Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function
Open accessAbstract
BACKGROUND AND OBJECTIVES: The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with CKD. We examined baseline demographic and clinical characteristics. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Seven clinical centers recruited adults who were aged 21 to 74 yr and had CKD using age-based estimated GFR (eGFR) inclusion criteria. At baseline, blood and urine specimens were collected and information regarding health behaviors, diet, quality of life, and functional status was obtained. GFR was measured using radiolabeled iothalamate in one third of participants. RESULTS: A total of 3612 participants were enrolled with mean age +/- SD of 58.2 +/- 11.0 yr; 46% were women, and 47% had diabetes. Overall, 45% were non-Hispanic white, 46% were non-Hispanic black, and 5% were Hispanic. Eighty-six percent reported hypertension, 22% coronary disease, and 10% heart failure. Mean body mass index was 32.1 +/- 7.9 kg/m(2), and 47% had a BP >130/80 mmHg. Mean eGFR was 43.4 +/- 13.5 ml/min per 1.73 m(2), and median (interquartile range) protein excretion was 0.17 g/24 h (0.07 to 0.81 g/24 h). Lower eGFR was associated with older age, lower socioeconomic and educational level, cigarette smoking, self-reported CVD, peripheral arterial disease, and elevated BP. CONCLUSIONS: Lower level of eGFR was associated with a greater burden of CVD as well as lower socioeconomic and educational status. Long-term follow-up of participants will provide critical insights into the epidemiology of CKD and its relationship to adverse outcomes.
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In CRIC, 88% of participants had stage 3 or 4 chronic kidney disease.
“Difficulty controlling BP in late stages of CKD was also seen in CRIC (Chronic Renal Insufficiency Cohort), in which 88% of participants had stage 3 or 4 CKD.”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [302]
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Physical Performance and Frailty in Chronic Kidney Disease
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Self-citationAtrial Fibrillation and Risk of ESRD in Adults with CKD
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Self-citationIndoxyl sulfate suppresses endothelial progenitor cell–mediated neovascularization
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Arterial Stiffness in CKD: A Review
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Self-citationPrevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease
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Mortality and Cardiovascular Disease Among Older Live Kidney Donors
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Mobile Health (mHealth) Technology: Assessment of Availability, Acceptability, and Use in CKD
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Self-citationGenome-Wide Association Studies in Nephrology Research
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Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study
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Self-citationThe Association of Sleep Duration and Quality with CKD Progression
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Self-citation
- Authors
- Lash, J. P., Go, A. S., Appel, L. J., He, J., Ojo, A., Rahman, M., Townsend, R. R., Xie, D., Cifelli, D., Cohan, J., Fink, J. C., Fischer, M. J., Gadegbeku, C., Hamm, L. L., Kusek, J. W., Landis, J. R., Narva, A., Robinson, N., Teal, V., & Feldman, H. I.
- Affiliations
- University of Illinois Chicago (US)
- Kaiser Permanente (US)
- Johns Hopkins University (US)
- Tulane University (US)
- University of Michigan (US)
- University of Maryland, Baltimore (US)
- Edward Hines, Jr. VA Hospital (US)
- National Institutes of Health (US)
- Corresponding author
- Lash, James P.
- Rahman, Mahboob
- Cohan, Janet
- Fischer, Michael J.
- Kusek, John W.
- Narva, Andrew
- ORCID
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2009-08
- Volume
- 4
- Issue
- 8
- Pages
- 1302-1311
- ISSN
- 1555-9041 (ISSN-L)
- PMC
- PMC2723966
- OpenAlex
- W2160134719
- Cited by
- 619
- References
- 52
- Citations by year
- 2026: 37 · 2025: 36 · 2024: 42 · 2023: 40 · 2022: 58 · 2021: 52 · 2020: 51 · 2019: 39 · 2018: 34 · 2017: 32 · 2016: 48 · 2015: 34 · 2014: 27 · 2013: 37 · 2012: 23
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k24dk002651-10)
- University of Illinois at Urbana-Champaign
- National Institute of Diabetes and Digestive and Kidney Diseases (5U01DK06102, 5K24DK002651, R01DK072231, K24-DK002651, U01DK060990, 5U01 DK60980, T32DK060455, U01DK060984, U01DK060902, U01DK060980, U01DK060963, U01DK061021, U01DK061028)
- National Center for Research Resources (UL1RR024131, RR-05096, UL1RR024989, UL1RR025005, M01RR013987, M01RR016500, M01RR-013987-06, UL1RR024986, M01RR005096, M01 RR-024986, M01RR 16500, M01RR000042)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- chronic kidney disease, estimated glomerular filtration rate, cardiovascular disease, chronic kidney disease progression, risk factors, socioeconomic status, educational attainment, hypertension, diabetes mellitus, proteinuria, peripheral arterial disease, smoking, quality of life, functional status, CRIC study
- MeSH terms
- Adult, Age Factors, Aged, Blood Pressure, Cardiovascular Diseases, Educational Status, Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Male, Middle Aged, Prospective Studies, Proteinuria, Risk Factors, Smoking, Social Class, United States, Disease Progression, Risk Assessment, Patient Selection, Renal Insufficiency, Chronic, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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