The DOI matches its Crossref record; 140 of the 141 references it cites were found in a registry or an index.
Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management
Open accessAbstract
Functional foods contain biologically active ingredients associated with physiological health benefits for preventing and managing chronic diseases, such as type 2 diabetes mellitus (T2DM). A regular consumption of functional foods may be associated with enhanced anti-oxidant, anti-inflammatory, insulin sensitivity, and anti-cholesterol functions, which are considered integral to prevent and manage T2DM. Components of the Mediterranean diet (MD)—such as fruits, vegetables, oily fish, olive oil, and tree nuts—serve as a model for functional foods based on their natural contents of nutraceuticals, including polyphenols, terpenoids, flavonoids, alkaloids, sterols, pigments, and unsaturated fatty acids. Polyphenols within MD and polyphenol-rich herbs—such as coffee, green tea, black tea, and yerba maté—have shown clinically-meaningful benefits on metabolic and microvascular activities, cholesterol and fasting glucose lowering, and anti-inflammation and anti-oxidation in high-risk and T2DM patients. However, combining exercise with functional food consumption can trigger and augment several metabolic and cardiovascular protective benefits, but it is under-investigated in people with T2DM and bariatric surgery patients. Detecting functional food benefits can now rely on an “omics” biological profiling of individuals’ molecular, genetics, transcriptomics, proteomics, and metabolomics, but is under-investigated in multi-component interventions. A personalized approach for preventing and managing T2DM should consider biological and behavioral models, and embed nutrition education as part of lifestyle diabetes prevention studies. Functional foods may provide additional benefits in such an approach.
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“Thus, according to Alkhatib et al., the tea has beneficial effects on the pathogenesis of diabetes mellitus by improving glucose metabolism and consequently lowering the fasting glucose level.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [10]
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“Finally, the positive properties of the MedDiet for prevention and management of T2D are not confined within selected PUFA- and/or MUFA-enriched functional foods, but incorporate additional and synergistic benefits from the ingestion of numerous promising bioactive polyphenol compounds [56], which are currently under investigation.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [56]
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Metadata
- Authors
- Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., & Tuomilehto, J.
- Affiliations
- Dasman Diabetes Institute (KW)
- Edge Hill University (GB)
- Mauritius Sugarcane Industry Research Institute (MU)
- Dasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait
- King Abdulaziz University (SA)
- Corresponding author
- Alkhatib, Ahmad
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-12-01
- Volume
- 9
- Issue
- 12
- Pages
- 1310
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5748760
- OpenAlex
- W2772650360
- Cited by
- 376
- References
- 141
- Citations by year
- 2026: 26 · 2025: 48 · 2024: 42 · 2023: 50 · 2022: 53 · 2021: 69 · 2020: 51 · 2019: 24 · 2018: 12 · 2017: 1
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Edge Hill University Research Information Repository (Edge Hill University) (publishedVersion, cc-by)
- TeesRep (Teesside University) (acceptedVersion, other-oa)
- Northumbria Research Link (Northumbria University) (acceptedVersion, other-oa)
- Edge Hill University (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Queen Margaret University Publications Repository (Queen Margaret University) (submittedVersion, cc-by)
- Funders
- Dasman Diabetes Institute
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- functional foods, type 2 diabetes, diabetes prevention, diabetes management, Mediterranean diet, nutraceuticals, polyphenols, anti-inflammatory activity, antioxidant activity, insulin sensitivity, physical activity, bariatric surgery, personalized nutrition, omics profiling, lifestyle intervention, nutrition education, olive oil, green tea, Ilex paraguariensis
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Life Style, Diet, Mediterranean, Functional Food
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