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Cited by 57Wound Healing and TreatmentsSeaweed-derived Bioactive CompoundsProteoglycans and glycosaminoglycans research

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

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Kim, Tae-Hee, Heo, Seong-Yeong, Oh, Gun-Woo, Heo, Soo-Jin, Jung, Won-Kyo·2021·Marine Drugs
DOI 10.3390/md19060296PMC PMC8224764
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Abstract

Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.

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  • In Korea, PDRN is approved for the treatment of graft-induced wounds and tissue regeneration, whereas PN is designated as a medical device.

    “In Korea, PDRN is approved for the treatment of graft-induced wounds and tissue regeneration [48,152,153], whereas PN is designated as a medical device [154].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [48]

    The Introduction (page unavailable) says PDRN is approved by the Korea Food and Drug Administration and used in tissue repair and wound treatment. Section 2.3 (page unavailable) reports improved composite-graft survival, but does not say that graft-induced wounds are an approved indication. The PN medical-device designation is attached to a different citation [154] and is not assessed here. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Structurally, PDRN consists exclusively of deoxyribose sugars in its backbone.

    “Structurally, PDRN consists exclusively of deoxyribose sugars in its backbone [48,49].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [48]

    The Introduction identifies PDRN as a mixture of polynucleotides with a high DNA percentage, but does not describe the sugars in its backbone. Searches for deoxyribose and sugar-phosphate backbone composition found no passage establishing the claimed exclusivity. (LLM, conf=0.70)

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  83. [84]Kim T.H. Lee H.S. Oh S.-J. Hwang C.-W. Jung W.-K. Phlorotannins ameliorate extracellular matrix production in human vocal fold fibroblasts and prevent vocal fold fibrosis via aerosol inhalation in a laser-induced fibrosis model J. Tissue Eng. Regen. Med. 2020 14 1918 1928 10.1002/term.3140 33049121 · DOI
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  85. [86]Chen X. Zhou W. Zha K. Liu G. Yang S. Ye S. Liu Y. Xiong Y. Wu Y. Cao F. Treatment of chronic ulcer in diabetic rats with self assembling nanofiber gel encapsulated-polydeoxyribonucleotide Am. J. Transl. Res. 2016 8 3067 3076 27508027 PMC4969443

Cited by

Sorted by citations

Authors
Kim, T.-H., Heo, S.-Y., Oh, G.-W., Heo, S.-J., & Jung, W.-K.
Affiliations
  • Pukyong National University (KR)
  • Korea Institute of Ocean Science and Technology (KR)
Corresponding author
  • Heo, Soo-Jin
  • Jung, Won-Kyo
ORCID
Venue
Marine Drugs
Publisher
MDPI AG
Published
2021-05-22
Volume
19
Issue
6
Pages
296
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md19060296
PMC
PMC8224764
OpenAlex
W3164729721
Cited by
57
References
0
Citations by year
2026: 14 · 2025: 15 · 2024: 13 · 2023: 11 · 2022: 3 · 2021: 1
FWCI
0.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Marine Drugs (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Research Foundation of Korea (2019R1A2C1007218)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords
polydeoxyribonucleotide, marine organisms, salmon sperm DNA, wound healing, anti-inflammatory activity, adenosine A2A receptor, salvage pathway, osteoblast activity, collagen synthesis, angiogenesis, biomedical applications
MeSH terms
Animals, Biomedical Engineering, Humans, Polydeoxyribonucleotides, Oncorhynchus, Aquatic Organisms

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