Role of Hypoxia-Inducible Factors in Breast Cancer Metastasis

Molecular portraits of human breast tumours

Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551

Comprehensive molecular portraits of human breast tumours

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · cited 2×

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

Involvement of chemokine receptors in breast cancer metastasis

Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,917

Hypoxia-inducible factors in physiology and medicine

Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251

Genes that mediate breast cancer metastasis to lung

Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922

A multigenic program mediating breast cancer metastasis to bone

Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600

Regulation of angiogenesis by hypoxia: role of the HIF system

Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520

Untitled work

(1999) · PubMed · Cited by 2,204

Genes that mediate breast cancer metastasis to the brain

Bos, P. D., Zhang, X. H.-F., Nadal, C., Shu, W., Gomis, R. R., Nguyen, D. X., Minn, A. J., van de Vijver, M. J., Gerald, W. L., Foekens, J. A., et al. (2009) · Nature · doi:10.1038/nature08021 · Cited by 1,863

Collagen reorganization at the tumor-stromal interface facilitates local invasion

Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-38 · Cited by 1,804

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Semenza, G. L. (2010) · Oncogene · doi:10.1038/onc.2009.441 · Cited by 1,712

Lymphangiogenesis: Molecular Mechanisms and Future Promise

Tammela, T., & Alitalo, K. K. (2010) · Cell · doi:10.1016/j.cell.2010.01.045 · Cited by 1,485

Direct regulation of TWIST by HIF-1α promotes metastasis

Yang, M.-H., Wu, M.-Z., Chiou, S.-H., Chen, P.-M., Chang, S.-Y., Liu, C.-J., Teng, S.-C., & Wu, K.-J. (2008) · Nature Cell Biology · doi:10.1038/ncb1691 · Cited by 1,345

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,321

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Pennacchietti, S., Michieli, P., Galluzzo, M., Mazzone, M., Giordano, S., & Comoglio, P. M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00085-0 · Cited by 1,311

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.11.012 · Cited by 1,231

Collagens, modifying enzymes and their mutations in humans, flies and worms

Myllyharju, J. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.11.004 · Cited by 1,229

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

Lin, E. Y., Jones, J. G., Li, P., Zhu, L., Whitney, K. D., Muller, W. J., & Pollard, J. W. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63568-7 · Cited by 1,109

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

Ravi, R. K., Mookerjee, B., Bhujwalla, Z. M., Sutter, T. R., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · PubMed Central · Cited by 1,099

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S. K., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1823 · Cited by 1,089

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 982

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development · doi:10.1101/gad.14.1.34 · Cited by 967

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870

Molecular mechanisms of lymphangiogenesis in health and disease

Alitalo, K. K., & Carmeliet, P. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00051-x · Cited by 737

Detection and Characterization of Tumor Hypoxia Using pO 2 Histography

Vaupel, P., Höckel, M., & Mayer, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1628 · Cited by 728

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Schödel, J., Oikonomopoulos, S., Ragoussis, J., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2011) · Blood · doi:10.1182/blood-2010-10-314427 · Cited by 724

Metalloproteinases: role in breast carcinogenesis, invasion and metastasis

Duffy, M. J., Maguire, T. M., Hill, A. D. K., McDermott, E. W. M., & O’Higgins, N. J. (2000) · Breast Cancer Research · doi:10.1186/bcr65 · Cited by 628

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809763105 · Cited by 624

Untitled work

(2003) · PubMed · Cited by 624

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1

Kelly, B. D., Hackett, S. F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P. A., & Semenza, G. L. (2003) · Circulation Research · doi:10.1161/01.res.0000102937.50486.1b · Cited by 611

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523

Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis

Myllyharju, J. (2003) · Matrix Biology · doi:10.1016/s0945-053x(03)00006-4 · Cited by 500

Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

Bos, R., van der Groep, P., Greijer, A. E., Shvarts, A., Meijer, S., Pinedo, H. M., Semenza, G. L., van Diest, P. J., & van der Wall, E. (2003) · Cancer · doi:10.1002/cncr.11246 · Cited by 500

Tumor hypoxia and malignant progression

Vaupel, P., Mayer, A., & Höckel, M. (2004) · Methods in Enzymology · doi:10.1016/s0076-6879(04)81023-1 · Cited by 496

HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical

Loboda, A., Jozkowicz, A., & Dulak, J. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0067-2 · Cited by 477

Requirement for Specific Proteases in Cancer Cell Intravasation as Revealed by a Novel Semiquantitative PCR-Based Assay

Kim, J., Yu, W., Kovalski, K., & Ossowski, L. (1998) · Cell · doi:10.1016/s0092-8674(00)81478-6 · Cited by 468

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113483108 · Cited by 437

Hypoxia-driven selection of the metastatic phenotype

Sullivan, R., & Graham, C. H. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9062-2 · Cited by 423

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

Wang, W., Wyckoff, J. B., Frohlich, V. C., Oleynikov, Y., Hüttelmaier, S., Zavadil, J., C̆ermák, L., Böttinger, E. P., Singer, R. H., White, J. G., et al. (2002) · PubMed · Cited by 417

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

Xia, X., Lemieux, M. E., Li, W., Carroll, J. S., Brown, M., Liu, X. S., & Kung, A. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810067106 · Cited by 410

Silencing of CXCR4 Blocks Breast Cancer Metastasis

Liang, Z., Yoon, Y., Votaw, J. R., Goodman, M. M., Williams, L. G., & Shim, H. (2005) · Cancer Research · doi:10.1158/0008-5472.967.65.3 · Cited by 406

Methylation Patterns of the E-cadherin 5′ CpG Island Are Unstable and Reflect the Dynamic, Heterogeneous Loss of E-cadherin Expression during Metastatic Progression

Graff, J. R., Gabrielson, E. W., Fujii, H., Baylin, S. B., & Herman, J. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2727 · Cited by 396

Untitled work

(2002) · PubMed · Cited by 385

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

Sceneay, J., Chow, M. T., Chen, A., Halse, H. M., Wong, C. S. F., Andrews, D. M., Sloan, E. K., Parker, B. S., Bowtell, D. D. L., Smyth, M. J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3873 · Cited by 375

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

Chen, J., Imanaka, N., Chen, J., & Griffin, J. D. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605486 · Cited by 346

Hypoxia-Inducible Factor-1α Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression

Liao, D., Corle, C., Seagroves, T. N., & Johnson, R. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2701 · Cited by 339

Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4

Liang, Z., Wu, T., Lou, H. X., Yu, X., Taichman, R. S., Lau, S. K., Nie, S., Umbreit, J. N., & Shim, H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3958 · Cited by 338

Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia

Kaidi, A., Qualtrough, D., Williams, A. C., & Paraskeva, C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0425 · Cited by 300

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

Huang, R.-L., Teo, Z., Chong, H. C., Zhu, P., Tan, M., Tan, C. K., Lam, C. R. I., Sng, M. K., Leong, D. T., Tan, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-328716 · Cited by 290

The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia

Schietke, R. E., Warnecke, C., Wacker, I., Schödel, J., Mole, D. R., Câmpean, V., Amann, K., Goppelt‐Struebe, M., Behrens, J., Eckardt, K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.042424 · Cited by 266

Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients

Dalès, J.-P., Garcia, S., Meunier-Carpentier, S., Andrac, L., Haddad, O., Lavaut, M., Allasia, C., Bonnier, P., & Charpin, C. (2005) · International Journal of Cancer · doi:10.1002/ijc.20984 · Cited by 263

Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis

Huang, Y., Song, N., Ding, Y., Yuan, S., Li, X., Cai, H., Shi, H., & Luo, Y. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4382 · Cited by 257

EMT: A new vision of hypoxia promoting cancer progression

Jiang, J. D., Tang, Y., & Liang, X. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.8.15274 · Cited by 254

Hypoxia-Inducible Factor-1α Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

Generali, D., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., Wigfield, S., Bersiga, A., Allevi, G., Milani, M., Aguggini, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2690 · Cited by 253

Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

Chaturvedi, P., Gilkes, D. M., Wong, C. C., Gupta, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64993 · Cited by 244

HIF‐1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome

Trastour, C., Benizri, E. I., Ettore, F., Ramaioli, A., Chamorey, E., Pouysségur, J., & Berra, E. (2007) · International Journal of Cancer · doi:10.1002/ijc.22436 · Cited by 233

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

Luo, W., Chang, R., Zhong, J., Pandey, A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217394109 · Cited by 228

Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer

Vleugel, M. M., Greijer, A. E., Shvarts, A., van der Groep, P., van Berkel, M., Aarbodem, Y., van Tinteren, H., Harris, A. L., van Diest, P. J., & van der Wall, E. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.019885 · Cited by 227

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

Wong, C. C., Zhang, H., Gilkes, D. M., Chen, J., Wei, H., Chaturvedi, P., Hubbi, M. E., & Semenza, G. L. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0855-y · Cited by 226

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

Semenza, G. L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.08.001 · Cited by 225

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

Schito, L., Rey, S., Tafani, M., Zhang, H., Wong, C. C.-L., Russo, A., Russo, M. A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214019109 · Cited by 224

The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1

Simon, M., Tournaire, R., & Pouysségur, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21558 · Cited by 220

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

Xing, F., Okuda, H., Watabe, M., Kobayashi, A., Pai, S., Liu, W., Pandey, P., Fukuda, K., Hirota, S., Sugai, T., et al. (2011) · Oncogene · doi:10.1038/onc.2011.122 · Cited by 219

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

Dunn, L. K., Mohammad, K. S., Fournier, P. G. J., McKenna, C. R., Davis, H. W., Niewolna, M., Peng, X. H., Chirgwin, J. M., & Guise, T. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006896 · Cited by 212

Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation

Muñoz-Nájar, U. M., Neurath, K. M., Vumbaca, F., & Claffey, K. P. (2006) · Oncogene · doi:10.1038/sj.onc.1209273 · Cited by 209

Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel–Lindau renal cell carcinoma

Petrella, B. L., Lohi, J., & Brinckerhoff, C. (2004) · Oncogene · doi:10.1038/sj.onc.1208305 · Cited by 195

TNFalpha up‐regulates SLUG via the NF‐kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell‐like phenotype

Storci, G., Sansone, P., Mari, S., D’Uva, G., Tavolari, S., Guarnieri, T., Taffurelli, M., Ceccarelli, C., Santini, D., Chieco, P., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22264 · Cited by 188

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69244 · Cited by 181

Cancer spread and micrometastasis development: Quantitative approaches for in vivo models

MacDonald, I. C., Groom, A. C., & Chambers, A. F. (2002) · BioEssays · doi:10.1002/bies.10156 · Cited by 181

Hypoxia, Snail and incomplete epithelial–mesenchymal transition in breast cancer

Lundgren, K., Nordenskjöld, B. A., & Landberg, G. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605369 · Cited by 174

ROS: Really involved in Oxygen Sensing

Kaelin, W. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.006 · Cited by 173

Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer

Yamamoto, Y., Ibusuki, M., Okumura, Y., Kawasoe, T., Kai, K., Iyama, K., & Iwase, H. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9742-1 · Cited by 151

Ephrin-A1 Facilitates Mammary Tumor Metastasis through an Angiogenesis-Dependent Mechanism Mediated by EphA Receptor and Vascular Endothelial Growth Factor in Mice

Brantley‐Sieders, D. M., Fang, W. B., Hwang, Y., Hicks, D. J., & Chen, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1560 · Cited by 143

Alternative and complementary cancer therapies

Cassileth, B. R., & Chapman, C. C. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960315)77:6 · Cited by 142

Hypoxia-inducible factor-1α and vascular endothelial growth factor expression in circulating tumor cells of breast cancer patients

Kallergi, G., Markomanolaki, H., Giannoukaraki, V., Papadaki, M. A., Strati, A. D., Lianidou, E. S., Georgoulias, V., Mavroudis, D., & Agelaki, S. (2009) · Breast Cancer Research · doi:10.1186/bcr2452 · Cited by 140

Hypoxia-Inducible Factor-2α Correlates to Distant Recurrence and Poor Outcome in Invasive Breast Cancer

Helczynska, K., Larsson, A.-M., Holmquist Mengelbier, L., Bridges, E., Fredlund, E., Borgquist, S., Landberg, G., Påhlman, S., & Jirström, K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1135 · Cited by 136

Mechanisms of bone metastases of breast cancer

Suva, L. J., Griffin, R. J., & Makhoul, I. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0012 · Cited by 131

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

Jin, F., Brockmeier, U., Otterbach, F., & Metzen, E. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0498 · Cited by 129

CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis

Thomas, S., Harding, M. A., Smith, S. C., Overdevest, J. B., Nitz, M. D., Frierson, H. F., Tomlins, S. A., Kristiansen, G., & Theodorescu, D. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3666 · Cited by 128

HIF1α is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development

Bentovim, L., Amarilio, R., & Zelzer, E. (2012) · Development · doi:10.1242/dev.083881 · Cited by 125

The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: involvement in myeloma-induced angiogenesis

Colla, S., Tagliaferri, S., Morandi, F., Lunghi, P., Donofrío, G., Martorana, D., Mancini, C., Lazzaretti, M., Mazzera, L., Ravanetti, L., et al. (2007) · Blood · doi:10.1182/blood-2007-02-074617 · Cited by 123

Mouse Snail Is a Target Gene for HIF

Luo, D., Wang, J., Li, J., & Post, M. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0214 · Cited by 116

Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1α in Advanced Solid Tumors

Kummar, S., Raffeld, M., Juwara, L., Horneffer, Y., Strassberger, A., Allen, D., Steinberg, S. M., Rapisarda, A., Spencer, S. D., Figg, W. D., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0682 · Cited by 115

Proteasomal Inhibition Attenuates Transcriptional Activity of Hypoxia-Inducible Factor 1 (HIF-1) via Specific Effect on the HIF-1α C-Terminal Activation Domain

Kaluz, S., Kaluzová, M., & Stanbridge, E. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00552-06 · Cited by 108

Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer

Schoppmann, S. F., Fenzl, A., Schindl, M., Bachleitner-Hofmann, T., Nagy, K., Gnant, M., Horvat, R., Jakesz, R., & Birner, P. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9190-3 · Cited by 106

Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1α in Cancer: Role of Free Radical Formation

Quintero, M., Brennan, P. A., Thomas, G. J., & Moncada, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-0333 · Cited by 105

Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs

Loayza‐Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., & Noda, M. (2010) · Oncogene · doi:10.1038/onc.2010.23 · Cited by 97

A CD44−/CD24+ phenotype is a poor prognostic marker in early invasive breast cancer

Ahmed, M. A. H., Aleskandarany, M. A., Rakha, E. A., Moustafa, R. Z. A., Benhasouna, A., Nolan, C. C., Green, A. R., Ilyas, M., & Ellis, I. O. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1865-8 · Cited by 95

Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression

Carbonaro, M., O’Brate, A., & Giannakakou, P. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201004145 · Cited by 95

Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia

Funasaka, T., Yanagawa, T., Hogan, V. A., & Raz, A. (2005) · The FASEB Journal · doi:10.1096/fj.05-3699com · Cited by 93

Chemokine C ‐ C motif receptor 5 and C ‐ C motif ligand 5 promote cancer cell migration under hypoxia

Lin, S., Wan, S., Sun, L., Hu, J., Fang, D., Zhao, R., Yuan, S., & Zhang, L. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02259.x · Cited by 92

In vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer

Lü, X., Yan, C. H., Yuan, M., Wei, Y., Hu, G., & Kang, Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3739 · Cited by 91

Hypoxia inducible factor‐1α is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response

Kronblad, Å., Jirström, K., Rydén, L., Nordenskjöld, B. A., & Landberg, G. (2005) · International Journal of Cancer · doi:10.1002/ijc.21676 · Cited by 84

Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes

Kita, K., Saito, S., Morioka, C. Y., & Watanabe, A. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990209)80:4 · Cited by 82

c- erb B-2 Related Aggressiveness in Breast Cancer Is Hypoxia Inducible Factor-1α Dependent

Giatromanolaki, A. N., Koukourakis, M. I., Simopoulos, C., Polychronidis, A., Gatter, K. C., Harris, A. L., & Sivridis, E. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1068 · Cited by 81

Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial and Mesenchymal Phenotype Conversions in Breast Cancer

Funasaka, T., Hogan, V. A., & Raz, A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0488 · Cited by 81

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Büchler, P., Reber, H. A., Tomlinson, J. S., Hankinson, O., Kallifatidis, G., Frieß, H., Herr, I., & Hines, O. J. (2009) · Neoplasia · doi:10.1593/neo.08734 · Cited by 75

Hypoxia-inducible Transcription Factor-2α in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1

