Cited by 236Genetic Neurodegenerative DiseasesRedox biology and oxidative stressParkinson's Disease Mechanisms and Treatments

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Oxidative Stress and Huntington’s Disease: The Good, The Bad, and The Ugly

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Kumar, Amit, Ratan, Rajiv R.·2016·Journal of Huntington s Disease

DOI 10.3233/jhd-160205PMC PMC5310831

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Abstract

Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a balance between oxidants and antioxidants. This balance facilitates the ability of oxidants, such as reactive oxygen species, to play critical regulatory functions through a direct modification of a small number of amino acids (e.g. cysteine) on signaling proteins. These signaling functions leverage tight spatial, amplitude, and temporal control of oxidant concentrations. However, when oxidants overwhelm the antioxidant capacity, they lead to a harmful condition of oxidative stress. Oxidative stress has long been held to be one of the key players in disease progression for Huntington's disease (HD). In this review, we will critically review this evidence, drawing some intermediate conclusions, and ultimately provide a framework for thinking about the role of oxidative stress in the pathophysiology of HD.

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Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
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See all 236

Authors: Kumar, A., & Ratan, R. R.
Affiliations: Cornell University (US)
Corresponding author: Ratan, Rajiv R.
ORCID: Kumar, Amit
Ratan, Rajiv R.
Venue: Journal of Huntington s Disease
Publisher: SAGE Publications
Published: 2016-09-20
Volume: 5
Issue: 3
Pages: 217-237
ISSN: 1879-6397 (ISSN-L)
1879-6400
DOI: 10.3233/jhd-160205
PMC: PMC5310831
OpenAlex: W2522941116
Cited by: 236
References: 183
Citations by year: 2026: 19 · 2025: 32 · 2024: 31 · 2023: 26 · 2022: 34 · 2021: 31 · 2020: 21 · 2019: 20 · 2018: 18 · 2017: 4
FWCI: 1.53
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (unspecified)
Locations: Journal of Huntington s Disease (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
PubMed Central (acceptedVersion, cc-by-nc)
Funders: Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
National Institutes of Health (P01 AG14930-15A1)
National Institute on Aging (P01AG014930, AG14930)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: oxidative stress, Huntington's disease, redox homeostasis, reactive oxygen species, antioxidants, cysteine oxidation, protein oxidation, receptor tyrosine kinase signaling, protein folding, xenobiotic detoxification, disease pathophysiology
MeSH terms: Humans, Huntington Disease, Oxidative Stress

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Oxidative Stress and Huntington’s Disease: The Good, The Bad, and The Ugly

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