Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works

Role of nrf2 in oxidative stress and toxicity

Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works

Efficacy of a New Tonic Containing Urea, Lactate, Polidocanol, and Glycyrrhiza inflata Root Extract in the Treatment of a Dry, Itchy, and Subclinically Inflamed Scalp

Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A. W., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,348 · see citing works

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative

Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264 · see citing works

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., & Ohtsuki, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060868 · Cited by 1,099 · see citing works

Hyaluronic acid: A key molecule in skin aging

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031 · see citing works

UV-light-induced signal cascades and skin aging

Rittié, L. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00024-7 · Cited by 987 · see citing works

Intrinsic and extrinsic factors in skin ageing: a review

Farage, M. A., Miller, K. W., Elsner, P., & Maibach, H. I. (2008) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2007.00415.x · Cited by 950 · see citing works

Photoageing: mechanism, prevention and therapy

Yaar, M., & Gilchrest, B. A. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08108.x · Cited by 755 · see citing works

Matrix-Degrading Metalloproteinases in Photoaging

Quan, T., Qin, Z., Xia, W., Shao, Y., Voorhees, J. J., & Fisher, G. J. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.8 · Cited by 740 · see citing works

Natural and Sun-Induced Aging of Human Skin

Rittie, L., & Fisher, G. J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015370 · Cited by 600 · see citing works

Collagen: A review on its sources and potential cosmetic applications

Rodríguez, M. I. A., Barroso, L. G. R., & Sánchez, M. L. (2017) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12450 · Cited by 593 · see citing works

The six hyaluronidase-like genes in the human and mouse genomes

Csoka, A. B., Frost, G. I., & Stern, R. (2001) · Matrix Biology · doi:10.1016/s0945-053x(01)00172-x · Cited by 590 · see citing works

One remarkable molecule: filaggrin

Brown, S. J., & Irwin McLean, W. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.393 · Cited by 527 · see citing works

The Proteins Elafin, Filaggrin, Keratin Intermediate Filaments, Loricrin, and Small Proline-rich Proteins 1 and 2 Are Isodipeptide Cross-linked Components of the Human Epidermal Cornified Cell Envelope

Steinert, P. M., & Marekov, L. N. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17702 · Cited by 519 · see citing works

Mammalian Hyaluronan Synthases

Itano, N., & Kimata, K. (2002) · IUBMB Life · doi:10.1080/15216540214929 · Cited by 428 · see citing works

Function and regulation of AP-1 subunits in skin physiology and pathology

Angel, P. E., Szabowski, A., & Schorpp‐Kistner, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204380 · Cited by 409 · see citing works

Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals

Bosch, R., Philips, N., Suárez-Pérez, J., Juarranz, A., Devmurari, A., Chalensouk-Khaosaat, J., & González, S. (2015) · Antioxidants · doi:10.3390/antiox4020248 · Cited by 407 · see citing works

Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema

Menzinger, S., Kaya, A., Saurat, J. ‐., & Kaya, G. (2016) · Dermatopathology · doi:10.1159/000446699 · Cited by 398 · see citing works

Stratum Corneum Moisturization at the Molecular Level: An Update in Relation to the Dry Skin Cycle

Rawlings, A. V., & Matts, P. J. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2005.23726.x · Cited by 360 · see citing works

Matrix Metalloproteinase-1 is the Major Collagenolytic Enzyme Responsible for Collagen Damage in UV-irradiated Human Skin¶

Brennan, M. M., Bhatti, H., Nerusu, K. C., Bhagavathula, N., Kang, S., Fisher, G. J., Varani, J., & Voorhees, J. J. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0780043mmitmc2.0.co2 · Cited by 358 · see citing works

Solar UV radiation reduces the barrier function of human skin

Biniek, K., Levi, K., & Dauskardt, R. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206851109 · Cited by 324 · see citing works

Plant extracts and natural compounds used against UVB-induced photoaging

Cavinato, M., Waltenberger, B., Baraldo, G., Grade, C. V. C., Stuppner, H., & Jansen-Dürr, P. (2017) · Biogerontology · doi:10.1007/s10522-017-9715-7 · Cited by 218 · see citing works

