Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome
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The last ten years' wide progress in the gut microbiota phylogenetic and functional characterization has been made evidencing dysbiosis in several gastrointestinal diseases including inflammatory bowel diseases and irritable bowel syndrome (IBS). IBS is a functional gut disease with high prevalence and negative impact on patient's quality of life characterized mainly by visceral pain and/or discomfort, representing a good paradigm of chronic gut hypersensitivity. The IBS features are strongly regulated by bidirectional gut-brain interactions and there is increasing evidence for the involvement of gut bacteria and/or their metabolites in these features, including visceral pain. Further, gut microbiota modulation by antibiotics or probiotics has been promising in IBS. Mechanistic data provided mainly by animal studies highlight that commensals or probiotics may exert a direct action through bacterial metabolites on sensitive nerve endings in the gut mucosa, or indirect pathways targeting the intestinal epithelial barrier, the mucosal and/or systemic immune activation, and subsequent neuronal sensitization and/or activation.
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Gut microbiota may directly modulate several systems involved in visceral hypersensitivity.
“Recent data have shown that gut microbiota may directly modulate several systems involved in visceral hypersensitivity.”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [117]
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Can probiotics modulate human disease by impacting intestinal barrier function?
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The progress of gut microbiome research related to brain disorders
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Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works
Altered microbiome composition in individuals with fibromyalgia
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Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms
Felice, V. D., Quigley, E. M., Sullivan, A. M., O'Keeffe, G. W., & O'Mahony, S. M. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.03.012 · Cited by 205 · see citing works
The effect of gut microbiome on tolerance to morphine mediated antinociception in mice
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- Authors
- Theodorou, V., Ait-Belgnaoui, A., Agostini, S., & Eutamene, H.
- Affiliations
- Ecole d'Ingénieurs de PURPAN (FR)
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2014-05
- Volume
- 5
- Issue
- 3
- Pages
- 430-629
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4153783
- OpenAlex
- W2077113985
- Cited by
- 83
- References
- 85
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 3 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 15 · 2016: 5 · 2015: 7
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- irritable bowel syndrome, gut microbiota, commensal bacteria, probiotics, visceral pain, visceral hypersensitivity, gut-brain axis, dysbiosis, bacterial metabolites, intestinal epithelial barrier, immune activation, neuronal sensitization
- MeSH terms
- Animals, Disease Models, Animal, Humans, Pain, Symbiosis, Probiotics, Irritable Bowel Syndrome, Microbiota
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