Cited by 133Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchLiver physiology and pathology

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Construction of a Portal Implantable Functional Tissue-Engineered Liver Using Perfusion-Decellularized Matrix and Hepatocytes in Rats

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Bao, Ji, Shi, Yujun, Sun, Huaiqiang, Yin, Xiangli, Yang, Ruina, Li, Li, Chen, Xi, Bu, Hong·2011·Cell Transplantation

DOI 10.3727/096368910x536572

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Abstract

Innovative cell-based therapies, including hepatic tissue engineering following hepatocyte transplantation, are considered as theoretical alternatives to liver transplant or for partial replacement of liver function in patients. However, recent progress in hepatic tissue engineering has been hampered by low initial hepatocyte engraftment and insufficient blood supply in vivo. We developed an intact 3D scaffold of an extracellular matrix (ECM) derived from a decellularized liver lobe, with layer-by-layer (LbL) heparin deposition to avoid thrombosis, which we repopulated with hepatocytes and successfully implanted as a tissue-engineered liver (TEL) into the portal system. The TEL provided sufficient volume for transplantation of cell numbers representing up to 10% of whole-liver equivalents and was perfused by portal vein blood. Treatment of extended hepatectomized rats with a TEL improved liver function and prolonged survival; mean lifespan was extended from 16 to 72 h. At 72 h postoperation, the TEL sustained functional and viable hepatocytes. In conclusion, we propose the TEL as a state-of-the-art substitute for whole-liver transplantation and as a proof of concept for the technology that will eventually allow for the transplantation of a reconstituted liver.

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Authors: Bao, J., Shi, Y., Sun, H., Yin, X., Yang, R., Li, L., Chen, X., & Bu, H.
Affiliations: Sichuan University (CN)
ORCID: Bao, Ji
Shi, Yujun
Sun, Huaiqiang
Li, Li
Chen, Xi
Bu, Hong
Venue: Cell Transplantation
Publisher: SAGE Publications
Published: 2011-06
Volume: 20
Issue: 5
Pages: 753-766
ISSN: 0963-6897 (ISSN-L)
1555-3892
DOI: 10.3727/096368910x536572
OpenAlex: W1965557044
Cited by: 133
References: 29
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 9 · 2017: 15 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 12 · 2012: 5
FWCI: 7.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Cell Transplantation (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: hepatocyte transplantation, extracellular matrix scaffolds, heparin coating, thromboprophylaxis, portal vein perfusion, extended hepatectomy, liver transplantation alternatives, hepatocyte engraftment, rat model
MeSH terms: Animals, Extracellular Matrix, Liver Diseases, Male, Portal Vein, Rats, Inbred Lew, Liver Transplantation, Liver, Artificial, Hepatocytes, Tissue Engineering, Rats

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Construction of a Portal Implantable Functional Tissue-Engineered Liver Using Perfusion-Decellularized Matrix and Hepatocytes in Rats

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