Applications of blockchain technology in medicine and healthcare: challenges and future perspectives
Open accessAbstract
Blockchain technology has gained considerable attention, with an escalating interest in a plethora of numerous applications, ranging from data management, financial services, cyber security, IoT, and food science to healthcare industry and brain research. There has been a remarkable interest witnessed in utilizing applications of blockchain for the delivery of safe and secure healthcare data management. Also, blockchain is reforming the traditional healthcare practices to a more reliable means, in terms of effective diagnosis and treatment through safe and secure data sharing. In the future, blockchain could be a technology that may potentially help in personalized, authentic, and secure healthcare by merging the entire real-time clinical data of a patient’s health and presenting it in an up-to-date secure healthcare setup. In this paper, we review both the existing and latest developments in the field of healthcare by implementing blockchain as a model. We also discuss the applications of blockchain, along with the challenges faced and future perspectives.
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Blockchain technology makes it simple to trace a medicine from the maker to the patient.
“Blockchain technology also makes it simple to trace a medicine from the maker to the patient.”
From Medical 4.0 technologies for healthcare: Features, capabilities, and applications (2022) · cites this paper as [360]
Blockchain increases a drug's traceability as it passes through the supply chain and aids in the prevention of drug counterfeiting.
“It increases a drug's traceability as it passes through the supply chain and aids in the prevention of drug counterfeiting.”
From Medical 4.0 technologies for healthcare: Features, capabilities, and applications (2022) · cites this paper as [360]
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Cites
An Overview of Blockchain Technology: Architecture, Consensus, and Future Trends
Zheng, Z., Xie, S., Dai, H., Chen, X., & Wang, H. (2017) · 2017 IEEE International Congress on Big Data (BigData Congress) · doi:10.1109/bigdatacongress.2017.85 · Cited by 4,515 · see citing works
MedRec: Using Blockchain for Medical Data Access and Permission Management
Azaria, A., Ekblaw, A., Vieira, T., & Lippman, A. (2016) · 2016 2nd International Conference on Open and Big Data (OBD) · doi:10.1109/obd.2016.11 · Cited by 2,526 · see citing works
Blockchain distributed ledger technologies for biomedical and health care applications
Kuo, T.-T., Kim, H.-E., & Ohno-Machado, L. (2017) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocx068 · Cited by 1,350 · see citing works
Yue, X., Wang, H., Jin, D., Li, M., & Jiang, W. (2016) · Journal of Medical Systems · doi:10.1007/s10916-016-0574-6 · Cited by 1,240 · see citing works
Blockchain technology in healthcare: The revolution starts here
Mettler, M. (2016) · 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom) · doi:10.1109/healthcom.2016.7749510 · Cited by 1,237 · see citing works
MeDShare: Trust-Less Medical Data Sharing Among Cloud Service Providers via Blockchain
Xia, Q., Sifah, E. B., Asamoah, K. O., Gao, J., Du, X., & Guizani, M. (2017) · IEEE Access · doi:10.1109/access.2017.2730843 · Cited by 1,148 · see citing works
A Review on the Use of Blockchain for the Internet of Things
Fernandez-Carames, T. M., & Fraga-Lamas, P. (2018) · IEEE Access · doi:10.1109/access.2018.2842685 · Cited by 1,078 · see citing works
Healthcare blockchain system using smart contracts for secure automated remote patient monitoring
Griggs, K. N., Ossipova, O., Kohlios, C. P., Baccarini, A. N., Howson, E. A., & Hayajneh, T. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0982-x · Cited by 926 · see citing works
Blockchain: A Panacea for Healthcare Cloud-Based Data Security and Privacy?
