NADPH-oxidase activation and cognition in Alzheimer disease progression
Open accessAbstract
Superoxide production via NADPH-oxidase (NOX) has been shown to play a role in a variety of neurological disorders, including Alzheimer disease (AD). To improve our understanding of the NOX system and cognitive impairment, we studied the various protein components of the phagocytic isoform (gp91(phox), or NOX2) in the frontal and temporal cortex of age- and postmortem-matched samples. Individuals underwent antemortem cognitive testing and postmortem histopathologic assessment to determine disease progression and assignment to one of the following groups: no cognitive impairment (NCI), preclinical AD, mild cognitive impairment (MCI), early AD, and mild-to-moderate AD. Biochemical methods were used to determine overall NOX activity as well as levels of the various subunits (gp91(phox), p67(phox), p47(phox), p40(phox), and p22(phox)). Overall enzyme activity was significantly elevated in the MCI cohort in both cortical regions compared to the NCI cohort. This activity level remained elevated in the AD groups. Only the NOX cytosolic subunit proteins (p67(phox), p47(phox), and p40(phox) ) were significantly elevated with disease progression; the membrane-bound subunits (gp91(phox) and p22(phox)) remained stable. In addition, there was a robust correlation between NOX activity and the individual's cognitive status such that as the enzyme activity increased, cognitive performance decreased. Collectively, these data show that upregulated NADPH-oxidase in frontal and temporal cortex suggests that increases in NOX-associated redox pathways might participate in early pathogenesis and contribute to AD progression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ante-mortem cognitive impairment is correlated with post-mortem determination of NOX activity in the frontal and temporal cortices.
“Furthermore, ante-mortem cognitive impairment is correlated with post-mortem determination of NOX activity in the frontal and temporal cortices [68].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [68]
Oxidative damage is an early event in the pathogenesis of Alzheimer's disease, occurring before the onset of clinical symptoms, and is also a factor contributing to disease progression.
“Past and recent studies have demonstrated that oxidative damage is not only an early event in the pathogenesis of AD, occurring before the onset of clinical symptoms but also a factor contributing to the disease progression [17,18,19,20,21].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946 · see citing works
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works
Mild Cognitive Impairment as a Clinical Entity and Treatment Target
Petersen, R. C., & Morris, J. C. (2005) · Archives of Neurology · doi:10.1001/archneur.62.7.1160 · Cited by 935 · see citing works
BABIOR, B. M., Lambeth, J. D., & Nauseef, W. M. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2642 · Cited by 911 · see citing works
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801 · see citing works
Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy
Lambeth, J. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.027 · Cited by 677 · see citing works
Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship
Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works
Oxidative stress in the progression of Alzheimer disease in the frontal cortex
Ansari, M. A., & Scheff, S. W. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181cb5af4 · Cited by 605 · see citing works
Self-citationMorris, J. C., Storandt, M., McKeel, D. W., Rubin, E. H., Price, J. L., Grant, E. A., & Berg, L. (1996) · Neurology · doi:10.1212/wnl.46.3.707 · Cited by 603 · see citing works
Evidence of increased oxidative damage in subjects with mild cognitive impairment
Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005) · Neurology · doi:10.1212/01.wnl.0000156156.13641.ba · Cited by 539 · see citing works
Chong, Z. Z., Li, F., & Maiese, K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.004 · Cited by 536 · see citing works
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works
NOX Enzymes in the Central Nervous System: From Signaling to Disease
Sorce, S., & Krause, K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2578 · Cited by 472 · see citing works
Neuropathologic Substrate of Mild Cognitive Impairment
Markesbery, W. R., Schmitt, F. A., Kryscio, R. J., Davis, D. G., Smith, C. D., & Wekstein, D. R. (2006) · Archives of Neurology · doi:10.1001/archneur.63.1.38 · Cited by 460 · see citing works
Cytochrome b 558 : the Flavin-Binding Component of the Phagocyte NADPH Oxidase
Rotrosen, D., Yeung, C. L., Leto, T. L., Malech, H. L., & Kwong, C. H. (1992) · Science · doi:10.1126/science.1318579 · Cited by 378 · see citing works
“Preclinical” AD revisited: Neuropathology of cognitively normal older adults
Schmitt, F. A., Davis, D. G., Wekstein, D. R., Smith, C. D., Ashford, J. W., & Markesbery, W. R. (2000) · Neurology · doi:10.1212/wnl.55.3.370 · Cited by 369 · see citing works
Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy
Mcgeer, E., & McGeer, P. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1219 · Cited by 349 · see citing works
de la Monte, S. M., & Wands, J. R. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9209 · Cited by 318 · see citing works
Activation of NADPH Oxidase in Alzheimer’s Disease Brains
Shimohama, S., Tanino, H., Kawakami, N., Okamura, N., Kodama, H., Yamaguchi, T., Hayakawa, T., Nunomura, A., Chiba, S., Perry, G., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2897 · Cited by 292 · see citing works
Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.
