Cited by 165Medicinal Plants and NeuroprotectionFlavonoids in Medical ResearchNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.

Neuropharmacological Effects of Quercetin: A Literature-Based Review

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Abstract

animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer's disease, Amyloid β peptide, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

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Registry

Crossref · 10.3389/fphar.2021.665031

Cites

207 of 207 references verified0 citation errors · 0 not checkable

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Figures

FIGURE 1 Chemical structure of 2-(3,4-dihydroxy phenyl)-3,5,7-trihydroxychromen-4-one (Quercetin).
FIGURE 1 Chemical structure of 2-(3,4-dihydroxy phenyl)-3,5,7-trihydroxychromen-4-one (Quercetin).CC BY · PubMed Central
FIGURE 2 Diagram with possible neuroprotective mechanisms of QUR. The figure highlights the neuronal neuroprotective action in various signaling pathways that lead to the release of proinflammatory cytokines, neurodegeneration and cellular apoptosis. Abbreviations: ↑, increase; ↓, decrease; Aβ, amyloid beta-peptide; GCS, γ-glutamyl-cysteine synthetase; GSH, glutathione; IL, interleukin; JNK, c-Jun N-terminal kinase; NO, nitric oxide; Nrf2-ARE, Nuclear factor erythroid-derived 2-like 2- antioxidant responsive element; PNO2, paraoxygenase 2; ROS, reactive oxygen species; SIRT1, sirtuin 1; TNF-α, tumor necrosis factor-alfa.
FIGURE 2 Diagram with possible neuroprotective mechanisms of QUR. The figure highlights the neuronal neuroprotective action in various signaling pathways that lead to the release of proinflammatory cytokines, neurodegeneration and cellular apoptosis. Abbreviations: ↑, increase; ↓, decrease; Aβ, amyloid beta-peptide; GCS, γ-glutamyl-cysteine synthetase; GSH, glutathione; IL, interleukin; JNK, c-Jun N-terminal kinase; NO, nitric oxide; Nrf2-ARE, Nuclear factor erythroid-derived 2-like 2- antioxidant responsive element; PNO2, paraoxygenase 2; ROS, reactive oxygen species; SIRT1, sirtuin 1; TNF-α, tumor necrosis factor-alfa.CC BY · PubMed Central
FIGURE 3 Summarized scheme with relevant neuroprotective effects of Quercetin. Abbreviations: ↑, increase; ↓, decrease; Aβ, amyloid beta-peptide; BACE1, beta-secretase 1; GCS, γ-glutamyl-cysteine synthetase; GSH, glutathione; IL, interleukin; NO, nitric oxide; Nrf2-ARE, Nuclear factor erythroid-derived 2-like 2- antioxidant responsive element; ROS, reactive oxygen species; SIRT1, sirtuin 1; TNF-α, tumor necrosis factor-alfa.
FIGURE 3 Summarized scheme with relevant neuroprotective effects of Quercetin. Abbreviations: ↑, increase; ↓, decrease; Aβ, amyloid beta-peptide; BACE1, beta-secretase 1; GCS, γ-glutamyl-cysteine synthetase; GSH, glutathione; IL, interleukin; NO, nitric oxide; Nrf2-ARE, Nuclear factor erythroid-derived 2-like 2- antioxidant responsive element; ROS, reactive oxygen species; SIRT1, sirtuin 1; TNF-α, tumor necrosis factor-alfa.CC BY · PubMed Central

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Cites

Show all 207 references

Research works printed but not linked: 4

  1. Assi, 1998, Evaluation of the Anti-inflammatory Profile of Quercetin Enhancing its Effects by Beta-Cyclodextrin, J. Drug Res. Egypt., 22, 293
  2. 2010, Agency Response Letter GRAS Notice No. GRN 000341
  3. Nussbaum, 2017, Modern Treatment Approaches in Psychoses. Pharmacogenetic, Neuroimagistic and Clinical Implications, Farmacia, 65, 75
  4. Pany, 2014, Neuroprotective Effect of Quercetin in Neurotoxicity Induced Rats: Role of Neuroinflammation in Neurodegeneration, Asian J. Pharm. Clin. Res., 7, 152

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Metadata

Authors
Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., Abdullayeva, B., Docea, A. O., Calina, D., & Sharifi-Rad, J.
Affiliations
  • Gopalganj Science and Technology University (BD)
  • Arturo Prat University (CL)
  • University of Nizwa (OM)
  • University of Concepción (CL)
  • Al-Farabi Kazakh National University (KZ)
  • University of Medicine and Pharmacy of Craiova (RO)
Corresponding author
Islam, Muhammad Torequl
Venue
Frontiers in Pharmacology
Published
2021-06-17
Volume
12
Pages
665031-665031
ISSN
1663-9812 (ISSN-L)
OpenAlex
W3175593057
Cited by
165
References
207
Citations by year
2026: 25 · 2025: 25 · 2024: 30 · 2023: 42 · 2022: 36 · 2021: 7
FWCI
6.60
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords
quercetin, neuroprotection, neurodegenerative diseases, neurotoxicity, Alzheimer's disease, amyloid-beta, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, complementary and alternative medicine, flavonoids

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