Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal neurogenesis in aged mice, Am J Pathol, 169, 154, 10.2353/ajpath.2006.051272 · DOI · Paper page
  20. Conboy, 2009, Molecular aging and rejuvenation of human muscle stem cells, EMBO molecular medicine, 1, 381, 10.1002/emmm.200900045 · DOI · Paper page
  21. Wang, 2012, The pro-inflammatory role of TGFbeta1: a paradox?, International journal of biological sciences, 8, 228, 10.7150/ijbs.8.228 · DOI
  22. Raivich, 2004, Microglial major histocompatibility complex glycoprotein-1 in the axotomized facial motor nucleus: regulation and role of tumor necrosis factor receptors 1 and 2, The Journal of comparative neurology, 470, 382, 10.1002/cne.20017 · DOI
  23. DeLa Cadena, 2010, The axis of thrombospondin-1, transforming growth factor beta and connective tissue growth factor: an emerging therapeutic target in rheumatoid arthritis, Current vascular pharmacology, 8, 338, 10.2174/157016110791112296 · DOI
  24. Flavell, 2009, Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity, Current opinion in pharmacology, 9, 447, 10.1016/j.coph.2009.04.008 · DOI
  25. Tan, 2013, Vascular fibrosis in atherosclerosis, Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology, 22, 401, 10.1016/j.carpath.2013.01.003 · DOI
  26. Conboy, 2008, Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells, Nature, 454, 528, 10.1038/nature07034 · DOI
  27. Inman, 2011, Switching TGFbeta from a tumor suppressor to a tumor promoter, Current opinion in genetics & development, 21, 93, 10.1016/j.gde.2010.12.004 · DOI
  28. Kang, 1999, TGF-beta-induced cell-cycle arrest through the p21(WAF1/CIP1)-G1 cyclin/Cdks-p130 pathway in gastric-carcinoma cells, International journal of cancer Journal international du cancer, 83, 512, 10.1002/(SICI)1097-0215(19991112)83:4<512::AID-IJC13>3.0.CO;2-Z · DOI
  29. Wyss-Coray, 2014, ALK5-dependent TGF-beta signaling is a major determinant of late-stage adult neurogenesis, Nature neuroscience, 17, 943, 10.1038/nn.3732 · DOI
  30. Friedman, 2012, Blood-brain barrier dysfunction, TGFbeta signaling, and astrocyte dysfunction in epilepsy, Glia, 60, 1251, 10.1002/glia.22311 · DOI
  31. Harry, 2013, Microglia during development and aging, Pharmacology & therapeutics, 139, 313, 10.1016/j.pharmthera.2013.04.013 · DOI · Paper page
  32. Mouthon, 2013, [TGFbeta, a troublemaker in the adult neural stem cell niche], Medecine sciences: M/S, 29, 572
  33. Radhakrishnan, 2005, Lost in transcription: p21 repression, mechanisms, and consequences, Cancer research, 65, 3980, 10.1158/0008-5472.CAN-04-3995 · DOI
  34. Conboy, 2013, Pharmacological inhibition of myostatin/TGF-beta receptor/pSmad3 signaling rescues muscle regenerative responses in mouse model of type 1 diabetes, Acta pharmacologica Sinica, 34, 1052, 10.1038/aps.2013.67 · DOI
  35. Kaspar, 2012, Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling, Aging cell, 11, 542, 10.1111/j.1474-9726.2012.00816.x · DOI
  36. Song, 2005, Adult neurogenesis in the mammalian central nervous system, Annual review of neuroscience, 28, 223, 10.1146/annurev.neuro.28.051804.101459 · DOI
  37. Rando, 2005, Cell cycle, 4, 407
  38. Arteaga, 2003, A kinase-inactive type II TGFbeta receptor impairs BMP signaling in human breast cancer cells, Biochem Biophys Res Commun, 301, 108, 10.1016/S0006-291X(02)02977-7 · DOI
  39. Hanisch, 2013, Proteins in microglial activation—inputs and outputs by subsets, Current protein & peptide science, 14, 3, 10.2174/1389203711314010003 · DOI
