Short‐term melatonin consumption protects the heart of obese rats independent of body weight change and visceral adiposity

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070 · see citing works

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

Danaei, G., Finucane, M. M., Lu, Y., Singh, G. M., Cowan, M. J., Paciorek, C. J., Lin, J. K., Farzadfar, F., Khang, Y.-H., Stevens, G. A., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60679-x · Cited by 3,568 · see citing works

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works

Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism

Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., & Eckel, R. H. (2006) · Circulation · doi:10.1161/circulationaha.106.171016 · Cited by 3,165 · see citing works

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3815 · Cited by 1,181 · see citing works

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,154 · see citing works

Obesity, insulin resistance and free fatty acids

Boden, G. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3283444b09 · Cited by 848 · see citing works

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

Galano, A., Tan, D. X., & Reiter, R. J. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12010 · Cited by 829 · see citing works

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

Vincent, H. K., & Taylor, A. G. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803177 · Cited by 738 · see citing works

The Reperfusion Injury Salvage Kinase Pathway: A Common Target for Both Ischemic Preconditioning and Postconditioning

Hausenloy, D. J., Tsang, A., & Yellon, D. M. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.03.001 · Cited by 449 · see citing works

Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat1

Wolden‐Hanson, T., Mitton, D. R., McCants, R. L., Yellon, S. M., Wilkinson, C. W., Matsumoto, A. M., & Rasmussen, D. D. (2000) · Endocrinology · doi:10.1210/endo.141.2.7311 · Cited by 390 · see citing works

Role of Glycogen Synthase Kinase-3β in Cardioprotection

Juhaszova, M., Zorov, D. B., Yaniv, Y., Nuss, H. B., Wang, S., & Sollott, S. J. (2009) · Circulation Research · doi:10.1161/circresaha.109.197996 · Cited by 353 · see citing works

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 343 · see citing works

Cardiovascular diseases: protective effects of melatonin

Tengattini, S., Reiter, R. J., Tan, D., Terrón, M. P., Rodella, L. F., & Rezzani, R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00518.x · Cited by 337 · see citing works

Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?

Lecour, S. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.03.019 · Cited by 330 · see citing works

Long-term cardiovascular consequences of obesity: 20-year follow-up of more than 15 000 middle-aged men and women (the Renfrew-Paisley study)

Murphy, N. F., MacIntyre, K., Stewart, S., Hart, C. L., Hole, D., & McMurray, J. J. V. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi506 · Cited by 298 · see citing works

Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis

Grattagliano, I., Palmieri, V. O., Portincasa, P., Moschetta, A., & Palasciano, G. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.011 · Cited by 293 · see citing works

Adiponectin and cardiovascular health: an update

Hui, X. H., Lam, K. S., Vanhoutte, P. M., & Xu, A. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01395.x · Cited by 287 · see citing works

Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity

Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281 · see citing works

Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation

Patel, V. B., Upaganlawar, A., Zalawadia, R., & Balaraman, R. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.06.065 · Cited by 251 · see citing works

Adiponectin, driver or passenger on the road to insulin sensitivity?

Ye, R., & Scherer, P. E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.001 · Cited by 251 · see citing works

Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression

Reiter, R. J., Tan, D., Korkmaz, A., & Ma, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.586365 · Cited by 242 · see citing works

JAK 2/ STAT 3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

Yang, Y., Duan, W., Jin, Z., Yi, W., Yan, J., Zhang, S., Wang, N., Liang, Z., Li, Y., Chen, W., et al. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12070 · Cited by 232 · see citing works

Oxidative stress and myocardial injury in the diabetic heart

Ansley, D. M., & Wang, B. (2012) · The Journal of Pathology · doi:10.1002/path.4113 · Cited by 231 · see citing works

Seasonal Changes in Adiposity: the Roles of the Photoperiod, Melatonin and Other Hormones, and Sympathetic Nervous System

Bartness, T. J., Demas, G. E., & Song, C. K. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700601 · Cited by 221 · see citing works

Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats

Jiménez‐Aranda, A., Fernández‐Vázquez, G., Campos, D., Tassi, M., Velasco‐Perez, L., Tan, D. X., Reiter, R. J., & Agil, A. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12089 · Cited by 189 · see citing works

Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

Otani, H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3739 · Cited by 181 · see citing works

Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats

Agil, A., Rosado, I., Ruiz, R., Figueroa, A., Zen, N., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00928.x · Cited by 169 · see citing works

Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats

Agil, A., Navarro‐Alarcón, M., Ruiz, R., Abuhamdah, S. M. A., El‐Mir, M., & Vázquez, G. F. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00830.x · Cited by 168 · see citing works

Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Petrosillo, G., Colantuono, G., Moro, N., Ruggiero, F. M., Tiravanti, E., Venosa, N. D., Fiore, T., & Paradies, G. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00163.2009 · Cited by 168 · see citing works

Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice

Sartori, C. S., Dessen, P., Mathieu, C., Monney, A., Bloch, J., NICOD, P. H., Scherrer, U., & Duplain, H. (2009) · Endocrinology · doi:10.1210/en.2009-0425 · Cited by 164 · see citing works

Melatonin ameliorates low‐grade inflammation and oxidative stress in young Zucker diabetic fatty rats

Agil, A., Reiter, R. J., Jiménez‐Aranda, A., Arias, R. I., Navarro‐Alarcón, M., Marchal, J. A., Adem, A., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12012 · Cited by 159 · see citing works

Insulin modulates leptin‐induced STAT3 activation in rat hypothalamus

Carvalheira, J. B. C., Siloto, R. M. P., Ignacchitti, I., Brenelli, S. L., Carvalho, C. R. D. O., Leite, A., Velloso, L. A., Gontijo, J. A. R., & Saad, M. J. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02591-1 · Cited by 157 · see citing works

Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Miki, T., Itoh, T., Sunaga, D., & Miura, T. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-67 · Cited by 154 · see citing works

Chronic melatonin consumption prevents obesity‐related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet‐induced obesity

Nduhirabandi, F., Toit, E. F. D., Blackhurst, D., MARAIS, D. P., & Lochner, A. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00826.x · Cited by 144 · see citing works

RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning

Tamareille, S., Mateus, V., Ghaboura, N., Jeanneteau, J., Croué, A., Henrion, D., Furber, A., & Prunier, F. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0210-z · Cited by 138 · see citing works

Cytokine Biomarkers, Endothelial Inflammation, and Atherosclerosis in the Metabolic Syndrome: Emerging Concepts

Rizvi, A. A. (2009) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181a4158c · Cited by 137 · see citing works

Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance

Katakam, P. V. G., Jordan, J. E., Snipes, J. A., Tulbert, C. D., Miller, A. W., & Busija, D. W. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00520.2006 · Cited by 133 · see citing works

Decreased nocturnal melatonin levels during acute myocardial infarction

Domínguez-Rodríguez, A., Abreu-González, P., García, M. J., Sánchez, J. J., Marrero, F., & Trujillo, D. D. A. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.02938.x · Cited by 125 · see citing works

Activation of insulin and IGF‐1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets

Picinato, M. C., Hirata, A. E., Cipolla‐Neto, J., Curi, R., Carvalho, C. R. D. O., Anhê, G. F., & Carpinelli, Â. R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00493.x · Cited by 124 · see citing works

Serum cholesterol and lipid peroxidation are decreased by melatonin in diet‐induced hypercholesterolemic rats

Hoyos, M. G., Guerrero, J. M., Pérez‐Cano, R., Oliván, J., Romero, F. F., García‐Pergañeda, A., & Osuna, C. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.280304.x · Cited by 123 · see citing works

Melatonin improves metabolic syndrome induced by high fructose intake in rats

Kitagawa, A., Ohta, Y., & Ohashi, K. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00955.x · Cited by 116 · see citing works

Melatonin and the metabolic syndrome: a tool for effective therapy in obesity‐associated abnormalities?

