Cited by 563Phytochemicals and Antioxidant ActivitiesGut microbiota and healthPomegranate: compositions and health benefits

The DOI matches its Crossref record; 169 of the 171 references it cites were found in a registry or an index.

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

Open access

Kawabata, Kyuichi, Yoshioka, Yasukiyo, Terao, Junji·2019·Molecules

DOI 10.3390/molecules24020370PMC PMC6359708

Open this paper in CoChat — free account Open PDF

Abstract

Polyphenols are categorized as plant secondary metabolites, and they have attracted much attention in relation to human health and the prevention of chronic diseases. In recent years, a considerable number of studies have been published concerning their physiological function in the digestive tract, such as their prebiotic properties and their modification of intestinal microbiota. It has also been suggested that several hydrolyzed and/or fission products, derived from the catabolism of polyphenols by intestinal bacteria, exert their physiological functions in target sites after transportation into the body. Thus, this review article focuses on the role of intestinal microbiota in the bioavailability and physiological function of dietary polyphenols. Monomeric polyphenols, such as flavonoids and oligomeric polyphenols, such as proanthocyanidins, are usually catabolized to chain fission products by intestinal bacteria in the colon. Gallic acid and ellagic acid derived from the hydrolysis of gallotannin, and ellagitannin are also subjected to intestinal catabolism. These catabolites may play a large role in the physiological functions of dietary polyphenols. They may also affect the microbiome, resulting in health promotion by the activation of short chain fatty acids (SCFA) excretion and intestinal immune function. The intestinal microbiota is a key factor in mediating the physiological functions of dietary polyphenols.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/molecules24020370

Cites

169 of 169 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094
Benefits of polyphenols on gut microbiota and implications in human health
Cardona, F., Andrés‐Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.05.001 · Cited by 1,615

Flagged first, then by citations

Show all 171 references

2 of the 171 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Silverman, R.B. (2002). Organic Chemistry of Enzyme-Catalyzed Reactions, Academic Press. Revised ed.
Has, 2006, Of the Major Phenolic Acids Formed during Human Microbial Fermentation of Tea, Citrus, and Soy Flavonoid Supplements, Only, Joournal Nutr., 136, 52