  40. Knight, 2013, Genomic modulators of the immune response, Trends in genetics: TIG, 29, 74, 10.1016/j.tig.2012.10.006 · DOI
  41. van den Elsen, 2011, Expression regulation of major histocompatibility complex class I and class II encoding genes, Frontiers in immunology, 2, 48, 10.3389/fimmu.2011.00048 · DOI
  42. Solheim, 1999, Class I MHC molecules: assembly and antigen presentation, Immunological reviews, 172, 11, 10.1111/j.1600-065X.1999.tb01352.x · DOI
  43. Momburg, 1993, Cell biology of antigen presentation, Current opinion in immunology, 5, 27, 10.1016/0952-7915(93)90077-6 · DOI
  44. Euller-Ziegler, 2011, Oxytocin and bone remodelling: relationships with neuropituitary hormones, bone status and body composition, Joint, bone, spine: revue du rhumatisme, 78, 611, 10.1016/j.jbspin.2011.02.002 · DOI
  45. Soloff, 1998, ERK2 mediates oxytocin-stimulated PGE2 synthesis, The American journal of physiology, 274, E634
  46. Kuwabara, 2011, Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis, FASEB J, 25, 3570, 10.1096/fj.11-184697 · DOI
  47. Martin-Villalba, 2013, Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline, Cell stem cell, 12, 204, 10.1016/j.stem.2012.11.010 · DOI
  48. Newman, 2011, Inflammatory markers in population studies of aging, Ageing research reviews, 10, 319, 10.1016/j.arr.2010.11.002 · DOI
  49. Blander, 2010, T helper 17 cells: discovery, function, and physiological trigger, Cellular and molecular life sciences: CMLS, 67, 1407, 10.1007/s00018-009-0248-3 · DOI
  50. Amri, 2008, Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis, Stem cells (Dayton, Ohio), 26, 2399, 10.1634/stemcells.2008-0127 · DOI · Paper page
  51. Schaffer, 2012, Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling, Nature neuroscience, 15, 1399, 10.1038/nn.3212 · DOI
  52. Kempermann, 2011, A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus, Frontiers in neuroscience, 5, 89
  53. Conboy, 2010, Preparation of adult muscle fiber-associated stem/precursor cells, Methods in molecular biology (Clifton, NJ), 621, 149, 10.1007/978-1-60761-063-2_10 · DOI
  54. Schmittgen, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method, Methods, 25, 402, 10.1006/meth.2001.1262 · DOI · Paper page
  55. Schaffer, 2010, Viral packaging and transduction of adult hippocampal neural progenitors, Methods in molecular biology (Clifton, NJ), 621, 103, 10.1007/978-1-60761-063-2_7 · DOI
  56. Schaffer, 2006, High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells, J Virol, 80, 8981, 10.1128/JVI.00615-06 · DOI
  57. Conboy, 2010, Immuno-analysis and FACS sorting of adult muscle fiber-associated stem/precursor cells, Methods in molecular biology (Clifton, NJ), 621, 165, 10.1007/978-1-60761-063-2_11 · DOI

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Metadata

Authors
Yousef, H., Conboy, M. J., Morgenthaler, A., Schlesinger, C., Bugaj, L., Paliwal, P., Greer, C., Conboy, I. M., & Schaffer, D.
Affiliations
  • Department of Molecular and Cellular Biology, UC Berkeley, Berkeley, CA, USA
  • Department of Bioengineering and California Institute for Quantitative Biosciences (QB3), UC Berkeley, Berkeley, CA, USA
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2015-05-06
Volume
6
Issue
14
Pages
11959-11978
ISSN
1949-2553
DOI
10.18632/oncotarget.3851
PMC
PMC4494916
Cited by
113
References
12
Language
en

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