Cited by 1,551Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

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Alzheimer's disease: Targeting the Cholinergic System

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H. Ferreira-Vieira, Talita, M. Guimaraes, Isabella, R. Silva, Flavia, M. Ribeiro, Fabiola·2016·Current Neuropharmacology

DOI 10.2174/1570159x13666150716165726PMC PMC4787279

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Abstract

Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter (VAChT) uptakes the neurotransmitter into synaptic vesicles. Following depolarization, ACh undergoes exocytosis reaching the synaptic cleft, where it can bind its receptors, including muscarinic and nicotinic receptors. ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Cholinergic neurons located in the basal forebrain, including the neurons that form the nucleus basalis of Meynert, are severely lost in Alzheimer's disease (AD). AD is the most ordinary cause of dementia affecting 25 million people worldwide. The hallmarks of the disease are the accumulation of neurofibrillary tangles and amyloid plaques. However, there is no real correlation between levels of cortical plaques and AD-related cognitive impairment. Nevertheless, synaptic loss is the principal correlate of disease progression and loss of cholinergic neurons contributes to memory and attention deficits. Thus, drugs that act on the cholinergic system represent a promising option to treat AD patients.

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Fig. (1) Schematic representation of biological aspects involving acetylcholine neurotransmission. Acetylcholine (ACh) is synthesized in the cytosol of cholinergic presynaptic neurons from choline and acetyl-coenzyme A (acetyl-CoA) by the enzyme choline acetyltransferase (ChAT) and is then transferred into synaptic vesicles by the vesicular acetylcholine transporter (VAChT). Depolarization of the presynaptic neuron promotes ACh exocytosis from synaptic vesicles into the synaptic cleft, where it can bind nicotinic or muscarinic receptors, leading to either a stimulatory or an inhibitory response. In the synaptic cleft, ACh is rapidly hydrolyzed by the enzyme acetylcholinesterase (AChE), releasing acetate and choline, which is reuptaken into the presynaptic cholinergic neuron by the high-affinity choline transporter (CHT1).CC BY-NC · PubMed Central

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329
Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962
Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study
Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2007) · Neuroepidemiology · doi:10.1159/000109998 · Cited by 1,932
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., & DeLong, M. R. (1981) · Annals of Neurology · doi:10.1002/ana.410100203 · Cited by 1,736
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,506
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.
Kosik, K. S., Joachim, C. L., & Selkoe, D. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4044 · Cited by 1,491
International Union of Pharmacology. XVII. Classification of Muscarinic Acetylcholine Receptors
Caulfield, M. P., & Birdsall, N. J. M. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01362-0 · Cited by 1,474
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
Acetylcholinesterase — new roles for an old actor
Soreq, H., & Seidman, S. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067589 · Cited by 1,437
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431
Identification of a Family of Muscarinic Acetylcholine Receptor Genes
Bonner, T. I., Buckley, N. J., Young, A. C., & Brann, M. R. (1987) · Science · doi:10.1126/science.3037705 · Cited by 1,423
Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348
Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000159740.16984.3c · Cited by 1,329
NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES
Bowen, D. M., Smith, C. B., White, P., & DAVISON, A. N. (1976) · Brain · doi:10.1093/brain/99.3.459 · Cited by 1,313
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308
Pirenzepine distinguishes between different subclasses of muscarinic receptors
Hammer, R., Berrie, C. P., Birdsall, N. J. M., Burgen, A. S. V., & Hulme, E. C. (1980) · Nature · doi:10.1038/283090a0 · Cited by 1,273
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261
Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups
Hobson, J. A., McCarley, R. W., & Wyzinski, P. (1975) · Science · doi:10.1126/science.1094539 · Cited by 1,238
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski, M. H., Thal, L., Pay, M., Salmon, D. P., U, H. S., Bakay, R., Patel, P., Blesch, A., Vahlsing, H. L., Ho, G., et al. (2005) · Nature Medicine · doi:10.1038/nm1239 · Cited by 1,050
Voltage-clamp analysis of muscarinic excitation in hippocampal neurons
Halliwell, J. V., & Adams, P. R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90954-4 · Cited by 1,046
Classification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
Fischer, W., Wictorin, K., Björklund, A., Williams, L., Varon, S. S., & Gage, F. H. (1987) · Nature · doi:10.1038/329065a0 · Cited by 1,024
Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase
Armstrong, D. M., Saper, C. B., Levey, A. I., Wainer, B. H., & Terry, R. D. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902160106 · Cited by 970
The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat
Kimura, H., McGeer, P. L., Peng, J. H., & McGeer, E. G. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902000202 · Cited by 966
Cholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947
Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies
Levey, A. I., Kitt, C. A., Wf, S., Price, D., & Brann, M. R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03218.1991 · Cited by 920
Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors
Nitsch, R. M., Slack, B. E., Wurtman, R. J., & Growdon, J. H. (1992) · Science · doi:10.1126/science.1411529 · Cited by 898
Efferent connections and nigral afferents of the nucleus accumbens septi in the rat
Nauta, W. J. H., Smith, G. P., Faull, R. L. M., & Domesick, V. B. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90041-6 · Cited by 876
On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis
Bartus, R. T. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7397 · Cited by 829
Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease
Arendt, T., Bigl, V., Arendt, A., & Tennstedt, A. (1983) · Acta Neuropathologica · doi:10.1007/bf00697388 · Cited by 817
Donepezil and memantine for moderate-to-severe Alzheimer's disease
Howard, R., McShane, R., Lindesay, J., Ritchie, C., Baldwin, A., Barber, R., Burns, A., Dening, T., Findlay, D., Holmes, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1106668 · Cited by 782
Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline
Raina, P., Santaguida, P., Ismaila, A., Patterson, C., Cowan, D., Levine, M., Booker, L., & Oremus, M. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-5-200803040-00009 · Cited by 771
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)
Wood, J. G., Mirra, S. S., Pollock, N. J., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4040 · Cited by 763
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Role, L. W., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80134-8 · Cited by 762
Organization and morphological characteristics of cholonergic neurons: an immunocytochemical study with a monoclonal antibody to choline acetyltransferase
Houser, C. R., Crawford, G. D., Barber, R. P., Salvaterra, P. M., & Vaughn, J. E. (1983) · Brain Research · doi:10.1016/0006-8993(83)91312-4 · Cited by 748
The mechanism of excitation by acetylcholine in the cerebral cortex
Krnjević, K., Pumain, R., & Renaud, L. P. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009467 · Cited by 708
Current issues in organophosphate toxicology
Costa, L. G. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.10.008 · Cited by 700
Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease
Bodick, N. C., Offen, W., Levey, A. I., Cutler, N. R., Gauthier, S. G., Satlin, A., Shannon, H. E., Tollefson, G. D., Rasmussen, K., Bymaster, F. P., et al. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550160091022 · Cited by 697
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 675
Cognitive functions of cortical acetylcholine: toward a unifying hypothesis
Sarter, M. F., & Bruno, J. P. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00009-4 · Cited by 675
Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline
Waldemar, G., Dubois, B., Emre, M., Georges, J., McKeith, I. G., Rossor, M. N., Scheltens, P., Tariska, P., & Winblad, B. G. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01605.x · Cited by 634
Choline, an essential nutrient for humans
Zeisel, S. H., da Costa, K.-A., Franklin, P. D., ALEXANDER, E. A., LaMont, J. T., Sheard, N. F., & Beiser, A. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.7.2010061 · Cited by 623
Cellular bases of neocortical activation: modulation of neural oscillations by the nucleus basalis and endogenous acetylcholine
Metherate, R., Cox, C. L., & Ashe, J. H. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04701.1992 · Cited by 575
Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Anatomy and Terminology
Hamani, C., Aziz, T. Z., Bloem, B. R., Brown, P., Chabardès, S., Coyne, T. J., Foote, K. D., García‐Rill, E., Hirsch, É. C., Lozano, A. M., et al. (2016) · Stereotactic and Functional Neurosurgery · doi:10.1159/000449010 · Cited by 571
Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.
Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas‐Kramarski, R., JAFFE, E. A., Gandy, S., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10075 · Cited by 563
Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease
SZE, C.-I., TRONCOSO, J. C., KAWAS, C., MOUTION, P., PRICE, D. L., & MARTIN, L. J. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199708000-00011 · Cited by 562 · cited 1×
“In fact, the memory deficit and neuropathology severity observed in patients exhibiting AD highly correlate with changes in hippocampal synaptic transmission, especially with changes in synaptophysin expression, a presynaptic vesicle protein [220-222].”
