Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 359

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Magnesium in Aging, Health and Diseases

Open access
Barbagallo, Mario, Veronese, Nicola, Dominguez, Ligia J.·2021·Nutrients
DOI 10.3390/nu13020463
Open this paper in CoChat — free account

Abstract

Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer’s disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/nu13020463

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 173

  1. Saris, 2000, Magnesium. An update on physiological, clinical and analytical aspects, Clin. Chim. Acta, 294, 1, 10.1016/S0009-8981(99)00258-2 · DOI · Paper page
  2. Reinhart, 1988, Magnesium metabolism. A review with special reference to the relationship between intracellular content and serum levels, Arch. Intern. Med., 148, 2415, 10.1001/archinte.1988.00380110065013 · DOI
  3. Resnick, 2001, Relation of cellular potassium to other mineral ions in hypertension and diabetes, Hypertension, 38, 709, 10.1161/01.HYP.38.3.709 · DOI
  4. Reddy, 2018, Magnesium Balance and Measurement, Adv. Chronic Kidney Dis., 25, 224, 10.1053/j.ackd.2018.03.002 · DOI
  5. Barbagallo, 2003, Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X, Mol. Asp. Med., 24, 39, 10.1016/S0098-2997(02)00090-0 · DOI · Paper page
  6. Hoenderop, 2015, Magnesium in man: Implications for health and disease, Physiol. Rev., 95, 1, 10.1152/physrev.00012.2014 · DOI · Paper page
  7. Elin, 2010, Assessment of magnesium status for diagnosis and therapy, Magnes. Res., 23, S194
  8. Quamme, 2008, Recent developments in intestinal magnesium absorption, Curr. Opin. Gastroenterol., 24, 230, 10.1097/MOG.0b013e3282f37b59 · DOI
  9. Shils, 1969, Experimental production of magnesium deficiency in man, Ann. N. Y. Acad. Sci., 162, 847, 10.1111/j.1749-6632.1969.tb13014.x · DOI
  10. Quamme, 1997, Renal magnesium handling: New insights in understanding old problems, Kidney Int., 52, 1180, 10.1038/ki.1997.443 · DOI · Paper page
  11. Barbagallo, 2007, Magnesium metabolism in hypertension and type 2 diabetes mellitus, Am. J. Ther., 14, 375, 10.1097/01.mjt.0000209676.91582.46 · DOI
  12. DiNicolantonio, 2018, Subclinical magnesium deficiency: A principal driver of cardiovascular disease and a public health crisis, Open Heart, 5, e000668, 10.1136/openhrt-2017-000668 · DOI · Paper page
  13. Pickering, G., Mazur, A., Trousselard, M., Bienkowski, P., Yaltsewa, N., Amessou, M., Noah, L., and Pouteau, E. (2020). Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients, 12. · DOI
  14. King, 2005, Dietary magnesium and C-reactive protein levels, J. Am. Coll. Nutr., 24, 166, 10.1080/07315724.2005.10719461 · DOI · Paper page
  15. Michalczyk, M.M., Zajac-Gawlak, I., Zajac, A., Pelclova, J., Roczniok, R., and Langfort, J. (2020). Influence of Nutritional Education on the Diet and Nutritional Behaviors of Elderly Women at the University of the Third Age. Int. J. Environ. Res. Public Health, 17. · DOI
  16. Durlach, 1985, Magnesium level in drinking water and cardiovascular risk factor: A hypothesis, Magnesium, 4, 5
  17. Barbagallo, 2010, Magnesium and aging, Curr. Pharm. Des., 16, 832, 10.2174/138161210790883679 · DOI
  18. Russell, 1985, Enrichment and Isolation of Rumen Bacteria That Reduce trans-Aconitic Acid to Tricarballylic Acid, Appl. Environ. Microbiol., 49, 120, 10.1128/aem.49.1.120-126.1985 · DOI
  19. Schwartz, 1988, Effect of tricarballylic acid, a nonmetabolizable rumen fermentation product of trans-aconitic acid, on Mg, Ca and Zn utilization of rats, J. Nutr., 118, 183, 10.1093/jn/118.2.183 · DOI