Elevated Matrix Metalloproteinases and Collagen Fragmentation in Photodamaged Human Skin: Impact of Altered Extracellular Matrix Microenvironment on Dermal Fibroblast Function

Quan, T., Little, E., Quan, H., Qin, Z., Voorhees, J. J., & Fisher, G. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.509 · Cited by 202 · see citing works

In vitro anti-inflammatory and skin protective properties of Virgin coconut oil

Varma, S. R., Sivaprakasam, T. O., Arumugam, I., Dilip, N., Raghuraman, M., Pavan, K. B., Rafiq, M., & Paramesh, R. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2017.06.012 · Cited by 182 · see citing works

The significance of Nrf2 pathway in (photo)–oxidative stress response in melanocytes and keratinocytes of the human epidermis

Marrot, L., Jones, C., Perez, P., & Meunier, J. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2007.00424.x · Cited by 164 · see citing works

Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds.

Nozawa, K., Yamada, M., Tsuda, Y., Kawai, K., & Nakajima, S. (1981) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.29.2689 · Cited by 158 · see citing works

Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice

Hwang, E., Park, S., Lee, H. J., Lee, T. Y., Sun, Z., & Yi, T. (2014) · Phytotherapy Research · doi:10.1002/ptr.5198 · Cited by 148 · see citing works

Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway

Kim, H., Kang, C., Jayasooriya, R. G. P. T., Dilshara, M. G., Lee, S., Choi, Y. H., Seo, Y. T., & Kim, G. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.03.022 · Cited by 136 · see citing works

Aquaporin‐3 functions as a glycerol transporter in mammalian skin

Hara‐Chikuma, M., & Verkman, A. S. (2005) · Biology of the Cell · doi:10.1042/bc20040104 · Cited by 136 · see citing works

The role of near infrared radiation in photoaging of the skin

Schröeder, P., Haendeler, J., & Krutmann, J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.010 · Cited by 132 · see citing works

New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium)

Zhang, H., Matsuda, H., Kumahara, A., Ito, Y., Nakamura, S., & Yoshikawa, M. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.06.027 · Cited by 123 · see citing works

Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells

Ji, C., Cao, C., Lü, S., Kivlin, R., Amaral, A., KOUTTAB, N. M., Yang, H., Chu, W., Zhi-gang, B., Di, W. J., et al. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0674-6 · Cited by 115 · see citing works

All‐trans retinoic acid attenuates ultraviolet radiation‐induced down‐regulation of aquaporin‐3 and water permeability in human keratinocytes

Cao, C., Wan, S., Jiang, Q. L., Amaral, A., Lü, S., Hu, G., Zhi-gang, B., KOUTTAB, N. M., Chu, W., & Wan, Y. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21336 · Cited by 108 · see citing works

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

Tao, S., Justiniano, R., Zhang, D. D., & Wondrak, G. T. (2013) · Redox Biology · doi:10.1016/j.redox.2013.10.004 · Cited by 103 · see citing works

Skin Aquaporins: Function in Hydration, Wound Healing, and Skin Epidermis Homeostasis

Boury-Jamot, M., Daraspe, J., Bonté, F., Perrier, É., Schnebert, S., Dumas, M., & Verbavatz, J. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-79885-9_10 · Cited by 96 · see citing works

Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis

Kang, M. C., Yumnam, S., & Kim, S. Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113551 · Cited by 87 · see citing works

Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3

Strong, C. D. G., Wertz, P. W., Wang, C., Yang, F., Meltzer, P. S., Andl, T., Millar, S. E., Ho, I., Pai, S., & Segre, J. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605057 · Cited by 84 · see citing works

<i>Lycium barbarum</i> polysaccharide protects human keratinocytes against UVB-induced photo-damage

Li, H., Li, Z., Peng, L., Jiang, N., Liu, Q., Zhang, E., Liang, B., Li, R., & Zhu, H. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1294755 · Cited by 79 · see citing works

Targeting NRF2 for improved skin barrier function and photoprotection: focus on the achiote-derived apocarotenoid bixin

Rojo de la Vega, M., Krajisnik, A., Zhang, D., & Wondrak, G. (2017) · Nutrients · doi:10.3390/nu9121371 · Cited by 77 · see citing works

Ultraviolet B induces hyperproliferation and modification of epidermal differentiation in normal human skin grafted on to nude mice

