Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
Open accessAbstract
Many attempts have been made to manufacture multi-contact nerve cuff electrodes that are safe, robust and reliable for long term neuroprosthetic applications. This protocol describes a fabrication technique of a modified cylindrical nerve cuff electrode to meet these criteria. Minimum computer-aided design and manufacturing (CAD and CAM) skills are necessary to consistently produce cuffs with high precision (contact placement 0.51 ± 0.04 mm) and various cuff sizes. The precision in spatially distributing the contacts and the ability to retain a predefined geometry accomplished with this design are two criteria essential to optimize the cuff's interface for selective recording and stimulation. The presented design also maximizes the flexibility in the longitudinal direction while maintaining sufficient rigidity in the transverse direction to reshape the nerve by using materials with different elasticities. The expansion of the cuff's cross sectional area as a result of increasing the pressure inside the cuff was observed to be 25% at 67 mm Hg. This test demonstrates the flexibility of the cuff and its response to nerve swelling post-implant. The stability of the contacts' interface and recording quality were also examined with contacts' impedance and signal-to-noise ratio metrics from a chronically implanted cuff (7.5 months), and observed to be 2.55 ± 0.25 kΩ and 5.10 ± 0.81 dB respectively.
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Cuff electrode failure modes after implantation include lead breakage, closing site failure, motion artifacts, and connection failure.
“Several failure modes have been reported including lead breakage, closing site failure, motion artifacts, and connection failure [77].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [77]
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Self-citation
- Authors
- Dweiri, Y. M., Stone, M. A., Tyler, D. J., McCallum, G. A., & Durand, D. M.
- Affiliations
- Jordan University of Science and Technology (JO)
- United States Department of Veterans Affairs (US)
- Case Western Reserve University (US)
- Venue
- Journal of Visualized Experiments
- Publisher
- MyJove Corporation
- Published
- 2016-10-04
- Issue
- 116
- ISSN
- 1940-087X (ISSN-L)
- PMC
- PMC5092158
- OpenAlex
- W2529404661
- Cited by
- 23
- References
- 27
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Visualized Experiments (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Defense Advanced Research Projects Agency (N66001-12-C-4173)
- Advanced Research Projects Agency
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- cuff electrodes, neural recording, neurostimulation, neuroprosthetics, electrode fabrication, contact density, flat interface, nerve swelling, contact impedance, signal-to-noise ratio, chronic implantation, CAD/CAM manufacturing
- MeSH terms
- Electric Stimulation, Electrodes, Electrodes, Implanted, Equipment Design, Peripheral Nerves, Computer-Aided Design
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