Sorted by citations

Items 401–500 of 562

Akkermansia Muciniphila as novel powerful bacterial player in colorectal cancer biotherapeutics
Eslami, M., & Yousefi, B. (2022) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000328 · Cited by 6
Consumption of an Oil Palm Fruit Extract Promotes Large Bowel Health in Rats
Conlon, M. A., Sambanthamurthi, R., Tan, Y., Sundram, K., Fairus, S., & Abeywardena, M. Y. (2020) · Nutrients · doi:10.3390/nu12030644 · Cited by 6
Role of Plant Secondary Metabolites in Metabolic Disorders
Hajam, Y. A., Rani, R., Sharma, P., Khan, I. A., & Kumar, R. (2022) · Springer eBooks · doi:10.1007/978-981-16-4779-6_8 · Cited by 7
Ferroptosis as a molecular target of epigallocatechin gallate in diseases
Wang, L., Tang, C., Zhang, Q., & Pan, Q. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2401892 · Cited by 5
The bioavailability of phytochemicals and its relation with health benefits on metabolic syndrome
Berni, P. R. D. A., Rodrigues, D. B., Zandoná, L. R., Morzelle, M. C., Geraldi, M. V., & Maróstica, M. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21873-6.00010-5 · Cited by 5
Polyphenols Target Apoptosis and Cell Cycle Regulation in Various Cancer Models: Emphasis on Flavonoid Subclasses
Cheriyan, B. V., Pandi, K., Murali, D., Boobalan, N., Harikrishnan, J., Kannan, D., Jebaraj, L. P. C., Munuswamy, S., & Manaksha, S. H. (2025) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3274 · Cited by 5
Inhibition of amyloid formation of bovine hemoglobin by bioactive phenolic acids: an elaborate investigation into their binding properties with the protein using multi-spectroscopic and computational techniques
Lyndem, S., Giri, P., Aneesha, S. L., Bhatta, A., Kumari, K., Jana, M., & Roy, A. S. (2024) · New Journal of Chemistry · doi:10.1039/d4nj01106f · Cited by 5
High hydrostatic pressure pretreated fermented apple juice attenuated anaphylaxis by improving gut microbiota and metabolic regulation
Ma, J., Zhang, L., Ren, X., Luo, Z., Zhao, M., Tong, P., & Long, F. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.105844 · Cited by 5
Bioactive Compounds and Antioxidant Properties of Sheep’s Milk Yogurt Enriched with a Postbiotic Extract from Lactiplantibacillus plantarum UCLM56: Effects of In Vitro Digestion and Fermentation
Ramos, I. M., Navajas-Porras, B., Delgado-Osorio, A., Rufián‐Henares, J. Á., & Poveda, J. M. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12744 · Cited by 5
A fibre and phenolic-rich flour from Isabel grape by-products with stimulatory effects on distinct probiotics and beneficial impacts on human colonic microbiota in vitro
Silva, F. A., de Souza, E. L., Queiroga, R. D. C. R. D. E., Voss, G. B., Pintado, M., & Vasconcelos, M. A. D. S. (2022) · Letters in Applied Microbiology · doi:10.1111/lam.13723 · Cited by 6
In Vitro Digestion and Colonic Fermentation of UHT Treated Faba Protein Emulsions: Effects of Enzymatic Hydrolysis and Thermal Processing on Proteins and Phenolics
Gu, J., Li, M., Nawaz, M. A., Stockmann, R., Buckow, R., & Suleria, H. A. R. (2022) · Nutrients · doi:10.3390/nu15010089 · Cited by 5
Optimization of the Acid Cleavage of Proanthocyanidins and Other Polyphenols Extracted from Plant Matrices
de Souza, J. N. S., Tolosa, T., Teixeira, B. J. B., Moura, F. G., da Silva, E. M., & Rogez, H. L. G. (2022) · Molecules · doi:10.3390/molecules28010066 · Cited by 5
Isorhamnetin: Current knowledge and potential benefits for disease management
Gómez‐Zorita, S., Trepiana, J., Milton‐Laskibar, I., Macarulla, M. T., Eseberri, I., Arellano-García, L., Merino-Valdeolmillos, R., McGeoch, I. A., Fernández‐Quintela, A., & Portillo, M. P. (2023) · Springer eBooks · doi:10.1007/978-3-030-94753-8_15-1 · Cited by 5
Nourishing Yin and moistening dryness formula inhibits colon cell apoptosis via activating the PI3K/AKT signaling pathway to ameliorate Yin-deficiency constipation in mice
Zhang, H., Diao, F., Fan, X., Ge, S., Han, X., Wei, L., Yin, Q., Zhuang, P., Zhang, M., & Zhang, Y. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105821 · Cited by 5
Recent updates on diet‐derived gut microbial metabolites
PRASAIN, J. K., & Barnes, S. (2024) · eFood · doi:10.1002/efd2.181 · Cited by 7
Effects of bamboo shoots (Phyllostachys edulis) dietary fibers prepared by different processes on the adsorption characteristics of polyphenols