Bino, S. D., Vioux, C., Rossio-Pasquier, P., Jomard, A., Démarchez, M., Asselineau, D., & Bernerd, F. (2004) · British Journal of Dermatology · doi:10.1111/j.0007-0963.2004.05886.x · Cited by 75 · see citing works

Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1

Zhao, P., Alam, M. B., & Lee, S. (2018) · Nutrients · doi:10.3390/nu11010060 · Cited by 71 · see citing works

P38/ERK MAPK signaling pathways are involved in the regulation of filaggrin and involucrin by IL-17

Tan, Q., Yang, H., Liu, E., & Wang, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7689 · Cited by 70 · see citing works

Zerumbone protects human skin keratinocytes against UVA-irradiated damages through Nrf2 induction

Yang, H., Lee, C.-L., Korivi, M., Liao, J., Rajendran, P., Wu, J., & Hseu, Y. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.014 · Cited by 64 · see citing works

Chemical Constituents from Leaves of Hydrangea serrata and Their Anti-photoaging Effects on UVB-Irradiated Human Fibroblasts

Shin, J., Han, H.-S., Lee, S.-B., Myung, D.-B., Lee, K., Lee, S. H., Kim, H. J., & Lee, K. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00742 · Cited by 56 · see citing works

Inhibitory Effects of Hydrangenol Derivatives on the Activation of Hyaluronidase and their Antiallergic Activities

Kakegawa, H., Matsumoto, H., & Satoh, T. (1988) · Planta Medica · doi:10.1055/s-2006-962477 · Cited by 55 · see citing works

Topical bixin confers NRF2-dependent protection against photodamage and hair graying in mouse skin

Rojo de la Vega, M., Zhang, D. D., & Wondrak, G. T. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00287 · Cited by 55 · see citing works

Effects of pre- and post-treatment with plant polyphenols on human keratinocyte responses to solar UV

Potapovich, A. I., Kostyuk, V. A., Kostyuk, T. V., Luca, C. D., & Korkina, L. G. (2013) · Inflammation Research · doi:10.1007/s00011-013-0634-z · Cited by 53 · see citing works

Reversine inhibits MMP ‐1 and MMP ‐3 expressions by suppressing of ROS / MAPK / AP ‐1 activation in UV ‐stimulated human keratinocytes and dermal fibroblasts

Kim, J., Kim, S. Y., Noh, E., Song, H., Lee, G., Kwon, K., & Lee, Y. (2018) · Experimental Dermatology · doi:10.1111/exd.13494 · Cited by 51 · see citing works

Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy

Hung, C., Chen, W.-Y., Aljuffali, I. A., Lin, Y.-K., Shih, H.-C., & Fang, J. Y. (2015) · AGE · doi:10.1007/s11357-015-9757-1 · Cited by 45 · see citing works

GATA3 regulates FLG and FLG2 expression in human primary keratinocytes

Zeitvogel, J., Jokmin, N., Rieker, S., Klug, I., Brandenberger, C., & Werfel, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-10252-x · Cited by 44 · see citing works

The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols

Zykova, T. A. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh334 · Cited by 42 · see citing works

Ginsenoside Rg1 attenuates ultraviolet B-induced glucocortisides resistance in keratinocytes via Nrf2/HDAC2 signalling

Li, J., Liu, D., Wu, J., Zhang, D., Cheng, B., Zhang, Y., Yin, Z., Wang, Y., Du, J., & Ling, C. (2016) · Scientific Reports · doi:10.1038/srep39336 · Cited by 41 · see citing works

Ultraviolet‐B Irradiation Induces Differential Regulations of Hyaluronidase Expression and Activity in Normal Human Keratinocytes

Kurdykowski, S., Mine, S., Bardey, V., Danoux, L., Jeanmaire, C., Pauly, G., Brabencová, E., Wegrowski, Y., & Maquart, F. X. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.00959.x · Cited by 34 · see citing works

Native hyaluronic acid in dermatology – results of an expert meeting

Wiest, L., & Kerscher, M. J. (2008) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2008.06639.x · Cited by 33 · see citing works

Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes

Chang, T., Tsen, J., Yen, H., Yang, T.-Y., & Huang, H. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/8325049 · Cited by 30 · see citing works

Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling

Ji, C., Huang, J., Xu, Q., Zhang, J., Lin, M., Tu, Y., He, L., Zhi-gang, B., & Cheng, B. (2016) · Oncotarget · doi:10.18632/oncotarget.12454 · Cited by 29 · see citing works

GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis

Masse, I., Barbollat‐Boutrand, L., Kharbili, M. E., Berthier‐Vergnes, O., Aubert, D., & Lamartine, J. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1435-5 · Cited by 27 · see citing works

Hydrangenol suppresses VEGF-stimulated angiogenesis by targeting p27KIP1-dependent G1-cell cycle arrest, VEGFR-2-mediated signaling, and MMP-2 expression

Gho, Y., Shin, S., Choi, Y. H., Ko, K., Kim, W., & Moon, S. (2019) · Animal Cells and Systems · doi:10.1080/19768354.2019.1578262 · Cited by 24 · see citing works

Pyrimidine Dimer Formation and Oxidative Damage in M13 Bacteriophage Inactivation by Ultraviolet C Irradiation¶

Kurosaki, Y., Abe, H., Morioka, H., Hirayama, J., Ikebuchi, K., Kamo, N., Nikaido, O., Azuma, H., & Ikeda, H. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)078 · Cited by 18 · see citing works

Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3

Son, D. N., Li, L., Katsuyama, H., Komatsu, N., Saito, M., Tanii, H., & Saijoh, K. (2009) · Gene · doi:10.1016/j.gene.2009.02.002 · Cited by 14 · see citing works

EPA attenuates ultraviolet radiation-induced downregulation of aquaporin-3 in human keratinocytes

Jeon, B., Kang, M., Lee, G.-T., Lee, K.-K., Lee, H.-S., Woo, W.-H., & Mun, Y. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0482-6 · Cited by 11 · see citing works

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Hassanein, E. H. M., Sayed, A. M. M., Hussein, O. E., & Mahmoud, A. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1675957 · Cited by 257 · see citing works

Boosting the Photoaged Skin: The Potential Role of Dietary Components

Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works

Natural polyphenols: a promising bioactive compounds for skin care and cosmetics

Bharadvaja, N., Gautam, S., & Singh, H. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08156-9 · Cited by 92 · see citing works

Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes

Li, Z., Jiang, R., Wang, M., Zhai, L., Liu, J., Xu, X., Sun, L., & Zhao, D. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.05.001 · Cited by 80 · see citing works

Antioxidant activity and inhibition of ultraviolet radiation-induced skin damage of Selenium-rich peptide fraction from selenium-rich yeast protein hydrolysate

Guo, H., Guo, S., & Liu, H. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104431 · Cited by 64 · see citing works

Eisenia bicyclis Extract Repairs UVB-Induced Skin Photoaging In Vitro and In Vivo: Photoprotective Effects

Choi, S.-I., Han, H.-S., Kim, J., Park, G., Jang, Y. P., Shin, Y., Ahn, H.-S., Lee, S. H., & Lee, K. (2021) · Marine Drugs · doi:10.3390/md19120693 · Cited by 62 · see citing works

Current trends in the anti-photoaging activities and mechanisms of dietary non-starch polysaccharides from natural resources

Yao, W., Chen, X., Li, X., Chang, S., Zhao, M., & You, L. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1939263 · Cited by 46 · see citing works

Discovery of matrix metalloproteinase inhibitors as anti-skin photoaging agents

Li, F., Zhi, J., Zhao, R., Sun, Y., Wen, H., Cai, H., Chen, W., Jiang, X., & Bai, R. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116152 · Cited by 46 · see citing works

Immune-enhancing activity of Hydrangea macrophylla subsp. serrata leaves through TLR4/ROS-dependent activation of JNK and NF-κB in RAW264.7 cells and immunosuppressed mice

Geum, N. G., Eo, H. J., Kim, H. J., Park, G. H., Son, H.-J., & Jeong, J. B. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104139 · Cited by 45 · see citing works

Kaempferide Prevents Photoaging of Ultraviolet-B Irradiated NIH-3T3 Cells and Mouse Skin via Regulating the Reactive Oxygen Species-Mediated Signalings