Yamashita, T., Ohneda, K., Nagano, M., Miyoshi, C., Kaneko, N., Miwa, Y., Yamamoto, M. P., Ohneda, O., & Fujii‐Kuriyama, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709133200 · Cited by 75

Polyomavirus middle T–induced mammary intraepithelial neoplasia outgrowths: Single origin, divergent evolution, and multiple outcomes

Maglione, J. E., McGoldrick, E. T., Young, L. J. T., Namba, R., Gregg, J. P., Liu, L., Moghanaki, D. M., Ellies, L. G., Borowsky, A. D., Cardiff, R. D., et al. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.941.3.8 · Cited by 73

Up‐regulation of pro‐inflammatory genes as adaptation to hypoxia in MCF‐7 cells and in human mammary invasive carcinoma microenvironment

Tafani, M., Russo, A., Vito, M. D., Sale, P., Pellegrini, L., Schito, L., Gentileschi, S., Bracaglia, R., Marandino, F., Garaci, E., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01493.x · Cited by 67

Hypoxia-inducible factor-1α correlates with MET and metastasis in node-negative breast cancer

Chen, H. H. W., Su, W., Lin, P. W., Guo, H., & Lee, W. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9360-3 · Cited by 66

Prognostic Potential Of The Pretherapeutic Tumor Oxygenation Status

Vaupel, P. W. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-85998-9_36 · Cited by 63

Lymphatic and angiogenic characteristics in breast cancer: morphometric analysis and prognostic implications

Mohammed, R. A., Ellis, I. O., Elsheikh, S. E., Paish, E. C., & Martin, S. G. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-9936-1 · Cited by 60

A signature predictive of disease outcome in breast carcinomas, identified by quantitative immunocytochemical assays

Charpin, C., Secq, V., Giusiano, S., Carpentier, S., Andrac, L., Lavaut, M., Allasia, C., Bonnier, P., & Garcia, S. (2008) · International Journal of Cancer · doi:10.1002/ijc.24177 · Cited by 58

The invasive front in endometrial carcinoma: Higher proliferation and associated derailment of cell cycle regulators

Horrée, N., van Diest, P. J., Sie-Go, D. M. D. S., & Heintz, A. P. M. (2007) · Human Pathology · doi:10.1016/j.humpath.2007.01.008 · Cited by 53

Chemokine C–X–C motif receptor 6 contributes to cell migration during hypoxia

Lin, S., Sun, L., Hu, J., Wan, S., Zhao, R., Yuan, S., & Zhang, L. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.01.029 · Cited by 49

The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells

Wan, J., Ma, J.-B., Mei, J., & Shan, G. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-150 · Cited by 45

Low expression of RECK indicates a shorter survival for patients with invasive breast cancer

Zhang, Y., Cheng, S., Zhang, G., Ma, W., Liu, Y., Zhao, R., Zhang, Q., & Pang, D. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02265.x · Cited by 36

Validation of an immunohistochemical signature predictive of 8‐year outcome for patients with breast carcinoma

Charpin, C., Tavassoli, F. A., Secq, V., Giusiano, S., Villeret, J., Garcia, S., Birnbaum, D., Bonnier, P., Lavaut, M., Boubli, L., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.27371 · Cited by 25

Advances in cancer biology and therapy

Semenza, G. L. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1024-2 · Cited by 6

NF-κB, inflammation, immunity and cancer: coming of age

Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

Schito, L., & Semenza, G. L. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.10.016 · Cited by 962

Molecular landmarks of tumor hypoxia across cancer types

Bhandari, V., Hoey, C., Liu, L. Y., Lalonde, E., Ray, J., Livingstone, J., Lesurf, R., Shiah, Y.-J., Vujcic, T., Huang, X., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0318-2 · Cited by 678

NF‐κB signaling in inflammation and cancer

Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 639

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

Semenza, G. L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.08.001 · Cited by 225

Implications of Hypoxia in Breast Cancer Metastasis to Bone

Gilkes, D. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101669 · Cited by 65

Hypoxia and Breast Cancer Metastasis

Schito, L., & Semenza, G. L. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-9167-5_1 · Cited by 5

Hypoxic pathobiology of breast cancer metastasis

Schito, L., & Rey, S. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.05.004 · Cited by 63

Hypoxia and Metastasis in Breast Cancer

Rundqvist, H., & Johnson, R. S. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_77 · Cited by 33