Cerebrospinal Fluid Biomarkers and Clinical Progression in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment
Abstract
BACKGROUND: There is very limited data on the prevalence of abnormal cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and their predictive value for clinical progression in memory clinic patients with subjective cognitive decline (SCD). OBJECTIVE: To assess the frequency of abnormal CSF biomarkers of AD and their predictive value for clinical progression in memory clinic patients with SCD in comparison to patients with mild cognitive impairment (MCI) from the same cohort. METHODS: We analyzed prospective data from memory clinic patients of the German Competence Network Dementia cohort with a baseline diagnosis of SCD (n = 82) or MCI (n = 134), distinguished by actuarial neuropsychological MCI criteria ("Jak-Bondi criteria"). Risk of clinical progression during 3-year follow-up was evaluated with Cox-Proportional-Hazard models. RESULTS: Prevalence of abnormal values in CSF markers of tau-mediated neurodegeneration (67.8% versus 46.3%) but not of amyloid deposition (40.3% versus 35.4%) was significantly higher in MCI compared to SCD. The rate of incident AD dementia (26.1% versus 12.2%) was also significantly higher in MCI. In SCD, additional 22% progressed to MCI during follow-up. Combined amyloid/tau abnormality was the strongest predictor of clinical progression in both groups. CONCLUSION: High prevalence of biomarker abnormality and clinical progression, together with the predictive value of CSF biomarkers, in memory clinic patients with SCD support the validity and usefulness of this condition as a "pre-MCI" at risk stage of AD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Individuals with subjective cognitive decline with biomarker-based evidence of Alzheimer's disease are at higher risk for developing cognitive decline.
“Individuals with SCD with a biomarker-based evidence of AD are at higher risk for developing cognitive decline [5–7].”
From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [5]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 7,925 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946 · see citing works
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130 · see citing works
Jessen, F., Amariglio, R. E., van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., Dubois, B., Dufouil, C., Ellis, K. A., van der Flier, W. M., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.01.001 · Cited by 3,014 · see citing works
Self-citationPreclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Feldman, H. H., Frisoni, G. B., Hampel, H., Jagust, W. J., Johnson, K. A., Knopman, D. S., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002923 · Cited by 1,864 · see citing works
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4668 · Cited by 1,610 · see citing works
Self-citationBondi, M. W., Initiative, F. T. A. D. N., Edmonds, E. C., Jak, A. J., Clark, L. R., Delano-Wood, L., McDonald, C. R., Nation, D. A., Libon, D. J., Au, R., et al. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-140276 · Cited by 750 · see citing works
Improved discrimination of AD patients using β-amyloid <sub>(1-42)</sub> and tau levels in CSF
Hulstaert, F., Blennow, K., Ivanoiu, A., Schoonderwaldt, H. C., Riemenschneider, M., Deyn, P. P. D., Bancher, C., Cras, P., Wiltfang, J., Mehta, P. D., et al. (1999) · Neurology · doi:10.1212/wnl.52.8.1555 · Cited by 724 · see citing works
Self-citationVisser, P. J., Verhey, F., Knol, D. L., Scheltens, P., Wahlund, L.-O., Freund-Levi, Y., Tsolaki, M., Minthon, L., Wallin, Å. K., Hampel, H., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70139-5 · Cited by 614 · see citing works
Implementation of subjective cognitive decline criteria in research studies
Molinuevo, J. L., Rabin, L. A., Amariglio, R., Buckley, R., Dubois, B., Ellis, K. A., Ewers, M., Hampel, H., Klöppel, S., Rami, L., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.09.012 · Cited by 575 · see citing works
Self-citationPreclinical Alzheimer's disease and its outcome: a longitudinal cohort study
Vos, S. J., Xiong, C., Visser, P. J., Jasielec, M. S., Hassenstab, J., Grant, E. A., Cairns, N. J., Morris, J. C., Holtzman, D. M., & Fagan, A. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70194-7 · Cited by 564 · see citing works
AD dementia risk in late MCI, in early MCI, and in subjective memory impairment.
