Cited by 563Phytochemicals and Antioxidant ActivitiesGut microbiota and healthPomegranate: compositions and health benefits

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Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

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Kawabata, Kyuichi, Yoshioka, Yasukiyo, Terao, Junji·2019·Molecules

DOI 10.3390/molecules24020370PMC PMC6359708

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Abstract

Polyphenols are categorized as plant secondary metabolites, and they have attracted much attention in relation to human health and the prevention of chronic diseases. In recent years, a considerable number of studies have been published concerning their physiological function in the digestive tract, such as their prebiotic properties and their modification of intestinal microbiota. It has also been suggested that several hydrolyzed and/or fission products, derived from the catabolism of polyphenols by intestinal bacteria, exert their physiological functions in target sites after transportation into the body. Thus, this review article focuses on the role of intestinal microbiota in the bioavailability and physiological function of dietary polyphenols. Monomeric polyphenols, such as flavonoids and oligomeric polyphenols, such as proanthocyanidins, are usually catabolized to chain fission products by intestinal bacteria in the colon. Gallic acid and ellagic acid derived from the hydrolysis of gallotannin, and ellagitannin are also subjected to intestinal catabolism. These catabolites may play a large role in the physiological functions of dietary polyphenols. They may also affect the microbiome, resulting in health promotion by the activation of short chain fatty acids (SCFA) excretion and intestinal immune function. The intestinal microbiota is a key factor in mediating the physiological functions of dietary polyphenols.

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Authors: Kawabata, K., Yoshioka, Y., & Terao, J.
Affiliations: Konan Women's University (JP)
Corresponding author: Terao, Junji
ORCID: Kawabata, Kyuichi
Yoshioka, Yasukiyo
Terao, Junji
Venue: Molecules
Publisher: MDPI AG
Published: 2019-01-21
Volume: 24
Issue: 2
Pages: 370
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules24020370
PMC: PMC6359708
OpenAlex: W2909540292
Cited by: 563
References: 171
Citations by year: 2026: 36 · 2025: 63 · 2024: 61 · 2023: 82 · 2022: 103 · 2021: 105 · 2020: 82 · 2019: 31
FWCI: 7.74
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Japan Society for the Promotion of Science (16K00815)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: gut microbiota, dietary polyphenols, polyphenol bioavailability, prebiotic properties, flavonoids, proanthocyanidins, gallotannins, ellagitannins, gallic acid, ellagic acid, short-chain fatty acids, intestinal immunity, chronic disease prevention
MeSH terms: Gastrointestinal Microbiome, Animals, Biological Availability, Energy Metabolism, Humans, Hydrolysis, Intestinal Mucosa, Research, Dietary Supplements, Gastrointestinal Tract, Prebiotics, Polyphenols, Gastrointestinal Absorption

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Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

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