Scheff, S. W., & Price, D. A. (2006) · Journal of Alzheimer's Disease · doi:10.3233/jad-2006-9s312 · Cited by 284 · see citing works
Self-citationNMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2
Girouard, H., Wang, G., Gallo, E. F., Anrather, J., Zhou, P., Pickel, V. M., & Iadecola, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0133-09.2009 · Cited by 254 · see citing works
The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease.
Wilkinson, B. L., & Landreth, G. E. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-30 · Cited by 235 · see citing works
Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.006 · Cited by 223 · see citing works
Synaptic localization of a functional NADPH oxidase in the mouse hippocampus
Tejada-Simon, M. V., Serrano, F., Villasana, L., Kanterewicz, B. I., Wu, G., Quinn, M. T., & Klann, E. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.01.007 · Cited by 203 · see citing works
NADPH oxidase as a therapeutic target in Alzheimer's disease
Block, M. L. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s2-s8 · Cited by 202 · see citing works
DeLeo, F. R., Burritt, J. B., Yu, L., Jesaitis, A. J., Dinauer, M. C., & Nauseef, W. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13986 · Cited by 176 · see citing works
Architecture of the p40-p47-p67 Complex in the Resting State of the NADPH Oxidase
Lapouge, K., Smith, S. J., Groemping, Y., & Rittinger, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112065200 · Cited by 166 · see citing works
Kishida, K. T., Hoeffer, C. A., Hu, D., Pao, M., Holland, S. M., & Klann, E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00269-06 · Cited by 159 · see citing works
Dang, P. M., Cross, A. R., Quinn, M. T., & BABIOR, B. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072345299 · Cited by 149 · see citing works
CLIC1 Function Is Required for β-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia
Milton, R. H., Abeti, R., Averaimo, S., Debiasi, S., Vitellaro‐Zuccarello, L., Jiang, L., Curmi, P. M. G., Breit, S. N., Duchen, M. R., & Mazzanti, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2431-08.2008 · Cited by 148 · see citing works
Inflammation and Anti-Inflammatory Strategies for Alzheimer’s Disease – A Mini-Review
McNaull, B., Todd, S., McGuinness, B., & Passmore, A. (2009) · Gerontology · doi:10.1159/000237873 · Cited by 120 · see citing works
Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
Wilkinson, B. L., Cramer, P. E., Varvel, N. H., Reed-Geaghan, E. G., Jiang, Q., Szabo, A., Herrup, K., Lamb, B. T., & Landreth, G. E. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.014 · Cited by 116 · see citing works
Alzheimer’ s disease, oxidative stress and gammahydroxybutyrate
Mamelak, M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.008 · Cited by 108 · see citing works
NOX Activity Is Increased in Mild Cognitive Impairment
Bruce‐Keller, A. J., Gupta, S., Parrino, T. E., Knight, A. G., Ebenezer, P. J., Weidner, A. M., LeVine, H., Keller, J. N., & Markesbery, W. R. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2823 · Cited by 100 · see citing works
Park, K. W., Baik, H. H., & Jin, B. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803392 · Cited by 84 · see citing works
Ansari, M. A., Keller, J. N., & Scheff, S. W. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.025 · Cited by 66 · see citing works
Mechanisms of the inhibitory effects of amyloid β-protein on synaptic plasticity
Rowan, M. J., Klyubin, I. V., Wang, Q., & Anwyl, R. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.020 · Cited by 60 · see citing works
Reduction of ascorbate free radical by the plasma membrane of synaptic terminals from rat brain
Samhan-Arias, A. K., Duarte, R. O., Martı́n-Romero, F. J., Moura, J. J. G., & Gutiérrez‐Merino, C. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.10.004 · Cited by 19 · see citing works
Predictors of Preclinical Alzheimer Disease and Dementia: A Clinicopathologic Study
Galvin, J. E., Powlishta, K. K., Wilkins, K., McKeel, D. W., Xiong, C., Grant, E., Storandt, M., & Morris, J. C. (2005) · Archives of Neurology · doi:10.1001/archneur.62.5.758 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044 · see citing works
