Effect of fecal microbiota transplantation combined with Mediterranean diet on insulin sensitivity in subjects with metabolic syndrome
Open accessAbstract
BACKGROUND: Recent studies demonstrate that a Mediterranean diet has beneficial metabolic effects in metabolic syndrome subjects. Since we have shown that fecal microbiota transplantation (FMT) from lean donors exerts beneficial effects on insulin sensitivity, in the present trial, we investigated the potential synergistic effects on insulin sensitivity of combining a Mediterranean diet with donor FMT in subjects with metabolic syndrome. DESIGN: = 12) FMT. Changes in the gut microbiota composition and bacterial strain engraftment after the 2-week dietary regimens and 6 weeks post-FMT were the primary endpoints. The secondary objectives were changes in glucose fluxes (both hepatic and peripheral insulin sensitivity), postprandial plasma incretin (GLP-1) levels, subcutaneous adipose tissue inflammation, and plasma metabolites. RESULTS: Consumption of the Mediterranean diet resulted in a reduction in body weight, HOMA-IR, and lipid levels. However, no large synergistic effects of combining the diet with lean donor FMT were seen on the gut microbiota diversity after 6 weeks. Although we did observe changes in specific bacterial species and plasma metabolites, no significant beneficial effects on glucose fluxes, postprandial incretins, or subcutaneous adipose tissue inflammation were detected. CONCLUSIONS: In this small pilot randomized controlled trial, no synergistic beneficial metabolic effects of combining a Mediterranean diet with lean donor FMT on glucose metabolism were achieved. However, we observed engraftment of specific bacterial species. Future trials are warranted to test the combination of other microbial interventions and diets in metabolic syndrome.
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In a randomized trial of FMT versus placebo plus Mediterranean diet in patients with MetS, there were no significant differences between the two groups.
“The synergistic effect of FMT and diet was explored in a randomized trial of FMT vs. placebo plus Mediterranean diet in patients with MetS, with no significant differences between the two groups, although this trial was not specifically designed to assess the value of this diet to FMT. 115”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [115]
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Wickham, H. (2016) · Use R! · doi:10.1007/978-3-319-24277-4 · Cited by 33,612 · see citing works
vegan: Community Ecology Package
Oksanen, J., Simpson, G. L., Blanchet, F. G., Kindt, R., Legendre, P., Minchin, P. R., O’Hara, R. B., Sólymos, P., Stevens, M. H. H., Szöcs, E., et al. (2001) · doi:10.32614/cran.package.vegan · Cited by 27,099 · see citing works
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,013 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
Gu, Z., Eils, R., & Schlesner, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw313 · Cited by 10,122 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01858.x · Cited by 6,597 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Zhou, B., Lu, Y., Hajifathalian, K., Bentham, J., Di Cesare, M., Danaei, G., Bixby, H., Cowan, M., Ali, M., Taddei, C., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00618-8 · Cited by 4,311 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1800389 · Cited by 3,616 · see citing works
Gut metagenome in European women with normal, impaired and diabetic glucose control
Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115 · see citing works
Personalized nutrition by prediction of glycemic responses
Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., Ben-Yacov, O., Lador, D., Avnit-Sagi, T., Lotan-Pompan, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.001 · Cited by 2,929 · see citing works
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works
Self-citationPopulation-level analysis of gut microbiome variation
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., et al. (2016) · Science · doi:10.1126/science.aad3503 · Cited by 2,400 · see citing works
Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357 · see citing works
MetaPhlAn2 for enhanced metagenomic taxonomic profiling