  20. Cakmak, 2009, Glyphosate reduced seed and leaf concentrations of calcium, manganese, magnesium, and iron in non-glyphosate resistant soybean, Eur. J. Agron., 31, 114, 10.1016/j.eja.2009.07.001 · DOI · Paper page
  21. Griffiths, 2012, A retail market study of organic and conventional potatoes (Solanum tuberosum): Mineral content and nutritional implications, Int. J. Food Sci. Nutr., 63, 393, 10.3109/09637486.2011.629602 · DOI
  22. Oey, 2019, Mitigation Strategies for the Reduction of 2- and 3-MCPD Esters and Glycidyl Esters in the Vegetable Oil Processing Industry, Compr. Rev. Food Sci. Food Saf., 18, 349, 10.1111/1541-4337.12415 · DOI
  23. Galan, 2002, Contribution of mineral waters to dietary calcium and magnesium intake in a French adult population, J. Am. Diet. Assoc., 102, 1658, 10.1016/S0002-8223(02)90353-6 · DOI
  24. Koren, 2017, Seawater desalination and serum magnesium concentrations in Israel, J. Water Health, 15, 296, 10.2166/wh.2016.164 · DOI
  25. Shlezinger, 2016, Desalinated seawater supply and all-cause mortality in hospitalized acute myocardial infarction patients from the Acute Coronary Syndrome Israeli Survey 2002–2013, Int. J. Cardiol., 220, 544, 10.1016/j.ijcard.2016.06.241 · DOI
  26. Yang, 1990, Blood magnesium parameters do not differ with age, J. Am. Coll. Nutr., 9, 308, 10.1080/07315724.1990.10720385 · DOI
  27. Barbagallo, 2000, Cellular ionic alterations with age: Relation to hypertension and diabetes, J. Am. Geriatr. Soc., 48, 1111, 10.1111/j.1532-5415.2000.tb04788.x · DOI
  28. Ford, 2003, Dietary magnesium intake in a national sample of US adults, J. Nutr., 133, 2879, 10.1093/jn/133.9.2879 · DOI · Paper page
  29. Galan, 1997, Dietary magnesium intake in a French adult population, Magnes. Res., 10, 321
  30. Hunt, 2006, Magnesium requirements: New estimations for men and women by cross-sectional statistical analyses of metabolic magnesium balance data, Am. J. Clin. Nutr., 84, 843, 10.1093/ajcn/84.4.843 · DOI
  31. Coudray, 2006, The effect of aging on intestinal absorption and status of calcium, magnesium, zinc, and copper in rats: A stable isotope study, J. Trace Elem. Med. Biol., 20, 73, 10.1016/j.jtemb.2005.10.007 · DOI
  32. Grober, U. (2019). Magnesium and Drugs. Int. J. Mol. Sci., 20. · DOI
  33. Nowacki, 2000, Inflammatory response following acute magnesium deficiency in the rat, Biochim. Biophys. Acta, 1501, 91, 10.1016/S0925-4439(00)00018-1 · DOI · Paper page
  34. Dominguez, L.J., Veronese, N., Guerrero-Romero, F., and Barbagallo, M. (2021). Magnesium in Infectious Diseases in Older People. Nutrients, 13. · DOI
  35. Bussiere, 2003, Increase in complement component C3 is an early response to experimental magnesium deficiency in rats, Life Sci., 73, 499, 10.1016/S0024-3205(03)00291-1 · DOI
  36. Kramer, 2003, Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress, Exp. Biol. Med., 228, 665, 10.1177/153537020322800604 · DOI
  37. Song, 2007, Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women, Am. J. Clin. Nutr., 85, 1068, 10.1093/ajcn/85.4.1068 · DOI
  38. 2011, Severe hypomagnesemia and low-grade inflammation in metabolic syndrome, Magnes. Res., 24, 45, 10.1684/mrh.2011.0281 · DOI
  39. Song, 2005, Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women, Diabetes Care, 28, 1438, 10.2337/diacare.28.6.1438 · DOI · Paper page
  40. Weglicki, 1996, Role of free radicals and substance P in magnesium deficiency, Cardiovasc. Res., 31, 677, 10.1016/S0008-6363(95)00196-4 · DOI
  41. Tohidi, 2011, Intra-erythrocyte magnesium is associated with gamma-glutamyl transferase in obese children and adolescents, Biol. Trace Elem. Res., 143, 835, 10.1007/s12011-010-8949-x · DOI