Esposito, C., Santis, A. D., Tortora, G., Chang, H., & Choo, K. R. (2018) · IEEE Cloud Computing · doi:10.1109/mcc.2018.011791712 · Cited by 857 · see citing works
Fhirchain: applying blockchain to securely and scalably share clinical data
Zhang, P., White, J., Schmidt, D. C., Lenz, G., & Rosenbloom, S. T. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.07.004 · Cited by 796 · see citing works
Blockchain-Based Medical Records Secure Storage and Medical Service Framework
Chen, Y., Ding, S., Xu, Z., Zheng, H., & Yang, S. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-1121-4 · Cited by 520 · see citing works
Secure and Trustable Electronic Medical Records Sharing using Blockchain
Dubovitskaya, A., Xu, Z., Ryu, S., Schumacher, M., & Wang, F. (2017) · PubMed Central · doi:10.48550/arxiv.1709.06528 · Cited by 465 · see citing works
Blockchain Technology: Applications in Health Care
Angraal, S., Krumholz, H. M., & Schulz, W. L. (2017) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.117.003800 · Cited by 430 · see citing works
Clinical Decision Support Systems for Improving Diagnostic Accuracy and Achieving Precision Medicine
Castaneda, C., Nalley, K., Mannion, C., Bhattacharyya, P., Blake, P., Pecora, A., Goy, A., & Suh, K. S. (2015) · Journal of Clinical Bioinformatics · doi:10.1186/s13336-015-0019-3 · Cited by 408 · see citing works
BlocHIE: A BLOCkchain-Based Platform for Healthcare Information Exchange
Jiang, S., Cao, J., Wu, H., Yang, Y., Ma, M., & He, J. (2018) · IEEE International Conference on Smart Computing · doi:10.1109/smartcomp.2018.00073 · Cited by 397 · see citing works
A secure system for pervasive social network-based healthcare
Zhang, J., Xue, N., & Huang, X. (2016) · IEEE Access · doi:10.1109/access.2016.2645904 · Cited by 361 · see citing works
Blockchain-Powered Parallel Healthcare Systems Based on the ACP Approach
Wang, S., Wang, J., Wang, X., Qiu, T., Yuan, Y., Ouyang, L., Guo, Y., & Wang, F.-Y. (2018) · IEEE Transactions on Computational Social Systems · doi:10.1109/tcss.2018.2865526 · Cited by 316 · see citing works
Improving data transparency in clinical trials using blockchain smart contracts
Nugent, T., Upton, D., & Cimpoesu, M. (2016) · F1000Research · doi:10.12688/f1000research.9756.1 · Cited by 309 · see citing works
A scoping review of cloud computing in healthcare
Griebel, L., Prokosch, H., Köpcke, F., Toddenroth, D., Christoph, J., Leb, I., Engel, I., & Sedlmayr, M. (2015) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-015-0145-7 · Cited by 269 · see citing works
Sylim, P. G., Liu, F., Marcelo, A., et al. (2018) · JMIR Research Protocols · doi:10.2196/10163 · Cited by 269 · see citing works
Geospatial blockchain: promises, challenges, and scenarios in health and healthcare
Boulos, M. N. K., Wilson, J. T., & Clauson, K. A. (2018) · International Journal of Health Geographics · doi:10.1186/s12942-018-0144-x · Cited by 253 · see citing works
Leveraging Blockchain Technology to Enhance Supply Chain Management in Healthcare:
Clauson, K. A., Breeden, E. A., Davidson, C., & Mackey, T. K. (2018) · Blockchain in Healthcare Today · doi:10.30953/bhty.v1.20 · Cited by 249 · see citing works
Blockchain Thinking : The Brain as a Decentralized Autonomous Corporation [Commentary]
Swan, M. (2015) · IEEE Technology and Society Magazine · doi:10.1109/mts.2015.2494358 · Cited by 246 · see citing works
On the Design of a Blockchain Platform for Clinical Trial and Precision Medicine
Shae, Z., & Tsai, J. J. P. (2017) · 2017 IEEE 37th International Conference on Distributed Computing Systems (ICDCS) · doi:10.1109/icdcs.2017.61 · Cited by 233 · see citing works
Introducing blockchains for healthcare
Alhadhrami, Z., Alghfeli, S., Alghfeli, M., Abdella, J., & Shuaib, K. (2017) · International Conference on Electrical and Computing Technologies and Applications (ICECTA) · doi:10.1109/icecta.2017.8252043 · Cited by 159 · see citing works
Blockchain for Healthcare: The Next Generation of Medical Records?
Pirtle, C. J., & Ehrenfeld, J. M. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-1025-3 · Cited by 139 · see citing works
Blockchain as a Foundation for Sharing Healthcare Data
Cyran, M. (2018) · Blockchain in Healthcare Today · doi:10.30953/bhty.v1.13 · Cited by 120 · see citing works
Blockchain protocols in clinical trials: Transparency and traceability of consent
Benchoufi, M., Porcher, R., & Ravaud, P. (2017) · F1000Research · doi:10.12688/f1000research.10531.1 · Cited by 78 · see citing works
Technology and managed care: patient benefits of telemedicine in a rural health care network
Berman, M., & Fenaughty, A. M. (2004) · Health Economics · doi:10.1002/hec.952 · Cited by 75 · see citing works
A Case Study in Blockchain Healthcare InnovationPreprint
Heston, T. F. (2017) · doi:10.22541/au.151060471.10755953 · Cited by 56 · see citing works
Downing, N. L., Adler‐Milstein, J., Palma, J. P., Lane, S., Eisenberg, M. A., Sharp, C., Collaborative, N. C. H., & Longhurst, C. (2016) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocw063 · Cited by 47 · see citing works
The Prospects for the Use of Digital Technology “Blockchain” in the Pharmaceutical Market
Plotnikov, V. A., & KUZNETSOVA, V. Y. (2018) · MATEC Web of Conferences · doi:10.1051/matecconf/201819302029 · Cited by 46 · see citing works
Clinical Consultations Using Store-and-Forward Telemedicine Technology
Houston, M. S., Myers, J. D., Levens, S. P., McEvoy, M. T., Smith, S. A., Khandheria, B. K., Shen, W.-K., Torchia, M. E., & Berry, D. J. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.8.764 · Cited by 43 · see citing works
Blockchain HIE Overview: A Framework for Healthcare Interoperability
Bennett, B. (2018) · Telehealth and Medicine Today · doi:10.30953/tmt.v2.14 · Cited by 27 · see citing works
Shubbar, S. (2017) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 21 · see citing works
Development of cost-effective tele-monitoring system for remote area patients
Bhatti, A., Siyal, A. A., Mehdi, A., et al. (2018) · International Conference on Engineering and Emerging Technologies (ICEET) · doi:10.1109/iceet1.2018.8338646 · Cited by 20 · see citing works
Self-citationPremiums without Benefits: Waste and Inefficiency in the Commercial Health Insurance Industry
Brandon, R., Podhorzer, M., & Pollak, T. H. (1991) · International Journal of Health Services · doi:10.2190/h824-r263-yl47-wrqd · Cited by 11 · see citing works
Ianculescu, M., Stanciu, A., Bica, O., et al. (2017) · International Journal of Economics and Management Systems · Cited by 9 · see citing works
Trujllo, G., & Guillermo, C. (2018) · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Ivan, D. Moving toward a blockchain-based method for the secure storage of patient records. In ONC/NIST Use of Blockchain for Healthcare and Research Workshop; ONC/NIST: Gaithersburg, MD, USA, 2016.
