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Cited by 61Regulation of Appetite and ObesityDiabetes Management and ResearchDiabetes Treatment and Management

Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects

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Hallschmid, Manfred, Jauch-Chara, Kamila, Korn, Oliver, Mölle, Matthias, Rasch, Björn, Born, Jan, Schultes, Bernd, Kern, Werner·2010·Diabetes
DOI 10.2337/db09-1493PMC PMC2844819
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Abstract

OBJECTIVE: In the treatment of diabetic patients, the long-acting insulin analog insulin detemir is less prone to induce weight gain than other insulin formulations. Assuming that because of its pharmacologic properties, detemir displays stronger central nervous anorexigenic efficacy than human insulin, we compared acute effects of human insulin and detemir on electroencephalography (EEG) measures and food intake. RESEARCH DESIGN AND METHODS: Frontocortical EEG direct current (DC) potentials were recorded in 15 healthy men during two hyperinsulinemic-euglycemic clamps that included an insulin bolus injection (human insulin, 17.75 mU/kg body wt; detemir, 90 mU/kg body wt) followed by a steady 90-min infusion (1.0 vs. 2.0 mU x kg(-1) x min(-1)). A higher dosage was chosen for detemir to compensate for its delay in impact relative to human insulin and to elicit similar systemic effects. At 20 min after infusion, subjects were allowed to eat ad libitum from a test buffet. RESULTS: Mean glucose infusions to maintain euglycemia (P > 0.93) and blood glucose concentrations (P > 0.34) did not differ between conditions. Detemir infusion induced a negative DC-potential shift, averaging -372.2 microV from 21 to 90 min that was not observed during human insulin infusion (146.5 microV, P = 0.02). Detemir, in comparison with human insulin, reduced subsequent food intake by 303 kcal (1,257 vs. 1,560, P < 0.04). CONCLUSIONS: While inducing comparable peripheral effects, detemir exerts stronger acute effects on brain functions than human insulin and triggers a relative decrease in food consumption, suggesting an enhanced anorexigenic impact of detemir compared with human insulin on central nervous networks that control nutrient uptake.

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  • The free-choice ad libitum test buffet enables precise assessment of primarily hunger-driven food intake in the fasted state.

    “This procedure has been repeatedly shown to enable the precise assessment of primarily hunger-driven food intake in the fasted state (20–22).”

    From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [21]

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  1. [31]Heinemann U Lux HD Marciani MG Hofmeier G: Slow potentials in relation to changes in extracellular potassium activity in the cortex of cats. In Origin of Cerebral Field Potentials. Speckmann EJ Caspers H: (Eds.). Stuttgart, Germany, Georg Thieme Publishers, 1979, p. 33– 43

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Authors
Hallschmid, M., Jauch-Chara, K., Korn, O., Mölle, M., Rasch, B., Born, J., Schultes, B., & Kern, W.
Affiliations
  • University of Lübeck (DE)
  • Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany;
  • Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany;
  • Kantonsspital St. Gallen (CH)
Corresponding author
Hallschmid, Manfred
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2010-01-12
Volume
59
Issue
4
Pages
1101-1107
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db09-1493
PMC
PMC2844819
OpenAlex
W2102704045
Cited by
61
References
38
Citations by year
2022: 1 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 6
FWCI
3.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Novo Nordisk
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
insulin detemir, human insulin, long-acting insulin analogues, hyperinsulinemic-euglycemic clamp, EEG, dietary intake, anorectic effect, central nervous system, insulin-induced weight gain, glucose infusion rate, blood glucose
MeSH terms
Insulin Detemir, Adult, Affect, Blood Glucose, Brain, Energy Intake, Electroencephalography, Electromyography, Electrooculography, Glucose, Humans, Hyperinsulinism, Hypoglycemic Agents, Infusions, Intravenous, Insulin, Male, Glucose Clamp Technique, Insulin, Long-Acting

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