  42. Weglicki, 1992, Antioxidants and the cardiomyopathy of Mg-deficiency, Am. J. Cardiovasc. Pathol., 4, 210
  43. Barbagallo, 1999, Effects of glutathione on red blood cell intracellular magnesium: Relation to glucose metabolism, Hypertension, 34, 76, 10.1161/01.HYP.34.1.76 · DOI
  44. Cernak, 2000, Alterations in magnesium and oxidative status during chronic emotional stress, Magnes. Res., 13, 29
  45. Barbagallo, 2009, Magnesium homeostasis and aging, Magnes. Res., 22, 235, 10.1684/mrh.2009.0187 · DOI
  46. Tam, 2003, Possible roles of magnesium on the immune system, Eur. J. Clin. Nutr., 57, 1193, 10.1038/sj.ejcn.1601689 · DOI
  47. Schmitz, 2003, Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7, Cell, 114, 191, 10.1016/S0092-8674(03)00556-7 · DOI · Paper page
  48. Nowacki, 1999, Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress, Br. J. Nutr., 81, 405, 10.1017/S0007114599000690 · DOI
  49. Chien, 1999, Fas-induced B cell apoptosis requires an increase in free cytosolic magnesium as an early event, J. Biol. Chem., 274, 7059, 10.1074/jbc.274.11.7059 · DOI
  50. Flink, 1981, Magnesium deficiency. Etiology and clinical spectrum, Acta Med. Scand. Suppl., 647, 125, 10.1111/j.0954-6820.1981.tb02648.x · DOI
  51. Rubin, 2005, Magnesium: The missing element in molecular views of cell proliferation control, Bioessays, 27, 311, 10.1002/bies.20183 · DOI
  52. Blackburn, 2000, Telomere states and cell fates, Nature, 408, 53, 10.1038/35040500 · DOI · Paper page
  53. Sgambato, 1999, Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells, J. Cell. Physiol., 180, 245, 10.1002/(SICI)1097-4652(199908)180:2<245::AID-JCP12>3.0.CO;2-R · DOI
  54. Killilea, 2008, Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts, Proc. Natl. Acad. Sci. USA, 105, 5768, 10.1073/pnas.0712401105 · DOI
  55. Killilea, 2008, A connection between magnesium deficiency and aging: New insights from cellular studies, Magnes. Res., 21, 77
  56. Rowe, 2012, Correcting magnesium deficiencies may prolong life, Clin. Interv. Aging, 7, 51, 10.2147/CIA.S28768 · DOI
  57. Dominguez, L., Veronese, N., and Barbagallo, M. (2020). Magnesium and Hypertension in Old Age. Nutrients, 13. · DOI
  58. Kobayashi, 1957, On geographical relationship between the chemical nature of river water and death rate from apoplexy, Ber. Ohara Inst., 11, 12
  59. Schroeder, 1966, Municipal drinking water and cardiovascular death rates, JAMA, 195, 81, 10.1001/jama.1966.03100020069016 · DOI
  60. Altura, 1981, Magnesium ions and contraction of vascular smooth muscles: Relationship to some vascular diseases, Fed. Proc., 40, 2672
  61. Altura, 1984, Magnesium deficiency and hypertension: Correlation between magnesium-deficient diets and microcirculatory changes in situ, Science, 223, 1315, 10.1126/science.6701524 · DOI · Paper page
  62. Turlapaty, 1980, Magnesium deficiency produces spasms of coronary arteries: Relationship to etiology of sudden death ischemic heart disease, Science, 208, 198, 10.1126/science.7361117 · DOI · Paper page
  63. Iseri, 1984, Magnesium: Nature’s physiologic calcium blocker, Am. Heart J., 108, 188, 10.1016/0002-8703(84)90572-6 · DOI · Paper page
  64. Agus, 1989, Cytosolic magnesium modulates calcium channel activity in mammalian ventricular cells, Am. J. Physiol., 256, C452, 10.1152/ajpcell.1989.256.2.C452 · DOI
  65. Maier, 2004, High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro, Biochim. Biophys. Acta, 1689, 6, 10.1016/j.bbadis.2004.02.004 · DOI
  66. Barbagallo, 2010, Oral magnesium supplementation improves vascular function in elderly diabetic patients, Magnes. Res., 23, 131