Nduhirabandi, F., Toit, E. F. D., & Lochner, A. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02410.x · Cited by 116 · see citing works

Long‐term melatonin administration reduces hyperinsulinemia and improves the altered fatty‐acid compositions in type 2 diabetic rats via the restoration of Δ‐5 desaturase activity

Nishida, S., Segawa, T., Murai, I., & Nakagawa, S. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.10797.x · Cited by 115 · see citing works

In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus

Anhê, G. F., Caperuto, L. C., Pereira‐da‐Silva, M., Souza, L. C., Hirata, A. E., Velloso, L. A., Cipolla‐Neto, J., & Carvalho, C. R. D. O. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02514.x · Cited by 113 · see citing works

Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore

Smith, C., Dixon, R. A., Wynne, A. M., Theodorou, L., Ong, S., Subrayan, S., Davidson, S. M., Hausenloy, D. J., & Yellon, D. M. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00092.2010 · Cited by 108 · see citing works

Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol‐ and melatonin‐induced cardioprotection

Lamont, K. T., Somers, S., Lacerda, L., Opie, L. H., & Lecour, S. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00853.x · Cited by 104 · see citing works

Melatonin improves insulin sensitivity independently of weight loss in old obese rats

Zanuto, R., de Siqueira-Filho, M. A., Caperuto, L. C., Bacurau, R. F. P., Hirata, E., Garcia, R. A. P., do Amaral, F. G., Marçal, A. C., Ribeiro, L. M., Camporez, J. P., et al. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12056 · Cited by 98 · see citing works

Effect of pinealectomy on plasma levels of insulin and leptin and on hepatic lipids in type 2 diabetic rats

Nishida, S., Sato, R., Murai, I., & Nakagawa, S. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00083.x · Cited by 97 · see citing works

Melatonin receptor‐mediated protection against myocardial ischaemia/reperfusion injury: role of its anti‐adrenergic actions

Genade, S., Genis, A., Kirsti Ytrehus, B., Huisamen, B., & Lochner, A. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00615.x · Cited by 86 · see citing works

Short‐ and long‐term effects of melatonin on myocardial post‐ischemic recovery

Lochner, A., Genade, S., Davids, A., Kirsti Ytrehus, B., & Moolman, J. A. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00280.x · Cited by 79 · see citing works

Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity

Toit, E. F. D., Smith, W. T., Muller, C. J. F., Strijdom, H., Stouthammer, B., Woodiwiss, A. J., Norton, G. R., & Lochner, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00481.2007 · Cited by 66 · see citing works

Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes

Radogna, F., Paternoster, L., Nicola, M. D., Cerella, C., Ammendola, S., Bedini, A., Tarzia, G., Aquilano, K., Ciriolo, M. R., & Ghibelli, L. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.05.012 · Cited by 65 · see citing works

Cardioprotective effect of melatonin against ischaemia reperfusion damage

Lochner, A. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e617 · Cited by 63 · see citing works

Low plasma adiponectin concentration is associated with myocardial infarction in young individuals

Persson, J., Lindberg, K. A., Gustafsson, T. P., Eriksson, P. O., Paulsson‐Berne, G., & Lundman, P. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02247.x · Cited by 63 · see citing works

The Diabetic Heart: Too Sweet for Its Own Good?

Whittington, H. J., Babu, G. G., Mocanu, M. M., Yellon, D. M., & Hausenloy, D. J. (2012) · Cardiology Research and Practice · doi:10.1155/2012/845698 · Cited by 58 · see citing works

Melatonin, given at the time of reperfusion, prevents ventricular arrhythmias in isolated hearts from fructose‐fed rats and spontaneously hypertensive rats

Diez, E. R., Renna, N. F., Prado, N. J., Lembo, C., Zumino, A. Z. P., Prieto, M. A. V., & Miatello, R. M. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12059 · Cited by 55 · see citing works

Melatonin May Curtail the Metabolic Syndrome: Studies on Initial and Fully Established Fructose-Induced Metabolic Syndrome in Rats

Cardinali, D. P., Bernasconi, P., Reynoso, R., Toso, C., & Scacchi, P. A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022502 · Cited by 54 · see citing works