Background
Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors
Luetje, C., & Patrick, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00837.1991 · Cited by 558
ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION
Birks, R. I., & MacIntosh, F. C. (1961) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o61-081 · Cited by 555
Alzheimer's disease
Wilcock, G. K., Esiri, M. M., Bowen, D. M., & Smith, C. C. T. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90045-4 · Cited by 553
The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease
Schliebs, R., & Arendt, T. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0579-2 · Cited by 548
Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum
Rye, D. B., Saper, C. B., Lee, H. J., & Wainer, B. H. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902590403 · Cited by 545
Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
Nisell, M., Nomikos, G. G., & Svensson, T. H. (1994) · Synapse · doi:10.1002/syn.890160105 · Cited by 521
Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents]
Voytko, M., Olton, D., Richardson, R., Gorman, L. K., Tobin, J., & Price, D. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00167.1994 · Cited by 520
Muscarinic acetylcholine receptors: signal transduction through multiple effectors
Felder, C. C. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.8.7768353 · Cited by 508
Multiple forms of acetylcholinesterase and their distribution in endplate and non‐endplate regions of rat diaphragm muscle
Hall, Z. W. (1973) · Journal of Neurobiology · doi:10.1002/neu.480040404 · Cited by 508
Voltage clamp analysis of cholinergic action in the hippocampus
Madison, D. V., Lancaster, B., & Nicoll, R. A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-03-00733.1987 · Cited by 503
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
McCormick, D. A., & Prince, D. A. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016112 · Cited by 499
Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy
Bolam, J. P., Wainer, B. H., & Smith, A. D. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90165-9 · Cited by 485
Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease
Jönhagen, M. E., Nordberg, A. K., Amberla, K., Bäckman, L., Ebendal, T., Meyerson, B. A., Olson, L., Seiger, Å., Shigeta, M., Theodorsson, E., et al. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017069 · Cited by 472
Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
Cooper, E., Couturier, S., & Ballivet, M. (1991) · Nature · doi:10.1038/350235a0 · Cited by 470
The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions
Dunnett, S. B., Everitt, B. J., & Robbins, T. W. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90061-x · Cited by 467
Alzheimer’s Disease
de Paula, V. D. J. R., Radanovic, M., Diniz, B. S., & Forlenza, O. V. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_14 · Cited by 466
The Neuropharmacological Basis for the Use of Memantine in the Treatment of Alzheimer's Disease
Rogawski, M. A., & Wenk, G. L. (2003) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2003.tb00254.x · Cited by 449
Physostigmine: Improvement of Long-Term Memory Processes in Normal Humans
Davis, K. L., Mohs, R. C., Tinklenberg, J. R., Pfefferbaum, A., Hollister, L. E., & Kopell, B. S. (1978) · Science · doi:10.1126/science.351807 · Cited by 442
Acetylcholine Liberation from Cerebral Cortex during Paradoxical (REM) Sleep
Jasper, H. H., & Tessier, J. (1971) · Science · doi:10.1126/science.172.3983.601 · Cited by 434
SODIUM‐DEPENDENT, HIGH AFFINITY CHOLINE UPTAKE
Kuhar, M. J., & Murrin, L. C. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb07029.x · Cited by 424
M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice
Caccamo, A., Oddo, S., Billings, L. M., Green, K. N., Martinez-Coria, H., Fisher, A., & LaFerla, F. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.020 · Cited by 417
A Structural Motif of Acetylcholinesterase That Promotes Amyloid β-Peptide Fibril Formation
Ferrari, G. V. D., Canales, M. A., Shin, I., Weiner, L. M., Silman, I., & Inestrosa, N. C. (2001) · Biochemistry · doi:10.1021/bi0101392 · Cited by 415
Choline acetyltransferase: The structure, distribution and pathologic changes in the central nervous system
Oda, Y. (1999) · Pathology International · doi:10.1046/j.1440-1827.1999.00977.x · Cited by 403
Cholinesterase is associated with the basal lamina at the neuromuscular junction
McMahan, U. J., Sanes, J. R., & Marshall, L. M. (1978) · Nature · doi:10.1038/271172a0 · Cited by 400
Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus.
Erickson, J. D., Varoqui, H., Schäfer, M. K.-H., Modi, W. S., Diebler, M. F., Weihe, E., Rand, J. B., Eiden, L. E., Bonner, T. I., & Usdin, T. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31734-9 · Cited by 394
Choline: an essential nutrient for humans
Zeisel, S. H. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00349-x · Cited by 392
Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.
Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · PubMed · Cited by 392
Cholinergic modulation of the functional organization of the cat visual cortex
Sillito, A. M., & Kemp, J. A. (1983) · Brain Research · doi:10.1016/0006-8993(83)90015-x · Cited by 387
Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease
Mesulam, M. M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23415 · Cited by 382
The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter
Alfonso, A., Grundahl, K. M., Duerr, J. S., Han, H. P., & Rand, J. B. (1993) · Science · doi:10.1126/science.8342028 · Cited by 378
Synthesis, storage and release of [14C]acetylcholine in isolated rat diaphragm muscles
Potter, L. T. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009003 · Cited by 359
Acetylcholine, Aging, and Alzheimer's Disease
Muir, J. L. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00431-5 · Cited by 357
Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence
Kubo, T., Maeda, A., Sugimoto, K., et al. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81144-9 · Cited by 344
Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
Fenster, C. P., Rains, M. F., Noerager, B., Quick, M. W., & Lester, R. A. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05747.1997 · Cited by 332
THE FORMATION OF ACETYLCHOLINE. A NEW ENZYME: "CHOLINE ACETYLASE"
Nachmansohn, D. A., & Machado, A. L. (1943) · Journal of Neurophysiology · doi:10.1152/jn.1943.6.5.397 · Cited by 331
Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex
Jones, B. E. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45011-5 · Cited by 304
Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
Rosenberg, P. B., Nowrangi, M. A., & Lyketsos, C. G. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.05.005 · Cited by 302
3 Regulation of ligand-gated ion channels by protein phosphorylation
Swope, S. L., Moss, S. J., Raymond, L. A., & Huganir, R. L. (1999) · Advances in second messenger and phosphoprotein research · doi:10.1016/s1040-7952(99)80005-6 · Cited by 299
Quaternary structure of the acetylcholine receptor
Brisson, A., & Unwin, P. N. T. (1985) · Nature · doi:10.1038/315474a0 · Cited by 286
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
Conn, P. J., Jones, C. K., & Lindsley, C. W. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.12.002 · Cited by 286
Safety and biomarker effects of solanezumab in patients with Alzheimer's disease
Farlow, M. R., Arnold, S. E., van Dyck, C. H., Aisen, P. S. S., Snider, B. J., Porsteinsson, A. P., Friedrich, S. W., Dean, R. A., Gonzales, C., Sethuraman, G., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.09.224 · Cited by 285
Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task
Muir, J. L., Dunnett, S. B., Robbins, T. W., & Everitt, B. J. (1992) · Experimental Brain Research · doi:10.1007/bf00229886 · Cited by 280
“Is dopamine involved in Alzheimer's disease?”
Martorana, A., & Koch, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00252 · Cited by 276
Nicotinic Stimulation Produces Multiple Forms of Increased Glutamatergic Synaptic Transmission
Radcliffe, K. A., & Dani, J. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07075.1998 · Cited by 271
Regulation of Acetylcholine Synthesis in the Brain
Tuček, S. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07106.x · Cited by 270
Monoclonal antibodies to choline acetyltransferase: production, specificity, and immunohistochemistry
Levey, A. I., Armstrong, D. M., Atweh, S., Terry, R. D., & Wainer, B. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-01-00001.1983 · Cited by 268
Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions
Baghdoyan, H. A., Rodrigo‐Angulo, M. L., McCarley, R. W., & Hobson, J. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)90354-8 · Cited by 266
Aβ Species Removal After Aβ 42 Immunization
Nicoll, J. A. R., Barton, E., Boche, D., Neal, J. W., Ferrer, I., Thompson, P., Vlachouli, C., Wilkinson, D., Bayer, A., Games, D., et al. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240466.10758.ce · Cited by 265
Release of [3H]‐noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]‐dopamine release
Clarke, P. B. S., & Reuben, M. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15232.x · Cited by 262
Muscarinic cholinergic influences in memory consolidation
Power, A. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00086-8 · Cited by 261
Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory
van der Zee, E. A., & Luiten, P. G. M. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00092-6 · Cited by 261
Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older
Berg, L., McKeel, D. W., Miller, J. P., Baty, J., & Morris, J. C. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540040011008 · Cited by 257
Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease
Ferrante, R. J., Beal, M. F., Kowall, N. W., Richardson, E. P., & Martin, J. B. (1987) · Brain Research · doi:10.1016/0006-8993(87)90694-9 · Cited by 257
Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission.
