Atrophy in Alzheimer's disease and semantic dementia: an ALE meta-analysis of voxel-based morphometry studies
Open accessAbstract
BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) and semantic dementia (SD) have distinct episodic memory profiles despite the hippocampal atrophy that characterizes both diseases. The aim of this study was to delineate the pattern of gray matter (GM) atrophy associated with AD and SD as well as any differences in these patterns by pooling together the results of previous voxel-based morphometry (VBM) studies.Methods/Overview: We conducted a meta-analysis of VBM studies that investigated GM atrophy in AD patients versus controls (CTRLs) and in SD patients versus CTRLs using the activation likelihood estimation (ALE) approach. Our systematic review allowed us to identify 63 VBM studies. RESULTS: The results confirmed that in addition to the classical cortical pattern of atrophy involving posterior medial and lateral regions in AD and the anterior lateral temporal lobes in SD, both AD and SD patients are characterized by bilateral atrophy of the hippocampus. Furthermore, in SD, the hippocampal atrophy was limited to the anterior portion of the hippocampus, while in AD, both the anterior and posterior parts of the hippocampus exhibited atrophy. When we compared the foci identified in the studies that compared AD patients versus CTRLs with those identified in the studies that compared SD patients versus CTRLs, we observed that the atrophy in the posterior hippocampus and precuneus was more severe in AD. CONCLUSION: These results support theories that propose that the deficits observed in AD result from damage to the episodic memory network, which involves the posterior hippocampus and posterior medial brain regions. However, sparing of the posterior hippocampus in SD could explain the absence of episodic memory deficits in this population.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This different pattern of results in bvFTD and AD may reflect the preferential and widespread damage within the AIN in bvFTD whereas in AD, AIN damage appears to be more circumscribed.
“This different pattern of results in bvFTD and AD may reflect the preferential and widespread damage within the AIN in bvFTD11,14,16, 17, 18, 19, 20,24 whereas in AD, AIN damage appears to be more circumscribed.17,38,88”
From Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia (2025) · cites this paper as [88]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554 · see citing works
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676 · see citing works
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561 · see citing works
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411 · see citing works
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70090-0 · Cited by 3,321 · see citing works
Where do you know what you know? The representation of semantic knowledge in the human brain
Patterson, K., Nestor, P. J., & Rogers, T. T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2277 · Cited by 2,706 · see citing works
Stereotaxic Display of Brain Lesions
Rorden, C., & Brett, M. (2000) · Behavioural Neurology · doi:10.1155/2000/421719 · Cited by 2,573 · see citing works
Eickhoff, S. B., Laird, A. R., Grefkes, C., Wang, L. E., Zilles, K., & Fox, P. T. (2009) · Human Brain Mapping · doi:10.1002/hbm.20718 · Cited by 1,924 · see citing works
SEMANTIC DEMENTIA: PROGRESSIVE FLUENT APHASIA WITH TEMPORAL LOBE ATROPHY
HODGES, J. R., PATTERSON, K., OXBURY, S., & FUNNELL, E. (1992) · Brain · doi:10.1093/brain/115.6.1783 · Cited by 1,710 · see citing works
Cognition and anatomy in three variants of primary progressive aphasia
Gorno‐Tempini, M. L., Dronkers, N. F., Rankin, K. P., Ogar, J. M., Phengrasamy, L., Rosen, H. J., Johnson, J. K., Weiner, M. W., & Miller, B. L. (2004) · Annals of Neurology · doi:10.1002/ana.10825 · Cited by 1,608 · see citing works
Meta-analysis of the functional neuroanatomy of single-word reading: method and validation
Turkeltaub, P. E., Eden, G. F., Jones, K. M., & Zeffiro, T. A. (2002) · NeuroImage · doi:10.1006/nimg.2002.1131 · Cited by 1,604 · see citing works
Activation Likelihood Estimation meta-analysis revisited
Eickhoff, S., Bzdok, D., Laird, A., Kurth, F., & Fox, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.017 · Cited by 1,448 · see citing works
Turkeltaub, P., Eickhoff, S., Laird, A. R., Fox, M., Wiener, M., & Fox, P. (2011) · Human Brain Mapping · doi:10.1002/hbm.21186 · Cited by 1,114 · see citing works
Long-axis specialization of the human hippocampus
Poppenk, J., Evensmoen, H. R., Moscovitch, M., & Nadel, L. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.03.005 · Cited by 1,100 · see citing works
ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts
Laird, A. R., Fox, P. M., Price, C. J., Glahn, D. C., Uecker, A. M., Lancaster, J. L., Turkeltaub, P. E., Kochunov, P., & Fox, P. T. (2005) · Human Brain Mapping · doi:10.1002/hbm.20136 · Cited by 868 · see citing works
Semantic dementia: a unique clinicopathological syndrome
Hodges, J. R., & Patterson, K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70266-1 · Cited by 772 · see citing works
Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
Chan, D., Fox, N. C., Scahill, R. I., Crum, W. R., Whitwell, J. L., Leschziner, G., Rossor, A. M., Stevens, J. M., Cipolotti, L., & Rossor, M. N. (2001) · Annals of Neurology · doi:10.1002/ana.92 · Cited by 749 · see citing works
A network dysfunction perspective on neurodegenerative diseases
Palop, J. J., Chin, J., & Mucke, L. (2006) · Nature · doi:10.1038/nature05289 · Cited by 683 · see citing works
In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease
Baron, J., Chételat, G., Desgranges, B., Perchey, G., Landeau, B., Sayette, V. D. L., & Eustache, F. (2001) · NeuroImage · doi:10.1006/nimg.2001.0848 · Cited by 683 · see citing works
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia
Galton, C. J., Patterson, K., Graham, K., Lambon-Ralph, M. A., Williams, G., Antoun, N., Sahakian, B. J., & Hodges, J. R. (2001) · Neurology · doi:10.1212/wnl.57.2.216 · Cited by 582 · see citing works
SEMANTIC MEMORY LOSS IN DEMENTIA OF ALZHEIMER'S TYPE
Chertkow, H. M., & Bub, D. N. (1990) · Brain · doi:10.1093/brain/113.2.397 · Cited by 571 · see citing works
Connected speech production in three variants of primary progressive aphasia
Wilson, S. M., Henry, M. L., Besbris, M., Ogar, J. M., Dronkers, N. F., Jarrold, W., Miller, B. L., & Gorno-Tempini, M. L. (2010) · Brain · doi:10.1093/brain/awq129 · Cited by 546 · see citing works
Kahn, I., Andrews‐Hanna, J. R., Vincent, J. L., Snyder, A. Z., & Buckner, R. L. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00077.2008 · Cited by 490 · see citing works
Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia
Irish, M., Addis, D. R., Hodges, J. R., & Piguet, O. (2012) · Brain · doi:10.1093/brain/aws119 · Cited by 405 · see citing works
Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry
Frisoni, G. B. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.6.657 · Cited by 386 · see citing works
Laird, A. R. (2009) · Frontiers in Neuroinformatics · doi:10.3389/neuro.11.023.2009 · Cited by 372 · see citing works
Declarative memory impairments in Alzheimer's disease and semantic dementia
Nestor, P. J., Fryer, T. D., & Hodges, J. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.008 · Cited by 370 · see citing works
Diagnosis and treatment of dementia: 2. Diagnosis
Feldman, H., Jacova, C., Robillard, A., Garcia, A. A., Chow, T. W., BORRIE, M. J., Schipper, H. M., Blair, M., Kertesz, A., & Chertkow, H. M. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.070798 · Cited by 350 · see citing works
Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment
Wilson, R. S., Leurgans, S. E., Boyle, P. A., & Bennett, D. A. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.31 · Cited by 346 · see citing works
Voxel-based morphometry to discriminate early Alzheimer's disease from controls
Hirata, Y., Matsuda, H., Nemoto, K., Ohnishi, T., Hirao, K., Yamashita, F., Asada, T., Iwabuchi, S., & Samejima, H. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.03.038 · Cited by 329 · see citing works
La Joie, R., Perrotin, A., de La Sayette, V., Egret, S., Doeuvre, L., Belliard, S., Eustache, F., Desgranges, B., & Chételat, G. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.08.007 · Cited by 290 · see citing works
White matter damage in Alzheimer disease and its relationship to gray matter atrophy
Agosta, F., Pievani, M., Sala, S., Geroldi, C., Galluzzi, S., Frisoni, G. B., & Filippi, M. (2011) · Radiology · doi:10.1148/radiol.10101284 · Cited by 288 · see citing works
Regional brain atrophy and functional disconnection across Alzheimer's disease evolution
Gili, T., Cercignani, M., Serra, L., Perri, R., Giove, F., Maraviglia, B., Caltagirone, C., & Bozzali, M. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.199935 · Cited by 285 · see citing works
Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?
