Cited by 95Advanced Sensor and Energy Harvesting MaterialsElectrochemical sensors and biosensorsNon-Invasive Vital Sign Monitoring

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

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Pillai, Sangeeth, Upadhyay, Akshaya, Sayson, Darren, Nguyen, Bich Hong, Tran, Simon D.·2021·Molecules

Abstract

In the past decade, wearable biosensors have radically changed our outlook on contemporary medical healthcare monitoring systems. These smart, multiplexed devices allow us to quantify dynamic biological signals in real time through highly sensitive, miniaturized sensing platforms, thereby decentralizing the concept of regular clinical check-ups and diagnosis towards more versatile, remote, and personalized healthcare monitoring. This paradigm shift in healthcare delivery can be attributed to the development of nanomaterials and improvements made to non-invasive biosignal detection systems alongside integrated approaches for multifaceted data acquisition and interpretation. The discovery of new biomarkers and the use of bioaffinity recognition elements like aptamers and peptide arrays combined with the use of newly developed, flexible, and conductive materials that interact with skin surfaces has led to the widespread application of biosensors in the biomedical field. This review focuses on the recent advances made in wearable technology for remote healthcare monitoring. It classifies their development and application in terms of electrochemical, mechanical, and optical modes of transduction and type of material used and discusses the shortcomings accompanying their large-scale fabrication and commercialization. A brief note on the most widely used materials and their improvements in wearable sensor development is outlined along with instructions for the future of medical wearables.

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Crossref · 10.3390/molecules27010165

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  • Optical transduction mechanisms in wearable biosensors face challenges of interference from ambient light and motion artifacts, which affect measurement accuracy and require advanced signal processing algorithms and motion compensation techniques.

    “The significant challenges are interference from ambient light and motion artifacts, which affect measurement accuracy and require advanced signal processing algorithms and motion compensation techniques [180].”

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Authors
Pillai, S., Upadhyay, A., Sayson, D., Nguyen, B. H., & Tran, S. D.
Affiliations
  • McGill University (CA)
  • Centre Hospitalier Universitaire Sainte-Justine (CA)
Corresponding author
Tran, Simon D.
Venue
Molecules
Publisher
MDPI AG
Published
2021-12-28
Volume
27
Issue
1
Pages
165
ISSN
1420-3049 (ISSN-L)
OpenAlex
W4200343235
Cited by
95
References
175
Citations by year
2026: 19 · 2025: 25 · 2024: 24 · 2023: 19 · 2022: 8
FWCI
1.08
Type
journal article
Language
en
Open access
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
Keywords
wearable biosensors, remote patient monitoring, nanomaterials, flexible conductive materials, electrochemical sensor, optical sensors, mechanical sensors, aptamers, peptide arrays, sensor fabrication, personalized healthcare, biomarkers
MeSH terms
Wearable Electronic Devices, Biocompatible Materials, Equipment Design, Humans, Monitoring, Physiologic, Biosensing Techniques, Electrochemical Techniques

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