Mrzljak, L., Levey, A. I., & Goldman-Rakic, P. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5194 · Cited by 256
Cholinergic modulation of cortical associative memory function
Hasselmo, M. E., Anderson, B. P., & Bower, J. M. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1230 · Cited by 250
Novel Selective Allosteric Activator of the M1Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats
Jones, C. K., Brady, A. E., Davis, A. A., Xiang, Z., Bubser, M., Tantawy, M. N., Kane, A. S., Bridges, T. M., Kennedy, J. P., Bradley, S. R., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1850-08.2008 · Cited by 248
Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition
Prado, V. F., Martins-Silva, C., de Castro, B. M., Lima, R. F., Barros, D. M., Amaral, E., Ramsey, A. J., Sotnikova, T. D., Ramirez, M. R., Kim, H.-G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.005 · Cited by 246
A Selective Allosteric Potentiator of the M 1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning
Shirey-Rice, J. K., Brady, A. E., Jones, P. J., Davis, A. A., Bridges, T. M., Kennedy, J. P., Jadhav, S. B., Menon, U. N., Xiang, Z., Watson, M. L., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3930-09.2009 · Cited by 237
Dopaminergic and cholinergic lesions in progressive supranuclear palsy
Ruberg, M., Javoy-Agid, F., Hirsch, É. C., Scatton, B., L'Heureux, R., Hauw, J., Duyckaerts, C. J., Gray, F., Morel-Maroger, A., Rascol, A., et al. (1985) · Annals of Neurology · doi:10.1002/ana.410180503 · Cited by 223
Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus
Hounsgaard, J. (1978) · Experimental Neurology · doi:10.1016/0014-4886(78)90284-4 · Cited by 221
Cholinergic neurons in the caudate-putamen complex proper are intrinsically organized: A combined evans blue and acetylcholinesterase analysis
Woolf, N. J., & Butcher, L. L. (1981) · Brain Research Bulletin · doi:10.1016/0361-9230(81)90004-6 · Cited by 221
Vesicular Localization and Activity-Dependent Trafficking of Presynaptic Choline Transporters
Ferguson, S. M., Savchenko, V. L., Apparsundaram, S., Zwick, M., Wright, J., Heilman, C. J., Yi, H. L., Levey, A. I., & Blakely, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09697.2003 · Cited by 218
Rivastigmine Transdermal Patch
Dhillon, S. (2011) · Drugs · doi:10.2165/11206380-000000000-00000 · Cited by 215
Differential Expression of Synaptic Proteins in the Frontal and Temporal Cortex of Elderly Subjects With Mild Cognitive Impairment
Counts, S., Nadeem, M., Lad, S. P., Wuu, J., & Mufson, E. J. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-200606000-00007 · Cited by 212
The cholinergic innervation of the human cerebral cortex.
Mesulam, M.-M. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45004-8 · Cited by 211
The Cholinergic Gene Locus
Eiden, L. E. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70062227.x · Cited by 209
Cholinergic modulation of the cortical neuronal network
Lucas-Meunier, E., Fossier, P., Baux, G., & Amar, M. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0999-2 · Cited by 207
Nicotinic Modulation of Glutamate and GABA Synaptic Transmission in Hippocampal Neurons
RADCLIFFE, K. A., FISHER, J. L., GRAY, R., & DANI, J. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11332.x · Cited by 205
Removal of Cholinergic Input to Rat Posterior Parietal Cortex Disrupts Incremental Processing of Conditioned Stimuli
Bucci, D. J., Holland, P. C., & Gallagher, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08038.1998 · Cited by 204
Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats
Brady, A. E., Jones, C. K., Bridges, T. M., Kennedy, J. P., Thompson, A. D., Heiman, J. U., Breininger, M. L., Gentry, P. R., Yin, H., Jadhav, S. B., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.140350 · Cited by 204
Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction.
Toyoshima, C., & Unwin, N. C. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.2623 · Cited by 198
Acetylcholine hyperpolarizes central neurones by acting on an M2 muscarinic receptor
Egan, T. M., & North, R. A. (1986) · Nature · doi:10.1038/319405a0 · Cited by 197
Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes
Wong, T. P., Debeir, T., Duff, K., & Cuello, A. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02706.1999 · Cited by 196
Potentiation of nicotinic receptor response by external calcium in rat central neurons
Mulle, C., Léna, C., & Changeux, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90208-u · Cited by 196
ALZHEIMER-LIKE CHOLINERGIC DEFICIENCY IN DOWN SYNDROME
Yates, C. M., Simpson, J., Maloney, A. F. J., Gordon, A., & Reid, A. H. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92137-6 · Cited by 190
Acetylcholine raises excitability by inhibiting the fast transient potassium current in cultured hippocampal neurons.
Nakajima, Y., Nakajima, S., Leonard, R. J., et al. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.3022 · Cited by 186
Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specific expression.
Li, Y., Camp, S., Rachinsky, T. L., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54466-5 · Cited by 185
The α7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca2+ dependent mechanism
Dajas‐Bailador, F., Lima, P. A., & Wonnacott, S. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00127-1 · Cited by 182
The Role of Neuronal Nicotinic Acetylcholine Receptors in Acute and Chronic Neurodegeneration
O'Neill, M., Murray, T., Lakics, V., Visanji, N. P., & Duty, S. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007023339166 · Cited by 181
A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative vesicular transporter of acetylcholine.
Bejanin, S., Cervini, R., Mallet, J. J., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31738-6 · Cited by 180
Molecular cloning of a putative vesicular transporter for acetylcholine.
Roghani, A., Feldman, J. D., Kohan, S. A., Shirzadi, A., Gundersen, C. B., Brecha, N. C., & Edwards, R. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10620 · Cited by 180
Impulse-flow regulation of high affinity choline uptake in brain cholinergic nerve terminals
Simon, J. R., & Kuhar, M. J. (1975) · Nature · doi:10.1038/255162a0 · Cited by 180
Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles.
