CoChat
Sign Up
Cited by 402Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsNonmelanoma Skin Cancer Studies

The DOI matches its Crossref record; 299 of the 302 references it cites were found in a registry or an index, and 1 are not checked yet.

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Open access
Gunaydin, Gurcan, Gedik, M. Emre, Ayan, Seylan·2021·Frontiers in Chemistry
DOI 10.3389/fchem.2021.686303PMC PMC8365093
Open this paper in CoChat — free accountOpen PDF

Abstract

Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long time and photosensitizers (PS) can be used in various types of tumors. Originally, light is an effective tool that has been used in the treatment of diseases for ages. The effects of combination of specific dyes with light illumination was demonstrated at the beginning of 20th century and novel PDT approaches have been developed ever since. Main strategies of current studies are to reduce off-target effects and improve pharmacokinetic properties. Given the high interest and vast literature about the topic, approval of PDT as the first drug/device combination by the FDA should come as no surprise. PDT consists of two stages of treatment, combining light energy with a PS in order to destruct tumor cells after activation by light. In general, PDT has fewer side effects and toxicity than chemotherapy and/or radiotherapy. In addition to the purpose of treatment, several types of PSs can be used for diagnostic purposes for tumors. Such approaches are called photodynamic diagnosis (PDD). In this Review, we provide a general overview of the clinical applications of PDT in cancer, including the diagnostic and therapeutic approaches. Assessment of PDT therapeutic efficacy in the clinic will be discussed, since identifying predictors to determine the response to treatment is crucial. In addition, examples of PDT in various types of tumors will be discussed. Furthermore, combination of PDT with other therapy modalities such as chemotherapy, radiotherapy, surgery and immunotherapy will be emphasized, since such approaches seem to be promising in terms of enhancing effectiveness against tumor. The combination of PDT with other treatments may yield better results than by single treatments. Moreover, the utilization of lower doses in a combination therapy setting may cause less side effects and better results than single therapy. A better understanding of the effectiveness of PDT in a combination setting in the clinic as well as the optimization of such complex multimodal treatments may expand the clinical applications of PDT.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fchem.2021.686303

Cites

299 of 300 references verified0 citation errors · 0 not checkable

Statistics

Figures

FIGURE 1 Phototherapy in Ancient Egypt. (A) Veneration of the sun eventually resulted in its utilization as heliotherapy (Shutterstock). (B) The Ebers Papyrus mentioned the Pharaoh’s utilization of phototherapy utilizing various plants (Ebers papyrus, University of Leipzig, Germany, https://commons.wikimedia.org, public domain) (Abdel-kader, 2016).
FIGURE 1 Phototherapy in Ancient Egypt. (A) Veneration of the sun eventually resulted in its utilization as heliotherapy (Shutterstock). (B) The Ebers Papyrus mentioned the Pharaoh’s utilization of phototherapy utilizing various plants (Ebers papyrus, University of Leipzig, Germany, https://commons.wikimedia.org, public domain) (Abdel-kader, 2016).CC BY · PubMed Central
FIGURE 2 Timeline of PDT. The timeline shows selected applications of PDT for cancer. PDT, photodynamic therapy.
FIGURE 2 Timeline of PDT. The timeline shows selected applications of PDT for cancer. PDT, photodynamic therapy.CC BY · PubMed Central
FIGURE 3 Selected Examples of First and Second Generation PSs. PS, photosensitizer.
FIGURE 3 Selected Examples of First and Second Generation PSs. PS, photosensitizer.CC BY · PubMed Central
FIGURE 4 Mechanisms of Action of PDT on Tumors. PDT can exert a plethora of actions such as inducing immune responses, direct killing of tumor cells, and damaging vascular structures.
FIGURE 4 Mechanisms of Action of PDT on Tumors. PDT can exert a plethora of actions such as inducing immune responses, direct killing of tumor cells, and damaging vascular structures.CC BY · PubMed Central
FIGURE 5 Therapeutic Application of PDT. The patient is administered with the PS, which concentrates at the tumor. The PS is then activated by a specific light, which generates reactive oxygen species; resulting in tumor destruction. PDT, photodynamic therapy; PS, photosensitizer.
FIGURE 5 Therapeutic Application of PDT. The patient is administered with the PS, which concentrates at the tumor. The PS is then activated by a specific light, which generates reactive oxygen species; resulting in tumor destruction. PDT, photodynamic therapy; PS, photosensitizer.CC BY · PubMed Central
FIGURE 6 Light Sources Utilized in PDT. Laser, lamp and LED sources can be used for PDT applications. LED, light emitting diodes.
FIGURE 6 Light Sources Utilized in PDT. Laser, lamp and LED sources can be used for PDT applications. LED, light emitting diodes.CC BY · PubMed Central
FIGURE 7 Immune Checkpoint Inhibition. Blocking of PD-1/PD-L1 or CTLA-4 with antibodies permits T cell activation. CTLA-4, cytotoxic T lymphocyte-associated protein 4; PD-1, programmed cell death protein 1; PD-L1, programmed cell death 1 ligand 1.
FIGURE 7 Immune Checkpoint Inhibition. Blocking of PD-1/PD-L1 or CTLA-4 with antibodies permits T cell activation. CTLA-4, cytotoxic T lymphocyte-associated protein 4; PD-1, programmed cell death protein 1; PD-L1, programmed cell death 1 ligand 1.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 6

  1. Bryan, 1930, The Papyrus Ebers/Translated from the German Version by Cyril P. Bryan ... With an Introduction by Professor J. Elliot Smith
  2. Ebers, 1875, Papyros Ebers: Das Hermetische Buch über die Arzneimittel der alten Ägypter in hieratischer Schrift (Band 1): Einleitung und Text
  3. Goldberg, 1930, Heliotherapy, Arch. Phys. Ther., 11, 263
  4. Moser, 1998, Photodynamic Tumor Therapy: 2nd and 3rd Generation Photosensitizers
  5. The Nobel Prize in Physiology or Medicine 1903
  6. Raab, 1900, Uber die wirkung Fluorescirender Stoffe auf Infusorien, Z. Biol., 39, 524

Cited by

Sorted by citations

See all 402

Related

See all

Metadata

Authors
Gunaydin, G., Gedik, M. E., & Ayan, S.
Affiliations
  • Hacettepe University Hospital (TR)
  • Bilkent University (TR)
Corresponding author
Ayan, Seylan
ORCID
Venue
Frontiers in Chemistry
Publisher
Frontiers Media SA
Published
2021-08-02
Volume
9
Pages
686303-686303
ISSN
2296-2646 (ISSN-L)
DOI
10.3389/fchem.2021.686303
PMC
PMC8365093
OpenAlex
W3189011149
Cited by
402
References
302
Citations by year
2026: 47 · 2025: 70 · 2024: 106 · 2023: 103 · 2022: 64 · 2021: 12
FWCI
11.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Chemistry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Keywords
photodynamic therapy, photodynamic diagnosis, photosensitizers, cancer therapy, combination therapy, multimodal cancer therapy, predictors of treatment response, off-target effects, photosensitizer pharmacokinetics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review