Role of Hyperglycemia in Nitrotyrosine Postprandial Generation
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OBJECTIVE—Recently, much attention has been paid to the possibility that postprandial hyperglycemia may be a cardiovascular risk factor in diabetes. Oxidative stress has been involved in the pathogenesis of diabetic complications, and increased plasma levels of nitrotyrosine, a product of peroxynitrite action, have been found in the plasma of diabetic subjects. The aim of the present study was to evaluate whether postprandial hyperglycemia is accompanied by nitrotyrosine generation and, if so, to explore a possible direct role of hyperglycemia in such a phenomenon. RESEARCH DESIGN AND METHODS—A total of 23 type 2 diabetic patients and 15 matched normal healthy subjects were recruited for this study. Two different tests were performed in diabetic patients: a standard meal preceded by regular insulin (0.15 units/kg body wt) or insulin aspart (0.15 units/kg body wt) to achieve different levels of postprandial hyperglycemia. The meal test was also performed in healthy control subjects. At 0 min and 1, 2, 4, and 6 h after each meal, blood glucose, triglyceride, and nitrotyrosine levels were measured. RESULTS—Fasting nitrotyrosine was significantly increased in diabetic patients and was further increased during both meal tests in diabetic subjects but not normal subjects. As compared with regular insulin, aspart administration significantly reduced the area under the curve of both glycemia (P < 0.04) and nitrotyrosine (P < 0.03), whereas that of triglycerides was not significantly affected by the treatment. CONCLUSIONS—This study shows a direct correlation between postprandial hyperglycemia and the production of nitrotyrosine, a marker of oxidative stress, in patients with type 2 diabetes.
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Patients with type 2 diabetes following postprandial hyperglycemia exhibit significantly increased oxidative stress markers.
“Patients with type 2 diabetes, following postprandial hyperglycemia (rapid increase in blood levels of glucose) exhibit significantly increased oxidative stress markers (Ceriello et al. 2002).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ceriello et al. 2002
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Self-citation
- Authors
- Ceriello, A., Quagliaro, L., Catone, B., Pascon, R., Piazzola, M., Bais, B., Marra, G., Tonutti, L., Taboga, C., & Motz, E.
- Affiliations
- University of Udine (IT)
- Novo Nordisk (Italy) (IT)
- Diabetology Unit, Udine General Hospital, Udine, Italy
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-08-01
- Volume
- 25
- Issue
- 8
- Pages
- 1439-1443
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2111076682
- Cited by
- 257
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 13 · 2016: 11 · 2015: 15 · 2014: 7 · 2013: 14 · 2012: 12
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- nitrotyrosine, postprandial hyperglycemia, type 2 diabetes, oxidative stress, peroxynitrite, insulin aspart, regular insulin, triglycerides, cardiovascular risk, diabetes complications
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 2, Female, Humans, Hyperglycemia, Male, Middle Aged, Triglycerides, Tyrosine, Biomarkers, Oxidative Stress, Postprandial Period
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