  67. Altura, 1991, Cardiovascular risk factors and magnesium: Relationships to atherosclerosis, ischemic heart disease and hypertension, Magnes. Trace Elem., 10, 182
  68. Joffres, 1987, Relationship of magnesium intake and other dietary factors to blood pressure: The Honolulu heart study, Am. J. Clin. Nutr., 45, 469, 10.1093/ajcn/45.2.469 · DOI · Paper page
  69. Petersen, 1977, Serum and erythrocyte magnesium in normal elderly danish people. Relationship to blood pressure and serum lipids, Acta Med. Scand., 201, 31, 10.1111/j.0954-6820.1977.tb15650.x · DOI
  70. Resnick, 1984, Intracellular free magnesium in erythrocytes of essential hypertension: Relation to blood pressure and serum divalent cations, Proc. Natl. Acad. Sci. USA, 81, 6511, 10.1073/pnas.81.20.6511 · DOI
  71. Barbagallo, 1992, Renal divalent cation excretion in secondary hypertension, Clin. Sci., 83, 561, 10.1042/cs0830561 · DOI
  72. Resnick, 1994, Intracellular ionic consequences of dietary salt loading in essential hypertension. Relation to blood pressure and effects of calcium channel blockade, J. Clin. Investig., 94, 1269, 10.1172/JCI117445 · DOI
  73. Blackfan, 1925, Uremia in acute glomerular nephritis: The cause and treatment in children, Med. Surg. J., 193, 617
  74. Chien, 1996, Magnesium sulphate in the treatment of eclampsia and pre-eclampsia: An overview of the evidence from randomised trials, Br. J. Obstet. Gynaecol., 103, 1085, 10.1111/j.1471-0528.1996.tb09587.x · DOI
  75. Winkler, 1942, Intravenous Magnesium Sulfate in the Treatment of Nephritic Convulsions in Adults, J. Clin. Investig., 21, 207, 10.1172/JCI101292 · DOI
  76. Dickinson, 2006, Magnesium supplementation for the management of essential hypertension in adults, Cochrane Database Syst. Rev., 3, CD004640
  77. Dibaba, 2017, The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: A meta-analysis of randomized controlled trials, Am. J. Clin. Nutr., 106, 921, 10.3945/ajcn.117.155291 · DOI
  78. Veronese, 2020, Magnesium and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational and intervention studies, Eur. J. Nutr., 59, 263, 10.1007/s00394-019-01905-w · DOI
  79. Rayssiguier, 1984, Role of magnesium and potassium in the pathogenesis of arteriosclerosis, Magnesium, 3, 226
  80. Randell, 2008, Relationship between serum magnesium values, lipids and anthropometric risk factors, Atherosclerosis, 196, 413, 10.1016/j.atherosclerosis.2006.11.024 · DOI
  81. Corsonello, 2007, Serum magnesium and lipids: More clarity is needed, Atherosclerosis, 192, 233, 10.1016/j.atherosclerosis.2007.02.014 · DOI
  82. Rosanoff, 2004, Comparison of mechanism and functional effects of magnesium and statin pharmaceuticals, J. Am. Coll. Nutr., 23, 501S, 10.1080/07315724.2004.10719389 · DOI
  83. DiCarlo, 1986, Effects of magnesium sulfate on cardiac conduction and refractoriness in humans, J. Am. Coll. Cardiol., 7, 1356, 10.1016/S0735-1097(86)80157-7 · DOI
  84. McLean, 1994, Magnesium and its therapeutic uses: A review, Am. J. Med., 96, 63, 10.1016/0002-9343(94)90117-1 · DOI
  85. Singh, 1976, Serum magnesium concentrations in atrial fibrillation, Acta Cardiol., 31, 221
  86. Khan, 2013, Low serum magnesium and the development of atrial fibrillation in the community: The Framingham Heart Study, Circulation, 127, 33, 10.1161/CIRCULATIONAHA.111.082511 · DOI
  87. Nielsen, 2007, Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women, J. Am. Coll. Nutr., 26, 121, 10.1080/07315724.2007.10719593 · DOI
  88. Onalan, 2007, Meta-analysis of magnesium therapy for the acute management of rapid atrial fibrillation, Am. J. Cardiol., 99, 1726, 10.1016/j.amjcard.2007.01.057 · DOI
