Cited by 343Ruminant Nutrition and Digestive PhysiologyAnimal Nutrition and PhysiologyGut microbiota and health

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Manipulating rumen microbiome and fermentation through interventions during early life: a review

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Yáñez-Ruiz, David R., Abecia, Leticia, Newbold, Charles J.·2015·Frontiers in Microbiology

DOI 10.3389/fmicb.2015.01133PMC PMC4604304

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Abstract

The nutritional manipulations of the rumen microbiome to enhance productivity and health are rather limited by the resilience of the ecosystem once established in the mature rumen. Based on recent studies, it has been suggested that the microbial colonization that occurs soon after birth opens a possibility of manipulation with potential to produce lasting effects into adult life. This paper presents the state-of-the-art in relation to early life nutritional interventions by addressing three areas: the development of the rumen as an organ in regards to the nutrition of the new-born, the main factors that determine the microbial population that first colonizes and establishes in the rumen, and the key immunity players that contribute to shaping the commensal microbiota in the early stage of life to understand host-microbiome specificity. The development of the rumen epithelium and muscularization are differently affected by the nature of the diet and special care should be taken with regards to transition from liquid (milk) to solid feed. The rumen is quickly colonized by all type of microorganisms straight after birth and the colonization pattern may be influenced by several factors such as presence/absence of adult animals, the first solid diet provided, and the inclusion of compounds that prevent/facilitate the establishment of some microorganisms or the direct inoculation of specific strains. The results presented show how early life events may be related to the microbial community structure and/or the rumen activity in the animals post-weaning. This would create differences in adaptive capacity due to different early life experiences and leads to the idea of microbial programming. However, many elements need to be further studied such as: the most sensitive window of time for interventions, the best means to test long term effectiveness, the role of key microbial groups and host-immune regulations.

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FIGURE 1 Illustration of different elements of the immune-regulation of the rumen microbiome. TLR, Toll-like receptor; PRR, pattern recognition receptors.CC BY · PubMed Central

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Authors: Yáñez-Ruiz, D. R., Abecia, L., & Newbold, C. J.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Aberystwyth University (GB)
ORCID: Abecia, Leticia
Newbold, Charles J.
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2015-10-14
Volume: 6
Pages: 1133-1133
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2015.01133
PMC: PMC4604304
OpenAlex: W1894193924
Cited by: 336
References: 112
Citations by year: 2026: 25 · 2025: 36 · 2024: 38 · 2023: 30 · 2022: 36 · 2021: 46 · 2020: 38 · 2019: 35 · 2018: 27 · 2017: 18 · 2016: 6 · 2015: 1
FWCI: 3.02
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Department for Environment, Food and Rural Affairs, UK Government
Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council (BBS/E/W/10964A01B, BB/J0013/1, grant number BB/J0013/1)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: rumen microbiome, rumen development, rumen epithelium, microbial colonization, host-microbiome interactions, immunity, weaning, direct inoculation, ruminant nutrition

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Manipulating rumen microbiome and fermentation through interventions during early life: a review

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