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Cited by 384Gestational Diabetes Research and ManagementBirth, Development, and HealthPrenatal Substance Exposure Effects

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

The Predisposition to Obesity and Diabetes in Offspring of Diabetic Mothers

Dabelea, Dana·2007·Diabetes Care
DOI 10.2337/dc07-s211
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Abstract

The hypothesis of fuel-mediated teratogenesis (1) proposes that intrauterine exposure to an excess of fuels (for example, glucose) causes permanent fetal changes. In pregnancies complicated by diabetes, this would lead to malformations, greater birth weight, and an increased risk of developing type 2 diabetes in later life. Recently, obesity in the offspring has been included as an outcome in pregnancies complicated by diabetes. The hypothesis is now widely accepted, although the relatively few studies that have examined the question are poorly comparable and focus almost exclusively on growth and glucose regulation. This article reviews the evidence that intrauterine exposure to maternal diabetes conveys high risks for obesity and type 2 diabetes in the offspring, in addition to genetic predisposition, and regardless of maternal diabetes type. It also discusses potential mediators as well as possible public health consequences of fuel-mediated teratogenesis driven by maternal hyperglycemia in utero. Development in a diabetic intrauterine environment results in excess fetal growth. While maternal glucose freely crosses the placenta, maternal insulin does not (1). The developing fetal pancreas responds to this increased glucose load by producing additional insulin, which in turn, acts as a fetal growth hormone promoting growth and adiposity (1). Only two studies have prospectively examined the role of exposure to diabetes in utero on childhood growth, later obesity, and risk for type 2 diabetes in the offspring: the Pima Indian Study and the Diabetes in Pregnancy Study at Northwestern University in Chicago. ### Growth and risk for obesity Researchers at the Diabetes in Pregnancy Center at Northwestern University in Chicago have reported excessive growth in a multiethnic population of offspring of women with diabetes during pregnancy, including both gestational diabetes mellitus (GDM) and insulin-treated preexistent diabetes (2). Children were examined at birth, at age 6 months, and annually to age 8 years. The symmetry index (an obesity index …

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Crossref · 10.2337/dc07-s211

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Metadata

Authors
Dabelea, D.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Dabelea, Dana
ORCID
Dabelea, Dana
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2007-07-01
Volume
30
Issue
Supplement_2
Pages
S169-S174
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc07-s211
OpenAlex
W2043530580
Cited by
384
References
51
Citations by year
2026: 4 · 2025: 10 · 2024: 7 · 2023: 15 · 2022: 18 · 2021: 31 · 2020: 26 · 2019: 21 · 2018: 34 · 2017: 18 · 2016: 26 · 2015: 21 · 2014: 28 · 2013: 24 · 2012: 28
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
offspring of diabetic mothers, maternal diabetes, gestational diabetes mellitus, type 2 diabetes, childhood obesity, intrauterine hyperglycemia, fetal growth, fetal insulin, placental glucose transfer, genetic susceptibility
MeSH terms
Diabetes Mellitus, Type 2, Female, Humans, Obesity, Pregnancy, Pregnancy in Diabetics, Prenatal Exposure Delayed Effects, Risk Factors, Glucose Intolerance, Genetic Predisposition to Disease

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