Tang, Y. M., Li, A. P., Xiao, J. P., Li, D. Y., & Wang, L. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13721 · Cited by 5
Encapsulation technologies applied to bioactive phenolic compounds and probiotics with potential application on chronic inflammation
Ferrer-Sierra, M., Rodríguez-López, P., Leyva‐Jiménez, F. J., Borrás‐Linares, I., Giacomazza, D., Fredes, C., Canales, P. S. R., Segura‐Carretero, A., & Lozano‐Sánchez, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823482-2.00010-8 · Cited by 5
Effects of colonic fermentation on the stability of fresh and black onion bioactives
Moreno-Ortega, A., Pede, G. D., Mena, P. R., Calani, L., Rio, D. D., Moreno‐Rojas, J. M., & Pereira‐Caro, G. (2022) · Food & Function · doi:10.1039/d1fo04240h · Cited by 5
The Role of Oxidative Stress and Changes in the Composition of the Gut Microbiota in the Genesis of Adolescent Obesity
Darenskaya, M. A., Rychkova, L. V., Semenova, N. V., Belkova, N. L., & Kolesnikova, L. I. (2022) · International Journal of Biomedicine · doi:10.21103/article12(3)_ra3 · Cited by 5
Relative Validity of an Online Herb and Spice Consumption Questionnaire
Blanton, C. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082757 · Cited by 7
Soft-shelled turtle-derived antioxidant peptides inhibit advanced glycation end products (AGEs) formation and mitigate AGE-induced damage to HUVECs via the AGEs/RAGE signaling pathway
Xu, X., Li, J., Wang, S., Liu, C., Ye, J., Jin, J., Zhong, Y., Wang, W., & Wang, N. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106828 · Cited by 4
Baru (Dipteryx alata Vog.) by-product following gastrointestinal digestion: bioaccessibility, antioxidant capacity and in vitro effects on inflammatory response of phenolic compounds
Fernandes, D. C., Neto, J. R. D. C., Matos, A. D. O., Lima, M. D. S., Sales‐Campos, H., & Naves, M. M. V. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116825 · Cited by 4
Resveratrol and salidroside, but not curcumin, improve cognition in mice with gut inflammation via microbiome modulation
Krutskikh, E. P., Babenkova, P., Nesterova, V., Tsvetkova, A. D., Burakova, I., & Gureev, A. P. (2025) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2025.1004122 · Cited by 4
Unravelling the Mechanisms of Tea Against NAFLD: An Integration of Bibliometrics, Network Pharmacology, and the Gut‐Liver Axis
Ren, J., Jiang, T., Wei, X., Bian, T., Xu, M., Zhao, Y., Zheng, Y., & Li, X. (2025) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.70118 · Cited by 4
Bile Acids: The Contribution of the Gut Microbiota to Atherosclerosis
Xu, L., Yang, H., He, C., Zhang, H., Jiang, Z., Zhang, Y., Luan, K., & Hu, H. (2026) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm44050 · Cited by 4
Regio-specific synthesis of flavonoid glucuronides using plant UDP-glucuronosyltransferase expressed in yeast
Sultana, M. J., Kurakawa, T., Nishikawa, M., & Ikushiro, S. (2025) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbaf049 · Cited by 4
Prevention of work-related stress, fatigue, loss of cognitive function, improved attention and recovery of stamina with Robuvit® in professionals with increased oxidative stress
Belcaro, G. V., Cesarone, M. R., Saggino, A., Dugall, M., Hu, S., SCIPIONE, C., SCIPIONE, V., Cornelli, U., Hosoi, M., Cotellese, R., et al. (2021) · Minerva Medica · doi:10.23736/s0026-4806.21.07776-4 · Cited by 4
Application of Phytochemicals in Immune Disorders: Their Roles Beyond Antioxidants.
Bland, J. S. (2021) · PubMed Central · Cited by 4
Molecular mechanisms for polyphenol functionality
Nakamura, Y. (2023) · Journal for the Integrated Study of Dietary Habits · doi:10.2740/jisdh.33.4_165 · Cited by 4
Hesperetin-7-O-rhamnoglucoside ameliorates dichlorvos-facilitated cardiotoxicity in rats by counteracting ionoregulatory, ion pumps, redox, and lipid homeostasis disruptions
Akamo, A. J., Ojelabi, A. O., Somade, O. T., Kehinde, I. A., Taiwo, A. M., Olagunju, B. A., Akinsanya, M. A., Adebisi, A. A., Adekunbi, T. S., Adenowo, A. F., et al. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101698 · Cited by 4
Metatranscriptomics reveals that plant tannins regulate the expression of intestinal antibiotic resistance genes in Qinghai voles (Neodon fuscus)
