Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women
Open accessAbstract
The role of brain insulin signaling in the control of food intake in humans has not been thoroughly defined. We hypothesized that the hormone contributes to the postprandial regulation of appetite for palatable food, and assessed the effects on appetite and snack intake of postprandial versus fasted intranasal insulin administration to the brain in healthy women. Two groups of subjects were intranasally administered 160 IU insulin or vehicle after lunch. Two hours later, consumption of cookies of varying palatability was measured under the pretext of a taste test. In a control study, the effects of intranasal insulin administered to fasted female subjects were assessed. Compared with placebo, insulin administration in the postprandial but not in the fasted state decreased appetite as well as intake and rated palatability of chocolate chip cookies (the most palatable snack offered). In both experiments, intranasal insulin induced a slight decrease in plasma glucose but did not affect serum insulin concentrations. Data indicate that brain insulin acts as a relevant satiety signal during the postprandial period, in particular reducing the intake of highly palatable food, and impacts peripheral glucose homeostasis. Postprandial intranasal insulin administration might be useful in curtailing overconsumption of snacks with accentuated rewarding value.
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Some studies reported effects of brain insulin on postprandial snacking in women.
“However, some studies reported effects of brain insulin on postprandial snacking in women25.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [25]
The snack test assesses reward-related eating in the absence of hunger.
“Reward-related eating in the absence of hunger was assessed using a snack test validated in a series of previous studies (22–24).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [23]
IN insulin administered to healthy women in the postprandial but not preprandial state reduced consumption and rated palatability of chocolate cookies offered after lunch.
“IN insulin administered to healthy women in the postprandial (but not in the preprandial) state reduced the consumption and rated palatability of chocolate cookies offered some time after lunch.”
From Intranasal insulin (2021) · cites this paper as [44]
Delivery schedules synced to food intake might be necessary for the catabolic impact of IN insulin to emerge.
“suggesting that delivery schedules synced to food intake 39,42,44,47 might be necessary for the catabolic impact of IN insulin to emerge.”
From Intranasal insulin (2021) · cites this paper as [44]
IN insulin modulates reward-processing pathways that regulate motivated behaviour, including the hedonic drive to eat.
“The conclusion that IN insulin modulates reward-processing pathways that regulate motivated behaviour including the 'hedonic' drive to eat is in line with experiments in humans showing that IN insulin decreases the intake of palatable snacks.44”
From Intranasal insulin (2021) · cites this paper as [44]
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Cites
The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger
Stunkard, A. J., & Messick, S. (1985) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(85)90010-8 · Cited by 4,687 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
Signals That Regulate Food Intake and Energy Homeostasis
Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,169 · see citing works
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114 · see citing works
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904 · see citing works
Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748 · see citing works
Intranasal insulin improves memory in humans
Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H. L., Born, J., & Kern, W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.04.003 · Cited by 699 · see citing works
Self-citationImages of desire: food-craving activation during fMRI
Pelchat, M. L., Johnson, A., Chan, R., Valdez, J., & Ragland, J. D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.023 · Cited by 667 · see citing works
Hypothalamic KATP channels control hepatic glucose production
Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645 · see citing works
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
Tataranni, P. A., Gautier, J., Chen, K., Uecker, A., Bandy, D. J., Salbe, A. D., Pratley, R. E., Lawson, M. A., Reiman, E. M., & Ravussin, É. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4569 · Cited by 592 · see citing works
Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin
Clegg, D. J., Brown, L. M., Woods, S. C., & Benoit, S. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1339 · Cited by 552 · see citing works
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J. (2000) · Nature Neuroscience · doi:10.1038/77660 · Cited by 495 · see citing works
Figlewicz, D. P., Evans, S. B., Murphy, J., Hoen, M., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04087-8 · Cited by 482 · see citing works
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
Batterham, R. L., Ffytche, D. H., Rosenthal, J., Zelaya, F. O., Barker, G. J., Withers, D. J., & Williams, S. (2007) · Nature · doi:10.1038/nature06212 · Cited by 474 · see citing works
Hunger selectively modulates corticolimbic activation to food stimuli in humans
LaBar, K. S., Gitelman, D. R., Parrish, T. B., Kim, Y.-H., Nobre, A. C., & Mesulam, M. M. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.493 · Cited by 444 · see citing works
Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats
Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C. (2003) · Diabetes · doi:10.2337/diabetes.52.3.682 · Cited by 332 · see citing works
Insulin and the Blood-Brain Barrier
Woods, S. C., Seeley, R. J., Baskin, D. G., & Schwartz, M. W. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033455323 · Cited by 321 · see citing works
Der Mehrdimensionale Befindlichkeitsfragebogen (MDBF)
