The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review
Open accessAbstract
Astaxanthin, a xanthophyll carotenoid, is a secondary metabolite naturally synthesized by a number of bacteria, microalgae, and yeasts. The commercial production of this pigment has traditionally been performed by chemical synthesis, but the microalga Haematococcus pluvialis appears to be the most promising source for its industrial biological production. Due to its collective diverse functions in skin biology, there is mounting evidence that astaxanthin possesses various health benefits and important nutraceutical applications in the field of dermatology. Although still debated, a range of potential mechanisms through which astaxanthin might exert its benefits on skin homeostasis have been proposed, including photoprotective, antioxidant, and anti-inflammatory effects. This review summarizes the available data on the functional role of astaxanthin in skin physiology, outlines potential mechanisms involved in the response to astaxanthin, and highlights the potential clinical implications associated with its consumption.
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In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
Experimental — accuracy not yet measuredIn the citing paper
“Oral administration of astaxanthin is protective against UV-induced skin deterioration and is helpful to maintain healthy skin.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [96]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
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Citations
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Metadata
- Authors
- Davinelli, S., Nielsen, M. E., & Scapagnini, G.
- Affiliations
- University of Molise (IT)
- FB Dermatology, Borupvang 5C, 2750 Ballerup, Denmark
- Corresponding author
- Davinelli, Sergio
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-04-22
- Volume
- 10
- Issue
- 4
- Pages
- 522
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5946307
- OpenAlex
- W2802266362
- Cited by
- 473
- References
- 84
- Citations by year
- 2026: 38 · 2025: 63 · 2024: 57 · 2023: 66 · 2022: 66 · 2021: 96 · 2020: 56 · 2019: 26 · 2018: 5
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- astaxanthin, xanthophyll carotenoids, skin health, skin repair, Haematococcus pluvialis, microalgae cultivation, nutraceuticals, photoprotection, antioxidant activity, anti-inflammatory activity, skin homeostasis, dietary supplementation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Biological Availability, DNA Damage, DNA Repair, Humans, Skin, Skin Aging, Dietary Supplements, Xanthophylls
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