  89. Tzivoni, 1988, Treatment of torsade de pointes with magnesium sulfate, Circulation, 77, 392, 10.1161/01.CIR.77.2.392 · DOI · Paper page
  90. Gupta, 2007, Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes, Am. Heart J., 153, 891, 10.1016/j.ahj.2007.01.040 · DOI · Paper page
  91. Chiuve, 2013, Dietary and plasma magnesium and risk of coronary heart disease among women, J. Am. Heart Assoc., 2, e000114, 10.1161/JAHA.113.000114 · DOI
  92. Stepura, 2009, Magnesium orotate in severe congestive heart failure (MACH), Int. J. Cardiol., 134, 145, 10.1016/j.ijcard.2009.01.047 · DOI
  93. Imamura, 2013, Circulating and dietary magnesium and risk of cardiovascular disease: A systematic review and meta-analysis of prospective studies, Am. J. Clin. Nutr., 98, 160, 10.3945/ajcn.112.053132 · DOI · Paper page
  94. Adebamowo, 2015, Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses, Am. J. Clin. Nutr., 101, 1269, 10.3945/ajcn.114.100354 · DOI
  95. Barbagallo, 2015, Magnesium and type 2 diabetes, World J. Diabetes, 6, 1152, 10.4239/wjd.v6.i10.1152 · DOI · Paper page
  96. Mather, 1979, Magnesium status in diabetes, Lancet, 1, 924, 10.1016/S0140-6736(79)91400-4 · DOI
  97. Schnack, 1992, Hypomagnesaemia in type 2 (non-insulin-dependent) diabetes mellitus is not corrected by improvement of long-term metabolic control, Diabetologia, 35, 77, 10.1007/BF00400855 · DOI
  98. Resnick, 1993, Intracellular and extracellular magnesium depletion in type 2 (non-insulin-dependent) diabetes mellitus, Diabetologia, 36, 767, 10.1007/BF00401149 · DOI
  99. Barbagallo, 2014, Serum ionized magnesium in diabetic older persons, Metabolism, 63, 502, 10.1016/j.metabol.2013.12.003 · DOI
  100. Walti, 2003, Measurement of magnesium absorption and retention in type 2 diabetic patients with the use of stable isotopes, Am. J. Clin. Nutr., 78, 448, 10.1093/ajcn/78.3.448 · DOI
  101. McNair, 1982, Renal hypomagnesaemia in human diabetes mellitus: Its relation to glucose homeostasis, Eur. J. Clin. Investig., 12, 81, 10.1111/j.1365-2362.1982.tb00942.x · DOI
  102. Djurhuus, 1995, Insulin increases renal magnesium excretion: A possible cause of magnesium depletion in hyperinsulinaemic states, Diabet. Med., 12, 664, 10.1111/j.1464-5491.1995.tb00566.x · DOI
  103. 2011, The role of magnesium in type 2 diabetes: A brief based-clinical review, Magnes. Res., 24, 156, 10.1684/mrh.2011.0299 · DOI
  104. Barbagallo, 2014, The significance of magnesium in insulin resistance, metabolic syndrome and diabetes—Recommendations of the association of magnesium research. V. |die bedeutung von magnesium für insulinresistenz, metabolisches sindrom un diabetes mellitus—Empfehlungen der gesellschaft für magnesium forschung e.V, Diabetol. Stoffwechs., 9, 96, 10.1055/s-0034-1366398 · DOI
  105. Veronese, 2016, Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: A systematic review and meta-analysis of double-blind randomized controlled trials, Eur. J. Clin. Nutr., 70, 1354, 10.1038/ejcn.2016.154 · DOI · Paper page
  106. Willett, 2004, Magnesium intake and risk of type 2 diabetes in men and women, Diabetes Care, 27, 134, 10.2337/diacare.27.1.134 · DOI · Paper page
  107. Song, 2004, Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women, Diabetes Care, 27, 59, 10.2337/diacare.27.1.59 · DOI · Paper page
  108. He, 2006, Magnesium intake and incidence of metabolic syndrome among young adults, Circulation, 113, 1675, 10.1161/CIRCULATIONAHA.105.588327 · DOI · Paper page
  109. Matsunobu, 1990, Insulin secretion and glucose uptake in hypomagnesemic sheep fed a low magnesium, high potassium diet, J. Nutr. Biochem., 1, 167, 10.1016/0955-2863(90)90018-G · DOI