Heinrichs, M., & Nater, U. M. (2002) · Zeitschrift für Klinische Psychologie und Psychotherapie · doi:10.1026//1616-3443.31.1.66 · Cited by 304 · see citing works
Benedict, C., Kern, W., Schultes, B., Born, J., & Hallschmid, M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2606 · Cited by 296 · cited 8× · see citing works
“Considering that remembering a preceding meal has been previously shown to decrease snack consumption (15,16) and that intranasal insulin improves declarative, hippocampus-dependent memory functions (6,17), experiment I included a free recall of lunch memory which, however, did not yield any signs of insulinimproved m…”
BackgroundResultInfluentialIntranasal Insulin Reduces Body Fat in Men but not in Women
Hallschmid, M., Benedict, C., Schultes, B., Fehm, H.-L., Born, J., & Kern, W. (2004) · Diabetes · doi:10.2337/diabetes.53.11.3024 · Cited by 281 · see citing works
Self-citationCNS leptin and insulin action in the control of energy homeostasis
Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 275 · see citing works
Rogers, P. J., & Hill, A. J. (1989) · Addictive Behaviors · doi:10.1016/0306-4603(89)90026-9 · Cited by 235 · see citing works
Tschritter, O., Preissl, H., Hennige, A. M., Stumvoll, M., Porubska, K., Frost, R., Marx, H., Klösel, B., Lutzenberger, W., Birbaumer, N., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604404103 · Cited by 223 · see citing works
Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond
Könner, A. C., Klöckener, T., & Brüning, J. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.027 · Cited by 215 · see citing works
Insulin, leptin, and food reward: update 2008
Figlewicz, D. P., & Benoit, S. C. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90725.2008 · Cited by 202 · see citing works
Insulin's direct effects on the liver dominate the control of hepatic glucose production
Edgerton, D. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27073 · Cited by 194 · see citing works
Flint, A., Gregersen, N. T., Gluud, L. L., Møller, B. K., Raben, A., Tetens, I., Verdich, C., & Astrup, A. (2007) · British Journal of Nutrition · doi:10.1017/s000711450768297x · Cited by 192 · see citing works
Memory for recent eating and its influence on subsequent food intake
Higgs, S. (2002) · Appetite · doi:10.1006/appe.2002.0500 · Cited by 176 · see citing works
Self-citationCentral insulin enhances sensitivity to cholecystokinin
RIEDY, C., Chavez, M., Figlewicz, D. P., & WOODS, S. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00108-u · Cited by 172 · see citing works
Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra
Figlewicz, D. P., Szot, P., Chavez, M., Woods, S. C., & Veith, R. C. (1994) · Brain Research · doi:10.1016/0006-8993(94)91698-5 · Cited by 172 · see citing works
Intraventricular Insulin and Leptin Reverse Place Preference Conditioned With High-Fat Diet in Rats.
Figlewicz, D. P., Bennett, J. L., Evans, S. B., Kaiyala, K. J., Sipols, A. J., & Benoit, S. C. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.3.479 · Cited by 172 · see citing works
Obese men respond to cognitive but not to catabolic brain insulin signaling
Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803722 · Cited by 165 · see citing works
Self-citationInsulin Modulates Food-Related Activity in the Central Nervous System
Guthoff, M., Grichisch, Y., Canova, C., Tschritter, O., Veit, R., Hallschmid, M., Häring, H., Preissl, H. T., Hennige, A. M., & Fritsche, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1677 · Cited by 157 · see citing works
Self-citationBenedict, C., Brede, S., Schiöth, H. B., Lehnert, H., Schultes, B., Born, J., & Hallschmid, M. (2011) · Diabetes · doi:10.2337/db10-0329 · Cited by 129 · see citing works
Self-citationMeasures of restrained eating.
Gorman, B. S., & Allison, D. B. (1995) · Cited by 124 · see citing works
Figlewicz, D. P., Bennett, J. L., Aliakbari, S., Zavosh, A., & Sipols, A. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90334.2008 · Cited by 115 · see citing works
Activation of KATP channels suppresses glucose production in humans
Kishore, P., Boucai, L., Zhang, K., Li, W., Koppaka, S., Kehlenbrink, S., Schiwek, A., Esterson, Y. B., Mehta, D., Bursheh, S. S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58035 · Cited by 107 · see citing works
Recall of recent lunch and its effect on subsequent snack intake
Higgs, S., Williamson, A. C., & Attwood, A. S. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.02.011 · Cited by 101 · see citing works
Self-citationRamnanan, C. J., Saraswathi, V., Smith, M. S., Donahue, E. P., Farmer, B., Farmer, T. D., Neal, D. W., Williams, P. E., Lautz, M., Mari, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45472 · Cited by 94 · see citing works
Chowers, I., LAVY, S., & Halpern, L. (1966) · Experimental Neurology · doi:10.1016/0014-4886(66)90122-1 · Cited by 77 · see citing works
Krug, R., Benedict, C., Jan Born, A., & Hallschmid, M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0744 · Cited by 74 · see citing works
Self-citationHallschmid, M., Jauch-Chara, K., Korn, O., Mölle, M., Rasch, B., Born, J., Schultes, B., & Kern, W. (2010) · Diabetes · doi:10.2337/db09-1493 · Cited by 61 · see citing works
Self-citationThe Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects
Guthoff, M., Stingl, K. T., Tschritter, O., Vidaković, M. R., Heni, M., Štingl, K., Hallschmid, M., Häring, H., Fritsche, A., Preissl, H. T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019482 · Cited by 59 · see citing works
Self-citationHallschmid, M., Schultes, B., Marshall, L., Mölle, M., Kern, W., Bredthauer, J., Fehm, H. L., & Jan Born, A. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2202 · Cited by 50 · see citing works
Self-citationInsulin and raclopride combine to decrease short-term intake of sucrose solutions
Sipols, A. J., Stuber, G. D., Klein, S. N., Higgins, M. S., & Figlewicz, D. P. (2000) · Peptides · doi:10.1016/s0196-9781(00)00279-5 · Cited by 38 · see citing works
Effect of centrally administered insulin on blood glucose levels in dogs.
