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Cited by 97Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function

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Murton, Andrew J., Marimuthu, Kanagaraj, Mallinson, Joanne E., Selby, Anna L., Smith, Kenneth, Rennie, Michael J., Greenhaff, Paul L.·2015·Diabetes
DOI 10.2337/db15-0021
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Abstract

Obesity is increasing, yet despite the necessity of maintaining muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ± 1.1 kg · m−2) and 15 healthy-weight (BMI 23.4 ± 0.3 kg · m−2) older men (55–75 years old) participated in a study that determined muscle protein synthesis (MPS) and leg protein breakdown (LPB) under postabsorptive (hypoinsulinemic-euglycemic clamp) and postprandial (hyperinsulinemic hyperaminoacidemic-euglycemic clamp) conditions. Obesity was associated with systemic inflammation, greater leg fat mass, and patterns of mRNA expression consistent with muscle deconditioning, whereas leg lean mass, strength, and work done during maximal exercise were no different. Under postabsorptive conditions, MPS and LPB were equivalent between groups, whereas insulin and amino acid administration increased MPS in only healthy-weight subjects and was associated with lower leg glucose disposal (LGD) (63%) in obese men. Blunting of MPS in the obese men was offset by an apparent decline in LPB, which was absent in healthy-weight subjects. Lower postprandial LGD in obese subjects and blunting of MPS responses to amino acids suggest that obesity in older adults is associated with diminished muscle metabolic quality. This does not, however, appear to be associated with lower leg lean mass or strength.

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Crossref · 10.2337/db15-0021

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  • With ageing, the impaired balance between protein synthesis and proteolysis in skeletal muscle results in a progressive decline in skeletal muscle mass, strength, and function.

    “With ageing, the impaired balance between protein synthesis and proteolysis in skeletal muscle results in a progressive decline in skeletal muscle mass, strength, and function and is defined as sarcopenia.[ 3 ]”

    From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [3]

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Authors
Murton, A. J., Marimuthu, K., Mallinson, J. E., Selby, A. L., Smith, K., Rennie, M. J., & Greenhaff, P. L.
Affiliations
  • University of Nottingham (GB)
  • Royal Derby Hospital (GB)
Corresponding author
Greenhaff, Paul L.
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2015-05-26
Volume
64
Issue
9
Pages
3160-3171
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db15-0021
OpenAlex
W1946678503
Cited by
97
References
35
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 3 · 2016: 11 · 2015: 1
FWCI
5.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
  • Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
  • Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
Funders
Biotechnology and Biological Sciences Research Council (BB/G011435/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
obesity, muscle protein synthesis, muscle protein degradation, older men, muscle protein turnover, insulin resistance, amino acids, systemic inflammation, muscle deconditioning, muscle mass, muscle strength, exercise capacity, leg fat mass
MeSH terms
Adipose Tissue, Aged, Amino Acids, Atrophy, Humans, Hypoglycemic Agents, Inflammation, Insulin, Leg, Male, Middle Aged, Muscle Contraction, Muscle Proteins, Obesity, RNA, Messenger, Glucose Clamp Technique, Case-Control Studies, Muscle, Skeletal, Gene Expression Profiling, Adipokines

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