Choi, J., Kwon, O.-Y., & Lee, S. H. (2022) · Antioxidants · doi:10.3390/antiox12010011 · Cited by 37 · see citing works

Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway

Liu, T., Zhu, S., Yang, Y., Qin, W., Wang, Z., Zhao, Z., Liu, T., Wang, X., Duan, T., Liu, Y., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116110 · Cited by 33 · see citing works

Protective effect of oligosaccharides isolated from Panax ginseng C. A. Meyer against UVB-induced skin barrier damage in BALB/c hairless mice and human keratinocytes

Li, Z., Jiang, R., Jing, C., Liu, J., Xu, X., Sun, L., & Zhao, D. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114677 · Cited by 33 · see citing works

Chromium/Photoredox Dual Catalyzed Synthesis of α‐Benzylic Alcohols, Isochromanones, 1,2‐Oxy Alcohols and 1,2‐Thio Alcohols

Dutta, S., Erchinger, J. E., Schäfers, F., Das, A., Daniliuc, C. G., & Glorius, F. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202212136 · Cited by 29 · see citing works

Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Myung, D.-B., Lee, J.-H., Han, H.-S., Lee, K.-Y., Ahn, H. S., Ahn, H. S., Song, E., Kim, B.-H., Lee, K. H., Lee, K. H., et al. (2020) · Nutrients · doi:10.3390/nu12061588 · Cited by 29 · see citing works

Corylin from Psoralea fructus ( Psoralea corylifolia L.) protects against UV ‐induced skin aging by activating Nrf2 defense mechanisms

Li, N., Liu, T., Zhu, S., Yang, Y. A., Wang, Z., Zhao, Z., Liu, T., Wang, X., Qin, W., Yan, Y., et al. (2022) · Phytotherapy Research · doi:10.1002/ptr.7501 · Cited by 28 · see citing works

Standardized hot water extract from the leaves of Hydrangea serrata (Thunb.) Ser. alleviates obesity via the AMPK pathway and modulation of the gut microbiota composition in high fat diet-induced obese mice

Han, H.-S., Lee, H.-H., Gil, H.-S., Chung, K., Kim, J.-K., Kim, D., Yoon, J., Chung, E. K., Lee, J. K., Yang, W. M., et al. (2021) · Food & Function · doi:10.1039/d0fo02185g · Cited by 25 · see citing works

Dieckol Isolated from Eisenia bicyclis Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice

Kim, J.-M., Chung, K., Yoon, Y., Jang, S.-Y., Heo, S.-W., Park, G., Jang, Y. P., Ahn, H.-S., Shin, Y., Lee, S.-H., et al. (2022) · Marine Drugs · doi:10.3390/md20120779 · Cited by 24 · see citing works

The Protective Effect of Adenocaulon himalaicum Edgew. and Its Bioactive Compound Neochlorogenic Acid against UVB-Induced Skin Damage in Human Dermal Fibroblasts and Epidermal Keratinocytes

Ahn, H. S., Kim, H. J., Na, C., Jang, D. S., Shin, Y., & Lee, S. H. (2021) · Plants · doi:10.3390/plants10081669 · Cited by 24 · see citing works

The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth

Wei, K., Guo, C., Zhu, J., Wei, Y., Wu, M., Huang, X., Zhang, M., Li, J., Wang, X., Wang, Y., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.837168 · Cited by 23 · see citing works

Premna microphylla Turcz pectin protected UVB-induced skin aging in BALB/c-nu mice via Nrf2 pathway

Chen, Y., Liu, X., Lei, X., Lei, L., Zhao, J., Zeng, K., & Ming, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.06.076 · Cited by 23 · see citing works

The Natural Defense: Anti-Aging Potential of Plant-Derived Substances and Technological Solutions Against Photoaging

Nowak-Perlak, M., Olszowy, M., & Woźniak, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168061 · Cited by 22 · see citing works

Are TRPA1 and TRPV1 channel-mediated signalling cascades involved in UVB radiation-induced sunburn?