  110. Balon, 1995, Magnesium supplementation reduces development of diabetes in a rat model of spontaneous NIDDM, Am. J. Physiol., 269, E745
  111. Fung, 2003, The association between magnesium intake and fasting insulin concentration in healthy middle-aged women, J. Am. Coll. Nutr., 22, 533, 10.1080/07315724.2003.10719332 · DOI
  112. Humphries, 1999, Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans, Am. J. Hypertens., 12, 747, 10.1016/S0895-7061(99)00041-2 · DOI
  113. Haury, 1940, Blood serum magnesium in bronchial asthma and its treatment by the administration of magnesium sulfate, J. Lab. Clin. Med., 26, 340
  114. Okayama, 1987, Bronchodilating effect of intravenous magnesium sulfate in bronchial asthma, JAMA, 257, 1076, 10.1001/jama.1987.03390080066032 · DOI
  115. Bloch, 1995, Intravenous magnesium sulfate as an adjunct in the treatment of acute asthma, Chest, 107, 1576, 10.1378/chest.107.6.1576 · DOI
  116. Tiffany, 1993, Magnesium bolus or infusion fails to improve expiratory flow in acute asthma exacerbations, Chest, 104, 831, 10.1378/chest.104.3.831 · DOI
  117. Bernstein, 1995, Lack of effectiveness of magnesium in chronic stable asthma. A prospective, randomized, double-blind, placebo-controlled, crossover trial in normal subjects and in patients with chronic stable asthma, Arch. Intern. Med., 155, 271, 10.1001/archinte.1995.00430030061006 · DOI
  118. Skorodin, 1994, Magnesium sulfate potentiates several cardiovascular and metabolic actions of terbutaline, Chest, 105, 701, 10.1378/chest.105.3.701 · DOI
  119. Rolla, 1994, Effect of intravenous magnesium infusion on salbutamol-induced bronchodilatation in patients with asthma, Magnes. Res., 7, 129
  120. Obrzut, 1978, The relation between magnesium, blood histamine level and eosinophilia in the acute stage of the allergic reactions in humans, Arch. Immunol. Ther. Exp., 26, 709
  121. Kemp, 1994, Effects of NG-nitro-L-arginine methyl ester on regional haemodynamic responses to MgSO4 in conscious rats, Br. J. Pharmacol., 111, 325, 10.1111/j.1476-5381.1994.tb14063.x · DOI
  122. Nadler, 1987, Evidence that prostacyclin mediates the vascular action of magnesium in humans, Hypertension, 9, 379, 10.1161/01.HYP.9.4.379 · DOI
  123. Britton, 1994, Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample, Lancet, 344, 357, 10.1016/S0140-6736(94)91399-4 · DOI · Paper page
  124. Falkner, 1992, Serum magnesium levels in asthmatic patients during acute exacerbations of asthma, Am. J. Emerg. Med., 10, 1, 10.1016/0735-6757(92)90114-D · DOI
  125. Gustafson, 1996, Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists, Eur. Respir. J., 9, 237, 10.1183/09031936.96.09020237 · DOI
  126. Dominguez, 1998, Bronchial reactivity and intracellular magnesium: A possible mechanism for the bronchodilating effects of magnesium in asthma, Clin. Sci., 95, 137, 10.1042/cs0950137 · DOI
  127. Seelig, 1994, Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review), J. Am. Coll. Nutr., 13, 429, 10.1080/07315724.1994.10718432 · DOI
  128. Durlach, 2000, Physiopathology of symptomatic and latent forms of central nervous hyperexcitability due to magnesium deficiency: A current general scheme, Magnes. Res., 13, 293
  129. Botturi, A., Ciappolino, V., Delvecchio, G., Boscutti, A., Viscardi, B., and Brambilla, P. (2020). The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients, 12. · DOI
  130. Noah, 2020, Impact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: Secondary data from a randomized controlled trial, Magnes. Res., 33, 45, 10.1684/mrh.2020.0468 · DOI
  131. Goto, 1993, Physiological correlates of abnormal behaviors in magnesium-deficient rats, Epilepsy Res., 15, 81, 10.1016/0920-1211(93)90089-P · DOI
