A Peripheral Nerve Information Transducer for Amputees: Long-Term Multichannel Recordings from Rabbit Peripheral Nerves

Edell, David J.

doi:10.1109/tbme.1986.325892

Cited by 177Neuroscience and Neural EngineeringMuscle activation and electromyography studiesAnalog and Mixed-Signal Circuit Design

A Peripheral Nerve Information Transducer for Amputees: Long-Term Multichannel Recordings from Rabbit Peripheral Nerves

Edell, David J.·1986·IEEE Transactions on Biomedical Engineering

DOI 10.1109/tbme.1986.325892

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Abstract

A micromachined silicon technology is being developed for the purpose of sensing information from the stumps of amputated mammalian peripheral nerves. Information on long-term biocompatibility, anatomy, and physiology related to the structural design of this sensor is presented. Pertinent materials, fabrication, and surgical implantation issues are discussed. Noise, signal amplitude, and receptive field are considered as the prime determinants of the design of an appropriate electrode contact geometry for the structure. The selectivity of the device is also discussed in terms of the fine structure of the regenerated nerve. Examples of waveforms recorded from rabbit peripheral nerves using this sensor are presented and discussed in terms of electrical and physiological parameters. Possible use of the sensor as a source for a binary code suitable for communication of information to a computer is presented along with discussion of the limitations of the current technology and possible future applications.

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Regenerating axons grow through the holes of regenerative electrodes, making it possible to record action potentials from and stimulate individual axons or small fascicles.
“Regenerating axons eventually grow through the holes (Fig. 12), making it possible to record action potentials from and to stimulate individual axons or small fascicles.”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Edell, 1986
Regenerative electrodes are designed to interface a high number of nerve fibers using an array of holes with electrodes built around them, implanted between the severed stumps of a peripheral nerve.
“Regenerative electrodes are designed to interface a high number of nerve fibers by using an array of holes, with electrodes built around them, implanted between the severed stumps of a peripheral nerve (Llina ´ s et al., 1973; Edell, 1986; Kovacs et al., 1992; Dario et al., 1998) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Edell, 1986
Silicon regenerative interfaces cause frequent signs of axonopathy and constitute a physical barrier that limits elongation of regenerating axons depending on the size of the holes.
“However, such silicon interfaces cause frequent signs of axonopathy and constitute a physical barrier that limits the elongation of regenerating axons depending on the size of the holes (Edell, 1986; Rosen et al., 1990; Navarro et al., 1996; Zhao et al., 1997) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Edell, 1986
A one-to-one design allowing access to each individual regenerated axon through one hole of 2-10 μm diameter has proved impossible, because nerve regeneration fails with holes of such small size.
“Ideally a one-to-one design would allow access to each individual regenerated axon grown through one hole (2-10 m m in diameter). However, this has been proved impossible; nerve regeneration fails with holes of such small size.”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Edell, 1986
Efferent neural signals recorded from regenerative electrodes can be used to control the motion of a mechanical prosthesis.
“recording of neural efferent signals can be used for the motion control of a mechanical prosthesis (Edell, 1986)”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Edell, 1986

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Authors: Edell, D. J.
Affiliations: Harvard University (US)
Corresponding author: Edell, David J.
Venue: IEEE Transactions on Biomedical Engineering
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Published: 1986-02
Volume: BME-33
Issue: 2
Pages: 203-214
ISSN: 0018-9294 (ISSN-L)
DOI: 10.1109/tbme.1986.325892
OpenAlex: W1974827846
Cited by: 177
References: 24
Citations by year: 2025: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations: IEEE Transactions on Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (5R23NS18459-03)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
Keywords: peripheral nerve recording, amputees, nerve stump, biocompatibility, nerve regeneration, receptive fields, signal-to-noise ratio, surgical implantation
MeSH terms: Amputation, Surgical, Animals, Biocompatible Materials, Nerve Regeneration, Synaptic Transmission, Peripheral Nerves, Rabbits, Tibial Nerve, Transducers

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A Peripheral Nerve Information Transducer for Amputees: Long-Term Multichannel Recordings from Rabbit Peripheral Nerves

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