Camponogara, C., & Oliveira, S. M. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.103836 · Cited by 20 · see citing works

Beneficial Effect of Gastrodia elata Blume and Poria cocos Wolf Administration on Acute UVB Irradiation by Alleviating Inflammation through Promoting the Gut-Skin Axis

Zhang, T., Huang, S., Qiu, J., Wu, X., Yuan, H., & Park, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810833 · Cited by 17 · see citing works

Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action

Żynda, W., Ruczaj, A., & Galicka, A. (2025) · Antioxidants · doi:10.3390/antiox14040389 · Cited by 16 · see citing works

Molecular targets of exercise mimetics and their natural activators

Jang, Y. J., & Byun, S. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.12.151 · Cited by 16 · see citing works

Maternal supplementation with konjac glucomannan and κ-carrageenan promotes sow performance and benefits the gut barrier in offspring

Gao, F., Du, Y., Liu, H., Ding, H., Zhang, W., Li, Z., & Shi, B. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.05.011 · Cited by 13 · see citing works

Hydrangea serrata Hot Water Extract and Its Major Ingredient Hydrangenol Improve Skin Moisturization and Wrinkle Conditions via AP-1 and Akt/PI3K Pathway Upregulation

Yoon, J. H., Park, S. H., Yoon, S. E., Hong, S. Y., Lee, J. B., Lee, J., & Cho, J. Y. (2023) · Nutrients · doi:10.3390/nu15112436 · Cited by 12 · see citing works

Effect of Standardized Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat Reduction in Overweight or Obese Humans: A Randomized Double-Blind Placebo-Controlled Study

Han, H.-S., Chung, K., Shin, Y., Yu, J.-S., Kang, S., Lee, S.-H., & Lee, K. (2022) · Nutrients · doi:10.3390/nu14010208 · Cited by 11 · see citing works

LncRNA PVT1 delays skin photoaging by sequestering miR-551b-3p to release AQP3 expression via ceRNA mechanism

Tang, H., Xiong, Q., Yin, M., Feng, H., Yao, F., Xiao, X., Hu, F., & Liao, Y. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01834-4 · Cited by 11 · see citing works

Protective effect of Schizonepeta tenuifolia Briq. ethanolic extract against UVB-induced skin aging and photodamage in hairless mice

Gu, M. J., Lee, H.-W., Yoo, G., Kim, D., Choi, I., Kim, Y., & Ha, S. K. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1176073 · Cited by 11 · see citing works

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Jang, S.-Y., Kim, S., Song, H.-A., Kim, H., Chung, K., Lee, J. K., & Lee, K. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111083 · Cited by 11 · see citing works

Preventive and Therapeutic Benefits of Natural Ingredients in Photo-Induced Epidermal Dysfunction

Lei, D., Ye, L., Wen, S., Zhang, J., Zhang, L., & Man, M. (2024) · Skin Pharmacology and Physiology · doi:10.1159/000538832 · Cited by 9 · see citing works

Inhibitory Effect of Coumarins and Isocoumarins Isolated from the Stems and Branches of Acer mono Maxim. against Escherichia coli β-Glucuronidase

Phong, N. V., Min, B. S., Yang, S. Y., & Kim, J. A. (2022) · Applied Sciences · doi:10.3390/app122010685 · Cited by 9 · see citing works

Panax ginseng C. A. Meyer Phenolic Acid Extract Alleviates Ultraviolet B-Irradiation-Induced Photoaging in a Hairless Mouse Skin Photodamage Model

Li, Z., Jiang, R., Liu, J., Xu, X., Sun, L., & Zhao, D. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9962007 · Cited by 7 · see citing works

Anti-inflammatory Effects of Myrrh Ethanol Extract on Particulate Matter-induced Skin Injury

Jung, Y. H., Roh, Y. W., & Chong, M.-S. (2022) · 대한한의학회지 · doi:10.13048/jkm.22026 · Cited by 6 · see citing works

Phytochemical constituents of Hydrangea macrophylla var. acuminata leaves and their inhibitory activity against PTP1B and α-glucosidase

Pham, T. L., Phong, N. V., Nguyen, T. T. A., Min, B. S., & Kim, J. A. (2025) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2025.2584940 · Cited by 5 · see citing works

Skincare Benefits of a Postbiotic Ferment Produced Through Djon Djon Mushroom Fermentation by Saccharomyces

Pu, C., Shi, D., Ingrassia, M., Gedeon, H., Chu, T., Zhang, J., & Wang, C. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70067 · Cited by 5 · see citing works

