In Vitro Evaluation and Clinical Effects of a Regenerative Complex with Non-Cross-Linked Hyaluronic Acid and a High-Molecular-Weight Polynucleotide for Periorbital Treatment
Open accessAbstract
Skin aging is a complex and multifactorial process influenced by both intrinsic and extrinsic factors. The periorbital area of the face is particularly susceptible to premature aging signs due to its delicate skin structure, and is a major concern for many individuals. While hyaluronic acid (HA)-based dermal filler products are commonly used for periorbital rejuvenation, novel approaches to effectively locally address the visible signs of aging are available. This study aimed to investigate Innovyal Regenerative Action (IRA), an injectable polynucleotide–HA (PN-HA) regenerative complex designed for periocular prejuvenation. Firstly, PN-HA was compared to other commercially available HA-based dermbooster products (Profhilo®, Suisselle Cellbooster® Glow, and NCTF® 135 HA) in terms of rheological properties, in vitro antioxidant capacity, and total collagen production stimulation in human fibroblasts. Secondly, the clinical effects of the IRA PN-HA complex were evaluated in two case reports (monotherapy for periorbital prejuvenation). It was shown that the PN-HA complex outperformed its comparators in terms of relative rheological behavior (biophysical attributes normalized to polymer contents), intrinsic antioxidant activity (CUPRAC, FRAP, and ORAC assays), as well as total collagen level induction (72-h in vitro dermal fibroblast induction model). Generally, the results of this study provided mechanistic and preliminary clinical insights into the potential benefits of the IRA PN-HA complex for periocular cutaneous treatment. Overall, it was underscored that combining the structural support and regenerative properties of PN with the hydrating and volumizing effects of HA bares tangible potential for multifactorial skin quality enhancement and for periocular prejuvenation in particular.
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PN is derived from the testes of fishes such as salmon or trout.
“PN, derived from the testes of fishes such as salmon or trout, typically consists of relatively longer chains [21,22].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [21]
The Introduction states that PN is extracted from the gonads of salmon or trout, supporting the fish species and general tissue source. It does not specify testes; gonads is a broader term, so that detail is not established by our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes.
“PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes [21,24,31,32,33,34,35,40,41,42,150].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [21]
The Introduction and §3.5 describe a PN–HA formulation containing niacinamide and discuss its potential benefits for skin rejuvenation. The paper does not establish that PNs are often combined with a broad range of polymers or bioactive compounds, and it does not address poly-L-lactic acid; those parts of the multi-cited claim are not supported by this source. (LLM, conf=0.84)
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- Authors
- Abuyousif, H. S., Porcello, A., Cerrano, M., Marques, C., Scaletta, C., Lourenço, K., Abdel-Sayed, P., Chemali, M., Raffoul, W., Hirt-Burri, N., Applegate, L. A., & Laurent, A. E.
- Affiliations
- For Ever Young Clinics, Jeddah 23431, Saudi Arabia
- Development Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, Switzerland
- Aesthetic Surgery Department, Clinique Entourage, CH-1003 Lausanne, Switzerland
- Centre Hospitalier Universitaire Vaudois (CH)
- Plastic and Aesthetic Surgery Service, Centre Médical Lausanne Ouest, CH-1008 Prilly, Switzerland
- Hôpital de Morges (CH)
- Regenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland
- University of Zurich (CH)
- Corresponding author
- Laurent, Alexis E.
- ORCID
- Venue
- Polymers
- Publisher
- MDPI AG
- Published
- 2025-02-27
- Volume
- 17
- Issue
- 5
- Pages
- 638
- ISSN
- 2073-4360 (ISSN-L)
- PMC
- PMC11902836
- OpenAlex
- W4407996964
- Cited by
- 19
- References
- 55
- Citations by year
- 2026: 14 · 2025: 5
- FWCI
- 18.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Polymers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, cc-by)
- IRIS (submittedVersion, cc-by)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- periorbital rejuvenation, skin aging, dermal fillers, rheological properties, antioxidant capacity, collagen induction, dermal fibroblasts
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