Jessen, F., Wolfsgruber, S., Wiese, B., Bickel, H., Mösch, E., Kaduszkiewicz, H., Pentzek, M., Riedel‐Heller, S. G., Luck, T., Fuchs, A., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.09.017 · Cited by 511 · see citing works
Self-citationThe Bayer Activities of Daily Living Scale (B-ADL)
Hindmarch, I., Lehfeld, H., de Jongh, P., & Erzigkeit, H. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051195 · Cited by 466 · see citing works
The cerebrospinal fluid “Alzheimer profile”: Easily said, but what does it mean?
Duits, F. H., Teunissen, C. E., Bouwman, F. H., Visser, P. J., Mattsson, N., Zetterberg, H., Blennow, K., Hansson, O., Minthon, L., Andreasen, N., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.023 · Cited by 300 · see citing works
Müller, M. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00120-9 · Cited by 282 · see citing works
Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease
Knopman, D. S., Jack, C. R., Wiste, H. J., Weigand, S. D., Vemuri, P., Lowe, V. J., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182563bbe · Cited by 243 · see citing works
van Harten, A. C., Visser, P. J., Pijnenburg, Y. A. L., Teunissen, C. E., Blankenstein, M. A., Scheltens, P., & van der Flier, W. M. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.08.004 · Cited by 197 · see citing works
Perrotin, A., La Joie, R., de La Sayette, V., Barré, L., Mézenge, F., Mutlu, J., Guilloteau, D., Egret, S., Eustache, F., & Chételat, G. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.08.011 · Cited by 179 · see citing works
Preclinical AD predicts decline in memory and executive functions in subjective complaints
van Harten, A. C., Smits, L. L., Teunissen, C. E., Visser, P. J., Koene, T., Blankenstein, M. A., Scheltens, P., & van der Flier, W. M. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a8418b · Cited by 143 · see citing works
Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment
Kornhuber, J., Schmidtke, K., Frölich, L., Perneczky, R., Wolf, S., Hampel, H. J., Jessen, F., Heuser, I., Peters, O., Weih, M., et al. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000210388 · Cited by 82 · see citing works
Self-citationWhitwell, J. L. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3029 · Cited by 72 · see citing works
Mistridis, P., Egli, S. C., Iverson, G. L., Berres, M., Willmes, K., Welsh-Bohmer, K. A., & Monsch, A. U. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0571-z · Cited by 66 · see citing works
Lewczuk, P., Kornhuber, J., & Wiltfang, J. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0511-9 · Cited by 60 · see citing works
Self-citationLewczuk, P., on behalf of the German Dementia Competence Network, US-ADNI, O. B. O. T., Kornhuber, J., Toledo, J. B., Trojanowski, J. Q., Knapik-Czajka, M. E., Peters, O., Wiltfang, J., & Shaw, L. M. J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150342 · Cited by 54 · see citing works
Self-citationSierra, A., Balasa, M., Olives, J., Antonell, A., Iranzo, Á., Castellvı́, M., Bosch, B., Grau‐Rivera, O., Fernández‐Villullas, G., Rami, L., et al. (2015) · Neurodegenerative Diseases · doi:10.1159/000439258 · Cited by 40 · see citing works
Eckerström, M., Berg, A. I., Nordlund, A., Rolstad, S., Sacuiu, S. F., & Wallin, A. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000448326 · Cited by 19 · see citing works
Amyloid Pathology, Cognitive Impairment, and Alzheimer Disease Risk
Wagner, M., & Jessen, F. (2015) · JAMA · doi:10.1001/jama.2015.9716 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The characterisation of subjective cognitive decline
Jessen, F., Amariglio, R. E., Buckley, R. F., van der Flier, W. M., Han, Y., Molinuevo, J. L., Rabin, L., Rentz, D. M., Rodriguez-Gomez, O., Saykin, A. J., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30368-0 · Cited by 1,389 · see citing works