Truong, D. T., Franzosa, E. A., Tickle, T. L., Scholz, M., Weingart, G., Pasolli, E., Tett, A., Huttenhower, C., & Segata, N. (2015) · Nature Methods · doi:10.1038/nmeth.3589 · Cited by 2,185 · see citing works
Blundell, J. E., Baker, J. L., Boyland, E. J., Blaak, E. E., Charzewska, J., Henauw, S. D., Frühbeck, G., González‐Gross, M., Hebebrand, J., Holm, L., et al. (2017) · Obesity Facts · doi:10.1159/000455952 · Cited by 1,980 · see citing works
Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931 · see citing works
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
Species-level functional profiling of metagenomes and metatranscriptomes
Franzosa, E. A., McIver, L. J., Rahnavard, G., Thompson, L. R., Schirmer, M., Weingart, G., Lipson, K. S., Knight, R., Caporaso, J. G., Segata, N., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0176-y · Cited by 1,693 · see citing works
De Filippis, F., Pellegrini, N., Vannini, L., Jeffery, I. B., La Storia, A., Laghi, L., Serrazanetti, D. I., Di Cagno, R., Ferrocino, I., Lazzi, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309957 · Cited by 1,638 · see citing works
Self-citationExercise and associated dietary extremes impact on gut microbial diversity
Clarke, S. F., Murphy, E. F., O'Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A., Hayes, P., O'Reilly, M., Jeffery, I. B., Wood-Martin, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306541 · Cited by 1,439 · see citing works
Self-citationDiscrepancy between Self-Reported and Actual Caloric Intake and Exercise in Obese Subjects
Lichtman, S. W., Pisarska, K., Berman, E. R., Pestone, M., Dowling, H. J., Offenbacher, E. G., Weisel, H., Heshka, S., Matthews, D. E., & Heymsfield, S. B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272701 · Cited by 1,270 · see citing works
European consensus conference on faecal microbiota transplantation in clinical practice
Cammarota, G., Ianiro, G., Tilg, H., Rajilić-Stojanović, M., Kump, P., Satokari, R., Sokol, H., Arkkila, P., Pintus, C., Hart, A., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313017 · Cited by 1,207 · see citing works
Self-citationThe gut microbiota at the intersection of diet and human health
Gentile, C. L., & Weir, T. L. (2018) · Science · doi:10.1126/science.aau5812 · Cited by 1,049 · see citing works
Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.008 · Cited by 1,039 · see citing works
Self-citationGhosh, T. S., Rampelli, S., Jeffery, I. B., Santoro, A., Neto, M., Capri, M., Giampieri, E., Jennings, A., Candela, M., Turroni, S., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319654 · Cited by 991 · see citing works
Self-citationHuman Gut Microbiota Changes Reveal the Progression of Glucose Intolerance
Zhang, X., Shen, D., Fang, Z., Jie, Z., Qiu, X., Zhang, C., Chen, Y., & Ji, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071108 · Cited by 946 · see citing works
Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet
Salas-Salvadó, J., Bulló, M., Babio, N., Martínez-González, M. Á., Ibarrola-Jurado, N., Basora, J., Estruch, R., Covas, M. I., Corella, D., Arós, F., et al. (2011) · Diabetes Care · doi:10.2337/dc10-1288 · Cited by 901 · cited 1× · see citing works
“not that pronounced and other studies corroborate the beneficial metabolic health effects of the Mediterranean diet (including non-calorie-restricted diets) (Salas-Salvadó et al., 2011; Estruch et al., 2018), the decreased total energy intake per se may have influenced the metabolic outcomes.”
ResultMitochondrial Myopathy Caused by Long-Term Zidovudine Therapy
Dalakas, M. C., Illa, I., Pezeshkpour, G. H., Laukaitis, J. P., Cohen, B. H., & Griffin, J. L. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004193221602 · Cited by 837 · see citing works
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Koh, A., Molinaro, A., Ståhlman, M., Khan, M. T., Schmidt, C., Mannerås-Holm, L., Wu, H., Carreras, A., Jeong, H., Olofsson, L. E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.055 · Cited by 824 · see citing works
Self-citationDeschasaux, M., Bouter, K. E., Prodan, A., Levin, E., Groen, A. K., Herrema, H., Tremaroli, V., Bakker, G. J., Attaye, I., Pinto-Sietsma, S.-J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0160-1 · Cited by 695 · see citing works
