Health Effects of Coffee: Mechanism Unraveled?
Open accessAbstract
The association of habitual coffee consumption with a lower risk of diseases, like type 2 diabetes mellitus, chronic liver disease, certain cancer types, or with reduced all-cause mortality, has been confirmed in prospective cohort studies in many regions of the world. The molecular mechanism is still unresolved. The radical-scavenging and anti-inflammatory activity of coffee constituents is too weak to account for such effects. We argue here that coffee as a plant food has similar beneficial properties to many vegetables and fruits. Recent studies have identified a health promoting mechanism common to coffee, vegetables and fruits, i.e., the activation of an adaptive cellular response characterized by the upregulation of proteins involved in cell protection, notably antioxidant, detoxifying and repair enzymes. Key to this response is the activation of the Nrf2 (Nuclear factor erythroid 2-related factor-2) system by phenolic phytochemicals, which induces the expression of cell defense genes. Coffee plays a dominant role in that regard because it is the major dietary source of phenolic acids and polyphenols in the developed world. A possible supportive action may be the modulation of the gut microbiota by non-digested prebiotic constituents of coffee, but the available data are still scarce. We conclude that coffee employs similar pathways of promoting health as assumed for other vegetables and fruits. Coffee beans may be viewed as healthy vegetable food and a main supplier of dietary phenolic phytochemicals.
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Coffee polyphenols such as caffeoylquinic acids, trigonelline, and N-methylpyridinium lead to upregulation of antioxidant and detoxifying enzymes and downregulation of proinflammatory mediators via activation of nuclear factor erythroid 2-related factor 2.
“The mechanism behind this observation could be explained by the polyphenols contained in coffee such as caffeoylquinic acids, trigonelline and N-methylpyridinium. These lead to the upregulation of antioxidant and detoxifying enzymes and the downregulation of proinflammatory mediators via the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) [20].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [20]
Coffee consumption reduces the risk of several diseases such as diabetes mellitus and non-alcoholic fatty liver disease.
“Furthermore, coffee consumption has been shown to reduce the risk of several diseases such as diabetes mellitus and non-alcoholic fatty liver disease [20].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [20]
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Coffee and Caffeine Consumption for Human Health
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- Authors
- Kolb, H., Kempf, K., & Martin, S.
- Affiliations
- Westdeutsches Diabetes- und GesundheitsZentrum (DE)
- Faculty of Medicine, University of Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany
- Corresponding author
- Kempf, Kerstin
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-06-20
- Volume
- 12
- Issue
- 6
- Pages
- 1842
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7353358
- OpenAlex
- W3036363797
- Cited by
- 105
- References
- 105
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 21 · 2023: 17 · 2022: 20 · 2021: 11 · 2020: 8
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Heinrich-Heine-Universität Düsseldorf
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- coffee consumption, health effects of coffee, Nrf2 signaling, phenolic phytochemicals, polyphenols, phenolic acids, antioxidant enzymes, detoxification enzymes, gut microbiota, prebiotics, fruits and vegetables, type 2 diabetes, chronic liver disease, cancer risk, all-cause mortality
- MeSH terms
- Gastrointestinal Microbiome, Antioxidants, Coffee, Diabetes Mellitus, Type 2, Diet, DNA Damage, Humans, Liver Diseases, Neoplasms, Plant Extracts, Coffea, NF-E2-Related Factor 2, Prebiotics, Polyphenols, Phytochemicals
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