Frontoparietal connectivity and hierarchical structure of the brain's functional network during sleep
Open accessAbstract
Frontal and parietal regions are associated with some of the most complex cognitive functions, and several frontoparietal resting-state networks can be observed in wakefulness. We used functional magnetic resonance imaging data acquired in polysomnographically validated wakefulness, light sleep, and slow-wave sleep to examine the hierarchical structure of a low-frequency functional brain network, and to examine whether frontoparietal connectivity would disintegrate in sleep. Whole-brain analyses with hierarchical cluster analysis on predefined atlases were performed, as well as regression of inferior parietal lobules (IPL) seeds against all voxels in the brain, and an evaluation of the integrity of voxel time-courses in subcortical regions-of-interest. We observed that frontoparietal functional connectivity disintegrated in sleep stage 1 and was absent in deeper sleep stages. Slow-wave sleep was characterized by strong hierarchical clustering of local submodules. Frontoparietal connectivity between IPL and superior medial and right frontal gyrus was lower in sleep stages than in wakefulness. Moreover, thalamus voxels showed maintained integrity in sleep stage 1, making intrathalamic desynchronization an unlikely source of reduced thalamocortical connectivity in this sleep stage. Our data suggest a transition from a globally integrated functional brain network in wakefulness to a disintegrated network consisting of local submodules in slow-wave sleep, in which frontoparietal inter-modular nodes may play a role, possibly in combination with the thalamus.
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Disruption of REM sleep impairs extinction.
“It should be considered that the percentage of REM sleep obtained following fear extinction was demonstrated to predict a decrease in autonomic arousal based on skin conductance (Spoormaker et al., 2010) and the disruption of REM sleep impaired extinction (Spoormaker et al., 2012).”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Spoormaker et al., 2012
The Introduction and Discussion passages address functional connectivity during sleep, particularly light and slow-wave sleep, not fear extinction. Searches for REM-sleep disruption, fear extinction, and skin conductance found no passage in our copy addressing whether disrupting REM sleep impairs extinction. No page numbers were provided for these passages. (LLM, conf=0.78)
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“Moreover, Spoormaker and colleagues [166] reported that the suppression of REM sleep would impair fear extinction and that the percentage of REM sleep obtained in consequence of fear extinction can predict decreased arousal as measured by skin conductance [167].”
- Authors
- Spoormaker, V. I., Gleiser, P. M., & Czisch, M.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Spoormaker, Victor I.
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 3
- Pages
- 80-80
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC3354331
- OpenAlex
- W1965123677
- Cited by
- 83
- References
- 57
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 10 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 1
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Frontiers in Neurology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- slow-wave sleep, sleep stages, resting-state networks, inferior parietal lobule, thalamus, thalamocortical connections, network disintegration, wakefulness
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