NADPH oxidase in brain injury and neurodegenerative disorders
Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0150-7 · Cited by 432 · see citing works
The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders
Tarafdar, A., & Pula, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123824 · Cited by 373 · see citing works
New Insights on <i>NOX</i> Enzymes in the Central Nervous System
Nayernia, Z., Jaquet, V., & Krause, K.-H. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5703 · Cited by 279 · see citing works
Manganese Superoxide Dismutase and Oxidative Stress Modulation
Bresciani, G., da Cruz, I. B. M., & González‐Gallego, J. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.11.001 · Cited by 285 · see citing works
NADPH oxidases: novel therapeutic targets for neurodegenerative diseases
Gao, H., Zhou, H., & Hong, J. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.008 · Cited by 212 · see citing works
Old Maids: Aging and Its Impact on Microglia Function
Koellhoffer, E. C., McCullough, L. D., & Ritzel, R. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040769 · Cited by 205 · see citing works
Actin dynamics and cofilin‐actin rods in alzheimer disease
Bamburg, J. R., & Bernstein, B. W. (2016) · Cytoskeleton · doi:10.1002/cm.21282 · Cited by 181 · see citing works
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease
Uddin, M. S., Tewari, D., Sharma, G., Kabir, M. T., Barreto, G. E., Bin-Jumah, M. N., Perveen, A., Abdel‐Daim, M. M., & Ashraf, G. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01929-y · Cited by 166 · see citing works
Synaptic Change in the Posterior Cingulate Gyrus in the Progression of Alzheimer's Disease
Scheff, S. W., PRICE, D. A., Ansari, M. A., Roberts, K. N., Schmitt, F. A., Ikonomović, M. D., & Mufson, E. J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141518 · Cited by 163 · see citing works
Khalifa, A. R. M., Abdel‐Rahman, E. A., Mahmoud, A. M., Ali, M. H., Noureldin, M., Saber, S. H., Mohsen, M., & Ali, S. S. (2017) · Physiological Reports · doi:10.14814/phy2.13125 · Cited by 154 · see citing works
Ferreiro, E. B., Baldeiras, I., Ferreira, I. L., Costa, R. O., Rego, A. C., Pereira, C., & Oliveira, C. R. (2012) · International Journal of Cell Biology · doi:10.1155/2012/735206 · Cited by 152 · see citing works
Ganguly, U., Kaur, U., Chakrabarti, S. S., Sharma, P., Agrawal, B. K., Saso, L., & Chakrabarti, S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7086512 · Cited by 150 · see citing works
Sullivan, M., & Lewandowski, P. A. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-104 · Cited by 138 · see citing works
Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors
Surace, M. J., & Block, M. L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1015-4 · Cited by 131 · see citing works
Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2
Kahles, T., & Brandes, R. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4721 · Cited by 125 · see citing works
Bamburg, J. R., Minamide, L. S., Wiggan, O., Tahtamouni, L. H., & Kuhn, T. B. (2021) · Cells · doi:10.3390/cells10102726 · Cited by 122 · see citing works
Sex-related differences in oxidative stress and neurodegeneration
Tenkorang, M. A. A., Snyder, B., & Cunningham, R. L. (2017) · Steroids · doi:10.1016/j.steroids.2017.12.010 · Cited by 116 · see citing works
Ghosh, A., Langley, M. R., Harischandra, D. S., Neal, M. P., Jin, H., Anantharam, V., Joseph, J., Brenza, T. M., Narasimhan, B., Kanthasamy, A., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9650-4 · Cited by 107 · see citing works
Hajipour, S., Sarkaki, A., Farbood, Y., Eidi, A., Mortazavi, P., & Valizadeh, Z. (2016) · Basic and Clinical Neuroscience Journal · doi:10.15412/j.bcn.03070203 · Cited by 109 · see citing works
Tong, H., Zhang, X., Meng, X., Lu, L., Mai, D., & Qu, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00165 · Cited by 109 · see citing works
Cahill‐Smith, S., & Li, J. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12357 · Cited by 106 · see citing works
