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Cited by 193Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches

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Sung, Pi-Shan, Lin, Po-Yu, Liu, Chi-Hung, Su, Hui-Chen, Tsai, Kuen-Jer·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21030701PMC PMC7037892
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Abstract

In adult brain, new neurons are generated throughout adulthood in the subventricular zone and the dentate gyrus; this process is commonly known as adult neurogenesis. The regulation or modulation of adult neurogenesis includes various intrinsic pathways (signal transduction pathway and epigenetic or genetic modulation pathways) or extrinsic pathways (metabolic growth factor modulation, vascular, and immune system pathways). Altered neurogenesis has been identified in Alzheimer’s disease (AD), in both human AD brains and AD rodent models. The exact mechanism of the dysregulation of adult neurogenesis in AD has not been completely elucidated. However, neuroinflammation has been demonstrated to alter adult neurogenesis. The presence of various inflammatory components, such as immune cells, cytokines, or chemokines, plays a role in regulating the survival, proliferation, and maturation of neural stem cells. Neuroinflammation has also been considered as a hallmark neuropathological feature of AD. In this review, we summarize current, state-of-the art perspectives on adult neurogenesis, neuroinflammation, and the relationship between these two phenomena in AD. Furthermore, we discuss the potential therapeutic approaches, focusing on the anti-inflammatory and proneurogenic interventions that have been reported in this field.

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Authors
Sung, P.-S., Lin, P.-Y., Liu, C.-H., Su, H.-C., & Tsai, K.-J.
Affiliations
  • National Cheng Kung University Hospital (TW)
  • Chang Gung University (TW)
Corresponding author
Tsai, Kuen-Jer
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-01-21
Volume
21
Issue
3
Pages
701
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms21030701
PMC
PMC7037892
OpenAlex
W3001721938
Cited by
193
References
225
Citations by year
2026: 18 · 2025: 27 · 2024: 33 · 2023: 37 · 2022: 45 · 2021: 24 · 2020: 9
FWCI
4.47
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ministry of Science and Technology, Taiwan (MOST-105-2628-B-006-016-MY3 and MOST-106-2628-B-006-001-MY4)
  • National Cheng Kung University Hospital (NCKUH-2020350)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, adult neurogenesis, neuroinflammation, subventricular zone, dentate gyrus, neural stem cells, cytokines, chemokines, immune cells, signal transduction, epigenetic regulation, anti-inflammatory therapy, treatment options
MeSH terms
Alzheimer Disease, Animals, Anti-Inflammatory Agents, Brain, Cell Differentiation, Humans, Inflammation, Neurons, Signal Transduction, Cytokines, Dentate Gyrus, Chemokines, Lateral Ventricles, Cell Proliferation, Neurogenesis, Neural Stem Cells

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