Shi, S., Gan, X., Qian, Y., Cao, Y., Wang, Y., Shi, C., Bi, J., Yu, Q., Han, Q., Qu, J., et al. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121119 · Cited by 4
The microbiota-microglia axis: A novel clue for diet and brain health
Song, Z., Song, R., Liu, Y., Zhu, Y., & Zhang, X. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.104942 · Cited by 4
Poor Diet Quality is Associated with Premature Senescence of the Immune System in Survivors of Childhood Acute Lymphoblastic Leukaemia
Benmoussa, A., Kientega, T., Morel, S., Cardin, G. B., Bérard, S., Wajnberg, M., Valtchev, P., Massé, A. B., Curnier, D. Y., Krajinović, M., et al. (2025) · Nutrition and Cancer · doi:10.1080/01635581.2025.2474263 · Cited by 4
Strawberry phenolic extracts effectively mitigated metabolic disturbances associated with high-fat ingestion in rats depending on the ellagitannin polymerization degree
Żary-Sikorska, E., Fotschki, B., Kołodziejczyk, K., Jurgoński, A., Kosmala, M., Milala, J., Majewski, M. S., Ognik, K., & Juśkiewicz, J. (2021) · Food & Function · doi:10.1039/d1fo00894c · Cited by 4
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Muñoz-Bernal, Ó. A., Vazquez-Flores, A. A., ́Álvarez-Parrilla, E., Martínez–Ruiz, N. D. R., & la Rosa, L. A. D. (2022) · Journal of Visualized Experiments · doi:10.3791/63164 · Cited by 4
In vitro anti-inflammatory properties of twelve Norwegian medicinal plants
Eltvik, A. A., Inngjerdingen, M., & Wangensteen, H. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120159 · Cited by 3
Anthocyanins: a comprehensive review of their chemical properties and health impacts on glucose metabolism in Gestational Diabetes Mellitus
Escobar, G. M. V., Li, L., Cheng, W., Li, Z., Gao, Q. F., Sun, J., & Hao, L. (2025) · Food, Nutrition and Health. · doi:10.1007/s44403-025-00041-0 · Cited by 6
Nutritional importance and value-added application of sprouts: Worldwide awareness toward introducing new food
Siddique, F., Imtiaz, S., Khizar, A., Noreen, S., Rasool, I. F. U., Kumar, P., Moreno, A., Khalid, W., & Esatbeyoglu, T. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.102838 · Cited by 3
A comprehensive review on bioaccessibility and bioavailability of legume-derived polyphenols
Zahir, A., Dhillon, G. K., Akhter, S., & Bora, P. P. (2026) · Food Production Processing and Nutrition · doi:10.1186/s43014-026-00371-2 · Cited by 6
Some Polyphenolic Compounds as Potential Therapeutic Agents in Cervical Cancer: The Most Recent Advances and Future Prospects
Şanlıer, N. T., Saçıntı, K. G., Türkoğlu, İ., & Şanlıer, N. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae126 · Cited by 3
Novel Piperazine Based Compounds Target Alzheimer’s Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein
Armstrong, C., Luo, D., Gretzinger, A., Pandey, D., Lipchik, A. M., Todi, S. V., & Dutta, A. K. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00220 · Cited by 3
Impact of Lactiplantibacillus plantarum UCLM56 on the bioactive properties of sheep's milk yogurt before and after in vitro digestion and fermentation
Ramos, I. M., Navajas-Porras, B., Delgado-Osorio, A., Rufián‐Henares, J. Á., & Poveda, J. M. (2025) · LWT · doi:10.1016/j.lwt.2025.118101 · Cited by 3
Insights on the modulatory role of Ayurveda-based herbal preparations on gut microbiome and neuroprotection
Rajini, P. S., Bharath, M. M. S., & Muralidhara, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00020-4 · Cited by 4
Kanserin Önlenmesi ve Tedavisinde Polifenollerin Rolü
Alkan, Ş. B., & Rakıcıoğlu, N. (2021) · Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi · doi:10.34087/cbusbed.814154 · Cited by 3
The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content
Dorothy, V., Lucy, H., Sunday, O. O., & Mary, O. U. (2022) · African Journal of Biochemistry Research · doi:10.5897/ajbr2021.1134 · Cited by 3
Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine
Blachier, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-26322-4_3 · Cited by 4
Beer-gut microbiome alliance: a discussion of beer-mediated immunomodulation via the gut microbiome
Zhang, S., Jin, S., Zhang, C., Hu, S., & Li, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1186927 · Cited by 4
The Effects of Feed Additives on Farm Animals Under Heat Stress Conditions
Sakkas, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-42855-5_11 · Cited by 4