Anderson, D. C., King, S. C., & Parsons, S. M. (1983) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14413-1 · Cited by 179
Long-term enhancement of evoked potentials in cat somatosensory cortex produced by co-activation of the basal forebrain and cutaneous receptors
Rasmusson, D. D., & Dykes, R. W. (1988) · Experimental Brain Research · doi:10.1007/bf00248353 · Cited by 177
A subcortico-cortical cholinergic system is affected in Parkinson's disease
Dunois, B., Ruberg, M., Javoy-Agid, F., Ploska, A., & Agid, Y. (1983) · Brain Research · doi:10.1016/0006-8993(83)90096-3 · Cited by 175
Cholinergic systems mediate action from movement to higher consciousness
Woolf, N. J., & Butcher, L. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.046 · Cited by 173
Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
Fitzjohn, S. M., Morton, R. A., Kuenzi, F., Rosahl, T. W., Shearman, M., Lewis, H., Smith, D., Reynolds, D. S., Davies, C. H., Collingridge, G. L., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04691.2001 · Cited by 168
A Subpopulation of Neuronal M4Muscarinic Acetylcholine Receptors Plays a Critical Role in Modulating Dopamine-Dependent Behaviors
Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3843-09.2010 · Cited by 168
The nucleus basalis and memory codes: Auditory cortical plasticity and the induction of specific, associative behavioral memory
Weinberger, N. M. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00072-8 · Cited by 165
Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice
Ferguson, S. M., Bazalakova, M. H., Savchenko, V. L., Tapia, J. C., Wright, J., & Blakely, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401667101 · Cited by 163
Distinction between Acetylcholine-Esterase and Other Choline Ester-splitting Enzymes
Augustinsson, K., & Nachmansohn, D. A. (1949) · Science · doi:10.1126/science.110.2847.98 · Cited by 162
Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats
Felix, R. A., & Levin, E. D. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00224-8 · Cited by 160
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
Shirey-Rice, J. K., Xiang, Z., Orton, D., Brady, A. E., Johnson, K. A., Williams, R. D., Ayala, J. E., Rodriguez, A. L., Wess, J., Weaver, D., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.55 · Cited by 160
The inositol 1,4,5‐trisphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA.
Markram, H., & Segal, M. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019015 · Cited by 156
Molecular biology of the vesicular ACh transporter
Usdin, T. B., Eiden, L. E., Bonner, T. I., & Erickson, J. D. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93906-e · Cited by 155
A reappraisal of the functions of the nucleus basalis of Meynert
Richardson, R. T., & DeLong, M. R. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90107-5 · Cited by 154
α7 Neuronal Nicotinic Acetylcholine Receptors Are Negatively Regulated by Tyrosine Phosphorylation and Src-Family Kinases
Charpantier, E., Wiesner, A., Huh, K.-H., Ogier, R., Hoda, J., Allaman, G., Raggenbass, M., Feuerbach, D., Bertrand, D., & Fuhrer, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3497-05.2005 · Cited by 152
SYNTHESIS AND RELEASE OF [14C]ACETYLCH0LINE IN SYNAPTOSOMES
Haga, T. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb12008.x · Cited by 151
Acute and chronic nicotine effects on working memory in aged rats
Levin, E. D., & Torry, D. J. (1996) · Psychopharmacology · doi:10.1007/bf02246285 · Cited by 150
Removal of cholinergic input to perirhinal cortex disrupts object recognition but not spatial working memory in the rat
Winters, B. D., & Bussey, T. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04055.x · Cited by 149
Methyllycaconitine Is a Potent Antagonist of α-Conotoxin-MII-Sensitive Presynaptic Nicotinic Acetylcholine Receptors in Rat Striatum
Mogg, A. J., Whiteaker, P., McIntosh, J. M., Marks, M. J., Collins, A. C., & Wonnacott, S. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.197 · Cited by 146
Muscarine affects calcium-currents in rat hippocampal pyramidal cells in vitro
Gähwiler, B. H., & Brown, D. A. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90419-8 · Cited by 141
Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis
Paez-Gonzalez, P., Asrican, B., Rodriguez, E., & Kuo, C. T. (2014) · Nature Neuroscience · doi:10.1038/nn.3734 · Cited by 140
The amyloid pathology progresses in a neurotransmitter-specific manner
Bell, K. F. S., Ducatenzeiler, A., Ribeiro‐da‐Silva, A., Duff, K., Bennett, D. A., & Cuello, A. C. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.034 · Cited by 139
Response of the hypothalamo-pituitary-adrenal axis to nicotine
Matta, S. G., Fu, Y., Valentine, J. D., & Sharp, B. M. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00079-6 · Cited by 139
Intracranial infusion of purified nerve growth factor to an Alzheimer patient: The first attempt of a possible future treatment strategy
Seiger, Å., Nordberg, A. K., von Holst, H., Bäckman, L., Ebendal, T., Alafuzoff, I. I., Amberla, K., Hartvig, P., Herlitz, A., Lilja, A., et al. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90141-c · Cited by 139
Rat hippocampal neurons in culture: responses to electrical and chemical stimuli
Segal, M. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.50.6.1249 · Cited by 139
Learning impairments following injection of a selective cholinergic immunotoxin, ME20.4 IgG-saporin, into the basal nucleus of Meynert in monkeys
Fine, A., Hoyle, C., Maclean, C. J., LeVatte, T. L., Baker, H. F., & Ridley, R. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00208-x · Cited by 138
Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer's dementia
Kish, S. J., El‐Awar, M., Schut, L. J., Leach, L. R., Oscar‐Berman, M., & Freedman, M. (1988) · Annals of Neurology · doi:10.1002/ana.410240205 · Cited by 138
Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine
Wenk, G. L., Parsons, C. G., & Danysz, W. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00007 · Cited by 134
Differences in the glycolipid membrane anchors of bovine and human erythrocyte acetylcholinesterases.