NADPH oxidases: redox regulation of cell homeostasis and disease
Kračun, D., Lopes, L. R., Cifuentes-Pagano, E., & Pagano, P. J. (2025) · Physiological Reviews · doi:10.1152/physrev.00034.2023 · Cited by 104 · see citing works
Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2
Loffredo, L., Ettorre, E., Zicari, A. M., Inghilleri, M., Nocella, C., Perri, L., Spalice, A., Fossati, C., De Lucia, M. C., Pigozzi, F., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8630275 · Cited by 100 · see citing works
Scheff, S. W., Ansari, M. A., & Mufson, E. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.030 · Cited by 100 · see citing works
Self-citationCognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation
Bruce-Keller, A. J., Gupta, S., Knight, A. G., Beckett, T. L., McMullen, J. M., Davis, P. R., Murphy, M. P., Van Eldik, L. J., St Clair, D., & Keller, J. N. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.012 · Cited by 96 · see citing works
NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress
Diebold, B. A., Smith, S. M., Yang, L., & Lambeth, J. D. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5862 · Cited by 96 · see citing works
The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls
Cifuentes-Pagano, E., Meijles, D. N., & Pagano, P. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5620 · Cited by 84 · see citing works
Lourenço, C. F., & Laranjinha, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.729201 · Cited by 85 · see citing works
Amyloid β‐induced astrogliosis is mediated by β1‐integrin via NADPH oxidase 2 in Alzheimer's disease
Wyssenbach, A., Quintela‐López, T., Llavero, F., Zugaza, J. L., Matute, C., & Alberdi, E. M. (2016) · Aging Cell · doi:10.1111/acel.12521 · Cited by 81 · see citing works
Noxious Iron–Calcium Connections in Neurodegeneration
Núñez, M., & Hidalgo, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00048 · Cited by 71 · see citing works
Targeting NOX enzymes in the central nervous system: therapeutic opportunities
Sorce, S., Krause, K., & Jaquet, V. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1014-5 · Cited by 78 · see citing works
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice
Zhang, H., Su, Y., Sun, Z., Chen, M., Han, Y., Li, Y., Dong, X., Ding, S., Fang, Z., Li, W., et al. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.03.003 · Cited by 76 · see citing works
Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease
Uddin, M. S., Kabir, M. T., Jalouli, M., Rahman, M. A., Jeandet, P., Behl, T., Alexiou, A. T., Albadrani, G. M., Abdel‐Daim, M. M., Perveen, A., et al. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210826130210 · Cited by 76 · see citing works
The neuroprotective effects of apocynin
Simonyi, Á. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e535 · Cited by 71 · see citing works
Ogunlade, B., Adelakun, S. A., & Agie, J. A. (2020) · Drug and Chemical Toxicology · doi:10.1080/01480545.2020.1754849 · Cited by 72 · see citing works
Kim, H. A., Miller, A. A., Drummond, G. R., Thrift, A. G., Arumugam, T. V., Phan, T. G., Srikanth, V. K., & Sobey, C. G. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0790-7 · Cited by 68 · see citing works
Nutritional status, oxidative stress and dementia: the role of selenium in Alzheimer's disease
dos Santos, J. R., de Gois, A. M., Mendonça, D. M. F., & Freire, M. A. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00206 · Cited by 66 · see citing works
Walsh, K. P., Minamide, L. S., Kane, S. J., Shaw, A. E., Brown, D. R., Pulford, B. E., Zabel, M. D., Lambeth, J. D., Kuhn, T. B., & Bamburg, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095995 · Cited by 65 · see citing works
Li, X., Cai, L., Liu, J., Ma, Y., Kong, Y., He, L., & Jiang, M. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3720 · Cited by 65 · see citing works
The neuroprotective effects of apocynin
Simonyi, Á. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/535 · Cited by 62 · see citing works
Targeting redox imbalance in neurodegeneration: characterizing the role of GLP-1 receptor agonists