Decreased long‐chain fatty acid oxidation impairs postischemic recovery of the insulin‐resistant rat heart

Harmancey, R., Vasquez, H. G., Guthrie, P. H., & Taegtmeyer, H. (2013) · The FASEB Journal · doi:10.1096/fj.13-234914 · Cited by 54 · see citing works

The effect of myocardial infarction on the synthesis, concentration and receptor expression of endogenous melatonin

Sallinen, P., Mänttäri, S. K., Leskinen, H. K., Ilves, M., Vakkuri, O., Ruskoaho, H. J., & Saarela, S. Y. O. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00413.x · Cited by 44 · see citing works

Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats

Donner, D. G., Headrick, J. P., Peart, J. N., & Toit, E. F. D. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010959 · Cited by 43 · see citing works

Myocardial structure, function and ischaemic tolerance in a rodent model of obesity with insulin resistance

Wensley, I., Salaveria, K., Bulmer, A. C., Donner, D. G., & Toit, E. F. D. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.074948 · Cited by 40 · see citing works

Dancing rhinos in stilettos

Zouein, F. A., Kurdi, M., & Booz, G. W. (2013) · JAK-STAT · doi:10.4161/jkst.24352 · Cited by 34 · see citing works

Increased Myocardial Susceptibility to Repetitive Ischemia With High‐fat diet‐induced Obesit

Thakker, G. D., Frangogiannis, N. G., Zymek, P. T., Sharma, S., Raya, J. L., Barger, P. M., Taegtmeyer, H., Entman, M. L., & Ballantyne, C. M. (2008) · Obesity · doi:10.1038/oby.2008.414 · Cited by 34 · see citing works

Differential STAT3 signaling in the heart

Zgheib, C., Zouein, F. A., Kurdi, M., & Booz, G. W. (2012) · JAK-STAT · doi:10.4161/jkst.19776 · Cited by 30 · see citing works

Comparison of Melatonin Effect on Oxidant Status and Antioxidant Capacity in Liver and Heart of Young and Aged Rats

Güney, Ş., Cumaoğlu, A., Öztürk, G., AKBULUT, K. G., & Karasu, Ç. (2012) · International journal of gerontology · doi:10.1016/j.ijge.2012.11.010 · Cited by 16 · see citing works

Protection of endogenous β-carotene in LDL oxidized by oxygen free radicals in the presence of supraphysiological concentrations of melatonin

Bonnefont‐Rousselot, D., Guilloz, V., Lepage, S., Bizard, C., Duriez, P., Lesieur, D., Delattre, J., Jore, D., & Gardès-Albert, M. (2003) · Redox Report · doi:10.1179/135100003125001413 · Cited by 10 · see citing works

Dietary Sources and Bioactivities of Melatonin

Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R.-Y., Xu, D.-P., & Li, H.-B. (2017) · Nutrients · doi:10.3390/nu9040367 · Cited by 362 · see citing works

Effects of melatonin on cardiovascular diseases: progress in the past year

Sun, H., Gusdon, A. M., & Qu, S. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000314 · Cited by 133 · see citing works

Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity

Szewczyk‐Golec, K., Woźniak, A., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12257 · Cited by 153 · see citing works

Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review

Lochner, A., Marais, E., & Huisamen, B. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12490 · Cited by 112 · see citing works

Natural and synthetic antioxidants targeting cardiac oxidative stress and redox signaling in cardiometabolic diseases

Barteková, M., Adameová, A., Görbe, A., Ferenczyová, K., Pecháňová, O., Lazou, A., Dhalla, N. S., Ferdinandy, P., & Giricz, Z. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.045 · Cited by 98 · see citing works

Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie‐Restricted Diet

Szewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8494107 · Cited by 92 · see citing works

Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation

Cao, K., Xu, J., Pu, W., Dong, Z., Sun, L., Zang, W., Gao, F., Zhang, Y., Feng, Z., & Liu, J. (2015) · Scientific Reports · doi:10.1038/srep14014 · Cited by 90 · see citing works