Modulation of Porcine Gut Microbiota and Microbiome: Hologenomic, Dietary, and Endogenous Factors
Fan, M. Z., & Kim, S. W. (2024) · Pathogens · doi:10.3390/pathogens13030225 · Cited by 3
Potential of nutraceuticals in celiac disease
Jahdkaran, M., Asri, N., Esmaily, H., & Rostami‐Nejad, M. (2024) · Tissue Barriers · doi:10.1080/21688370.2024.2374628 · Cited by 3
Recent advances in metabolomic analyses of berry fruits and their in vivo metabolites
Çatalkaya, G., Sieniawska, E., Maciejewska‐Turska, M., Kai, G., & Çapanoğlu, E. (2021) · Journal of Berry Research · doi:10.3233/jbr-211528 · Cited by 3
Reversal of Metabolic Disorder Through the Restoration of Gut Microbiota
Upadhyay, P., Kalra, D., Gupta, S., & Mishra, S. K. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-4530-4_11 · Cited by 3
Biological Markers of Plant Phenolic Compounds Intake
Augusti, P. R., Denardin, C. C., Conterato, G. M. M., Silva, D. T., Lozano‐Sánchez, J., Borrás‐Linares, I., & Emanuelli, T. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-07389-2_60 · Cited by 3
Effect of Two Different Pretreatments of Brewers Spent Grain Used as Feed Ingredient on Nutritional, Immunological, and Metabolical Parameters in Gilthead Seabream (Sparus aurata)
Martínez-Antequera, F. P., Simó‐Mirabet, P., Heras, V. D. L., Román, M., Mancera, J. M., Martos-Sitcha, J. A., & Moyano, F. J. (2025) · Biology · doi:10.3390/biology14060585 · Cited by 2
Water-in-oil nanoemulsions as a delivery system for polyphenolic compounds from edible flower and fruit matrix: Modulating bioaccessibility, bioavailability, and health benefits by in vitro
Haładyn, K., Wojdyło, A., & Nowicka, P. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145885 · Cited by 4
Nutraceutical Interception of Cachexia: Grape-Derived Compounds as Pathophysiological Network Modulators
Verdi, A. M. O. H., Rizzardi, M. L., Soares, J. M., Schiessel, D. L., Coletti, D., Seelaender, M. C. L., & Gonçalves, D. C. (2025) · Biology · doi:10.3390/biology14091159 · Cited by 2
Dietary Polyphenols in Metabolic Diseases: Roles of Gut Microbiota‐Derived Metabolites
Tang, P., Feng, H., Zhang, D., Wu, J., Zhou, Y., Feng, W., & Peng, C. Y. (2026) · Phytotherapy Research · doi:10.1002/ptr.70180 · Cited by 3
Dietary Polyphenols and Their Impact on Nrf2 Pathway in Non‐Alcoholic Fatty Liver Disease: A Review of In Vitro and In Vivo Studies
Soleimani, A. A., Sarajar, B. O., Aliabadi, M., Shiri, H., Shahrezaei, S. N., & Meshkani, R. (2026) · Phytotherapy Research · doi:10.1002/ptr.70350 · Cited by 2
The Gut-Liver Axis in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Mechanisms, Microbiome Interactions and Therapeutic Targets
Sahu, P., & Satapathy, T. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11050-6 · Cited by 3
Indirect pharmacology of phytopolyphenols: The role of intermediate substances in cross-organ regulation and phenotypic outcomes
Linh, T. C., & Chong, K. T. D. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158466 · Cited by 2
Electro-Spinning and Electro-Spraying as Innovative Approaches in Developing of a Suitable Food Vehicle for Polyphenols-Based Functional Ingredients
Ghorbani, M., & Alemán, R. S. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98626 · Cited by 2
D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson’s Disease Animal Models
Dutta, A. K., Armstrong, C., Luo, D., Das, B., Spencer, B. J., & Rissman, R. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00655 · Cited by 2
Role of Gut Microbiota in the Development and Management of Rheumatoid Arthritis: A Narrative Review
Godha, Y., Kumar, S., & Wanjari, A. (2023) · Cureus · doi:10.7759/cureus.49458 · Cited by 2
Mechanistic Studies on the Antidiabetic Properties of Gallotannins
Li, X., Wu, W., Liu, Y., Zhao, J., Gui, Y., Wang, H., Wang, L., Luo, Y., Zhou, G., YuMin, H., et al. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128338114241021110221 · Cited by 2
Mechanisms Underlying the Anti-Atherosclerotic Effects of EGCG
Wang, L., Pan, Q., & Tang, C. (2025) · Current Molecular Medicine · doi:10.2174/0115665240354839241113044604 · Cited by 2
Gut Microbiota‐Targeted Polyphenol Interventions: A Novel Paradigm and Synergistic Strategies for Obesity Management
Cai, Y., Xu, J., & Wang, B. (2025) · Phytotherapy Research · doi:10.1002/ptr.70068 · Cited by 6