18β-Glycyrrhetinic acid reduces skin damage from UVB exposure by inhibiting the MyD88/MAPK signaling pathway

Xie, Y., Liu, A., Zhang, C., Chen, H., Chen, W., Chen, M. Q., Lu, W., Zeng, X., Mei, M., & Zhu, W. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116212 · Cited by 3 · see citing works

In Vitro Evidence for Inhibitory Action of Hydrangea serrata (Thunb.) Ser. Leaf Extract on Urate Crystal-Induced inflammation

Na, C., Kim, H., Ahn, H. S., Shin, Y., & Lee, S. H. (2021) · Food Supplements and Biomaterials for Health · doi:10.52361/fsbh.2021.1.e27 · Cited by 3 · see citing works

Melatonin-mediated intestinal microbiota homeostasis improves skin barrier damage involvement of gut-skin axis dysfunction in aging mice

Quan, T., Zhang, W., Shi, Y., & Gao, T. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111859 · Cited by 3 · see citing works

Qualitative and quantitative analyses in sulfated glycosaminoglycans, chondroitin sulfate/dermatan sulfate, during 3T3‐L1 adipocytes differentiation

Cahyadi, D. D., Warita, K., Takeda‐Okuda, N., Tamura, J., & Hosaka, Y. Z. (2023) · Animal Science Journal · doi:10.1111/asj.13894 · Cited by 3 · see citing works

In vitro and in vivo anti-inflammatory and antinociceptive activities of a synthetic hydrangenol derivative: 5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Yoo, H., Yoon, Y., Shin, J.-W., Choi, S.-I., Son, S. H., Jang, Y. H., Yang, Y., Kim, S., Kim, Y.-R., Chung, K., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114175 · Cited by 3 · see citing works

VIS-NIR Modeling of Hydrangenol and Phyllodulcin Contents in Tea-Hortensia (Hydrangea macrophylla subsp. serrata)

Moll, M. D., Kahlert, L., Gross, E., Schwarze, E.-C., Blings, M., Hillebrand, S., Ley, J. P., Kraska, T., & Pude, R. (2022) · Horticulturae · doi:10.3390/horticulturae8030264 · Cited by 3 · see citing works

Actinidia chinensis Planch Ameliorates Photoaging in UVB-Irradiated NIH-3T3 Cells and SKH-1 Hairless Mice by Controlling the Reactive Oxygen Species/AKT Pathway

Jung, J. M., Kim, S.-Y., Kwon, O.-Y., & Lee, S. H. (2024) · Antioxidants · doi:10.3390/antiox13091091 · Cited by 2 · see citing works

Hair Growth-Promoting Effect of Hydrangea serrata (Thunb.) Ser. Extract and Its Active Component Hydrangenol: In Vitro and In Vivo Study

Park, S., Kim, H., Ahn, H. S., Na, C., & Shin, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910370 · Cited by 2 · see citing works

Improved Anti-Atopic Dermatitis Effect of H. macrophylla through the Generation of Hydrangenol by Microwave Processing

Kim, Y. S., Ju, H.-N., Choi, P., Kim, T., Park, Y., Lee, D., & Ham, J. (2021) · Records of Natural Products · doi:10.25135/rnp.298.21.10.2250 · Cited by 1 · see citing works

Amacha, a Japanese sweet tea, inhibits infection by pseudoviruses expressing the SARS-CoV-2 spike protein

Ohishi, T., Yuki, S., Yoshida, J., Tatsuda, D., Kawada, M., Shiraishi, A., Siddiqi, F., Yadav, A., Baig, M. S., & Yano, A. (2025) · Food Chemistry Advances · doi:10.1016/j.focha.2025.101046 · Cited by 1 · see citing works

Protective Effect of Betula Platyphylla on Ultraviolet B-irradiated HaCaT Keratinocytes

Choi, H. S., Kim, H. J., Lee, H. S., Paik, S., Kim, J. E., & Song, Y. S. (2023) · 대한한의학회지 · doi:10.13048/jkm.23020 · Cited by 1 · see citing works

Chrom/Photoredox‐dualkatalysierte Synthese von α‐benzylischen Alkoholen, Isochromanonen, 1,2‐Oxyalkoholen und 1,2‐Thioalkoholen

