Diabetes and incidence of functional disability in older women
Open accessAbstract
OBJECTIVE: To examine the relationship between diabetes and the incidence of functional disability and to determine the predictors of functional disability among older women with diabetes. RESEARCH DESIGN AND METHODS: We analyzed data from 8,344 women enrolled in the Study of Osteoporotic Fractures, a prospective cohort of women aged > or =65 years. Diabetes (n = 527, 6.3% prevalence) and comorbidities (coronary heart disease, stroke, arthritis, depression, and visual impairment) were assessed by questionnaire and physical examination. Incident disability, defined as onset of inability to do one or more major functional tasks (walking 0.25 mile, climbing 10 steps, performing household chores, shopping, and cooking meals), was assessed by questionnaire over 12 years. RESULTS: The yearly incidence of any functional disability was 9.8% among women with diabetes and 4.8% among women without diabetes. The age-adjusted hazard rate ratio (HRR) of disability for specific tasks associated with diabetes ranged from 2.12 (1.82-2.48) for doing housework to 2.50 (2.05-3.04) for walking two to three blocks. After adjustment for potential confounders at baseline (BMI, physical activity, estrogen use, baseline functional status, visual impairment, and marital status) and comorbidities (heart disease, stroke, depression, and arthritis), diabetes remained associated with a 42% increased risk of any incident disability and a 53-98% increased risk of disability for specific tasks. Among women with diabetes, older age, higher BMI, coronary heart disease, arthritis, physical inactivity, and severe visual impairment at baseline were each independently associated with disability. CONCLUSIONS: Diabetes is associated with an increased incidence of functional disability, which is likely to further erode health status and quality of life.
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Functional limitations related to poor sleep have been reported as difficulty performing six IADLs, including walking 2-3 blocks, walking up or down 10 steps, preparing meals, heavy housework, and shopping.
“Functional limitations related to poor sleep have been reported as difficulty performing 6 instrumental activities of daily living (IADLs) which included walking 2–3 blocks, walking up or down 10 steps, preparing meals, heavy housework, and shopping.(Gregg, Mangione, Cauley, Thompson, Schwartz, Ensrud, and Nevitt 2002)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Gregg et al. 2002
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- Authors
- Gregg, E. W., Mangione, C. M., Cauley, J. A., Thompson, T. J., Schwartz, A. V., Ensrud, K. E., Nevitt, M. C., & for the Study of Osteoporotic Fractures Research Group
- Affiliations
- Centers for Disease Control and Prevention (US)
- RAND Corporation (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Minnesota (US)
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-01-01
- Volume
- 25
- Issue
- 1
- Pages
- 61-67
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2094323726
- Cited by
- 333
- References
- 26
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 14 · 2017: 16 · 2016: 18 · 2015: 23 · 2014: 17 · 2013: 16 · 2012: 22
- FWCI
- 14.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (AG05394, AG-05407)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR035584, AR35583, AR-35584, AR 35582, R01AR035582, R01AR035583)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- diabetes mellitus, functional disability, older women, disability incidence, comorbidities, coronary artery disease, arthritis, visual impairment, physical inactivity, body mass index, housework, walking ability, predictors of disability
- MeSH terms
- Aged, Aged, 80 and over, Cognition Disorders, Coronary Disease, Diabetes Mellitus, Female, Follow-Up Studies, Persons with Disabilities, Humans, Osteoarthritis, Predictive Value of Tests, Smoking, United States, Cohort Studies, Exercise, Osteoporosis, Postmenopausal, Comorbidity, Body Mass Index, Incidence, Prevalence, Multivariate Analysis, Age of Onset, Diabetes Complications
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