Self-citationShaw, L. M., Arias, J., Blennow, K., Galasko, D., Molinuevo, J. L., Salloway, S., Schindler, S., Carrillo, M. C., Hendrix, J. A., Ross, A., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.220 · Cited by 266 · see citing works
Jessen, F., Spottke, A. E., Boecker, H., Brosseron, F., Büerger, K., Catak, C., Fließbach, K., Franke, C., Fuentes, M., Heneka, M. T., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0314-2 · Cited by 233 · see citing works
Self-citationParnetti, L., Chipi, E., Salvadori, N., D’Andrea, K., & Eusebi, P. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0459-7 · Cited by 194 · see citing works
Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology
Hampel, H. J., (APMI), F. T. A. P. M. I., Toschi, N., Babiloni, C., Baldacci, F., Black, K. L., Bokde, A. L. W., Bun, R. S., Cacciola, F., Cavedo, E., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179932 · Cited by 181 · see citing works
Interventions for subjective cognitive decline: systematic review and meta-analysis
Bhome, R., Berry, A. J., Huntley, J. D., & Howard, R. J. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-021610 · Cited by 123 · see citing works
Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers
Jessen, F., Wolfsgruber, S., Kleineidam, L., Spottke, A. E., Altenstein, S., Bartels, C., Berger, M., Brosseron, F., Daamen, M., Dichgans, M., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12674 · Cited by 100 · see citing works
Self-citationSubjective Cognitive Decline and Related Cognitive Deficits
Si, T., Xing, G., & Han, Y. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00247 · Cited by 104 · see citing works
Decreased Cerebrospinal Fluid Flow Is Associated With Cognitive Deficit in Elderly Patients
Attier‐Zmudka, J., Sérot, J., Valluy, J., Saffarini, M., Macaret, A.-S., Diouf, M., Dao, S., Douadi, Y., Malinowski, K. P., & Balédent, O. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00087 · Cited by 79 · see citing works
Cognitive and neuroscientific perspectives of healthy ageing
Prince, J. B., Davis, H. L., Tan, J., Muller-Townsend, K. L., Markovic, S. J., Lewis, D. M. G., Hastie, B., Thompson, M. B., Drummond, P. D., Fujiyama, H., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105649 · Cited by 68 · see citing works
Tzeng, R.-C., Yang, Y., Hsu, K.-C., Chang, H.-T., & Chiu, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1021792 · Cited by 62 · see citing works
Rostamzadeh, A., Bohr, L., Wagner, M., Baethge, C., & Jessen, F. (2022) · Neurology · doi:10.1212/wnl.0000000000201072 · Cited by 61 · see citing works
Self-citationVerberk, I. M. W., Hendriksen, H. M. A., van Harten, A. C., Wesselman, L. M. P., Verfaillie, S. C. J., van den Bosch, K. A., Slot, R. E. R., Prins, N. D., Scheltens, P., Teunissen, C. E., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.01.007 · Cited by 57 · see citing works
Petrazzuoli, F., Vestberg, S., Midlöv, P., Thulesius, H. O., Stomrud, E., & Palmqvist, S. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191191 · Cited by 49 · see citing works
Personalized risk for clinical progression in cognitively normal subjects-the ABIDE project
Initiative, F. T. A. D. N., van Maurik, I. S., Slot, R. E. R., Verfaillie, S. C. J., Zwan, M. D., Bouwman, F. H., Prins, N. D., Teunissen, C. E., Scheltens, P., Barkhof, F., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0487-y · Cited by 47 · see citing works
Self-citationDiminution of context association memory structure in subjects with subjective cognitive decline