- Gorman, L. The history of health care costs and health insurance. Wisconsin Policy Res. Inst. Rep. 2006, 19, 1-31.
- Ekblaw, A.; Azaria, A.; Halamka, J.D.; Lippman, A. A Case Study for Blockchain in Healthcare: "MedRec" prototype for electronic health records and medical research data. In Proceedings of the IEEE Open and Big Data Conference, Vienna, Austria, 24 August 2016; Volume 13.
- Kuo, T.-T.; Hsu, C.-N.; Ohno-Machado, L. ModelChain: Decentralized Privacy-Preserving Healthcare Predictive Modeling Framework on Private Blockchain Networks. arXiv 2016, arXiv:1802.01746 . · arXiv
- Linn, L.A., Koo, M.B. Blockchain for health data and its potential use in health it and health care related research. In ONC/NIST Use of Blockchain for Healthcare and Research Workshop; ONC/NIST: Gaithersburg, MD, USA, 2016.
Cited by
Sorted by citations
Blockchain Technology in Healthcare: A Comprehensive Review and Directions for Future Research
Khezr, S., Moniruzzaman, M., Yassine, A., & Benlamri, R. (2019) · Applied Sciences · doi:10.3390/app9091736 · Cited by 575 · see citing works
Medical 4.0 technologies for healthcare: Features, capabilities, and applications
Haleem, A., Javaid, M., Pratap Singh, R., & Suman, R. (2022) · Internet of Things and Cyber-Physical Systems · doi:10.1016/j.iotcps.2022.04.001 · Cited by 468 · see citing works
Tandon, A., Dhir, A., Islam, A. K. M. N., & Mäntymäki, M. (2020) · Computers in Industry · doi:10.1016/j.compind.2020.103290 · Cited by 439 · see citing works
Blockchain and Artificial Intelligence Technology in E-Health
Tagde, P., Tagde, S., Bhattacharya, T., Tagde, P., Chopra, H., Akter, R., Kaushik, D., & Rahman, M. H. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16223-0 · Cited by 281 · see citing works
A novel blockchain-based electronic health record automation system for healthcare
Chelladurai, U., & Pandian, S. (2022) · Journal of Ambient Intelligence and Humanized Computing · doi:10.1007/s12652-021-03163-3 · Cited by 210 · see citing works
Blockchain Enabled Anonymous Privacy-Preserving Authentication Scheme for Internet of Health Things
Rajasekaran, A. S., Maria, A., Rajagopal, M., & Lorincz, J. (2022) · Sensors · doi:10.3390/s23010240 · Cited by 26 · see citing works
- Authors
- Siyal, A. A., Junejo, A. Z., Zawish, M., Ahmed, K., Khalil, A., & Soursou, G.
- Affiliations
- Mehran University of Engineering and Technology (PK)
- Trinity College Dublin (IE)
- University of Crete (GR)
- Corresponding author
- Siyal, Asad Ali
- Venue
- Cryptography
- Publisher
- MDPI AG
- Published
- 2019-01-02
- Volume
- 3
- Issue
- 1
- Pages
- 3
- ISSN
- 2410-387X (ISSN-L)
- OpenAlex
- W2907251489
- Cited by
- 531
- References
- 40
- Citations by year
- 2026: 25 · 2025: 61 · 2024: 80 · 2023: 104 · 2022: 117 · 2021: 84 · 2020: 45 · 2019: 14 · 2018: 1
- FWCI
- 80.95
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cryptography (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Computer Science › Information Systems › Blockchain Technology Applications and Security
- Physical Sciences › Computer Science › Information Systems › Blockchain Technology in Education and Learning
- Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
- Keywords
- blockchain, health care, health data management, secure data sharing, clinical data interoperability, personalized healthcare, healthcare data security, blockchain adoption barriers
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