Does 3-pentadecylcatechol, an urushiol derivative, get absorbed in the body? A rat oral administration experiment
Jeong, H. Y., Lee, H. J., Cho, J., & Moon, J. (2020) · Food Science and Biotechnology · doi:10.1007/s10068-020-00739-1 · Cited by 2
Influence of 8-week daily consumption of a new product combining green coffee hydroxycinnamates and beta-glucans on polyphenol bioavailability in subjects with overweight and obesity
Seguido, M. Á., Tarradas, R. M., González-Rámila, S., García-Cordero, J., Sarriá, B., Bravo, L., & Mateos, R. (2022) · Food & Function · doi:10.1039/d1fo03327a · Cited by 2
Pharmacology of Anti-obesity and Antidiabetic Phytochemicals Isolated from Various Natural Sources (Plants, Seaweeds, Mushrooms, Marine Animals, and Microorganisms)
Dinda, B., Dinda, S., & Chakraborty, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-92196-5_5 · Cited by 2
Bioactive Compounds of Pili (Canarium ovatum Engl.)
Pham, L. J., & Dumandan, N. G. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-30182-8_22 · Cited by 2
Properties of free and microencapsulated quercetin: A literature review
Frez, F. L. V., Querubin, B. E., Rampani, E. M., Teixeira, F., Maschio, I. M. D., Rocha, L. C., Sério, M. E., Lima, T. K. G., Oliveira, V. H. D., & Frez, F. C. V. (2024) · Seven Editora eBooks · doi:10.56238/sevened2023.007-024 · Cited by 2
The Effects of Berry Bioactive Compounds on Vascular Function
Rodriguez‐Mateos, A., Sayec, M. L., Istas, G., & Johnson, S. A. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839165450-00120 · Cited by 2
Increased bioavailability of plasma polyphenols via the intestinal fermentation of soybean fibers: a role for gut microbiome?
Chirumbolo, S. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02029-x · Cited by 2
Impact of Dietary Flavonoid Metabolism on Gut Microbiome
Sharif, M., Ejaz, M., Nawaz, A., Saeeda, U. H., Naeem, S., & Khan, S. (2024) · doi:10.1002/9781394238071.ch6 · Cited by 2
Bioactive Compounds of Pili (Canarium ovatum Engl.)
Pham, L. J., & Dumandan, N. G. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-030-06120-3_22-1 · Cited by 1
Nutraceutical prospects of phenolic compounds from desugared sugarcane extract: an in vitro study of its bioaccessibility and bioactivity
Dumandan, N. G., Acda, R. D. P., Kagaoan, A. C. T., & Tumambing, C. R. (2024) · Food Materials Research · doi:10.48130/fmr-0024-0014 · Cited by 1
Personalized Dietary Approaches to Optimizing Intestinal Microbial Health and Homeostasis
Deleu, S., & Sabino, J. (2025) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2024.12.008 · Cited by 1
Molecular Aspects of Tannin-Anthelmintic Interactions as Revealed by NMR Spectroscopy
Sillanpää, M., Tähtinen, P., & Karonen, M. (2025) · ACS Omega · doi:10.1021/acsomega.5c03937 · Cited by 3
Polyprenylated Acylphloroglucinols from Hypericum rochelii and Hypericum olympicum—Cytotoxic Effects on Non-Tumorigenic Cell Lines and Antibacterial Potential
Ilieva, Y. E., Zaharieva, M. M., Dimitrova, L. L., Kaleva, M. D., Marinov, T., Dobreva, L. I., Kim, T. C., Kokanova-Nedialkova, Z. K., Trayanov, I. I., Titorenkova, S., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18101591 · Cited by 1
Pecan shell phytochemicals: chemical fingerprint, agro-industrial applications and delivery systems
Siebeneichler, T. J., Peixoto, E. C., Rombaldi, C. V., Hoffmann, J. F., & Dias, Á. R. G. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.147035 · Cited by 1
Enteric microbiome and obesity: a multidimensional narrative review
Barat, B., Ghosh, K., Kulkarni, B. P., Banerjee, P., & Ghosh, K. (2025) · Microbial Genomics · doi:10.1099/mgen.0.001562 · Cited by 1
Polyphenol-Enriched Extracts from Leaves of Mediterranean Plants as Natural Inhibitors of Monoamine Oxidase (MAO)-A and MAO-B Enzymes
D’Errico, A., Nasso, R., Ruggiero, M., Rullo, R., Vendittis, E. D., Masullo, M., Mazzeo, F., & Arcone, R. (2025) · Nutrients · doi:10.3390/nu18010022 · Cited by 1
Sex- and photoperiod-dependent differences in the bioavailability of (poly)phenols from mixtures of seasonal fruit extracts in obese rats
Gómez‐Roncal, S., Ávila‐Gálvez, M. Á., Alemany-Fornés, M., Soliz‐Rueda, J. R., Muguerza, B., Espı́n, J. C., & Arola‐Arnal, A. (2026) · Food Research International · doi:10.1016/j.foodres.2026.119110 · Cited by 1