Fan, L., Lai, Y., Chen, T., Hsu, Y., Chen, P., Huang, K., Cheng, T., Tseng, W. I., Hua, M., Chen, Y., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24022 · Cited by 40 · see citing works
Buckley, R. F., Sikkes, S. A. M., Villemagne, V. L., Mormino, E. C., Rabin, J. S., Burnham, S. C., Papp, K. V., Doré, V., Masters, C. L., Properzi, M. J., et al. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.08.004 · Cited by 34 · see citing works
Daunt, P., Ballard, C. G., Creese, B., Davidson, G., Hardy, J., Oshota, O., Pither, R. J., & Gibson, A. M. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.64 · Cited by 29 · see citing works
Manousakis, J. E., Scovelle, A. J., Rajaratnam, S. M. W., Naismith, S. L., & Anderson, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180612 · Cited by 29 · see citing works
The A-to-Z factors associated with cognitive impairment. Results of the DeCo study
Gil‐Peinado, M., Alacreu, M., Ramos, H., Sendra‐Lillo, J., García-García, C., García‐Lluch, G., de Coca, T. L., Sala‐Climent, M., & Moreno, L. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1152527 · Cited by 29 · see citing works
Biomarker-based signature of alzheimer's disease in pre-MCI individuals
Chipi, E., Salvadori, N., Farotti, L., & Parnetti, L. (2019) · Brain Sciences · doi:10.3390/brainsci9090213 · Cited by 27 · see citing works
Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
Rostamzadeh, A., Kahlert, A., Kalthegener, F., & Jessen, F. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00956-8 · Cited by 26 · see citing works
Self-citationTavares-Júnior, J. W. L., Oliveira, D. N., da Silva, J. B. S., Feitosa, W. L. Q., Sousa, A. V. M., Cunha, L. C. V., Gaspar, S. D. B., Gomes, C. M. P., de Oliveira, L. L. B., Moreira-Nunes, C. A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.947583 · Cited by 26 · see citing works
Schermer, M. (2023) · The Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of Medicine · doi:10.1093/jmp/jhad009 · Cited by 24 · see citing works
García, M. A., Warner, D. F., García, C., Downer, B. G., & Raji, M. A. (2021) · Innovation in Aging · doi:10.1093/geroni/igab039 · Cited by 23 · see citing works
Prognostic and Predictive Factors in Early Alzheimer’s Disease: A Systematic Review
Garcia, M. J., Leadley, R. M., Ross, J., Bozeat, S., Redhead, G., Hansson, O., Iwatsubo, T., Villain, N., & Cummings, J. L. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230045 · Cited by 53 · see citing works
Sánchez‐Benavides, G., Suárez‐Calvet, M., Milà‐Alomà, M., Arenaza‐Urquijo, E. M., Grau‐Rivera, O., Operto, G., Gispert, J. D., Vilor‐Tejedor, N., Sala‐Vila, A., Crous‐Bou, M., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.02.026 · Cited by 22 · see citing works
Biomarkers and Tools for Predicting Alzheimer’s Disease in the Preclinical Stage
Li, T.-R., Yang, Q., Hu, X., & Han, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210524153901 · Cited by 22 · see citing works
Wang, S., Sun, H., Hu, G., Xue, C., Qi, W., Rao, J., Zhang, F., Zhang, X., & Chen, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.597455 · Cited by 22 · see citing works
Tort‐Merino, A., Valech, N., Laine, M., Olives, J., León, M., Ecay‐Torres, M., Estanga, A., Martínez‐Lage, P., Fortea, J., Molinuevo, J. L., et al. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5539 · Cited by 21 · see citing works
Jafari, Z., Andrew, M. K., & Rockwood, K. J. (2025) · Age and Ageing · doi:10.1093/ageing/afaf316 · Cited by 20 · see citing works
Ramos, H., Alacreu, M., Guerrero, M. D., Sánchez, R. M., & Moreno, L. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121366 · Cited by 20 · see citing works
Fischer, M., Ruhnau, J., Schulze, J., Obst, D., Flöel, A., & Vogelgesang, A. (2020) · Aging · doi:10.18632/aging.103527 · Cited by 20 · see citing works
Computer‐assisted prediction of clinical progression in the earliest stages of AD
Rhodius‐Meester, H. F. M., Liedes, H., Koikkalainen, J. R., Wolfsgruber, S., Coll‐Padrós, N., Kornhuber, J., Peters, O., Jessen, F., Kleineidam, L., Molinuevo, J. L., et al. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.09.001 · Cited by 19 · see citing works
Self-citationMazzeo, S., Lassi, M., Padiglioni, S., Vergani, A. A., Moschini, V., Scarpino, M., Giacomucci, G., Burali, R., Morinelli, C., Fabbiani, C., et al. (2023) · BMC Neurology · doi:10.1186/s12883-023-03347-8 · Cited by 18 · see citing works
Pharmacists’ Knowledge of Factors Associated with Dementia: The A-to-Z Dementia Knowledge List
Ramos, H., Moreno, L., Gil‐Peinado, M., García‐Lluch, G., Sendra‐Lillo, J., & Alacreu, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18199934 · Cited by 18 · see citing works
Counseling and disclosure practices in predictive Alzheimer's disease diagnostics: A scoping review
Perry, J., Radenbach, K., Geschke, K., & Rostamzadeh, A. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14365 · Cited by 17 · see citing works
Pu, Z., Huang, H., Li, M., Li, H., Shen, X., Du, L., Wu, Q., Fang, X., Meng, X., Ni, Q., et al. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121130 · Cited by 17 · see citing works
Früherkennung der Alzheimer-Krankheit und Ansätze der Prävention
Jessen, F. (2019) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-019-02877-2 · Cited by 17 · see citing works
Self-citationScarth, M., Rissanen, I. L., Scholten, R. J. P. M., & Geerlings, M. I. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210218 · Cited by 18 · see citing works
Lazarou, I., Georgiadis, K., Nikolopoulos, S., Oikonomou, V., Stavropoulos, T., Tsolaki, A., Kompatsiaris, I., & Tsolaki, M. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-215421 · Cited by 12 · see citing works
Biomarkers and Tools for Predicting Alzheimer's Disease in the Preclinical Stage
Li, T., Yang, Q. Z., Hu, X., & Han, Y. (2022) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 17 · see citing works
Jukkola, J., Kaakinen, M., Singh, A., Moradi, S., Ferdinando, H., Myllylä, T., Kiviniemi, V. J., & Eklund, L. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00509-9 · Cited by 17 · see citing works
Chao, R.-Y., Chen, T., & Chang, Y. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.61 · Cited by 17 · see citing works
Disease stage–specific atrophy markers in Alzheimer's disease
Baumeister, H., Gellersen, H. M., Polk, S. E., Lattmann, R., Wuestefeld, A., Wisse, L. E. M., Glenn, T. W., Yakupov, R., Stark, M., Kleineidam, L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70482 · Cited by 16 · see citing works
Self-citationJester, D. J., Vyhnálek, M., Andel, R., Marková, H., Nikolai, T., Laczó, J., Matušková, V., Čechová, K., Sheardová, K., & Hort, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215291 · Cited by 14 · see citing works
A Comparison of Operational Definitions for Mild Cognitive Impairment
Polcher, A. A., Wolfsgruber, S., Peters, O., Frölich, L., Wiltfang, J., Kornhuber, J., Hüll, M., Rüther, E., Lewczuk, P., Maier, W., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215548 · Cited by 14 · see citing works
Self-citationChuang, Y.-C., Chiu, M., Chen, T., Chang, Y., Lai, Y., Cheng, T., & Hua, M. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200916 · Cited by 14 · see citing works
Wen, C., Bi, Y.-L., Hu, H., Huang, S.-Y., Ma, Y.-H., Hu, H.-Y., Tan, L., & Yu, J.-T. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215178 · Cited by 14 · see citing works
Dolcet-Negre, M. M., Imaz, L., de Eulate, M. R. G., Martí‐Andrés, G., Fernández‐Matarrubia, M., Domínguez, P. D., Fernández‐Seara, M. A., & Riverol, M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221002 · Cited by 13 · see citing works