Ghosh, P., Fontanella, R. A., Scisciola, L., Pesapane, A., Taktaz, F., Franzese, M., Puocci, A., Ceriello, A., Prattichizzo, F., Rizzo, M. R., et al. (2023) · Theranostics · doi:10.7150/thno.86831 · Cited by 59 · see citing works
Nuclear and mitochondrial DNA oxidation in Alzheimer's disease
Santos, R. X., Correia, S. C., Zhu, X., Lee, H.-G., Petersen, R. B., Nunomura, A., Smith, M. A., Perry, G., & Moreira, P. I. (2012) · Free Radical Research · doi:10.3109/10715762.2011.648188 · Cited by 57 · see citing works
Simpson, J. E., Ince, P. G., Matthews, F. E., Shaw, P. J., Heath, P. R., Brayne, C., Garwood, C., Higginbottom, A., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12202 · Cited by 56 · see citing works
Inflamma-MicroRNAs in Alzheimer’s Disease: From Disease Pathogenesis to Therapeutic Potentials
Liang, Y., & Wang, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.785433 · Cited by 55 · see citing works
Gage, M., & Thippeswamy, T. (2021) · CNS Drugs · doi:10.1007/s40263-020-00787-5 · Cited by 54 · see citing works
Ibrahim, W. W., Abdelkader, N. F., Ismail, H. M., & Khattab, M. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-46558-1 · Cited by 49 · see citing works
Xu, T., Shen, X., Sun, L., Chen, Y., Zhang, B., Huang, D., & Li, W. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.4005 · Cited by 48 · see citing works
Oxidative Stress: Pathological Driver in Chronic Neurodegenerative Diseases
Chong, Z. Z., & Souayah, N. (2025) · Antioxidants · doi:10.3390/antiox14060696 · Cited by 50 · see citing works
Angeloni, C., Malaguti, M., Prata, C., Freschi, M., Barbalace, M. C., & Hrelia, S. (2022) · Antioxidants · doi:10.3390/antiox12010094 · Cited by 52 · see citing works
Alghamdi, B. S. A. (2018) · Journal of Integrative Neuroscience · doi:10.3233/jin-180089 · Cited by 46 · see citing works
Tian, Y., Wang, W., Xu, L., Li, H., Wei, Y., Wu, Q., & Jia, J. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24357 · Cited by 46 · see citing works
Shi, G., Wang, X., Yan, C.-Q., He, T., Yang, J., Zeng, X., Xu, Q., Zhu, W. X., Du, S., & Liu, C. (2015) · Scientific Reports · doi:10.1038/srep17981 · Cited by 44 · see citing works
RetractedSun, G. Y., He, Y., Chuang, D. Y., Lee, J. C., Gu, Z., Simonyi, Á., & Sun, A. Y. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8261-1 · Cited by 44 · see citing works
Implication of type 4 NADPH oxidase (NOX4) in tauopathy
Luengo, E., Trigo-Alonso, P., Fernández‐Mendívil, C., Núñez, Á., del Campo, M., Porrero, C., García‐Magro, N., Negredo, P., Senar, S., Sánchez‐Ramos, C., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.redox.2021.102210 · Cited by 42 · see citing works
Ansari, M., Roberts, K. N., & Scheff, S. (2014) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2014.08.025 · Cited by 38 · see citing works
Choi, D., & Lee, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112500 · Cited by 40 · see citing works
Chronic hypoxia of endothelial cells boosts HIF-1α-NLRP1 circuit in Alzheimer’s disease
Jung, E., Kim, Y. E., Jeon, H. S., Yoo, M., Kim, M., Kim, Y., Koh, S., & Choi, Y. K. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.05.011 · Cited by 39 · see citing works
Morales, L. G. F., Correa‐Basurto, J., & Rosales‐Hernández, M. C. (2021) · Antioxidants · doi:10.3390/antiox10020218 · Cited by 38 · see citing works
Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors
Cifuentes-Pagano, E., Saha, J., Csányi, G., Ghouleh, I. A., Sahoo, S., Rodriguez, A. I., Wipf, P., Pagano, P. J., & Skoda, E. M. (2013) · MedChemComm · doi:10.1039/c3md00061c · Cited by 39 · see citing works
Harijith, A. K., Pendyala, S., Ebenezer, D. L., Ha, A. W., Fu, P., Wang, Y.-T., Ma, K., Tóth, P. T., Berdyshev, E. V., Kanteti, P. V. S., et al. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00447.2015 · Cited by 38 · see citing works
Xu, T., Sun, L., Shen, X., Chen, Y., Yin, Y., Zhang, J., Huang, D., Li, W., & Li, W. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.025 · Cited by 38 · see citing works
The Role of Vitamin D in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512473196 · Cited by 36 · see citing works
Sun, L., Chen, Y., Shen, X., Xu, T., Yin, Y., Zhang, H., Ding, S., Zhao, Y., Zhang, Y., Guan, Y., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105721 · Cited by 36 · see citing works
NADPH oxidase 4 (NOX4) as a biomarker and therapeutic target in neurodegenerative diseases
Boonpraman, N., & Yi, S. S. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390973 · Cited by 35 · see citing works
Chen, X.-H., Zhou, X. P., Yang, X., Zhou, Z., Lu, D., Tang, Y., Ling, Z., Zhou, L., & Feng, X. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0235-1 · Cited by 35 · see citing works
Ibrahim, W. W., Ismail, H. M., Khattab, M. M., & Abdelkader, N. F. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115028 · Cited by 34 · see citing works
Izuo, N., Kume, T., Sato, M., Murakami, K., Irie, K., Izumi, Y., & Akaike, A. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300033k · Cited by 34 · see citing works
NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders
Zilberter, Y., Tabuena, D. R., & Zilberter, M. Y. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102539 · Cited by 34 · see citing works
(−)-Epicatechin mitigates high fat diet-induced neuroinflammation and altered behavior in mice
Kang, J., Wang, Z., & Oteiza, P. I. (2020) · Food & Function · doi:10.1039/d0fo00486c · Cited by 33 · see citing works
The Role of Beta-Adrenergic Receptor Blockers in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513488924 · Cited by 32 · see citing works
Lobine, D., Sadeer, N., Jugreet, S., Suroowan, S., Keenoo, B. S., Imran, M., Venugopala, K. N., Ibrahim, F. M., Zengin, G., & Mahomoodally, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210412095251 · Cited by 32 · see citing works
Unifying mechanism behind the onset of acquired epilepsy
Zilberter, Y., Popova, I. Y., & Zilberter, M. Y. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.11.009 · Cited by 30 · see citing works
Oxidative Stress, Neuroinflammation, and Neurodegeneration
Gao, H., Zhou, H., & Hong, J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_5 · Cited by 30 · see citing works
Pepping, J. K., Vandanmagsar, B., Fernandez-Kim, S.-O., Zhang, J., Mynatt, R. L., & Bruce‐Keller, A. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181500 · Cited by 29 · see citing works
Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease
Maia, M. D. S., Rodrigues, G. C. S., de Sousa, N. F., Scotti, M. T., Scotti, L., & Mendonça, F. J. B. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3098673 · Cited by 28 · see citing works
Patrick, S., Corrigan, R. R., Grizzanti, J., Mey, M., Blair, J., Pallàs, M., Camins, A., Lee, H., & Casadesús, G. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180421 · Cited by 27 · see citing works
Zhou, Z., Wang, M., Huang, C., Li, Y., Gao, L., Zhu, Y., Ying, C., & Zhou, X. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.09.018 · Cited by 26 · see citing works
Glutamine Supplementation Prevents Chronic Stress-Induced Mild Cognitive Impairment
Baek, J. H., Jung, S., Son, H., Kang, J. S., & Kim, H. J. (2020) · Nutrients · doi:10.3390/nu12040910 · Cited by 24 · see citing works
Hashimoto, Y., Toyama, Y., Kusakari, S., Nawa, M., & Matsuoka, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.698092 · Cited by 26 · see citing works
Reddan, J. M., White, D., Macpherson, H., Scholey, A. B., & Pipingas, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00049 · Cited by 25 · see citing works
Kan, H., Hu, W., Wang, Y., Wu, W., Yin, Y., Liang, Y., Wang, C., Huang, D., & Li, W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3894 · Cited by 24 · see citing works
The Hidden Notes of Redox Balance in Neurodegenerative Diseases
Piccirillo, S., Magi, S., Preziuso, A., Serfilippi, T., Cerqueni, G., Orciani, M., Amoroso, S., & Lariccia, V. (2022) · Antioxidants · doi:10.3390/antiox11081456 · Cited by 25 · see citing works
Ansari, M. A., Rao, M. S. R., & Al‐Jarallah, A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1273626 · Cited by 23 · see citing works
Kim, J., & Moon, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212299 · Cited by 23 · see citing works
