Neuropharmacological Effects of Quercetin: A Literature-Based Review

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

Colovic, M. B., Krstic, D. Z., Lazarevic-Pasti, T. D., Bondzic, A. M., & Vasic, V. M. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311030006 · Cited by 2,611

Excitotoxic cell death

Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,329

The role of autophagy in neurodegenerative disease

Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059

Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases

Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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The microglial sensome revealed by direct RNA sequencing

Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

Dong, X.-X., Wang, Y., & Qin, Z.-H. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.24 · Cited by 1,297

Role of Pro-Inflammatory Cytokines Released from Microglia in Neurodegenerative Diseases

Smith, J. A., Das, A., Ray, S. K., & Banik, N. L. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.004 · Cited by 1,165

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application

Naseri, N., Valizadeh, H., & Zakeri‐Milani, P. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.043 · Cited by 1,115

K -Profiles: A Nonlinear Clustering Method for Pattern Detection in High Dimensional Data

Wang, K., Zhao, Q., Lu, J., & Yu, T. (2015) · BioMed Research International · doi:10.1155/2015/918954 · Cited by 991

Mechanism of Oxidative Stress in Neurodegeneration

Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

Dabeek, W. M., & Marra, M. V. (2019) · Nutrients · doi:10.3390/nu11102288 · Cited by 876

Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier

Gilgun‐Sherki, Y., Melamed, E., & Offen, D. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00019-3 · Cited by 850

Flavonoids Protect Neuronal Cells from Oxidative Stress by Three Distinct Mechanisms

Ishige, K., Schubert, D., & Sagara, Y. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00498-6 · Cited by 841

Calcium, ischemia and excitotoxicity

Szydłowska, K., & Tymianski, M. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.01.003 · Cited by 793

Neuroinflammation: The role and consequences

Lyman, M., Lloyd, D. G., Ji, X., Vizcaychipi, M. P., & Ma, D. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.10.004 · Cited by 776

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Batiha, G. E., Beshbishy, A. M., Ikram, M., Mulla, Z. S., El-Hack, M. E. A., Taha, A. E.-S., Algammal, A. M., & Elewa, Y. H. A. (2020) · Foods · doi:10.3390/foods9030374 · Cited by 750

A review on cholinesterase inhibitors for Alzheimer’s disease

Anand, P., & Singh, B. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0036-3 · Cited by 722

Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine

Yang, D., Wang, T., Long, M., & Li, P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8825387 · Cited by 698

Expression of Concern: Potent anti‐amyloidogenic and fibril‐destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

Ono, K., Yoshiike, Y., Takashima, A., Hasegawa, K., Naiki, H., & Yamada, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01976.x · Cited by 681

Flavonoid permeability across an in situ model of the blood–brain barrier

Youdim, K. A., Qaiser, M. Z., Begley, D. J., Rice-Evans, C. A., & Abbott, N. J. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.023 · Cited by 605

Nanoencapsulation of Promising Bioactive Compounds to Improve Their Absorption, Stability, Functionality and the Appearance of the Final Food Products

Pateiro, M., Gómez, B., Munekata, P. E. S., Barba, F. J., Putnik, P., Kovačević, D. B., & Lorenzo, J. M. (2021) · Molecules · doi:10.3390/molecules26061547 · Cited by 603

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Khan, H. Z., Ullah, H., Aschner, M., Cheang, W. S., & Akkol, E. K. (2019) · Biomolecules · doi:10.3390/biom10010059 · Cited by 563

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

Wang, S. F., Su, R., Nie, S., Sun, M., Zhang, J., Wu, D., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.10.002 · Cited by 545

Butyrylcholinesterase: An Important New Target in Alzheimer’s Disease Therapy

Greig, N. H., Lahiri, D. K., & Sambamurti, K. (2002) · International Psychogeriatrics · doi:10.1017/s1041610203008676 · Cited by 478

Mitochondrial Dysfunction and Reactive Oxygen Species in Excitotoxicity and Apoptosis: Implications for the Pathogenesis of Neurodegenerative Diseases

Rego, A. C., & Oliveira, C. R. (2003) · Neurochemical Research · doi:10.1023/a:1025682611389 · Cited by 476

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein

Selkoe, D. J. (2001) · Journal of Alzheimer's Disease · doi:10.3233/jad-2001-3111 · Cited by 466

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

Sabogal-Guáqueta, A. M., Muñoz‐Manco, J. I., Ramírez‐Pineda, J. R., Lamprea, M. R., Osorio, E., & Cardona‐Gómez, G. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.027 · Cited by 453

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

Tai, H.-C., Serrano-Pozo, A., Hashimoto, T., Frosch, M. P., Spires-Jones, T. L., & Hyman, B. T. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.06.033 · Cited by 443

Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke

Lee, S.-T., Chu, K., Jung, K.-H., Kim, S.-J., Kim, D.-H., Kang, K.-M., Hong, N. H., Kim, J.-H., Ban, J.-J., Park, H.-K., et al. (2008) · Brain · doi:10.1093/brain/awm306 · Cited by 424

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

Ansari, M. A., Abdul, H. M., Gururaj Joshi, A., Opii, W. O., & Butterfield, D. A. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.03.002 · Cited by 421

Microtubule-associated protein tau in development, degeneration and protection of neurons

Wang, J., & Liu, F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.03.002 · Cited by 405

Antioxidant Therapies for Alzheimer's Disease

Feng, Y., & Wang, X. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/472932 · Cited by 393

Molecular pharmacology of glutamate transporters, EAATs and VGLUTs

Shigeri, Y., Seal, R. P., & Shimamoto, K. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.004 · Cited by 391

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Salehi, B., Quispe, C., Chamkhi, I., Omari, N. E., Balahbib, A., Sharifi‐Rad, J., Bouyahya, A., Akram, M., Iqbal, M., Docea, A. O., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.592654 · Cited by 377

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

Murray, A. P., Faraoni, M. B., Castro, M., Alza, N. P., & Cavallaro, V. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040004 · Cited by 352

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease

Parsons, C. G., Danysz, W., Dekundy, A., & Pulte, I. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9398-z · Cited by 346

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

Bureau, G., Longpré, F., & Martinoli, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21503 · Cited by 344

The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

Niranjan, R. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8483-x · Cited by 338

Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability

Kawabata, K., Mukai, R., & Ishisaka, A. (2015) · Food & Function · doi:10.1039/c4fo01178c · Cited by 336

Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten

Dok-Go, H., Lee, K. H., Kim, H. J., Lee, E. H., Lee, J., Song, Y. S., Lee, Y.-H., Jin, C., Lee, Y. S., & Cho, J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04150-1 · Cited by 314

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

Zaplatić, E., Bule, M. H., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.055 · Cited by 306

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Sharifi‐Rad, J., Rodrigues, C. F., Sharopov, F. S., Docea, A. O., Karaça, A. C., Sharifi‐Rad, M., Kahveci, D., Gülseren, G., Şenol, E., Demircan, E., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072326 · Cited by 303

Effects of Naturally Occurring Compounds on Fibril Formation and Oxidative Stress of β-Amyloid

Kim, H., Park, B., Lee, K., Choi, C. Y., Jang, S. S., Kim, Y., & Lee, S. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051985c · Cited by 297

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

Hooten, K. G., Beers, D. R., Zhao, W., & Appel, S. H. (2015) · Neurotherapeutics · doi:10.1007/s13311-014-0329-3 · Cited by 294

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Salehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Ž., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01300 · Cited by 293

Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin

Riva, A., Ronchi, M., Petrangolini, G., Bosisio, S., & Allegrini, P. (2018) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-018-0517-3 · Cited by 291

Antioxidant Properties of Quercetin

Zhang, M., Swarts, S. G., Yin, L., Liu, C., Tian, Y., Cao, Y., Swarts, M., Yang, S., Zhang, S. B., Zhang, K., et al. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7756-4_38 · Cited by 278

Bioavailability and metabolism of the flavonol quercetin in the pig

Ader, P. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00195-7 · Cited by 274

Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IκB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia

Chen, J.-C., Ho, F., Chao, P.-D. L., Chen, C., Jeng, K.-C. G., Hsu, H.-B., Lee, S. T., Wu, W. T., & Lin, W. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.08.005 · Cited by 271

Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa

Jung, M., & Park, M. (2007) · Molecules · doi:10.3390/12092130 · Cited by 270

Endogenous and exogenous mediators of quercetin bioavailability

Guo, Y., & Bruno, R. S. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.10.008 · Cited by 263

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Sharifi‐Rad, M., Lankatillake, C., Dias, D. A., Docea, A. O., Mahomoodally, M. F., Lobine, D., Chazot, P. L., Kurt, B., Tumer, T. B., Moreira, A. C., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041061 · Cited by 261

Multisite protein phosphorylation – from molecular mechanisms to kinetic models

Salazar, C., & Höfer, T. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07027.x · Cited by 257

Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish

Richetti, S. K., Blank, M., Capiotti, K. M., Piato, Â., Bogo, M. R., Vianna, M. R. M. R., & Bonan, C. D. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.09.027 · Cited by 247

Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

Suganthy, N., Devi, K. P., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.011 · Cited by 244

Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761

Smith, J. V., & Luo, Y. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2003-5404 · Cited by 243

Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of ??-Synuclein

Waxman, E. A., & Giasson, B. I. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3186fc995 · Cited by 241

Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells

Jiménez‐Aliaga, K., Bermejo‐Bescós, P., Benedı́, J., & Martín‐Aragón, S. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.09.023 · Cited by 239

Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., & Sugimoto, H. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.017 · Cited by 234

Modulation of neurotrophic signaling pathways by polyphenols

Firuzi, O., Moosavi, F., Hosseini, R., & Saso, L. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s96936 · Cited by 230

Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats

Karuppagounder, S. S., Madathil, S. K., Pandey, M., Haobam, R., Rajamma, U., & Mohanakumar, K. P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.032 · Cited by 225

Immobilized Concentration Gradients of Neurotrophic Factors Guide Neurite Outgrowth of Primary Neurons in Macroporous Scaffolds

Moore, K., Macsween, M., & Shoichet, M. S. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.267 · Cited by 221

Anti-ageing and rejuvenating effects of quercetin

Chondrogianni, N., Kapeta, S., Chinou, İ., Vassilatou, K., Papassideri, I. S., & Gonos, E. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.001 · Cited by 220

After Cellular Internalization, Quercetin Causes Nrf2 Nuclear Translocation, Increases Glutathione Levels, and Prevents Neuronal Death against an Oxidative Insult

Arredondo, F., Echeverry, C., Abin-Carriquiry, J. A., Blasina, F., Antúnez, K., Jones, D. P., Go, Y.-M., Liang, Y.-L., & Dajas, F. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.05.020 · Cited by 220

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

Alam, Q., Alam, M. Z., Mushtaq, G., Damanhouri, G. A., Rasool, M., Kamal, M. A., & Haque, A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151125000300 · Cited by 220

Hepatoprotective effect of quercetin: From chemistry to medicine

Miltonprabu, S., Tomczyk, M., Skalicka‐Woźniak, K., Rastrelli, L., Daglia, M., Nabavi, S. F., Alavian, S. M., & Nabavi, S. M. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.08.034 · Cited by 217

A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk

Blair, D. R., Lyttle, C. S., Mortensen, J. M., Bearden, C. F., Jensen, A. B., Khiabanian, H., Melamed, R., Rabadan, R., Bernstam, E. V., Brunak, S., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.030 · Cited by 215

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

Esposito, Z., Belli, L., Toniolo, S., Sancesario, G., Bianconi, C., & Martorana, A. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12095 · Cited by 215

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

Hsiao, H.-M., Sapinoro, R., Thatcher, T. H., Croasdell, A., Levy, E. P., Fulton, R. A., Olsen, K. C., Pollock, S. J., Serhan, C. N., Phipps, R. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058258 · Cited by 212

Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies

Rocha, N. P., de Miranda, A. S., & Teixeira, A. L. (2015) · BioMed Research International · doi:10.1155/2015/628192 · Cited by 207

Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy

Bienert, M., Plange, N., Remky, A., Arend, O., & Kuerten, D. (2018) · BioMed Research International · doi:10.1155/2018/4756313 · Cited by 207

Identification of brain‐targeted bioactive dietary quercetin‐3‐ O ‐glucuronide as a novel intervention for Alzheimer's disease

Ho, L., Ferruzzi, M. G., Janle, E. M., Wang, J., Gong, B., Chen, T., Lobo, J., Cooper, B. R., Wu, Q. L., Talcott, S. T., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-212118 · Cited by 206

Modulation of interleukin-1β mediated inflammatory response in human astrocytes by flavonoids: Implications in neuroprotection

Sharma, V., Mishra, M., Ghosh, S., Tewari, R., Basu, A., Seth, P., & Sen, E. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.01.016 · Cited by 202

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Salehi, B., Călina, D. C., Docea, A. O., Koirala, N., Aryal, S., Lombardo, D., Pasqua, L., Taheri, Y., Castillo, C. M. S., Martorell, M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020430 · Cited by 199

Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease

Pinheiro, R. G. R., Granja, A., Loureiro, J. A., Pereira, M. D. C., Pinheiro, M., Neves, A. R., & Reis, S. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105314 · Cited by 199

Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants

Saha, K., Lajis, N. H., Israf, D. A., Hamzah, A. S., Khozirah, S., Khamis, S., & Syahida, A. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.03.007 · Cited by 198

Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells

Chen, T.-J., Jeng, J.-Y., Lin, C., Wu, C.-Y., & Chen, Y. (2006) · Toxicology · doi:10.1016/j.tox.2006.03.007 · Cited by 192

Quercetin reverses d-galactose induced neurotoxicity in mouse brain

Lu, J. L., Zheng, Y., Luo, L., Wu, D., Sun, D., & You-jian, F. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.043 · Cited by 187

Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity

Lu, J. L., Wu, D., Zheng, Y., Hu, B., Zhang, Z., Shan, Q., Zheng, Z., Liu, C., & Wang, Y. (2010) · The Journal of Pathology · doi:10.1002/path.2754 · Cited by 186

Cholinergic Signaling Controls Conditioned Fear Behaviors and Enhances Plasticity of Cortical-Amygdala Circuits

Jiang, L., Kundu, S., Lederman, J., López‐Hernández, G. Y., Ballinger, E. C., Wang, S., Talmage, D. A., & Role, L. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.028 · Cited by 186

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

Sharifi-Rad, J., Dey, A., Koirala, N., Shaheen, S., El Omari, N., Salehi, B., Goloshvili, T., Cirone Silva, N. C., Bouyahya, A., Vitalini, S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.600139 · Cited by 183

Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease

Magalingam, K. B., Radhakrishnan, A., Ping, N. S., & Haleagrahara, N. (2018) · BioMed Research International · doi:10.1155/2018/3740461 · Cited by 178

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

Sun, G. Y., Chen, Z., Jasmer, K. J., Chuang, D. Y., Gu, Z., Hannink, M., & Simonyi, Á. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141509 · Cited by 177

Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: Implications in Huntington's disease

Sandhir, R., & Mehrotra, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.018 · Cited by 171

SIRT1 stimulation by polyphenols is affected by their stability and metabolism

de Boer, V. C. J., de Goffau, M. C., Arts, I. C. W., Hollman, P. C. H., & Keijer, J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.02.007 · Cited by 168

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

Tchantchou, F., Lacor, P. N., Cao, Z., Lao, L., Hou, Y., Cui, C., Klein, W. L., & Luo, Y. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1189 · Cited by 164

Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine

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Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

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Protective effect of quercetin against ICV colchicine‐induced cognitive dysfunctions and oxidative damage in rats

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Characterization of kinases involved in the phosphorylation of aggregated α‐synuclein

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Erratum to: Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid

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Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats.

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