Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
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BACKGROUND: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population. METHODS: In an open trial, we gave Bifidobacterium breve M-16V and Bifidobacterium longum BB536 prenatally to 130 mothers beginning 1 month prior to delivery and postnatally to their infants for 6 months. Another 36 mother-infant pairs served as controls and did not receive the bifidobacterial supplementation. Development of allergic symptoms in the infants was assessed at 4, 10 and 18 months of age. Fecal samples were collected from the mothers and infants. RESULTS: The risk of developing eczema/atopic dermatitis (AD) during the first 18 months of life was significantly reduced in infants in the probiotic group (OR: 0.231 [95% CI: 0.084-0.628] and 0.304 [0.105-0.892] at 10 and 18 months of age, respectively). Pyrosequencing analyses indicated an altered composition of the fecal microbiota at 4 months for infants who developed eczema/AD at 4 and 10 months of age. The proportion of Proteobacteria was significantly lower (P = 0.007) in mothers at the time of delivery who received the supplementation when compared with the control group and was positively correlated (r = 0.283, P = 0.024) with that of infants at 4 months of age. No adverse effects were related to the use of probiotics. CONCLUSIONS: These data suggest that the prenatal and postnatal supplementation of bifidobacteria is effective in primary preventing allergic diseases. Some limited changes in the composition of fecal microbiota by the bifidobacterial supplementation were observed.
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In vitro and in vivo studies have shown that modulating bifidobacterial levels through probiotic or prebiotic supplementation can change the overall composition and metabolism of the gut microbiota.
“In vitro and in vivo studies have shown that modulating bifidobacterial levels through probiotic or prebiotic supplementation can change the overall composition and metabolism of the gut microbiota (49–53).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [51]
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- Authors
- Enomoto, T., Sowa, M., Nishimori, K., Shimazu, S., Yoshida, A., Yamada, K., Furukawa, F., Nakagawa, T., Yanagisawa, N., Iwabuchi, N., Odamaki, T., Abe, F., Nakayama, J., & Xiao, J.-Z.
- Affiliations
- Hidaka Hospital (JP)
- Japanese Red Cross Society Wakayama Medical Center (JP)
- Wakayama Medical University (JP)
- Morinaga Milk Industry Co., Ltd. (Japan) (JP)
- Kyushu University (JP)
- Corresponding author
- Enomoto, Tadao
- ORCID
- Venue
- Allergology International
- Publisher
- Japanese Society of Allergology
- Published
- 2014
- Volume
- 63
- Issue
- 4
- Pages
- 575-585
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2000251859
- Cited by
- 165
- References
- 43
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 13 · 2023: 10 · 2022: 20 · 2021: 22 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 12 · 2016: 14 · 2015: 14 · 2014: 2
- FWCI
- 20.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Allergology International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Morinaga Milk Industry
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium, probiotics, Bifidobacterium breve M-16V, Bifidobacterium longum BB536, infant allergy prevention, atopic dermatitis, fecal microbiota, Proteobacteria, maternal gut microbiota, Japanese infants
- MeSH terms
- Adult, Bifidobacterium, Feces, Female, Humans, Hypersensitivity, Infant, Male, Patient Compliance, Pregnancy, Prevalence, Odds Ratio, Probiotics, Biodiversity, Young Adult, Metagenomics, High-Throughput Nucleotide Sequencing, Microbiota
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