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Cited by 118Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionConnexins and lens biology

Output of neurogliaform cells to various neuron types in the human and rat cerebral cortex

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Oláh, Szabolcs·2007·Frontiers in Neural Circuits
DOI 10.3389/neuro.04.004.2007PMC PMC2526278
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Abstract

Neurogliaform cells in the rat elicit combined GABAA and GABAB receptor-mediated postsynaptic responses on cortical pyramidal cells and establish electrical synapses with various interneuron types. However, the involvement of GABAB receptors in postsynaptic effects of neurogliaform cells on other GABAergic interneurons is not clear. We measured the postsynaptic effects of neurogliaform cells in vitro applying simultaneous whole-cell recordings in human and rat cortex. Single action potentials of human neurogliaform cells evoked unitary IPSPs composed of GABAA and GABAB receptor-mediated components in various types of inteneuron and in pyramidal cells. Slow IPSPs were combined with homologous and heterologous electrical coupling between neurogliaform cells and several human interneuron types. In the rat, single action potentials in neurogliaform cells elicited GABAB receptor-mediated component in responses of neurogliaform, regular spiking, and fast spiking interneurons following the GABAA receptor-mediated component in postsynaptic responses. In conclusion, human and rat neurogliaform cells elicit slow IPSPs and reach GABAA and GABAB receptors on several interneuron types with a connection-specific involvement of GABAB receptors. The electrical synapses recorded between human neurogliaform cells and various interneuron types represent the first electrical synapses recorded in the human cortex.

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Crossref · 10.3389/neuro.04.004.2007

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  • Neurogliaform cells have a characteristic multipolar morphology consisting of a small, round soma, multiple very short dendrites spreading radially, and a wider, spherical, very dense axonal plexus of fine branches.

    “NGFCs, called spiderweb cells by Cajal, have a characteristic multipolar morphology consisting of a small, round soma from which multiple, very short dendrites spread radially in all directions and have a wider, spherical, very dense axonal plexus composed of fine branches (Kawaguchi and Kubota, 1997; Kubota, 2014; Olah et al., 2007).”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Olah et al., 2007

    The Introduction describes a small, round soma, radially spreading dendrites, and a dense axonal plexus of fine branches. Results > Human experiments also describes a small dendritic field and dense axonal meshwork. Our copy does not establish that the dendrites are very short or that the axonal plexus is wider and spherical; no page numbers are available in the indexed passages. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Neurogliaform cell output synapses are distinct from those of other interneurons: they elicit slow, long-lasting inhibitory postsynaptic potentials on pyramidal cells and other interneurons through combined activation of GABAA and GABAB receptors.

    “The properties of the output synapses of NGFCs are very distinct from those of other INs. NGFCs elicit slow, long-lasting IPSPs on PCs and other INs through a combined activation of both GABAA and GABAB receptors (Olah et al., 2007; Tamas et al., 2003).”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Olah et al., 2007

  • Coupling coefficients for gap junctions between rosehip cells were similar to those found earlier between human and rodent interneurons.

    “coupling coefficients for gap junctions (0.05±0.05) were similar to those found earlier between human and rodent interneurons23.”

    From Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type (2018) · cites this paper as [23]

  • The cloud of GABA generated from NGFC release can also activate presynaptic GABABR to mediate homosynaptic and heterosynaptic depression of GABAergic and glutamatergic release sometimes with remarkable target cell specificity.

    “In addition, the cloud of GABA generated from NGFC release can also activate presynaptic GABABR to mediate homosynaptic and heterosynaptic depression of GABAergic and glutamatergic release (48, 858, 859, 926, 927) sometimes with remarkable target cell specificity (204).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [859]

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Research works printed but not linked: 1

  1. Cajal S. R. y. (1904). Textura del Systema Nervioso del Hombre y los Vertebrados (Madrid, Spain, Moya), Vol. 2

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Authors
Oláh, S.
Affiliations
University of Szeged (HU)
Corresponding author
Oláh, Szabolcs
Venue
Frontiers in Neural Circuits
Publisher
Frontiers Media SA
Published
2007
Volume
1
Pages
4-4
ISSN
1662-5110 (ISSN-L)
DOI
10.3389/neuro.04.004.2007
PMC
PMC2526278
OpenAlex
W2030434469
Cited by
118
References
44
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 4 · 2012: 4
FWCI
1.98
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neural Circuits (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Wellcome Trust
  • Boehringer Ingelheim Fonds
  • Hungarian Scientific Research Fund
  • Magyar Tudományos Akadémia
  • Nemzeti Kutatási és Technológiai Hivatal
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R29NS035915, R01NS035915, R37NS035915)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords
neurogliaform cells, GABAA receptor, GABAB receptors, inhibitory postsynaptic potentials, electrical synapses, cortical interneurons, pyramidal neurons, human cerebral cortex, rat cortex, fast-spiking interneurons, GABAergic inhibition

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