Plant-Derived Bioactive Metabolites from the Sonoran Desert: Redox Regulation, Nrf2/NF-κB Signaling, and Emerging Therapeutic Applications
Luján, L. M. L., Iloki-Lewis, A. P., Guerrero‐Magaña, D. E., Osadchuk, M. A., Trushin, M. V., Galvez-Ruiz, J. C., Vargas-Durazo, J. T., Martínez, C. J. P., Burboa‐Zazueta, M. G., Torres‐Figueroa, A. V., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104634 · Cited by 1
Low Brain Levels of Dietary Polyphenols and Their Conjugates: Reassessing Mechanisms of Alzheimer’s Disease Prevention
Sharma, R., Shkirkova, K., Mack, W. J., & Gopalakrishna, R. (2026) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad3020027 · Cited by 1
Flavonoids as Modulators of the p53–Bcl-2 Axis in Cancer: Molecular Mechanisms and Therapeutic Implications
Jankowska, J., Szeleszczuk, Ł., & Pisklak, D. M. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060738 · Cited by 1
Effects of anthocyanin-rich blackcurrant extract on cardiovascular and metabolic responses during rest and treadmill running: a case study in an elite national level female Southeast Asian endurance athlete
Willems, M. E. T., Nana, A., Hiranphan, P., Wannasorn, S., Ramyarangsi, P., & Ajjimaporn, A. (2026) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2026.1818132 · Cited by 1
Research progress on the metabolic fate of citrus flavonoids and strategies to improve bioavailability
Geng, J. J., Deng, J., Zhou, W., Li, W., He, J., Lin, Q., Bai, J., & Cao, Q. (2026) · Food Chemistry X · doi:10.1016/j.fochx.2026.104433 · Cited by 1
Methodology for the determination of polyphenol bioaccessibility
Ištuk, J., Šubarić, D., & Jakobek, L. (2020) · Croatian Journal of Food Science and Technology · doi:10.17508/cjfst.2020.12.2.16 · Cited by 1
Clinical Trials of Phytomedicines in the Management of Obesity and Diabetes
Dinda, B. (2022) · Springer eBooks · doi:10.1007/978-3-030-92196-5_8 · Cited by 1
Intestinal Epithelial Co-Culture Sensitivity to Pro-Inflammatory Stimuli and Polyphenols Is Medium-Independent
Haddad, M. J., Zuluaga-Arango, J., Mathieu, H., Barbezier, N., & Anton, P. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137360 · Cited by 1
Identification of Amino Acids and Polyphenolic Metabolites in Human Plasma by UHPLC-ESI-QTOF-MS/MS, after the Chronic Intake of a Functional Meal in an Elderly Population
Vazquez-Flores, A. A., Muñoz-Bernal, Ó. A., ́Álvarez-Parrilla, E., Rodríguez‐Tadeo, A., Martínez–Ruiz, N. D. R., & la Rosa, L. A. D. (2024) · Foods · doi:10.3390/foods13162471 · Cited by 1
Dietary Polyphenols in Male Infertility: Mechanistic Approach
Rotimi, D. E., Shalom, A. E., Rotimi, O. P., Nwonuma, C. O., Ojo, P. O., Bakare, O. E., & Adeyemı, O. S. (2024) · International Conference on Science, Engineering and Business for Driving Sustainable Development Goals (SEB4SDG) · doi:10.1109/seb4sdg60871.2024.10629689 · Cited by 1
Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults
Kay, C. D., Tejera, N., Jennings, A., Haldar, S., Diment, B. C., Bevan, D., Crossman, L. C., Li, S., Cassidy, A., & Minihane, A. M. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.05.006 · Cited by 1
Polyphenols and their impacts on the host epigenome and the gut microbiome
Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00002-5 · Cited by 1
Biological Markers of Plant Phenolic Compounds Intake
Augusti, P. R., Denardin, C. C., Conterato, G. M. M., Silva, D. T., Lozano‐Sánchez, J., Borrás‐Linares, I., & Emanuelli, T. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81304-8_60-1 · Cited by 1
食事由来ポリフェノールの機能性研究の展望と社会実装化
Terao, J., & Osakabe, N. (2021) · KAGAKU TO SEIBUTSU · doi:10.1271/kagakutoseibutsu.59.254 · Cited by 1
Self-citation
Phytochemical-induced mucin accumulation in the gastrointestinal lumen is independent of the microbiotaPreprint
Forgie, A. J., Ju, T., Tollenaar, S. L., & Willing, B. P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.11.483917 · Cited by 1
Polyphenols for Dietary Polyphenols Application
Berdimurodov, E. T., Berdimuradov, K., Eliboev, I., Choriev, A., Khamidov, A., Yusufov, M., & Yodgorov, C. (2024) · doi:10.1002/9781394203932.ch14 · Cited by 1
Flavonoids and Their Metabolites
Chakraborty, P., Kar, K., Chowdhury, S., & Mazumder, K. (2024) · Wiley eBooks · doi:10.1002/9781394238071.ch10 · Cited by 1