Gc, A., Mittal, R., Sk, B., et al. (1977) · PubMed · Cited by 9 · see citing works
van Strien (1986) · doi:10.1002/1098-108x(198605)5:4
Flagged first, then by citations
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Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.019 · Cited by 498 · see citing works
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407 · see citing works
Intranasal Treatment of Central Nervous System Dysfunction in Humans
Chapman, C. D., Frey, W. H., Craft, S., Danielyan, L., Hallschmid, M., Schiöth, H. B., & Benedict, C. (2013) · Pharmaceutical Research · doi:10.1007/s11095-012-0915-1 · Cited by 310 · see citing works
Self-citationFrom gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
Han, H., Yi, B., Zhong, R., Wang, M., Zhang, S., Ma, J., Yin, Y., Yin, J., Chen, L., & Zhang, H. (2021) · Microbiome · doi:10.1186/s40168-021-01093-y · Cited by 292 · see citing works
Impaired insulin action in the human brain: causes and metabolic consequences
Heni, M., Kullmann, S., Preissl, H., Fritsche, A., & Häring, H.-U. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.173 · Cited by 245 · see citing works
Central nervous pathways of insulin action in the control of metabolism and food intake
Kullmann, S., Kleinridders, A., Small, D. M., Fritsche, A., Häring, H.-U., Preissl, H., & Heni, M. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30113-3 · Cited by 233 · see citing works
Oxytocin Reduces Reward-Driven Food Intake in Humans
Ott, V., Finlayson, G., Lehnert, H., Heitmann, B., Heinrichs, M., Born, J., & Hallschmid, M. (2013) · Diabetes · doi:10.2337/db13-0663 · Cited by 226 · see citing works
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Scherer, T., Sakamoto, K., & Buettner, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00498-x · Cited by 205 · see citing works
Insulin Regulates Brain Function, but How Does It Get There?
Gray, S. M., Meijer, R. I., & Barrett, E. J. (2014) · Diabetes · doi:10.2337/db14-0340 · Cited by 206 · see citing works
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Lee, S.-H., Zabolotny, J. M., Huang, H., Lee, H., & Kim, Y.-B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.011 · Cited by 176 · see citing works
Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H.-U., Fritsche, A., & Preissl, H. (2015) · Diabetes Care · doi:10.2337/dc14-2319 · Cited by 175 · see citing works
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Insulin-associated weight gain in obese type 2 diabetes mellitus patients: What can be done?
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Schmid, V., Kullmann, S., Gfrörer, W., Hund, V., Hallschmid, M., Lipp, H., Häring, H., Preissl, H., Fritsche, A., & Heni, M. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13279 · Cited by 110 · see citing works
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Wingrove, J., Swedrowska, M., Scherließ, R., Parry, M., Ramjeeawon, M., Taylor, D., Gauthier, G., Brown, L., Amiel, S., Zelaya, F., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.032 · Cited by 67 · see citing works
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- Authors
- Hallschmid, M., Higgs, S., Thienel, M., Ott, V., & Lehnert, H.
- Affiliations
- University of Lübeck (DE)
- University of Birmingham (GB)
- Corresponding author
- Hallschmid, Manfred
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2012-03-14
- Volume
- 61
- Issue
- 4
- Pages
- 782-789
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3314365
- OpenAlex
- W2109962764
- Cited by
- 181
- References
- 47
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 11 · 2019: 14 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 14 · 2014: 10 · 2013: 17 · 2012: 12
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- intranasal insulin, brain insulin signaling, satiety, postprandial appetite, dietary intake, snacking, chocolate chip cookies, palatability, glucose homeostasis, women, overeating
- MeSH terms
- Administration, Intranasal, Adult, Appetite, Brain, Drug Administration Schedule, Eating, Female, Food, Humans, Insulin, Male, Satiety Response, Time Factors, Postprandial Period
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