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Cited by 521

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study

Open access
Cheng, Susan, Massaro, Joseph M., Fox, Caroline S., Larson, Martin G., Keyes, Michelle J., McCabe, Elizabeth L., Robins, Sander J., O'Donnell, Christopher J., Hoffmann, Udo, Jacques, Paul F., Booth, Sarah L., Vasan, Ramachandran S., Wolf, Myles, Wang, Thomas J.·2010·Diabetes
DOI 10.2337/db09-1011
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Abstract

OBJECTIVE: Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical implications. Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear. RESEARCH DESIGN AND METHODS: We investigated the relations of serum 25-hydroxyvitamin D (25[OH]D) concentrations with indexes of cardiometabolic risk in 3,890 nondiabetic individuals; 1,882 had subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volumes measured by multidetector computed tomography (CT). RESULTS: In multivariable-adjusted regression models, 25(OH)D was inversely associated with winter season, waist circumference, and serum insulin (P < 0.005 for all). In models further adjusted for CT measures, 25(OH)D was inversely related to SAT (−1.1 ng/ml per SD increment in SAT, P = 0.016) and VAT (−2.3 ng/ml per SD, P < 0.0001). The association of 25(OH)D with insulin resistance measures became nonsignificant after adjustment for VAT. Higher adiposity volumes were correlated with lower 25(OH)D across different categories of BMI, including in lean individuals (BMI <25 kg/m2). The prevalence of vitamin D deficiency (25[OH]D <20 ng/ml) was threefold higher in those with high SAT and high VAT than in those with low SAT and low VAT (P < 0.0001). CONCLUSIONS: Vitamin D status is strongly associated with variation in subcutaneous and especially visceral adiposity. The mechanisms by which adiposity promotes vitamin D deficiency warrant further study.

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Metadata

Authors
Cheng, S., Massaro, J. M., Fox, C. S., Larson, M. G., Keyes, M. J., McCabe, E. L., Robins, S. J., O'Donnell, C. J., Hoffmann, U., Jacques, P. F., Booth, S. L., Vasan, R. S., Wolf, M., & Wang, T. J.
Venue
Diabetes
Publisher
American Diabetes Association
Published
2009-10-15
Volume
59
Issue
1
Pages
242-248
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db09-1011
OpenAlex
W2115496586
Cited by
521
References
50
FWCI
24.61
Type
journal article
Language
en
Open access
hybrid

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