Cell Autonomous and non-autonomous effects of senescent cells in the skin
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Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
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The role of senescent cells in skin function is complex because they seem to have both beneficial and detrimental effects, depending on the context.
“However, the role of senescent cells in skin function is complex because they seem to have both beneficial and detrimental effects, depending on the context.57”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [57]
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- Authors
- Demaria, M., Desprez, P. Y., Campisi, J., & Velarde, M. C.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Velarde, Michael C.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 135
- Issue
- 7
- Pages
- 1722-1726
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC4466004
- OpenAlex
- W2067542143
- Cited by
- 127
- References
- 71
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K99-AG041221, P01- AG017242, P01-AG041122, R21-CA166347, R37-AG009909)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- senescent cells, senescence-associated secretory phenotype, skin aging, extrinsic aging, intrinsic aging, wound healing, epidermis, dermis, cell-autonomous effects, extracellular matrix
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, Cell Division, Epidermis, Female, Fibroblasts, Homeostasis, Humans, Male, Sensitivity and Specificity, Skin, Wound Healing, Skin Aging, Cellular Senescence, Mice
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