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Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews

Gào, Xīn, Schöttker, Ben·2017·Oncotarget
DOI 10.18632/oncotarget.17128PMC PMC5584299
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Figure 1 Flow chart of the systematic literature search
Figure 1 Flow chart of the systematic literature searchCC BY · PubMed Central
Figure 2 Intracellular ROS/RNS sources Abbreviations: ER, endoplasmic reticulum; ETC, Electronic transport chain; LCFAs, Long-chain fatty acids, ROS Reactive Oxygen Species.
Figure 2 Intracellular ROS/RNS sources Abbreviations: ER, endoplasmic reticulum; ETC, Electronic transport chain; LCFAs, Long-chain fatty acids, ROS Reactive Oxygen Species.CC BY · PubMed Central
Figure 3 Oxidative stress-stimulated MAPK signalling pathways Abbreviations: ASK1, Apoptosis signal-regulating kinase 1; BMK1, Big mitogen-activated protein kinase 1; ERK1/2, Extracellular signal-regulated kinase 1/2; ERK5, Extracellular signal-regulated kinase 5; JNK, c-Jun N-terminal kinases; MAPK, Mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPK kinase kinase; MEK1, MAPK/ERK kinase 1; MEK2, MAPK/ERK kinase 2; MEKK1, MAPK/ERK kinase kinase 1; MEKK2, MAPK/ERK kinase kinase 2; MEKK3, MAPK/ERK kinase kinase 3; MKK3/6, MAPK kinase 3/6; MKK4/7, MAPK kinase 4/7; MLK3, mixed-lineage protein kinase 3; p38, P38 mitogen-activated protein kinase.
Figure 3 Oxidative stress-stimulated MAPK signalling pathways Abbreviations: ASK1, Apoptosis signal-regulating kinase 1; BMK1, Big mitogen-activated protein kinase 1; ERK1/2, Extracellular signal-regulated kinase 1/2; ERK5, Extracellular signal-regulated kinase 5; JNK, c-Jun N-terminal kinases; MAPK, Mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPK kinase kinase; MEK1, MAPK/ERK kinase 1; MEK2, MAPK/ERK kinase 2; MEKK1, MAPK/ERK kinase kinase 1; MEKK2, MAPK/ERK kinase kinase 2; MEKK3, MAPK/ERK kinase kinase 3; MKK3/6, MAPK kinase 3/6; MKK4/7, MAPK kinase 4/7; MLK3, mixed-lineage protein kinase 3; p38, P38 mitogen-activated protein kinase.CC BY · PubMed Central
Figure 4 Schematic of the PI3K/AKT signalling pathway Abbreviations: AKT, also known as protein kinase B, PKB; FOXO, Forkhead Box O; MMP, Matrix metalloproteinase; mTORC, mammalian Target of Rapamycin Complex; NOX, NADPH Oxidase; PDK1: Phosphoinositide-Dependent Kinase-1; PIP2, Phosphatidylinositol 4,5-bisphosphate; PIP3, Phosphatidylinositol-3,4,5-trisphosphate; PTEN, Phosphatase and tensin homolog; ROS, Reactive Oxygen Species; VEGF, Vascular Endothelial Growth Factor.
Figure 4 Schematic of the PI3K/AKT signalling pathway Abbreviations: AKT, also known as protein kinase B, PKB; FOXO, Forkhead Box O; MMP, Matrix metalloproteinase; mTORC, mammalian Target of Rapamycin Complex; NOX, NADPH Oxidase; PDK1: Phosphoinositide-Dependent Kinase-1; PIP2, Phosphatidylinositol 4,5-bisphosphate; PIP3, Phosphatidylinositol-3,4,5-trisphosphate; PTEN, Phosphatase and tensin homolog; ROS, Reactive Oxygen Species; VEGF, Vascular Endothelial Growth Factor.CC BY · PubMed Central
Figure 5 Schematic of the Keap1-Nrf2-ARE pathway Abbreviations: AKT, also known as protein kinase B, PKB; FOXO, Forkhead Box O; MMP, Matrix metalloproteinase; mTORC, mammalian Target of Rapamycin Complex; NOX, NADPH Oxidase; PDK1: Phosphoinositide-Dependent Kinase-1; PIP2, Phosphatidylinositol 4,5-bisphosphate; PIP3, Phosphatidylinositol-3,4,5-trisphosphate; PTEN, Phosphatase and tensin homolog; ROS, Reactive Oxygen Species; VEGF, Vascular Endothelial Growth Factor.
Figure 5 Schematic of the Keap1-Nrf2-ARE pathway Abbreviations: AKT, also known as protein kinase B, PKB; FOXO, Forkhead Box O; MMP, Matrix metalloproteinase; mTORC, mammalian Target of Rapamycin Complex; NOX, NADPH Oxidase; PDK1: Phosphoinositide-Dependent Kinase-1; PIP2, Phosphatidylinositol 4,5-bisphosphate; PIP3, Phosphatidylinositol-3,4,5-trisphosphate; PTEN, Phosphatase and tensin homolog; ROS, Reactive Oxygen Species; VEGF, Vascular Endothelial Growth Factor.CC BY · PubMed Central
Figure 6 Functions of APE1/Ref-1 Abbreviations: AP-1, Activator protein 1; APE1, Apurinic/apyrimidinic endonuclease; Ref-1, Redox effector factor-1; Egr-1, Early growth response protein 1; Myb, Transcriptional activator Myb; NF-κB, Nuclear factor-κB; PAX, Paired box; P53, Tumor protein p53.
Figure 6 Functions of APE1/Ref-1 Abbreviations: AP-1, Activator protein 1; APE1, Apurinic/apyrimidinic endonuclease; Ref-1, Redox effector factor-1; Egr-1, Early growth response protein 1; Myb, Transcriptional activator Myb; NF-κB, Nuclear factor-κB; PAX, Paired box; P53, Tumor protein p53.CC BY · PubMed Central

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Metadata

Authors
Gào, X., & Schöttker, B.
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2017-04-16
Volume
8
Issue
31
Pages
51888-51906
ISSN
1949-2553
DOI
10.18632/oncotarget.17128
PMC
PMC5584299
Cited by
147
References
9
Language
en

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