Adlam, A., Patterson, K. E., Rogers, T. T., Nestor, P. J., Salmond, C. H., Acosta‐Cabronero, J., & Hodges, J. R. (2006) · Brain · doi:10.1093/brain/awl285 · Cited by 264 · see citing works
Rabinovici, G. D., Seeley, W. W., Kim, E. J., Gorno‐Tempini, M. L., Rascovsky, K., Pagliaro, T. A., Allison, S. C., Halabi, C., Kramer, J. H., Johnson, J. K., et al. (2007) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507308779 · Cited by 256 · see citing works
Structural MRI changes detectable up to ten years before clinical Alzheimer's disease
Tondelli, M., Wilcock, G. K., Nichelli, P., de Jager, C. A., Jenkinson, M., & Zamboni, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.018 · Cited by 251 · see citing works
Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI.
Deweer, B., Lehéricy, S., Pillon, B., Baulac, M., Chiras, J., Marsault, C., Agid, Y., & Dubois, B. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.5.590 · Cited by 250 · see citing works
The human perirhinal cortex and semantic memory
Davies, R. R., Graham, K. S., Xuereb, J. H., Williams, G. B., & Hodges, J. R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03710.x · Cited by 238 · see citing works
Joubert, S., Brambati, S. M., Ansado, J., Barbeau, E. J., Félician, O., Didic, M., Lacombe, J., Goldstein, R., Chayer, C., & Kergoat, M. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.11.019 · Cited by 235 · see citing works
Self-citationAge, Alzheimer disease, and brain structure
Raji, C. A., López, O. L., Kuller, L. H., Carmichael, O. T., & Becker, J. T. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c3f293 · Cited by 230 · see citing works
Brambati, S. M., Rankin, K. P., Narvid, J. A., Seeley, W. W., Dean, D., Rosen, H. J., Miller, B. L., Ashburner, J., & Gorno‐Tempini, M. L. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.014 · Cited by 230 · see citing works
Self-citationNestor, P. J., Fryer, T. D., Ikeda, M., & Hodges, J. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02999.x · Cited by 227 · see citing works
Patterns of Atrophy Differ Among Specific Subtypes of Mild Cognitive Impairment
Whitwell, J. L., Petersen, R. C., Negash, S., Weigand, S. D., Kantarci, K., Ivnik, R. J., Knopman, D. S., Boeve, B. F., Smith, G. E., & Jack, C. R. (2007) · Archives of Neurology · doi:10.1001/archneur.64.8.1130 · Cited by 224 · see citing works
Köhler, S., Black, S. E., Sinden, M., Szekely, C. A., Kidron, D., Parker, J. L., Foster, J. K., Moscovitch, M., Wincour, G., Szalai, J. P., et al. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(98)00017-7 · Cited by 216 · see citing works
Grossman, M., Mickanin, J., Onishi, K., Hughes, E., D’Esposito, M., Xin-sheng, D., Alavi, A. A., & Reivich, M. (1996) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1996.8.2.135 · Cited by 216 · see citing works
Episodic memory in frontotemporal dementia: a critical review
Hornberger, M., & Piguet, O. (2012) · Brain · doi:10.1093/brain/aws011 · Cited by 210 · see citing works
Voxel-based detection of white matter abnormalities in mild Alzheimer disease
Xie, S., Xiao, J., Gong, G., Zang, Y., Wang, Y., Wu, H., & Jiang, X. X. (2006) · Neurology · doi:10.1212/01.wnl.0000219625.77625.aa · Cited by 208 · see citing works
Left/right asymmetry of atrophy in semantic dementia
Thompson, S., Patterson, K., & Hodges, J. (2003) · Neurology · doi:10.1212/01.wnl.0000091868.28557.b8 · Cited by 201 · see citing works
Ishii, K., Kawachi, T., Sasaki, H., Kono, A. K., Fukuda, T., KOJIMA, Y., & Mori, E. (2005) · PubMed Central · Cited by 192 · see citing works
The contribution of voxel-based morphometry in staging patients with mild cognitive impairment
Bozzali, M., Filippi, M., Magnani, G., Cercignani, M., Franceschi, M., Schiatti, E., Castiglioni, S., Mossini, R., Falautano, M., Scotti, G., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000228243.56665.c2 · Cited by 179 · see citing works
The neural basis of surface dyslexia in semantic dementia
Wilson, S. M., Brambati, S. M., Henry, R. G., Handwerker, D. A., Agosta, F., Miller, B. L., Wilkins, D. P., Ogar, J. M., & Gorno‐Tempini, M. L. (2008) · Brain · doi:10.1093/brain/awn300 · Cited by 175 · see citing works
Self-citationIrish, M., Piguet, O., Hodges, J. R., & Hornberger, M. (2013) · Human Brain Mapping · doi:10.1002/hbm.22263 · Cited by 171 · see citing works
Voxel-based assessment of gray and white matter volumes in Alzheimer's disease
Guo, X., Wang, Z., Li, K., Li, Z., Qi, Z., Jin, Z. H., Yao, L., & Chen, K. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.086 · Cited by 164 · see citing works
Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study
Desgranges, B., Matuszewski, V., Piolino, P., Chételat, G., Mézenge, F., Landeau, B., Sayette, V. D. L., Belliard, S., & Eustache, F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.006 · Cited by 159 · see citing works
Joie, R. L., Landeau, B., Perrotin, A., Bejanin, A., Egret, S., Pèlerin, A., Mézenge, F., Belliard, S., Sayette, V. D. L., Eustache, F., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.026 · Cited by 156 · see citing works
Paola, M., Macaluso, E., Carlesimo, G. A., Tomaiuolo, F., Worsley, K. J., Fadda, L., & Caltagirone, C. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0435-1 · Cited by 156 · see citing works
Hippocampal atrophy in Alzheimer disease: Age matters
van de Pol, L. A., Hensel, A., Barkhof, F., Gertz, H.-J., Scheltens, P., & van der Flier, W. M. (2006) · Neurology · doi:10.1212/01.wnl.0000194240.47892.4d · Cited by 150 · see citing works
Shiino, A., Watanabe, T., Maeda, K., Kotani, E., Akiguchi, I., & Matsuda, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.010 · Cited by 147 · see citing works
Testa, C., Laakso, M. P., Sabattoli, F., Rossi, R., Beltramello, A., Soininen, H. S., & Frisoni, G. B. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20001 · Cited by 145 · see citing works
The Anatomy of Category-specific Object Naming in Neurodegenerative Diseases
Brambati, S. M., Myers, D., Wilson, A., Rankin, K. P., Allison, S. C., Rosen, H. J., Miller, B. L., & Gorno‐Tempini, M. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.10.1644 · Cited by 141 · see citing works
Self-citationNon-fluent speech in frontotemporal lobar degeneration
Ash, S., Moore, P., Vesely, L., Gunawardena, D., McMillan, C. T., Anderson, C., Avants, B., & Grossman, M. (2009) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2008.12.001 · Cited by 140 · see citing works
Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment
Hämäläinen, A., Tervo, S., Grau-Olivares, M., Niskanen, E. I., Pennanen, C., Huuskonen, J., Kivipelto, M., Hänninen, T., Tapiola, M., Vanhanen, M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.016 · Cited by 134 · see citing works
Kahn, I., & Daphna Shohamy, A. (2012) · Hippocampus · doi:10.1002/hipo.22077 · Cited by 132 · see citing works
The impact of aging on gray matter structural covariance networks
Montembeault, M., Joubert, S., Doyon, J., Carrier, J., Gagnon, J., Monchi, O., Lungu, O., Belleville, S., & Brambati, S. M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.052 · Cited by 132 · see citing works
Self-citationTemporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis
Whitwell, J., Clifford, R., Przybelski, S., Parisi, J., Senjem, M., Boeve, B., Knopman, D., Petersen, R., Dickson, D., & Josephs, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.012 · Cited by 131 · see citing works
Voxel-based meta-analysis of grey matter changes in Alzheimer’s disease
Wang, W., Yu, J., Liu, Y., Yin, R., Wang, H.-F., Wang, J., Tan, L., Raduà, J., & Tan, L. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0027-z · Cited by 124 · see citing works
Neurocognitive contributions to verbal fluency deficits in frontotemporal lobar degeneration
Libon, D. J., McMillan, C., Gunawardena, D., Powers, C., Massimo, L., Khan, A., Morgan, B., Farag, C., Richmond, L., Weinstein, J., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b2a4f5 · Cited by 122 · see citing works
Bone Density and Brain Atrophy in Early Alzheimer's Disease
Loskutova, N., Honea, R. A., Vidoni, E. D., Brooks, W. M., & Burns, J. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1185 · Cited by 118 · see citing works
Theory of mind impairments in patients with semantic dementia
Duval, C., Bejanin, A., Piolino, P., Laisney, M., Sayette, V. D. L., Belliard, S., Eustache, F., & Desgranges, B. (2012) · Brain · doi:10.1093/brain/awr309 · Cited by 118 · see citing works
Bozzali, M., Giulietti, G., Basile, B., Serra, L., Spanò, B., Perri, R., Giubilei, F., Marra, C., Caltagirone, C., & Cercignani, M. (2012) · Human Brain Mapping · doi:10.1002/hbm.21287 · Cited by 107 · see citing works
Lehmann, M., Douiri, A., Kim, L. G., Marc Modat, A., Chan, D., Sebastien Ourselin, A., Barnes, J., & Fox, N. C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.056 · Cited by 106 · see citing works
Cinguloparietal Atrophy Distinguishes Alzheimer Disease From Semantic Dementia
Boxer, A. L., Rankin, K. P., Miller, B. L., Schuff, N. W., Weiner, M. W., Gorno-Tempini, M.-L., & Rosen, H. J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.949 · Cited by 105 · see citing works
Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
Pereira, J., Williams, G. B., Acosta‐Cabronero, J., Pengas, G., Spillantini, M. G., Xuereb, J. H., Hodges, J. R., & Nestor, P. J. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a55fa2 · Cited by 103 · see citing works
Kanda, T., Ishii, K., Uemura, T., Miyamoto, N., Yoshikawa, T., Kono, A. K., & Mori, E. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0871-5 · Cited by 98 · see citing works
Changing Concepts of Alzheimer Disease
McKhann, G. M. (2011) · JAMA · doi:10.1001/jama.2011.810 · Cited by 94 · see citing works
Caroli, A., Testa, C., Geroldi, C., Nobili, F. M., Barnden, L. R., Guerra, U. P., Bonetti, M., & Frisoni, G. B. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0631-7 · Cited by 85 · see citing works
Microstructural alteration of the anterior cingulum is associated with apathy in Alzheimer disease
Kim, J. W., Lee, D. Y., Choo, I. H., Seo, E. H., Kim, S. G., Park, S. Y., & Woo, J. I. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820dcc73 · Cited by 79 · see citing works
Single- and Multiple-Domain Amnestic Mild Cognitive Impairment: Two Sides of the Same Coin
Brambati, S. M., Belleville, S., Kergoat, M., Chayer, C., Gauthier, S. G., & Joubert, S. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000255240 · Cited by 77 · see citing works
Self-citationColloby, S. J., O'Brien, J. T., & Taylor, J. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.06.006 · Cited by 77 · see citing works
Santos, V. D., Thomann, P. A., Wüstenberg, T., Seidl, U., Essig, M., & Schröder, J. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100156 · Cited by 73 · see citing works
Grossman, M., Payer, F., Onishi, K., D’Esposito, M., Morrison, D. F., Sadek, A. G., & Alavi, A. A. (1998) · Neurology · doi:10.1212/wnl.50.1.157 · Cited by 73 · see citing works