Authors: Kawabata, K., Yoshioka, Y., & Terao, J.
Affiliations: Konan Women's University (JP)
Corresponding author: Terao, Junji
ORCID: Kawabata, Kyuichi
Yoshioka, Yasukiyo
Terao, Junji
Venue: Molecules
Publisher: MDPI AG
Published: 2019-01-21
Volume: 24
Issue: 2
Pages: 370
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules24020370
PMC: PMC6359708
OpenAlex: W2909540292
Cited by: 563
References: 171
Citations by year: 2026: 36 · 2025: 63 · 2024: 61 · 2023: 82 · 2022: 103 · 2021: 105 · 2020: 82 · 2019: 31
FWCI: 7.74
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Japan Society for the Promotion of Science (16K00815)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: gut microbiota, dietary polyphenols, polyphenol bioavailability, prebiotic properties, flavonoids, proanthocyanidins, gallotannins, ellagitannins, gallic acid, ellagic acid, short-chain fatty acids, intestinal immunity, chronic disease prevention
MeSH terms: Gastrointestinal Microbiome, Animals, Biological Availability, Energy Metabolism, Humans, Hydrolysis, Intestinal Mucosa, Research, Dietary Supplements, Gastrointestinal Tract, Prebiotics, Polyphenols, Gastrointestinal Absorption

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks