Where to go from here? An exploratory meta-analysis of the most promising approaches to depression prevention programs for children and adolescents
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Objective: To examine the overall effect of individual depression prevention programs on future likelihood of depressive disorder and reduction in depressive symptoms. In addition, we have investigated whether Cognitive Behavioural Therapy (CBT), Interpersonal Therapy (IPT) and other therapeutic techniques may modify this effectiveness. Methods: This study is based on and includes the trial data from meta-analyses conducted in the Cochrane systematic review of depression prevention programs for children and adolescents by Merry et al. (2011). All trials were published or unpublished English language randomized controlled trials (RCTs) or cluster RCTs of any psychological or educational intervention compared to no intervention to prevent depression in children and adolescents aged 5–19 years. Results: There is some evidence that the therapeutic approach used in prevention programs modifies the overall effect. CBT is the most studied type of intervention for depression prevention, and there is some evidence of its effectiveness in reducing the risk of developing a depressive disorder, particularly in targeted populations. Fewer studies employed IPT, however this approach appears promising. To our knowledge, this is the first study to have explored how differences in the approach taken in the prevention programs modify the overall treatment effects of prevention programs for children and adolescents. Conclusions: More research is needed to identify the specific components of CBT that are most effective or indeed if there are other approaches that are more effective in reducing the risk of future depressive episodes. It is imperative that prevention programs are suitable for large scale roll-out, and that emerging popular modes of delivery, such as online dissemination continue to be rigorously tested.
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Stigma toward people with depression among health workers is associated with low rates of depression recognition or poor quality of care.
“This is associated with low rates of depression recognition 398,399 or poor quality of care.”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [399]
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Universal Anxiety Interventions in United States Schools: A Systematic Review
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School-based mental health literacy interventions
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Preventing Depressive Symptoms in Chinese Adolescents: A Pilot Cluster Randomized Controlled Trial
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Prevention of depression and anxiety: is the whole better than the sum of the parts?
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EFFECTIVENESS OF LIFE SKILLS EDUCATION AMONG ADOLESCENT GIRLS –A REVIEW
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School-based mental health literacy interventions
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Interpersonal Psychotherapy for the Treatment of Depression Among Adults and Adolescents
Mootz, J. J., Mufson, L. H., Chiao, S., & Weissman, M. M. (2026) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-061724-085002
- Authors
- Hetrick, S., Cox, G., & Merry, S.
- Affiliations
- Orygen (AU)
- University of Auckland (NZ)
- Corresponding author
- Hetrick, Sarah
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2015-04-30
- Volume
- 12
- Issue
- 5
- Pages
- 4758-4795
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC4454938
- OpenAlex
- W2105188507
- Cited by
- 62
- References
- 71
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression prevention, children and adolescents, cognitive behavioral therapy, interpersonal psychotherapy, depressive symptoms, psychological intervention, digital dissemination
- MeSH terms
- Child Health, Adolescent Health, Adolescent, Behavior Therapy, Child, Child, Preschool, Depression, Depressive Disorder, Female, Humans, Male, Cognitive Behavioral Therapy, Young Adult
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