Dutta, S., Erchinger, J. E., Schäfers, F., Das, A., Daniliuc, C. G., & Glorius, F. (2022) · Angewandte Chemie · doi:10.1002/ange.202212136

Studi Potensi Senyawa Hidrangenol dan Asam Hidrangeat dari Daun Hydrangea macrophylla sebagai Bahan Utama Aktif Khasiat Jamu Antidiabetes

Paramita, A. P. (2023) · Prosiding Workshop dan Seminar Nasional Farmasi · doi:10.24843/wsnf.2022.v01.i01.p42

Hydrangenol exerts anti-obesity effects by disturbing adipogenesis via mitotic clonal expansion and gut microbiota dysbiosis

Han, H.-S., Chung, K., Kim, Y.-R., Jang, S.-Y., Lee, K., & Lee, K. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110120

Gynostemma pentaphyllum Hydrodistillate and Damulin B Prevent UVB‐Induced Photoaging In Vitro and In Vivo via ROS Suppression and Restoration of MAPK/AP‐1 and TGF‐β/Smad Signaling

Lee, S., Kovale, L. M., Lee, J., Lee, C., Song, H.-A., Lee, K., Choe, W., Kang, I., Kim, S. S., & Ha, J. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70378

Effects of xanthoangelol on chronic ultraviolet B irradiation-induced skin damage and tumorigenesis in hairless mice

Kimura, Y., Sumiyoshi, M., & Taniguchi, M. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100577

수국(Hydrangea serrata)에서 분리된 Hygrangenol의 HCT116 세포 증식 억제에 대한 기전 연구

서, 아., 홍, 다., & 윤, 정. (2025) · 한국식품조리과학회지 · doi:10.9724/kfcs.2025.41.6.405

Construction of epigallocatechin gallate/exosomes co-loaded dual-layer sustained‑release microneedles for alleviating skin photoaging and pigmentation

Lu, X., Zhou, T., Deng, Q., Xu, B., Wu, T., Liang, J., Deng, W., Lai, L., Hu, T., Deng, S., et al. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116815

BindingDB Entry 50021143: Discovery of matrix metalloproteinase inhibitors as anti-skin photoaging agents.

BindingDB (2025) · UC San Diego · doi:10.7270/q2hd818f

Hydrangea serrata (Thunb.) Ser. Extract Attenuate UVB-Induced Photoaging through MAPK/AP-1 Inactivation in Human Skin Fibroblasts and Hairless Mice

Han, H.-S., Shin, J., Myung, D.-B., Ahn, H. S., Lee, S. H., Kim, H. J., & Lee, K. (2019) · Nutrients · doi:10.3390/nu11030533 · Cited by 60 · see citing works

Chemical Constituents from Leaves of Hydrangea serrata and Their Anti-photoaging Effects on UVB-Irradiated Human Fibroblasts

Shin, J., Han, H.-S., Lee, S.-B., Myung, D.-B., Lee, K., Lee, S. H., Kim, H. J., & Lee, K. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00742 · Cited by 56 · see citing works

Hydrangea serrata Hot Water Extract and Its Major Ingredient Hydrangenol Improve Skin Moisturization and Wrinkle Conditions via AP-1 and Akt/PI3K Pathway Upregulation

Yoon, J. H., Park, S. H., Yoon, S. E., Hong, S. Y., Lee, J. B., Lee, J., & Cho, J. Y. (2023) · Nutrients · doi:10.3390/nu15112436 · Cited by 12 · see citing works

Skin Hydration Effects of Scale‐Up Fermented Cyclopia intermedia against Ultraviolet B‐Induced Damage in Keratinocyte Cells and Hairless Mice

Im, A., Yeon, S. H., Ji, K.-Y., Son, R. H., Um, K. A., & Chae, S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/3121936 · Cited by 13 · see citing works

Oral administration of oyster (Crassostrea gigas) hydrolysates protects against wrinkle formation by regulating the MAPK pathway in UVB-irradiated hairless mice

Han, J.-H., Bang, J. S., Choi, Y. J., & Choung, S. (2019) · Photochemical & Photobiological Sciences · doi:10.1039/c9pp00036d · Cited by 17 · see citing works