Zhao, Z., Wang, J., Wang, Y., Liu, X., He, K., Guo, Q., Xie, F., Huang, Q., & Li, Z. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221251 · Cited by 13 · see citing works
Königsberg, A., Belau, M. H., Ascone, L., Gallinat, J., Kühn, S., Jensen, M., Gerloff, C. P., Cheng, B., & Thomalla, G. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220659 · Cited by 13 · see citing works
Distribution of Cerebrospinal Fluid Biomarker Profiles in Patients Explored for Cognitive Disorders
Paquet, C., Bouaziz-Amar, É., Cognat, E., Volpe‐Gillot, L., Haddad, V., Mahieux, F., Dekimeche, S., Defontaines, B., Chabriat, H., Belin, C., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180240 · Cited by 12 · see citing works
Miebach, L., Wolfsgruber, S., Frommann, I., Fließbach, K., Jessen, F., Buckley, R. F., & Wagner, M. (2017) · The Gerontologist · doi:10.1093/geront/gnx208 · Cited by 12 · see citing works
Self-citationDifferent Cognitive Complaint Profiles in Memory Clinic and Depressive Patients
Miebach, L., Wolfsgruber, S., Frommann, I., Buckley, R. F., & Wagner, M. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.10.018 · Cited by 12 · see citing works
Self-citationGuan, H., Novoa-Laurentiev, J., & Zhou, L. (2024) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2025.104830 · Cited by 11 · see citing works
Structural disruption in subjective cognitive decline and mild cognitive impairment
Song, J., Han, Y., Yan, H., Lu, Q., Guo, L., Zheng, H., Zhang, T., Lin, B., Zhao, Z., He, C., et al. (2024) · Brain Imaging and Behavior · doi:10.1007/s11682-024-00933-3 · Cited by 10 · see citing works
Ruzi, R., Pan, Y., Ng, M. L., Su, R., Wang, L., Dang, J., Liu, L., & Yan, N. (2025) · Bioengineering · doi:10.3390/bioengineering12020108 · Cited by 9 · see citing works
Neurological Changes and Depression
Greene, R. D., Cook, A. R., Nowaskie, D. Z., & Wang, S. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.11.009 · Cited by 9 · see citing works
CCCDTD5: Clinical role of neuroimaging and liquid biomarkers in patients with cognitive impairment
Brisson, M., Brodeur, C., Guillon, L. L., Masellis, M., Stoessl, A. J., Tamm, A., Zukotynski, K., Ismail, Z., Gauthier, S. G., Rosa‐Neto, P., et al. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12098 · Cited by 9 · see citing works
Feter, N., Caputo, E. L., Koth, A. P., Delpino, F. M., Tomaz, G. D. S., Doring, I. R., Leite, J. S., Cassuriaga, J., Treptow, J. G., Weymar, M. K., et al. (2021) · Public Health · doi:10.1016/j.puhe.2021.09.014 · Cited by 8 · see citing works
Preclinical Brain Network Abnormalities in Patients with Subjective Cognitive Decline
Serra, L., Bonarota, S., Domenico, C. D., Caruso, G., Giulietti, G., Caltagirone, C., Cercignani, M., & Bozzali, M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230536 · Cited by 8 · see citing works
Bartels, C., Kögel, A., Schweda, M., Wiltfang, J., Pentzek, M., Schicktanz, S., & Schneider, A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200794 · Cited by 8 · see citing works
Self-citationYe, L., Gao, P.-R., Zhang, Y.-B., Cheng, H.-R., Tao, Q., Wu, Z., & Li, H. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s294756 · Cited by 8 · see citing works
Yang, H. J., Dong, C., Cai, Y., Zhao, M., Liu, J., Bian, S., & Ding, X. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1596459 · Cited by 6 · see citing works
Katayama, O., Lee, S., Bae, S., Makino, K., Chiba, I., Harada, K., Morikawa, M., Tomida, K., & Shimada, H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247441 · Cited by 6 · see citing works
Neurologic Changes and Depression
Greene, R. D., & Wang, S. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.10.009 · Cited by 6 · see citing works
Parfenov, V. A., Гришина, Д. А., Борисовна, Л. А., Zakharov, V. V., Shevtsova, K. V., & Chervyakova, Y. I. (2025) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2025-1-4-9 · Cited by 5 · see citing works
Liu, Y., Su, N., Li, W., Hong, B., Yan, F., Wang, J., Li, X., Chen, J., Xiao, S., & Yue, L. (2024) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acad096 · Cited by 5 · see citing works
Blandino, V., Colletti, T., Ribisi, P., Tarantino, D., Mosca, V., Agnello, L., Ciaccio, M., & Piccoli, T. (2024) · Brain Sciences · doi:10.3390/brainsci14100960 · Cited by 5 · see citing works
Graessel, E., & Lauer, N. (2023) · Zeitschrift für Evidenz Fortbildung und Qualität im Gesundheitswesen · doi:10.1016/j.zefq.2023.04.004 · Cited by 4 · see citing works
Guan, D. X., Peters, M. E., Pike, G. B., Ballard, C. G., Creese, B., Corbett, A., Pickering, E., Roach, P., Smith, E. E., & Ismail, Z. (2024) · Journal of the Academy of Consultation-Liaison Psychiatry · doi:10.1016/j.jaclp.2024.12.004 · Cited by 4 · see citing works
Zhang, T., Huang, S., Lu, Q., Song, J., Teng, J., Wang, T., & Shen, Y. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1298065 · Cited by 4 · see citing works
Whitfield, T. J., Chouliaras, L., Morrell, R., Rubio, D., Radford, D., Marchant, N. L., & Walker, Z. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01516-6 · Cited by 4 · see citing works
Zhao, Y., Ou, Y., Ma, Y., Tan, L., & Yu, J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221154 · Cited by 4 · see citing works
Lund, A. E., Ostheim, A. F. V. S. Z. N. U., Ridley, H., Bobyreva, K., Foster, J., & Russell, C. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-097002 · Cited by 3 · see citing works
Subjective cognitive decline disrupts aspects of prospective memory in older adults with HIV disease
Thompson, J. L., Sheppard, D. P., Matchanova, A., Morgan, E. E., Loft, S. D., & Woods, S. P. (2022) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2022.2065241 · Cited by 3 · see citing works
Lee, H. H., & Kang, Y. (2019) · THE KOREAN JOURNAL OF DEVELOPMENTAL PSYCHOLOGY · doi:10.35574/kjdp.2019.12.32.4.21 · Cited by 3 · see citing works
Angelidou, I. A., Stocker, H. R., Beyreuther, K. T., & Teichmann, B. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230961 · Cited by 3 · see citing works
Sung, H. K., Wu, F., Afanasyeva, Y., Koenig, K. L., Clendenen, T. V., Zeleniuch‐Jacquotte, A., & Chen, Y. (2025) · Age and Ageing · doi:10.1093/ageing/afaf130 · Cited by 2 · see citing works
Hu, Z., Zhang, X. C., Hou, X., Wang, L., Chen, H., Huang, L., Yang, D., Mo, Y., Xu, Y., & Bai, F. (2024) · Brain and Behavior · doi:10.1002/brb3.3408 · Cited by 2 · see citing works
Lee, C.-K., Wei, X.-Y., Wang, Z.-Y., Zhou, H., Yan, C.-Q., Jiang, X.-Y., Shi, G.-X., Wang, X., & Liu, C.-Z. (2025) · Human Brain Mapping · doi:10.1002/hbm.70194 · Cited by 3 · see citing works
Gerards, M., Baumeister, A., Hübner, C., Ribaldi, F., Cantero‐Fortiz, Y., Braun, J., Boada, M., Frisoni, G. B., Jessen, F., Schmitz‐Luhn, B., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0319868 · Cited by 2 · see citing works
Self-citationCerveira, M. O., da Silva, E. S., Borelli, W. V., Castilhos, R. M., & Chaves, M. L. F. (2022) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000521 · Cited by 2 · see citing works
One step towards dementia prevention
Frisoni, G. B., & Jessen, F. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30086-3 · Cited by 2 · see citing works
Self-citationLi, S., Grothe, M. J., Daamen, M., Wolfsgruber, S., Brosseron, F., Büerger, K., Catak, C., Dobisch, L., Incesoy, E. I., Fließbach, K., et al. (2020) · doi:10.21203/rs.3.rs-20438/v1 · Cited by 2 · see citing works
Self-citationJiang, L., Gong, L., Sun, K., Xie, L., Yang, Y., & Wu, D. (2025) · Current Psychology · doi:10.1007/s12144-025-07776-1 · Cited by 1 · see citing works
Gil‐Peinado, M., Muñoz–Almaraz, F. J., Ramos, H., Sendra‐Lillo, J., & Moreno, L. (2025) · Healthcare · doi:10.3390/healthcare13141693 · Cited by 1 · see citing works
Nwakasi, C. C., & Nweke, C. (2025) · Research on Aging · doi:10.1177/01640275251409700 · Cited by 1 · see citing works
Prädiktive Diagnostik der Alzheimer-Demenz
Rostamzadeh, A., & Jessen, F. (2020) · PSYCH up2date · doi:10.1055/a-0981-4529 · Cited by 1 · see citing works
Self-citationPrädiktive Diagnostik der Alzheimer-Demenz
Rostamzadeh, A., & Jessen, F. (2021) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-1370-3142 · Cited by 1 · see citing works
Self-citationLogroscino, G., & Battista, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00008-6 · Cited by 1 · see citing works
Blood pressure lowering enhances cerebrospinal fluid efflux primarily via the lymphatic vasculaturePreprint
Jukkola, J., Kaakinen, M., Singh, A., Moradi, S., Ferdinando, H., Myllylä, T., Kiviniemi, V. J., & Eklund, L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.11.548482 · Cited by 1 · see citing works
Ein Blick in die Zukunft der Psychiatrie
von Kieseritzky, K. (2017) · DNP - Der Neurologe und Psychiater · doi:10.1007/s15202-017-1734-3
Jessen, F. (2021) · J.B. Metzler eBooks · doi:10.1007/978-3-476-05352-7_22
Self-citationRisk factors and cognitive domain markers of progression in Subjective Cognitive Decline
Bubu, O. M., Mbah, A. K., Bernard, M. A., Briggs, A., Faustin, A., Gurin, L. J., Rao, J. A., Tall, S. O., Osorio, R. S., & Masurkar, A. V. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.067675
Filho, L. C. F., Aranha, M. F. D. A. C., Cabeça, R. A. S., Massoud, R. O., Cohen, S. B., Fernandes, L. M. P., de Oliveira, R. D. C. S., & Cohen, P. B. (2023) · Arquivos de Ciências da Saúde da UNIPAR · doi:10.25110/arqsaude.v27i10.2023-012
Sampatakakis, S. N., Mourtzi, N., Charisis, S., Kalligerou, F., Mamalaki, E., Ntanasi, E., Hatzimanolis, A., Koutsis, G., Ramı́rez, A., Lambert, J., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12051053
Chan, D., Spires‐Jones, T. L., Provenzano, F. A., Glennon, E. B. C., & Duff, K. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0020
- Authors
- Wolfsgruber, S., Polcher, A., Koppara, A., Kleineidam, L., Frölich, L., Peters, O., Hüll, M., Rüther, E., Wiltfang, J., Maier, W., Kornhuber, J., Lewczuk, P., Jessen, F., & Wagner, M.
- Affiliations
- University of Bonn (DE)
- Central Institute of Mental Health (DE)
- Stiftung Charité (DE)
- University of Freiburg (DE)
- University of Göttingen (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Medical University of Białystok (PL)
- University of Cologne (DE)
- Corresponding author
- Wolfsgruber, Steffen
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2017-06-05
- Volume
- 58
- Issue
- 3
- Pages
- 939-950
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2614873104
- Cited by
- 114
- References
- 33
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 19 · 2023: 11 · 2022: 16 · 2021: 16 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 4
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- DZNE Pub (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid biomarkers, subjective cognitive decline
- MeSH terms
- Aged, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Peptide Fragments, Phosphorylation, Prospective Studies, Risk Factors, Biomarkers, Incidence, Prevalence, Proportional Hazards Models, Amyloid beta-Peptides, tau Proteins, Disease Progression, Kaplan-Meier Estimate, Diagnostic Self Evaluation, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review