Matsunari, I., Samuraki, M., Chen, W.-P., Yanase, D., Takeda, N., Ono, K., Yoshita, M., Matsuda, H., Yamada, M., & Kinuya, S. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.042820 · Cited by 68 · see citing works
Alzheimer disease family history impacts resting state functional connectivity
Wang, L. Y., Roe, C. M., Snyder, A. Z., Brier, M. R., Thomas, J., Xiong, C., Benzinger, T. L. S., Morris, J. C., & Ances, B. M. (2012) · Annals of Neurology · doi:10.1002/ana.23643 · Cited by 67 · see citing works
Frisch, S., Dukart, J., Vogt, B., Horstmann, A., Becker, G., Villringer, A., Barthel, H., Sabri, O., Müller, K., & Schroeter, M. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055251 · Cited by 66 · see citing works
Neuroimaging findings in frontotemporal lobar degeneration spectrum of disorders
Agosta, F., Canu, E., Sarro, L., Comı, G., & Filippi, M. (2011) · Cortex · doi:10.1016/j.cortex.2011.04.012 · Cited by 62 · see citing works
Bryś, M., Glodzik, L., Mosconi, L., Switalski, R., Santi, S. D., Pirraglia, E., Rich, K. E., Kim, B. C., Mehta, P. D., Zinkowski, R., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0968 · Cited by 61 · see citing works
Clinical and imaging characteristics of dementia in multiple system atrophy
Kim, H., Jeon, B. S., Kim, Y. E., Kim, J.-Y., Kim, Y. K., Sohn, C., Yun, J. Y., Jeon, S., Lee, J., & Lee, J. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.02.012 · Cited by 61 · see citing works
Mazère, J., Prunier, C., Barret, O., Guyot, M., Hommet, C., Guilloteau, D., Dartigues, J. F., Auriacombe, S., Fabrigoule, C., & Michèle Allard, A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.028 · Cited by 55 · see citing works
Schroeter, M. L., & Neumann, J. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00010 · Cited by 55 · see citing works
Takahashi, R., Ishii, K., Miyamoto, N., et al. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2200 · Cited by 55 · see citing works
Meningeal cells can communicate with astrocytes by calcium signaling
Grafstein, B., Liu, S., Cotrina, M. L., Goldman, S. A., & Nedergaard, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200001)47:1 · Cited by 50 · see citing works
‘I remember it as if it were yesterday’: Memory for recent events in patients with semantic dementia
Adlam, A.-L. R., Patterson, K., & Hodges, J. R. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.01.029 · Cited by 48 · see citing works
Zahn, R., Büchert, M., Overmans, J., Talazko, J., Specht, K., Ko, C.-W., Thiel, T., Kaufmann, R., Dykierek, P., Juengling, F. D., et al. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.08.001 · Cited by 45 · see citing works
Comparison between brain CT and MRI for voxel‐based morphometry of A lzheimer's disease
Imabayashi, E., Matsuda, H., Tabira, T., Arima, K., Araki, N., Ishii, K., Yamashita, F., Iwatsubo, T., & Initiative, J. A. D. N. (2013) · Brain and Behavior · doi:10.1002/brb3.146 · Cited by 44 · see citing works
White matter microstructural damage in Alzheimer's disease at different ages of onset
Canu, E., Agosta, F., Spinelli, E. G., Magnani, G., Marcone, A., Scola, E., Falautano, M., Comi, G., Falini, A., & Filippi, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.026 · Cited by 42 · see citing works
Basal forebrain atrophy is a distinctive pattern in dementia with Lewy bodies
Brenneis, C., Wenning, G. K., Egger, K. E., Schocke, M., Trieb, T., Seppi, K., Marksteiner, J., Ransmayr, G. N., Benke, T., & Poewe, W. H. (2004) · Neuroreport · doi:10.1097/01.wnr.0000136736.73895.03 · Cited by 40 · see citing works
Episodic memory and regional atrophy in frontotemporal lobar degeneration.