  132. Galland, 1991, Magnesium, stress and neuropsychiatric disorders, Magnes. Trace Elem., 10, 287
  133. Decollogne, 1997, NMDA receptor complex blockade by oral administration of magnesium: Comparison with MK-801, Pharmacol. Biochem. Behav., 58, 261, 10.1016/S0091-3057(96)00555-2 · DOI
  134. Eby, 2010, Magnesium for treatment-resistant depression: A review and hypothesis, Med. Hypotheses, 74, 649, 10.1016/j.mehy.2009.10.051 · DOI
  135. Nechifor, 2009, Magnesium in major depression, Magnes. Res., 22, 163S, 10.1684/mrh.2009.0177 · DOI
  136. Abbasi, 2012, The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial, J. Res. Med. Sci., 17, 1161
  137. Glick, 1990, Dementias: The role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer’s disease, Med. Hypotheses, 31, 211, 10.1016/0306-9877(90)90095-V · DOI
  138. Yamanaka, R., Shindo, Y., and Oka, K. (2019). Magnesium Is a Key Player in Neuronal Maturation and Neuropathology. Int. J. Mol. Sci., 20. · DOI
  139. Vural, 2010, Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer’s disease, J. Trace Elem. Med. Biol., 24, 169, 10.1016/j.jtemb.2010.02.002 · DOI
  140. Cilliler, 2007, Serum magnesium level and clinical deterioration in Alzheimer’s disease, Gerontology, 53, 419, 10.1159/000110873 · DOI · Paper page
  141. Barbagallo, 2011, Altered ionized magnesium levels in mild-to-moderate Alzheimer’s disease, Magnes. Res., 24, S115, 10.1684/mrh.2011.0287 · DOI
  142. Toffa, 2019, Can magnesium reduce central neurodegeneration in Alzheimer’s disease? Basic evidences and research needs, Neurochem. Int., 126, 195, 10.1016/j.neuint.2019.03.014 · DOI
  143. Wang, 2017, Magnesium ion influx reduces neuroinflammation in Abeta precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1beta, Cell. Mol. Immunol., 14, 451, 10.1038/cmi.2015.93 · DOI
  144. Yu, 2015, By suppressing the expression of anterior pharynx-defective-1alpha and -1beta and inhibiting the aggregation of beta-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice, FASEB J., 29, 5044, 10.1096/fj.15-275578 · DOI
  145. Slutsky, 2010, Enhancement of learning and memory by elevating brain magnesium, Neuron, 65, 165, 10.1016/j.neuron.2009.12.026 · DOI · Paper page
  146. Xu, Z.P., Li, L., Bao, J., Wang, Z.H., Zeng, J., Liu, E.J., Li, X.G., Huang, R.X., Gao, D., and Li, M.Z. (2014). Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer’s model. PLoS ONE, 9. · DOI
  147. Cherbuin, 2014, Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project, Front. Aging Neurosci., 6, 4, 10.3389/fnagi.2014.00004 · DOI
  148. Ozawa, 2012, Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: The Hisayama Study, J. Am. Geriatr. Soc., 60, 1515, 10.1111/j.1532-5415.2012.04061.x · DOI
  149. Liu, 2016, Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial, J. Alzheimers Dis., 49, 971, 10.3233/JAD-150538 · DOI
  150. New, 2000, Dietary influences on bone mass and bone metabolism: Further evidence of a positive link between fruit and vegetable consumption and bone health?, Am. J. Clin. Nutr., 71, 142, 10.1093/ajcn/71.1.142 · DOI · Paper page
  151. Tucker, 2014, Vegetarian diets and bone status, Am. J. Clin. Nutr., 100, 329S, 10.3945/ajcn.113.071621 · DOI
  152. Ryder, 2005, Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects, J. Am. Geriatr. Soc., 53, 1875, 10.1111/j.1532-5415.2005.53561.x · DOI
  153. Kenney, 1994, Effects of magnesium deficiency on strength, mass, and composition of rat femur, Calcif. Tissue Int., 54, 44, 10.1007/BF00316289 · DOI
  154. Rude, 1999, Magnesium deficiency-induced osteoporosis in the rat: Uncoupling of bone formation and bone resorption, Magnes. Res., 12, 257