Roberts, W. L., Kim, B. H., & Rosenberry, T. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.7817 · Cited by 132
Cholinergic modulation of sensory responses in rat primary somatic sensory cortex
Donoghue, J. P., & Carroll, K. L. (1987) · Brain Research · doi:10.1016/0006-8993(87)90407-0 · Cited by 127
Cholinomimetic and anticholinergic drugs used to investigate an acetylcholine hypothesis of affective disorders and stress
Janowsky, D. S., & Risch, S. C. (1984) · Drug Development Research · doi:10.1002/ddr.430040202 · Cited by 126
and Alzheimer's disease
Brioni, J. D., Esbenshade, T. A., Garrison, T. R., Bitner, S. R., & Cowart, M. (2010) · Cited by 125
Gene expression of mouse choline acetyltransferase. Alternative splicing and identification of a highly active promoter region.
Misawa, H., Ishii, K., & Deguchi, T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)88714-8 · Cited by 124
Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A antibody
Bales, K. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27120 · Cited by 123
A multiplicity of muscarinic mechanisms: Enough signaling pathways to take your breath away
Nathanson, N. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6245 · Cited by 121
Alzheimer’s Disease and the Aging Brain
Terry, R. D. (2006) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988706291079 · Cited by 118
Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human β-amyloid precursor protein
Apelt, J., Kumar, A., & Schliebs, R. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03262-6 · Cited by 117
Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats
Kim, J. S., & Levin, E. D. (1996) · Brain Research · doi:10.1016/0006-8993(96)00213-2 · Cited by 115
Demonstration of a receptor in Torpedo synaptic vesicles for the acetylcholine storage blocker L-trans-2-(4-phenyl[3,4-3H]-piperidino) cyclohexanol.
Bahr, B. A., & Parsons, S. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.7.2267 · Cited by 115
Alternative Splicing Leads to Two Cholinergic Proteins in Caenorhabditis elegans
Alfonso, A., Grundahl, K. M., McManus, J. R., Asbury, J. M., & Rand, J. B. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1538 · Cited by 114
Tubular crystals of acetylcholine receptor.
Brisson, A., & Unwin, P. N. T. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.4.1202 · Cited by 112
Reversible inactivation of the nucleus basalis magnocellularis induces disruption of cortical acetylcholine release and acquisition, but not retrieval, of aversive memories
Miranda, M. I., & Bermúdez‐Rattoni, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6478 · Cited by 109
Cholinergic Modulation of the Hippocampus During Encoding and Retrieval of Tone/Shock-Induced Fear ConditioningPreprint
Rogers, J. L., & Kesner, R. P. (2004) · Learning & Memory · doi:10.1101/lm.64604 · Cited by 107
Slow Excitotoxicity in Alzheimer's Disease
Ong, W.-Y., Tanaka, K., Dawe, G. S., Ittner, L. M., & Farooqui, A. A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121990 · Cited by 106
Storage of dopamine and acetylcholine in granules of PC12, a clonal pheochromocytoma cell line
Rebois, R. V., Reynolds, E. E., Toll, L., & Howard, B. D. (1980) · Biochemistry · doi:10.1021/bi00547a031 · Cited by 106
Distribution of the high-affinity choline transporter in the central nervous system of the rat
Misawa, H., Nakata, K., Matsuura, J., Nagao, M., Okuda, T., & Haga, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00147-6 · Cited by 105
Deterministic functions of cortical acetylcholine
Sarter, M. F., Lustig, C., Howe, W. M., Gritton, H. J., & Berry, A. S. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12515 · Cited by 104
Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes
Wilkie, G., Hutson, P. H., Sullivan, J. P., & Wonnacott, S. (1996) · Neurochemical Research · doi:10.1007/bf02532425 · Cited by 103
Cloning and expression of the vesamicol binding protein from the marine ray Torpedo
Varoqui, H., Diebler, M., Meunier, F.-M., Rand, J. B., Usdin, T. B., Bonner, T. I., Eiden, L. E., & Erickson, J. D. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80592-x · Cited by 102
A Phosphorylation Site Regulates Sorting of the Vesicular Acetylcholine Transporter to Dense Core Vesicles