Söderlund, H., Black, S., Miller, B., Freedman, M., & Levine, B. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.08.003 · Cited by 38 · see citing works
Shiino, A., Watanabe, T., Kitagawa, T., Kotani, E., Takahashi, J., Morikawa, S., & Akiguchi, I. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000151241 · Cited by 37 · see citing works
Koenig, P. L., Smith, E. E., Troiani, V., Anderson, C., Moore, P., & Grossman, M. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn043 · Cited by 35 · see citing works
Change in Cognitive Function in Alzheimer’s Disease in African-American and White Persons
Barnes, L. L., Wilson, R. S., Li, Y., Gilley, D. W., Bennett, D. A., & Evans, D. A. (2005) · Neuroepidemiology · doi:10.1159/000089231 · Cited by 33 · see citing works
Pleizier, C. M., van der Vlies, A. E., Koedam, E., Koene, T., Barkhof, F., van der Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. L. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302437 · Cited by 29 · see citing works
Dashjamts, T., Yoshiura, T., Hiwatashi, A., Yamashita, K., Monji, A., Ohyagi, Y., Kamano, H., Kawashima, T., Kira, J., & Honda, H. (2011) · Academic Radiology · doi:10.1016/j.acra.2011.07.015 · Cited by 24 · see citing works
Rami, L., Gómez‐Ansón, B., Monté, G. C., et al. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2216 · Cited by 23 · see citing works
Direct Thrombin Inhibitors’ Potential Efficacy in Alzheimer’s Disease
Khalil, R. B. (2012) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512465667 · Cited by 20 · see citing works
Mok, G. S. P., Wu, Y.-Y., Lu, K.-M., Wu, J., Chen, L.-K., & Wu, T.-H. (2012) · Clinical Imaging · doi:10.1016/j.clinimag.2011.03.004 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723 · see citing works
Cacciaglia, R., Molinuevo, J. L., Falcón, C., Brugulat‐Serrat, A., Sánchez‐Benavides, G., Gramunt, N., Esteller, M., Morán, S., Minguillón, C., Fauria, K., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.01.016 · Cited by 124 · see citing works
Huang, H., Zheng, S., Yang, Z., Wu, Y., Li, Y., Qiu, J., Cheng, Y., Lin, P., Lin, Y., Guan, J., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhac099 · Cited by 57 · see citing works
Hazelton, J. L., Carneiro, F., Maito, M., Richter, F., Legaz, A., Altschuler, F., Cubillos-Pinilla, L., Chen, Y., Doherty, C. P., Baez, S., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.10.013 · Cited by 21 · see citing works
Hazelton, J. L., Della Bella, G., Barttfeld, P., Dottori, M., Gonzalez-Gomez, R., Migeot, J., Moguilner, S., Legaz, A., Hernandez, H., Prado, P., et al. (2025) · eBioMedicine · doi:10.1016/j.ebiom.2025.105614 · Cited by 14 · see citing works
Yoo, C.-H., Kim, J., Baek, H.-M., Chang, K.-A., & Choe, B.-Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065073 · Cited by 13 · see citing works
- Authors
- Chapleau, M., Aldebert, J., Montembeault, M., & Brambati, S. M.
- Affiliations
- Institut Universitaire de Gériatrie de Montréal (CA)
- Université de Montréal (CA)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2016-10-04
- Volume
- 54
- Issue
- 3
- Pages
- 941-955
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2513226720
- Cited by
- 73
- References
- 109
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Papyrus : Institutional Repository (Université de Montréal) (submittedVersion)
- Funders
- Alzheimer's Society
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- Alzheimer's disease, semantic dementia
- MeSH terms
- Alzheimer Disease, Atrophy, Brain, Humans, Nerve Net, Neuropsychological Tests, Frontotemporal Dementia, Memory, Episodic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