Mizutani, H., Sato, Y., Yamazaki, M., Yoshizawa, T., Ando, Y., Ueda, M., & Yamagata, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169027 · Cited by 22 · see citing works
Yang, L., Zhou, H., Huang, L., Su, Y., Kong, L., Ji, P., Sun, R., Wang, C., Li, W., & Li, W. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108972 · Cited by 23 · see citing works
Chronic stress alters the expression levels of longevity-related genes in the rat hippocampus
Sánchez-Hidalgo, A. C., Muñoz, M., Herrera, A. J., Espinosa‐Oliva, A. M., Stowell, R. D., Ayala, A., Machado, A., Venero, J. L., & de Pablos, R. M. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.04.009 · Cited by 22 · see citing works
Gao, M., Kang, Y., Zhang, L., Li, H., Qu, C., Luan, X., Liu, L., & Zhang, S. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4653 · Cited by 21 · see citing works
Walsh, K. P., Kuhn, T. B., & Bamburg, J. R. (2014) · Prion · doi:10.4161/pri.35504 · Cited by 21 · see citing works
Cooperation between neurovascular dysfunction and Aβ in Alzheimer’s disease
Wang, N., Yang, X., Zhao, Z., Liu, D., Wang, X., Tang, H., Zhong, C., Chen, X., Chen, W. K., & Meng, Q. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1227493 · Cited by 20 · see citing works
Pallebage‐Gamarallage, M. M., Takechi, R., Lam, V., Elahy, M., & Mamo, J. C. L. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1115820 · Cited by 19 · see citing works
Doğan, H. O., & Yıldız, Ö. K. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.05.011 · Cited by 19 · see citing works
da Silva, P. R., Andrade, J., de Sousa, N. F., Portela, A. C. R., Pires, H. F. O., Remígio, M. C. R. B., Alves, D. D. N., de Andrade, H. H. N., Dias, A. L., Salvadori, M. G. D. S. S., et al. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230221123059 · Cited by 19 · see citing works
Fu, Q., Gao, N., Yu, J., Ma, G., Du, Y., Wang, F., Su, Q., & Che, F. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1313-3 · Cited by 18 · see citing works
The Role of NOX4 in Parkinson’s Disease with Dementia
Choi, D., Choi, I.-A., Lee, C.-S., Yun, J. H., & Lee, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030696 · Cited by 18 · see citing works
Oxidative stress precedes mitochondrial dysfunction in gerbil brain after aluminum ingestion
Vucetic-Arsic, S., Radonjić, N. V., Jovanović, M., Selaković, V., Nikolić, T., Velimirović, M., Stojković, T., Milovanović, A., Milovanovic, J. P., & Petronijević, N. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.10.008 · Cited by 17 · see citing works
NOX2 in Alzheimer's and Parkinson's disease
Dustin, C. M., Shiva, S. S., Vazquez, A. L., Saeed, A., Pascoal, T. A., Cifuentes-Pagano, E., & Pagano, P. J. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103433 · Cited by 17 · see citing works
Radbruch, H., Mothes, R., Bremer, D., Seifert, S., Köhler, R., Pohlan, J., Ostendorf, L., Günther, R., Leben, R., Stenzel, W., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00844 · Cited by 15 · see citing works
- Authors
- Ansari, M. A., & Scheff, S. W.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Scheff, Stephen W.
- ORCID
- Ansari, Mubeen A.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 51
- Issue
- 1
- Pages
- 171-178
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC3109185
- OpenAlex
- W2068872788
- Cited by
- 131
- References
- 43
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 13 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 6 · 2014: 12 · 2013: 9 · 2012: 10
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AG27219, PO1 AG14449, AG028383)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- NADPH oxidase, Alzheimer's disease, cognitive impairment, mild cognitive impairment, superoxide production, gp91phox, p67phox, p47phox, p40phox, p22phox, frontal cortex, temporal cortex, redox pathways, disease progression, postmortem brain
- MeSH terms
- NADPH Oxidase 2, Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Enzyme Activation, Female, Humans, Male, Membrane Glycoproteins, Superoxides, Blotting, Western, Oxidative Stress, Disease Progression, NADPH Oxidases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