Cardiovascular Adiponectin Resistance: The Critical Role of Adiponectin Receptor Modification

Wang, Y., Ma, X. L., & Lau, W. B. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.03.004 · Cited by 88 · see citing works

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

Jiki, Z., Lecour, S., & Nduhirabandi, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00528 · Cited by 88 · see citing works

Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia–reperfusion injury: role of RISK and SAFE pathways interaction

Yu, L., Li, B., Zhang, M., Jin, Z., Duan, W., Zhao, G., Yang, Y., Liu, Z., Chen, W., Wang, S., et al. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1246-1 · Cited by 84 · see citing works

Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice

Farias, T. D. S. M. D., Cruz, M. M., Sa, R. C. D. C. D., Severi, I., Perugini, J., Senzacqua, M., Cerutti, S. M., Giordano, A., Cinti, S., & Alonso-Vale, M. I. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00750 · Cited by 74 · see citing works

Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review

Imenshahidi, M., Karimi, G., & Hosseinzadeh, H. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01822-4 · Cited by 66 · see citing works

Role of toll‐like receptor 4 in melatonin‐induced cardioprotection

Nduhirabandi, F., Lamont, K. T., Albertyn, Z., Opie, L. H., & Lecour, S. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12286 · Cited by 64 · see citing works

Melatonin in Heart Failure: A Promising Therapeutic Strategy?

Nduhirabandi, F., & Maarman, G. J. (2018) · Molecules · doi:10.3390/molecules23071819 · Cited by 61 · see citing works

Melatonin: A Molecule for Reducing Breast Cancer Risk

González-González, A., Mediavilla, M., & Sánchez‐Barceló, E. J. (2018) · Molecules · doi:10.3390/molecules23020336 · Cited by 62 · see citing works

Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin‐deficient mice

de Luxán‐Delgado, B., Potes, Y., Rubio‐González, A., Caballero, B., Solano, J. J., Fernández, M. F., Bermúdez, M., Guimarães, M. R. M., Vega‐Naredo, I., Boga, J. A., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12333 · Cited by 59 · see citing works

YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α

Zhao, Y., Xu, L., Qiao, Z., Gao, L., Ding, S. Z., Ying, X., Su, Y., Lin, N., He, B., & Pu, J. (2016) · Scientific Reports · doi:10.1038/srep23025 · Cited by 53 · see citing works

Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish

Montalbano, G., Mania, M., Abbate, F., Navarra, M., Guerrera, M. C., Laurà, R., Vega, J. A., Levanti, M. B., & Germanà, A. (2018) · Endocrine · doi:10.1007/s12020-018-1653-x · Cited by 53 · see citing works

Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway

Lan, H., Su, Y., Liu, Y., Deng, C., Wang, J., Chen, T., Jules, K. E. D., Masau, J. F., Li, H., & Wei, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.057 · Cited by 51 · see citing works

Melatonin Supplementation Attenuates the Pro-Inflammatory Adipokines Expression in Visceral Fat from Obese Mice Induced by A High-Fat Diet

de Farias, T. D. S. M., Paixão, R. I., Cruz, M. M., de, R. C. D. C., Simão, J. D. J., Antraco, V. J., & Alonso‐Vale, M. I. C. (2019) · Cells · doi:10.3390/cells8091041 · Cited by 52 · see citing works

Effects of Melatonin on Glucose Homeostasis, Antioxidant Ability, and Adipokine Secretion in ICR Mice with NA/STZ-Induced Hyperglycemia

Lo, C., Lin, S., Chang, J., & Chien, Y. (2017) · Nutrients · doi:10.3390/nu9111187 · Cited by 36 · see citing works

Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease

Rahbarghazi, A., Siahkouhian, M., Rahbarghazi‬, R., Ahmadi, M., Bolboli, L., Keyhanmanesh, ‬., Mahdipour, M., & Rajabi, H. (2021) · Journal of Inflammation · doi:10.1186/s12950-021-00269-5 · Cited by 33 · see citing works