Self-citationYoshida, N., Emoto, T., Yamashita, T., Watanabe, H., Hayashi, T., Tabata, T., Hoshi, N., Hatano, N., Ozawa, G., Sasaki, N., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.033714 · Cited by 619 · see citing works
Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
Mosca, A., Leclerc, M., & Hugot, J. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00455 · Cited by 612 · see citing works
Meslier, V., Laiola, M., Roager, H. M., De Filippis, F., Roume, H., Quinquis, B., Giacco, R., Mennella, I., Ferracane, R., Pons, N., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320438 · Cited by 583 · see citing works
Self-citationThe Gut Microbiome Profile in Obesity: A Systematic Review
Castaner, O., Goday, A., Park, Y.-M., Lee, S.-H., Magkos, F., Shiow, S.-A. T. E., & Schröder, H. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4095789 · Cited by 570 · see citing works
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Li, S. S., Zhu, A., Beneš, V., Costea, P. I., Hercog, R., Hildebrand, F., Huerta‐Cepas, J., Nieuwdorp, M., Salojärvi, J., Voigt, A. Y., et al. (2016) · Science · doi:10.1126/science.aad8852 · Cited by 544 · see citing works
Self-citationFreedman, L. S., Commins, J. M., Moler, J. E., Arab, L., Baer, D. J., Kipnis, V., Midthune, D., Moshfegh, A. J., Neuhouser, M. L., Prentice, R. L., et al. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu116 · Cited by 528 · see citing works
Wu, G. D., Compher, C., Chen, E. Z., Smith, S. A., Shah, R. D., Bittinger, K., Chehoud, C., Albenberg, L. G., Nessel, L., Gilroy, E., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308209 · Cited by 512 · see citing works
Limitations in the assessment of dietary energy intake by self-report
Schoeller, D. A. (1995) · Metabolism · doi:10.1016/0026-0495(95)90204-x · Cited by 496 · see citing works
Multivariate Analysis of Ecological Data with ade4
Thioulouse, J., Dray, S., Dufour, A., Siberchicot, A., Jombart, T., & Pavoine, S. (2018) · Springer eBooks · doi:10.1007/978-1-4939-8850-1 · Cited by 444 · see citing works
Gómez-Arango, L. F., Barrett, H. L., Wilkinson, S. A., Callaway, L. K., McIntyre, D. H., Morrison, M., & Nitert, M. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1406584 · Cited by 404 · see citing works
Reijnders, D., Goossens, G. H., Hermes, G. D. A., Neis, E. P. J. G., van der Beek, C. M., Most, J., Holst, J. J., Lenaerts, K., Kootte, R. S., Nieuwdorp, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.016 · Cited by 351 · see citing works
Self-citationYu, E. W.-Y., Gao, L., Stastka, P., Cheney, M. C., Mahabamunuge, J., Soto, M. T., Ford, C. B., Bryant, J. A., Henn, M. R., & Hohmann, E. L. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003051 · Cited by 336 · see citing works
Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients
Allegretti, J. R., Kassam, Z., Mullish, B. H., Chiang, A. L., Carrellas, M., Hurtado, J., Marchesi, J. R., McDonald, J. A. K., Pechlivanis, A., Barker, G. F., et al. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.07.006 · Cited by 324 · see citing works
de Groot, P. F., Scheithauer, T. P. M., Bakker, G. J., Prodan, A., Levin, E., Khan, M. T., Herrema, H., Ackermans, M. T., Serlie, M. J. M., de Brauw, M., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318320 · Cited by 309 · see citing works
Self-citationRoles of Sex Hormones and Gender in the Gut Microbiota
Yoon, K., & Kim, N. (2021) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20208 · Cited by 305 · see citing works
Haro, C., Montes-Borrego, M., Rangel-Zúñiga, O. A., Alcala-Diaz, J. F., Gómez-Delgado, F., Pérez‐Martínez, P., Delgado‐Lista, J., Quintana‐Navarro, G. M., Tinahones, F. J., Landa, B. B., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3351 · Cited by 302 · see citing works
Composition Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes
Shah, V. O., Lambeth, S. M., Carson, T., Lowe, J. R., Ramaraj, T., Leff, J. W., Luo, L., & Bell, C. J. (2015) · Journal of Diabetes and Obesity · doi:10.15436/2376-0949.15.031 · Cited by 286 · see citing works
Baere, S. D., Eeckhaut, V., Steppe, M., Maesschalck, C. D., Backer, J. F. A. D., Immerseel, F. V., & Croubels, S. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.02.032 · Cited by 212 · see citing works
Selma, M. V., Beltrán, D., Luna, M. C., Romo‐Vaquero, M., Garcı́a-Villalba, R., Mira, Á., Espı́n, J. C., & Tomás-Barberán, F. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01521 · Cited by 212 · see citing works
Moya-Pérez, A., Neef, A., & Sanz, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126976 · Cited by 211 · see citing works
Lahti, L., Salonen, A., Kekkonen, R. A., Salojärvi, J., Jalanka, J., Palva, A., Orešič, M., & de Vos, W. M. (2013) · PeerJ · doi:10.7717/peerj.32 · Cited by 196 · see citing works
Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain
Rinott, E., Youngster, I., Yaskolka Meir, A., Tsaban, G., Zelicha, H., Kaplan, A., Knights, D., Tuohy, K., Fava, F., Scholz, M. U., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.08.041 · Cited by 192 · see citing works
Effects of Fecal Microbiome Transfer in Adolescents With Obesity
Leong, K. S. W., Jayasinghe, T. N., Wilson, B. C., Derraik, J. G. B., Albert, B. B., Chiavaroli, V., Svirskis, D. M., Beck, K. L., Conlon, C. A., Jiang, Y., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.30415 · Cited by 173 · see citing works
Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans
Doumatey, A. P., Adeyemo, A., Zhou, J., Lei, L., Adebamowo, S. N., Adebamowo, C., & Rotimi, C. N. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00063 · Cited by 162 · see citing works
Jakulj, L., van Dijk, T. H., de Boer, J. F., Kootte, R. S., Schonewille, M., Paalvast, Y., Boer, T. S., Bloks, V. W., Boverhof, R., Nieuwdorp, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.001 · Cited by 144 · see citing works
Self-citationBédard, D., Shatenstein, B., & Nadon, S. (2004) · Public Health Nutrition · doi:10.1079/phn2003578 · Cited by 108 · see citing works
Dietary quality and the colonic mucosa–associated gut microbiome in humans
Liu, Y., Ajami, N. J., El‐Serag, H. B., Hair, C. D., Graham, D. Y., White, D. L., Chen, L., Wang, Z., Plew, S., Kramer, J. R., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz139 · Cited by 103 · see citing works
Sanchis-Chordà, J., del Pulgar, E. M. G., Carrasco‐Luna, J., Benítez‐Páez, A., Sanz, Y., & Codoñer‐Franch, P. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1828-5 · Cited by 100 · see citing works
Pitfalls in short‐chain fatty acid research: A methodological review
Sakata, T. (2018) · Animal Science Journal · doi:10.1111/asj.13118 · Cited by 76 · see citing works
Insulin resistance in obesity can be reliably identified from fasting plasma insulin
ter Horst, K. W., Gilijamse, P. W., Koopman, K. E., de Weijer, B. A., Brands, M., Kootte, R. S., Romijn, J. A., Ackermans, M. T., Nieuwdorp, M., Soeters, M. R., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.125 · Cited by 65 · see citing works
Self-citationDraper, C. F., Vassallo, I., Cara, A. D., Milone, C., Comminetti, O., Monnard, I., Godin, J., Scherer, M., Su, M., Jia, W. P., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700703 · Cited by 34 · see citing works
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- Wickham H. (2016). ggplot2: Elegant Graphics for Data Analysis. New York, NY: Springer-Verlag New York.
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Valles-Colomer, M., Blanco-Míguez, A., Manghi, P., Asnicar, F., Dubois, L., Golzato, D., Armanini, F., Cumbo, F., Huang, K. D., Manara, S., et al. (2023) · Nature · doi:10.1038/s41586-022-05620-1 · Cited by 449 · see citing works
Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Porcari, S., Benech, N., Valles-Colomer, M., Segata, N., Gasbarrini, A., Cammarota, G., Sokol, H., & Ianiro, G. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.020 · Cited by 331 · see citing works
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Schmidt, T. S. B., Li, S. S., Maistrenko, O. M., Akanni, W., Coelho, L. P., Dolai, S., Fullam, A., Glazek, A. M., Hercog, R., Herrema, H., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01913-0 · Cited by 233 · see citing works
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Giron, M., Thomas, M., Dardevet, D. P., Chassard, C., & Savary‐Auzeloux, I. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12964 · Cited by 195 · see citing works
Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics
Li, D. X., Li, Y., Yang, S., Lu, J., Jin, X., & Wu, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113290 · Cited by 186 · see citing works
Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective
Valles-Colomer, M., Menni, C., Berry, S. E., Valdes, A. M., Spector, T. D., & Segata, N. (2023) · Nature Medicine · doi:10.1038/s41591-023-02260-4 · Cited by 114 · see citing works
The Role of the Gut Microbiota on the Beneficial Effects of Ketogenic Diets
Attaye, I., van Oppenraaij, S. L., Warmbrunn, M. V., & Nieuwdorp, M. (2021) · Nutrients · doi:10.3390/nu14010191 · Cited by 85 · see citing works
Self-citationDigesting the complex metabolic effects of diet on the host and microbiome
Carmody, R. N., Varady, K. A., & Turnbaugh, P. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.032 · Cited by 71 · see citing works
Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation
Li, F., Armet, A. M., Korpela, K., Liu, J., Quevedo, R. M., Asnicar, F., Seethaler, B., Rusnak, T., Cole, J. L., Zhang, Z., et al. (2025) · Cell · doi:10.1016/j.cell.2024.12.034 · Cited by 73 · see citing works
Faecal Microbiota Transplantation and Chronic Kidney Disease
Bian, J., Liebert, A. D., Bicknell, B. T., Chen, X., Huang, C., & Pollock, C. A. (2022) · Nutrients · doi:10.3390/nu14122528 · Cited by 58 · see citing works
Gut microbes-muscle axis in muscle function and meat quality
He, Y., Hu, H., Liang, X., Liang, J., Li, F., & Zhou, X. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2885-4 · Cited by 57 · see citing works
Naseri, K., Saadati, S., Yari, Z., Asbaghi, O., Hezaveh, Z. S., Mafi, D., Hoseinian, P., Ashtary‐Larky, D., Hekmatdoost, A., & de Courten, B. V. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106288 · Cited by 51 · see citing works
An update on fecal microbiota transplantation for the treatment of gastrointestinal diseases
Waller, K. M. J., Leong, R. W. L., & Paramsothy, S. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15731 · Cited by 49 · see citing works
Chen, Q., Wu, C., Xu, J., Ye, C., Chen, X., Tian, H., Zong, N., Zhang, S., Li, L., Gao, Y., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.01.013 · Cited by 48 · see citing works
Mullish, B. H., Merrick, B., Quraishi, M. N., Bak, A., Green, C., Moore, D., Porter, R. J., Elumogo, N., Segal, J. P., Sharma, N., et al. (2024) · Journal of Hospital Infection · doi:10.1016/j.jhin.2024.03.001 · Cited by 41 · see citing works
Mullish, B. H., Merrick, B., Quraishi, M. N., Bak, A., Green, C., Moore, D., Porter, R. J., Elumogo, N., Segal, J. P., Sharma, N., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-331550 · Cited by 35 · see citing works
Type 2 Diabetes and the Multifaceted Gut-X Axes
Guo, H., Pan, L.-T., Wu, Q., Wang, L., Huang, Z., Wang, J., Wang, L., Fang, X., Dong, S., Zhu, Y., et al. (2025) · Nutrients · doi:10.3390/nu17162708 · Cited by 36 · see citing works
Wilson, B. C., Zuppi, M., Derraik, J., Albert, B. B., Tweedie-Cullen, R. Y., Leong, K. S. W., Beck, K. L., Vatanen, T., O'Sullivan, J., & Cutfield, W. (2025) · Nature Communications · doi:10.1038/s41467-025-62752-4 · Cited by 33 · see citing works
Ghorbani, Y., Schwenger, K. J. P., Sharma, D., Jung, H. J., Yadav, J., Xu, W., Lou, W. Y. W., Poutanen, S. M., Hota, S. S., Comelli, E. M., et al. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14891 · Cited by 33 · see citing works
Allegretti, J. R., Khanna, S., Mullish, B. H., & Feuerstadt, P. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.05.004 · Cited by 34 · see citing works
Questioning the foundations of the gut microbiota and obesity
Dalby, M. J. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0221 · Cited by 31 · see citing works
Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome
Ghani, R., Chrysostomou, D., Roberts, L. A., Pandiaraja, M., Marchesi, J. R., & Mullish, B. H. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2423026 · Cited by 31 · see citing works
Augustynowicz, G., Lasocka, M., Szyller, H. P., Dziedziak, M., Mytych, A., Braksator, J., & Pytrus, T. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14144933 · Cited by 30 · see citing works
Therapeutic Modulation of Gut Microbiome in Cardiovascular Disease: A Literature Review
Suresh, M. G., Mohamed, S., Yukselen, Z., Hatwal, J., Venkatakrishnan, A., Metri, A. A., Bhardwaj, A., Singh, A., Bush, N., & Batta, A. (2024) · Heart and Mind · doi:10.4103/hm.hm-d-24-00044 · Cited by 26 · see citing works
Eslami, M., Adampour, Z., Dowlat, B. F., Yaghmayee, S., Tabaei, F. M., Oksenych, V., & Naderian, R. (2025) · Biomedicines · doi:10.3390/biomedicines13040915 · Cited by 26 · see citing works
Olalekan, S. O., Bakare, O. O., Osonuga, I. O., Faponle, A. S., Adegbesan, B. O., & Ezima, E. N. (2024) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-024-00342-4 · Cited by 23 · see citing works
Pakmehr, A., Mousavi, S. M., Ejtahed, H., Tavassol, Z. H., Siadat, S. D., Hasani‐Ranjbar, S., & Larijani, B. A. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2023.11.015 · Cited by 21 · see citing works
Trust the gut: Outcomes of gut microbiota transplant in metabolic and cognitive disorders
Guzzardi, M. A., Rosa, F. L., & Iozzo, P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105143 · Cited by 18 · see citing works
Zhong, Y., Cao, J., Ma, Y., Zhang, Y., Liu, J., & Wang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.842669 · Cited by 17 · see citing works
Low-Molecular-Weight Compounds Produced by the Intestinal Microbiota and Cardiovascular Disease
Cuervo, L., McAlpine, P. L., Olano, C., Fernández, J., & Lombó, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910397 · Cited by 17 · see citing works
Ten reasons gastroenterologists and hepatologists should be treating obesity
Camilleri, M., & El-Omar, E. M. (2023) · Gut · doi:10.1136/gutjnl-2023-329639 · Cited by 16 · see citing works
Healthy and Unhealthy Aging and the Human Microbiome
Simbirtseva, K., & O’Toole, P. W. (2024) · Annual Review of Medicine · doi:10.1146/annurev-med-042423-042542 · Cited by 15 · see citing works
Self-citationZhou, H., Huang, Y., Chen, C., Song, M., & Hylemon, P. B. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100120 · Cited by 15 · see citing works
Evidence for proton-pump inhibitor (PPI)-associated dysbiosis in metabolically unhealthy obesity
Burmeister, M. A., Smith, T. E., Fincher, T. K., & Weldon, A. J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1205490 · Cited by 14 · see citing works
Kaul, R., Paul, P., Harfouche, M., Ayyan, M., Laws, S., & Châari, A. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.103118 · Cited by 13 · see citing works
Mohajeri, M., Mohajery, R., & Cicero, A. F. G. (2023) · Medicina · doi:10.3390/medicina59020227 · Cited by 13 · see citing works
Nutritional optimization of fecal microbiota transplantation in humans: a scoping review
Teigen, L. M., Hoeg, A., Zehra, H., Shah, P., Johnson, R., Hutchison, K., Kocher, M., Lin, A., Johnson, A. J., & Vaughn, B. P. (2025) · Gut Microbes · doi:10.1080/19490976.2024.2446378 · Cited by 11 · see citing works
Fenneman, A. C., Rampanelli, E., van der Spek, A. H., Fliers, E., & Nieuwdorp, M. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-073971 · Cited by 11 · see citing works
Self-citationGut Microbiota Disorders and Metabolic Syndrome: Tales of a Crosstalk Process
Nie, P., Hu, L., Feng, X., & Xu, H. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae157 · Cited by 8 · see citing works
Wang, H., Tian, J., & Mi, J. (2025) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2025.100415 · Cited by 7 · see citing works
Shalbaf, N., Sadeghi, S., Homaee, S., & Saberian, F. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100419 · Cited by 7 · see citing works
McLeod, A., Bernabé, B. P., Xia, Y., Sanchez-Flack, J., Lamar, M., Schiffer, L. A., Hemphill, N. O., Fantuzzi, G., Maki, P. M., Fitzgibbon, M., et al. (2023) · Nutrients · doi:10.3390/nu15153332 · Cited by 7 · see citing works
Host—microbial interactions in metabolic diseases: from diet to immunity
Lee, J.-H., & Park, J. (2022) · The Journal of Microbiology · doi:10.1007/s12275-022-2087-y · Cited by 7 · see citing works
Elbehiry, A., Marzouk, E., Alhumaydhi, F. A., & Abalkhail, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15051788 · Cited by 7 · see citing works
van der Vossen, E. W. J., Davids, M., Voermans, B., Wortelboer, K., Hartstra, A. V., Koopen, A. M., de Groot, P. F., Levin, E., & Nieuwdorp, M. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2388295 · Cited by 5 · see citing works
Self-citationPapadakis, Z. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00353.2025 · Cited by 5 · see citing works
Yu, G., Zhang, Q., Zhao, L., van Ree, R., & Fu, L. (2025) · Allergy medicine. · doi:10.1016/j.allmed.2025.100076 · Cited by 4 · see citing works
Su, Q., Chen, S., Lau, L. H., Lui, R. N.-S., Wang, Y., Xu, Z., Cheung, C. P., Ching, J. Y. L., Shen, X., Peng, Y., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117301 · Cited by 4 · see citing works
Acierno, C., Caturano, A., Barletta, F., Rinaldi, L., Sasso, F. C., Adinolfi, L. E., & Nevola, R. (2026) · Nutrients · doi:10.3390/nu18111765 · Cited by 4 · see citing works
Rivera-Carranza, T., Nájera-Medina, O., & Azaola‐Espinosa, A. (2022) · Revista chilena de nutrición · doi:10.4067/s0717-75182022000200238 · Cited by 3 · see citing works
Aslam, M., Habib‐ur‐Rehman, Tufail, T., Almehmadi, Y., Abualamah, W. A., Alzahrani, A. R., & Shahid, I. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1623478 · Cited by 1 · see citing works
Role of microbiota in the outcome of immune checkpoint inhibition therapy of cancer
Rijkers, G. T., Langcauon, Y., van Leersum, P., Popović, L., & van Overveld, F. J. (2025) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2025.1002348 · Cited by 1 · see citing works
Huang, Y., Huang, Y., Xu, B., Lin, C., Chen, X., Li, Y., Wang, Y., & Liu, X. (2025) · Nutrition Journal · doi:10.1186/s12937-025-01249-8 · Cited by 1 · see citing works
Wang, L., Liu, Z. H., Fan, F., Zhang, L., & Li, J. (2026) · BMC Gastroenterology · doi:10.1186/s12876-026-05037-4 · Cited by 1 · see citing works
Pharmacomicrobiomics in metabolic syndrome and type 2 diabetes: the microbiome–drug–host triad
Strilić, D., Stanimirov, B., Pavlović, N., Lazarević, S., Mikov, M., Stanivukovic, T., & Đanić, M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1831882 · Cited by 1 · see citing works
Scheithauer, T. P. M. (2023) · doi:10.5463/thesis.82
Self-citationAdipositas und metabolisches Syndrom
Tilg, H. (2024) · Springer eBooks · doi:10.1007/978-3-662-68455-9_13
Novel Therapies: Pharmacological Approaches to Modulate the Gut Microbiome in Metabolic Syndrome
Gunjan, & Vidić, J. (2025) · Springer eBooks · doi:10.1007/978-981-96-6246-3_5
Strain-level ecological filtering governs microbial colonization of the human gut
Baertschi, I., Jordi, S. B. U., Gardaz, L. J., Bigi, F. V., Sokollik, C., Juillerat, P., & Yılmaz, B. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117775
Paul, P., Dajani, I. A., Kaul, R., & Châari, A. (2026) · Obesity Reviews · doi:10.1111/obr.70215
Lim, E., Cheng, N. C. L., & Lim, C. E. D. (2026) · Nutrition & Food Science · doi:10.1108/nfs-05-2026-0239
Savytska, M., Halich, V.-S., Kuzmenko, L., Halabitska, I., Kamyshna, I. I., Petakh, P., Kamyshnyi, O., & Kobyliak, N. M. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1983162
- Authors
- Koopen, A. M., Almeida, E. L., Attaye, I., Witjes, J. J., Rampanelli, E., Majait, S., Kemper, M., Levels, J. H. M., Schimmel, A. W. M., Herrema, H., Scheithauer, T. P. M., Frei, W., Dragsted, L., Hartmann, B., Holst, J. J., O’Toole, P. W., Groen, A. K., & Nieuwdorp, M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- University College Cork (IE)
- University of Copenhagen (DK)
- Corresponding author
- Nieuwdorp, Max
- ORCID
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2021-06-10
- Volume
- 12
- Pages
- 662159-662159
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC8222733
- OpenAlex
- W3168743303
- Cited by
- 64
- References
- 70
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 15 · 2023: 13 · 2022: 9 · 2021: 2
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Pure Amsterdam UMC (acceptedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion, cc-by)
- Funders
- Joint Programming Initiative A healthy diet for a healthy life
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- fecal microbiota transplantation, Mediterranean diet, metabolic syndrome, insulin sensitivity, gut microbiota, glucose metabolism, glucagon-like peptide-1, HOMA-IR, plasma metabolites, dietary intervention
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