  155. Rude, 2004, Magnesium deficiency and osteoporosis: Animal and human observations, J. Nutr. Biochem., 15, 710, 10.1016/j.jnutbio.2004.08.001 · DOI · Paper page
  156. Medalle, 1976, Vitamin D resistance in magnesium deficiency, Am. J. Clin. Nutr., 29, 854, 10.1093/ajcn/29.8.854 · DOI
  157. Aydin, 2010, Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women, Biol. Trace Elem. Res., 133, 136, 10.1007/s12011-009-8416-8 · DOI
  158. Dimai, 1998, Daily oral magnesium supplementation suppresses bone turnover in young adult males, J. Clin. Endocrinol. Metab., 83, 2742
  159. Veronese, 2017, Dietary magnesium intake and fracture risk: Data from a large prospective study, Br. J. Nutr., 117, 1570, 10.1017/S0007114517001350 · DOI
  160. Sendur, 2008, The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia, Rheumatol. Int., 28, 1117, 10.1007/s00296-008-0593-9 · DOI
  161. Bagis, 2013, Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?, Rheumatol. Int., 33, 167, 10.1007/s00296-011-2334-8 · DOI
  162. Rock, 1995, Dietary magnesium deficiency in rats enhances free radical production in skeletal muscle, J. Nutr., 125, 1205
  163. Dominguez, 2006, Magnesium and muscle performance in older persons: The InCHIANTI study, Am. J. Clin. Nutr., 84, 419, 10.1093/ajcn/84.2.419 · DOI · Paper page
  164. Brilla, 1992, Effect of magnesium supplementation on strength training in humans, J. Am. Coll. Nutr., 11, 326, 10.1080/07315724.1992.10718233 · DOI · Paper page
  165. Feng, 2012, Serum total oxidant/antioxidant status and trace element levels in breast cancer patients, Int. J. Clin. Oncol., 17, 575, 10.1007/s10147-011-0327-y · DOI
  166. Bezerra, D.L.C., Mendes, P.M.V., Melo, S.R.S., Dos Santos, L.R., Santos, R.O., Vieira, S.C., Henriques, G.S., Freitas, B., and Marreiro, D.D.N. (2021). Hypomagnesemia and Its Relationship with Oxidative Stress Markers in Women with Breast Cancer. Biol. Trace Elem. Res., 1–9. · DOI
  167. Patiroglu, 1997, Protective effect of magnesium supplementation on experimental 3-methyl cholanthrene-induced fibrosarcoma and changes in tissue magnesium distribution during carcinogenesis in rats, Biol. Trace Elem. Res., 56, 179, 10.1007/BF02785391 · DOI
  168. Kasprzak, 1994, Iron accelerates while magnesium inhibits nickel-induced carcinogenesis in the rat kidney, Toxicology, 90, 129, 10.1016/0300-483X(94)90211-9 · DOI
  169. Hanano, 2004, Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells, J. Pharmacol. Sci., 95, 403, 10.1254/jphs.FP0040273 · DOI
  170. Wark, 2012, Magnesium intake and colorectal tumor risk: A case-control study and meta-analysis, Am. J. Clin. Nutr., 96, 622, 10.3945/ajcn.111.030924 · DOI
  171. Sahmoun, 2010, Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?, Med. Hypotheses, 75, 315, 10.1016/j.mehy.2010.02.037 · DOI
  172. Sun, 2017, Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps, J. Nutr. Biochem., 47, 35, 10.1016/j.jnutbio.2017.04.016 · DOI
  173. Shah, S.C., Zhu, X., Dai, Q., Peek, R.M., and Shrubsole, M.J. (2020). Magnesium intake is associated with a reduced risk of incident liver cancer, based on an analysis of the NIH-American Association of Retired Persons (NIH-AARP) Diet and Health Study prospective cohort. Am. J. Clin. Nutr., nqaa326. · DOI

Cited by

See all 359

Metadata

Authors
Barbagallo, M., Veronese, N., & Dominguez, L. J.
Venue
Nutrients
Publisher
MDPI AG
Published
2021-01-30
Volume
13
Issue
2
Pages
463
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu13020463
OpenAlex
W3126793704
Cited by
359
References
12
FWCI
30.14
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.