The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats

Yıldırım, A., Tamer, S. A., Şahin, D., Bagriacik, F., Kahraman, M., Onur, N. D., Cayirli, Y. B., Cilingir-Kaya, O. T., Aksu, B., Akdeniz, E., et al. (2019) · British Journal of Nutrition · doi:10.1017/s0007114519001466 · Cited by 28 · see citing works

Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors

Maity, J., Dey, T., Banerjee, A., Chattopadhyay, A., Das, A. R., & Bandyopadhyay, D. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12847 · Cited by 26 · see citing works

Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats

Gonzaga, N. A., Awata, W. M. C., Ficher, S. P., Assis, V. O., Alves, J. V., Tostes, R. C., & Tirapelli, C. R. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12710 · Cited by 25 · see citing works

Daily NO rhythms in peripheral clocks in aging male Wistar rats: protective effects of exogenous melatonin

Vinod, C., & Jagota, A. (2016) · Biogerontology · doi:10.1007/s10522-016-9656-6 · Cited by 25 · see citing works

Melatonin Efficacy in Obese Leptin-Deficient Mice Heart

Stacchiotti, A., Favero, G., Giugno, L., Golic, I., Korac, A., & Rezzani, R. (2017) · Nutrients · doi:10.3390/nu9121323 · Cited by 25 · see citing works

Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment

Dhanabalan, K., Mzezewa, S., Huisamen, B., & Lochner, A. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-06997-9 · Cited by 21 · see citing works

Cardioprotective Effects of Beta3-Adrenergic Receptor (β3-AR) Pre-, Per-, and Post-treatment in Ischemia–Reperfusion

Salie, R., Alsalhin, A. K. H., Marais, E., & Lochner, A. (2019) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-019-06861-5 · Cited by 18 · see citing works

The importance of melatonin in the regulation of metabolism, eating behavior, sleep, and the prospects for the use of melatonin drugs for obesity treatment

Tsvetkova, E. S., Romantsova, T. I., Poluektov, M. G., Евгеньевна, Р. Г., Glinkina, I. V., & Fadeev, V. V. (2021) · Obesity and metabolism · doi:10.14341/omet12279 · Cited by 17 · see citing works

Nuclear receptor retinoid-related orphan receptor α deficiency exacerbates high-fat diet-induced cardiac dysfunction despite improving metabolic abnormality

Zhao, Y., Xu, L., Ding, S. Z., Ji, Q., Lin, N., He, Q., Gao, L., Su, Y., Pu, J., & He, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.10.029 · Cited by 17 · see citing works

Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir, emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats

Everson, F., Genis, A., Ogundipe, T. R., Boever, P. D., Goswami, N., Lochner, A., Blackhurst, D., & Strijdom, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208537 · Cited by 16 · see citing works

Melatonin as a protective agent in cardiac ischemia-reperfusion injury: Vision/Illusion?

Randhawa, P. K., & Gupta, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173506 · Cited by 15 · see citing works

Exploring effects of melatonin supplementation on insulin resistance: An updated systematic review of animal and human studies

Fayazi, F., Kheirouri, S., & Alizadeh, M. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.103073 · Cited by 15 · see citing works

Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats

Singhanat, K., Apaijai, N., Sumneang, N., Maneechote, C., Arunsak, B., Chunchai, T., Chattipakorn, S. C., & Chattipakorn, N. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04330-1 · Cited by 14 · see citing works

Protective effects of melatonin against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cardiac injury in rats

Sarihan, M. E., Parlakpınar, H., Çiftçi, O., Yılmaz, F., Sağır, M., Yilmaz, O., & Çeker, G. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.054 · Cited by 13 · see citing works

Effects of ramelteon on cardiac injury and adipose tissue pathology in rats with metabolic syndrome

Uchinaka, A., Kawashima, Y., Sano, Y., Ito, S., Sano, Y., Nagasawa, K., Matsuura, N., Yoneda, M., Yamada, Y., Murohara, T., et al. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13578 · Cited by 13 · see citing works

Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa)

Zhou, R., Yao, W., Xie, C., Zhang, L., Pei, Y., Li, H., Zheng, F., Yang, Y., & Li, K. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00495-6 · Cited by 12 · see citing works

Role of melatonin in glucose uptake by cardiomyocytes from insulin-resistant Wistar rats

Nduhirabandi, F., Huisamen, B., Strijdom, H., & Lochner, A. (2017) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2017-018 · Cited by 12 · see citing works

Role of Melatonin in the Onset of Metabolic Syndrome in Women

Peneva, V., Terzieva, D. D., & Mitkov, M. (2023) · Biomedicines · doi:10.3390/biomedicines11061580 · Cited by 8 · see citing works

Effect of melatonin different time administration on the development of diet-induced obesity in rats

Kalmykova, O., Pustovalov, A. S., Vareniuk, І., & Dzerzhynsky, M. (2017) · Bulletin of Taras Shevchenko National University of Kyiv Series Problems of Physiological Functions Regulation · doi:10.17721/2616_6410.2017.23.20-27 · Cited by 6 · see citing works

Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial

Mesri Alamdari, N., Namazi Shabestari, A., Najafipour, F., & Mirmazhari, A. (2024) · Biomedicine Advances · doi:10.34172/bma.05 · Cited by 4 · see citing works

MELATONIN AS POTENTIAL CARDIOPROTECTOR: EXPERIMENTAL - CLINICAL ANALISIS OF EFFECTITY

Zaychenko, А. V., Горчакова, Н. А., Klymenko, O., YAKOVLEVA, N., & Sinitsina, O. S. (2019) · Bulletin of Problems Biology and Medicine · doi:10.29254/2077-4214-2019-2-1-150-26-35 · Cited by 3 · see citing works

Integrated proteomics and metabolomics analysis of D-pinitol function during hippocampal damage in streptozocin-induced aging-accelerated mice

Li, X., Gao, Y. J., Li, B., Zhao, W., Cai, Q., Yin, W., Zeng, S., Li, X., Gao, H., & Cheng, M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1251513 · Cited by 2 · see citing works

Caracterização dos receptores tipo Toll em glândulas pineais de rato e sua implicação no entendimento do eixo imune-pineal

Machado, S. D. S. C. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2015.tde-30032015-093506

Controle da resposta inflamatória do tecido adiposo por melatonina: papel da citocina IL-4

Pardinho, A. S. (2023) · doi:10.11606/d.41.2023.tde-23012024-202059

Additional file 1 of Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa)

Zhou, R., Yao, W., Xie, C., Zhang, L., Pei, Y., Li, H., Feng, Z., Yang, Y., & Li, K. (2020) · Figshare · doi:10.6084/m9.figshare.12924131

Microscopic and computational analysis of the stomach, duodenum, and liver of rats with induced hyperprolactinemia treated with exogenous melatonin

da Silva, J. V., da Silva, R. C., Ferreira, R. G. D. S., da Silva, A. J., da Silva, I. B. S., dos Santos, A. M. R., do Nascimento, B. J., de Carvalho, E. V. M. M., Júnior, F. C. A. D. A., Silva, E. F. D. A., et al. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1709295

Abstract 18554: Short-term Melatonin Treatment Protects the Hearts of Obese Rats Independent of Changes in Body Weight and Visceral Fat Mass

Lochner, A., & Nduhirabandi, F. (2014) · Circulation · doi:10.1161/circ.130.suppl_2.18554

The effects of chronic melatonin treatment on myocardial function and ischaemia and reperfusion injury in a rat model of diet-induced obesity

Nduhirabandi, F. (2010) · SUNScholar (Stellenbosch University)

Chronic melatonin consumption prevents obesity‐related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet‐induced obesity

Nduhirabandi, F., Toit, E. F. D., Blackhurst, D., MARAIS, D. P., & Lochner, A. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00826.x · Cited by 144 · see citing works

The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states

Nduhirabandi, F. (2014) · SUNScholar (Stellenbosch University)

Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity

Kaskar, R. (2015) · SUNScholar (Stellenbosch University)