Cited by 127Telomeres, Telomerase, and SenescenceSkin Protection and AgingWound Healing and Treatments

Cell Autonomous and non-autonomous effects of senescent cells in the skin

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Demaria, Marco, Desprez, Pierre Yves, Campisi, Judith, Velarde, Michael C.·2015·Journal of Investigative Dermatology

Abstract

Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.

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Crossref · 10.1038/jid.2015.108

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  • The role of senescent cells in skin function is complex because they seem to have both beneficial and detrimental effects, depending on the context.

    “However, the role of senescent cells in skin function is complex because they seem to have both beneficial and detrimental effects, depending on the context.57”

    From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [57]

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  1. Ziegler DV Wiley CD Velarde MC Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging Aging cell (in press) PMC4310776 25399755

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Authors
Demaria, M., Desprez, P. Y., Campisi, J., & Velarde, M. C.
Affiliations
Buck Institute for Research on Aging (US)
Corresponding author
Velarde, Michael C.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2015-07
Volume
135
Issue
7
Pages
1722-1726
ISSN
0022-202X (ISSN-L)
OpenAlex
W2067542143
Cited by
127
References
71
Citations by year
2026: 6 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 4
FWCI
1.43
Type
journal article
Language
en
Open access
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (K99-AG041221, P01- AG017242, P01-AG041122, R21-CA166347, R37-AG009909)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
senescent cells, senescence-associated secretory phenotype, skin aging, extrinsic aging, intrinsic aging, wound healing, epidermis, dermis, cell-autonomous effects, extracellular matrix
MeSH terms
Epidermal Cells, Animals, Cell Differentiation, Cell Division, Epidermis, Female, Fibroblasts, Homeostasis, Humans, Male, Sensitivity and Specificity, Skin, Wound Healing, Skin Aging, Cellular Senescence, Mice

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