Krantz, D. E., Waites, C. L., Oorschot, V. M. J., Liu, Y., Wilson, R. I., Tan, P. K., Klumperman, J., & Edwards, R. H. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.2.379 · Cited by 100
Single gene encodes glycophospholipid-anchored and asymmetric acetylcholinesterase forms: Alternative coding exons contain inverted repeat sequences
Maulet, Y., Camp, S., Gibney, G., Rachinsky, T. L., Ekströ, T. J., & Taylor, P. (1990) · Neuron · doi:10.1016/0896-6273(90)90103-m · Cited by 98
Structure and Organization of the DrosophilaCholinergic Locus
Kitamoto, T., Wang, W., & Salvaterra, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2706 · Cited by 94
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
Wang, B., Yang, L., Wang, Z., & Zheng, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704070104 · Cited by 94
One Hundred Years after the Discovery of Alzheimer's Disease. A Turning Point for Therapy?
Giacobini, E., & Becker, R. E. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12105 · Cited by 92
Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease
Tsang, S. W. Y., Lai, M. K. P., Kirvell, S. L., Francis, P. T., Esiri, M. M., Hope, T., Chen, C., & Wong, P. T. ‐. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.010 · Cited by 92
Memory consolidation and reconsolidation of an inhibitory avoidance response in mice: effects of i.c.v. injections of hemicholinium-3
Boccia, M. M., Acosta, G. B., Blake, M. G., & Baratti, C. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.001 · Cited by 90
M1 muscarinic receptor signaling in mouse hippocampus and cortex
Porter, A. C., Bymaster, F. P., DeLapp, N. W., Yamada, M., Wess, J., Hamilton, S. E., Nathanson, N. M., & Felder, C. C. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02721-x · Cited by 90
Regional distribution of choline acetyltransferase in the human brain: changes in Huntington's chorea.
Aquilonius, S., Eckernäs, S. ‐., & Sundwall, A. (1975) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.38.7.669 · Cited by 90
Quantitative light microscopic autoradiography of [3H]hemicholinium-3 binding sites in the rat central nervous system: a novel biochemical marker for mapping the distribution of cholinergic nerve terminals
Vickroy, T. W., Roeske, W. R., Gehlert, D. R., Wamsley, J. K., & Yamamura, H. I. (1985) · Brain Research · doi:10.1016/0006-8993(85)90553-0 · Cited by 89
Rapid Upregulation of α7 Nicotinic Acetylcholine Receptors by Tyrosine Dephosphorylation
Cho, C.-H., Song, W., Leitzell, K., Teo, E., Meleth, A. D., Quick, M. W., & Lester, R. A. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5389-03.2005 · Cited by 87

Research works printed but not linked: 1

[1]Loewi O. Über humerole übertragbarkeit der herznervenwirkung. I Mitteilung Pflugers Arch., 1921, 189, 239-242. 10. 1007/BF01738910 1921

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Authors: H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F.
Venue: Current Neuropharmacology
Publisher: Bentham Science Publishers Ltd.
Published: 2016-01-22
Volume: 14
Issue: 1
Pages: 101-115
ISSN: 1570-159X (ISSN-L)
DOI: 10.2174/1570159x13666150716165726
PMC: PMC4787279
OpenAlex: W2261085470
Cited by: 1,551
References: 277
Citations by year: 2026: 120 · 2025: 191 · 2024: 207 · 2023: 224 · 2022: 224 · 2021: 214 · 2020: 173 · 2019: 108 · 2018: 44 · 2017: 35 · 2016: 8
FWCI: 52.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc
Locations: Current Neuropharmacology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, cholinergic system, acetylcholine, choline acetyltransferase, vesicular acetylcholine transporter, acetylcholinesterase, choline transporter 1, muscarinic receptors, nicotinic acetylcholine receptors, cholinergic neurons, nucleus basalis of Meynert, synaptic loss, acetylcholinesterase inhibitors, cholinergic drugs
MeSH terms: Acetylcholine, Alzheimer Disease, Animals, Cholinesterase Inhibitors, Humans, Receptors, Cholinergic, Drug Delivery Systems, Cholinergic Agents, Cholinergic Neurons

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Alzheimer's disease: Targeting the Cholinergic System

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