Cited by 338Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

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Early life: gut microbiota and immune development in infancy

Martin, R., Nauta, A., Ben Amor, K., Knippels, L., Knol, J., Garssen, J.·2010·Beneficial Microbes

DOI 10.3920/bm2010.0027

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Abstract

The immune system of infants is actively downregulated during pregnancy and therefore the first months of life represent a period of heightened susceptibility to infection. After birth, there is an age-dependent maturation of the immune system. Exposure to environmental microbial components is suggested to play an important role in the maturation process. The gastrointestinal tract is the major site of interaction between the host immune system and microorganisms, both commensal as well as potentially pathogenic. It is well established that the mammalian immune system is designed to help protect the host from invading microorganisms and other danger signals. However, recent research is emerging in the field of host-microbe interactions showing that commensal microorganisms (microbiota) are most likely one of the drivers of immune development and, in turn the immune system shapes the composition of the microbiota. Specific early microbial exposure of the gut is thought to dramatically reduce the incidence of inflammatory, autoimmune and atopic diseases further fuelling the scientific view that microbial colonisation plays an important role in regulating and fine-tuning the immune system throughout life. Therefore, the use of pre-, pro- and synbiotics may result in a beneficial microbiota composition that might have a pivotal role on the prevention of several important diseases that develop in early life such as necrotizing enterocolitis and atopic eczema.

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Authors: Martin, R., Nauta, A., Ben Amor, K., Knippels, L., Knol, J., & Garssen, J.
Affiliations: Danone (Netherlands) (NL)
Danone Research, Center for Specialised Nutrition, P.O. Box 7005, 6700 CA Wageningen, the Netherlands
Utrecht University (NL)
ORCID: Knippels, L.
Knol, J.
Garssen, J.
Venue: Beneficial Microbes
Publisher: Walter de Gruyter GmbH
Published: 2010-11-01
Volume: 1
Issue: 4
Pages: 367-382
ISSN: 1876-2883 (ISSN-L)
1876-2891
DOI: 10.3920/bm2010.0027
OpenAlex: W2106985367
Cited by: 338
References: 164
Citations by year: 2026: 9 · 2025: 8 · 2024: 16 · 2023: 30 · 2022: 30 · 2021: 32 · 2020: 38 · 2019: 29 · 2018: 36 · 2017: 27 · 2016: 10 · 2015: 25 · 2014: 17 · 2013: 18 · 2012: 13
FWCI: 0.87
Type: journal article
Language: en
Open access: closed
Locations: Beneficial Microbes (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, infant immune development, host-microbe interactions, commensal microorganisms, microbial colonization, immune system maturation, prebiotics, probiotics, synbiotics, necrotizing enterocolitis, atopic dermatitis, inflammatory and autoimmune diseases
MeSH terms: Child Development, Humans, Immune System, Infant, Gastrointestinal Tract, Metagenome

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Early life: gut microbiota and immune development in infancy

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