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Food sources of nitrates and nitrites: the physiologic context for potential health benefits
Open accessAbstract
The presence of nitrates and nitrites in food is associated with an increased risk of gastrointestinal cancer and, in infants, methemoglobinemia. Despite the physiologic roles for nitrate and nitrite in vascular and immune function, consideration of food sources of nitrates and nitrites as healthful dietary components has received little attention. Approximately 80% of dietary nitrates are derived from vegetable consumption; sources of nitrites include vegetables, fruit, and processed meats. Nitrites are produced endogenously through the oxidation of nitric oxide and through a reduction of nitrate by commensal bacteria in the mouth and gastrointestinal tract. As such, the dietary provision of nitrates and nitrites from vegetables and fruit may contribute to the blood pressure-lowering effects of the Dietary Approaches to Stop Hypertension (DASH) diet. We quantified nitrate and nitrite concentrations by HPLC in a convenience sample of foods. Incorporating these values into 2 hypothetical dietary patterns that emphasize high-nitrate or low-nitrate vegetable and fruit choices based on the DASH diet, we found that nitrate concentrations in these 2 patterns vary from 174 to 1222 mg. The hypothetical high-nitrate DASH diet pattern exceeds the World Health Organization's Acceptable Daily Intake for nitrate by 550% for a 60-kg adult. These data call into question the rationale for recommendations to limit nitrate and nitrite consumption from plant foods; a comprehensive reevaluation of the health effects of food sources of nitrates and nitrites is appropriate. The strength of the evidence linking the consumption of nitrate- and nitrite-containing plant foods to beneficial health effects supports the consideration of these compounds as nutrients.
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“These dosing amounts appear to be well tolerated when consumed as both supplemental [587] and supplemental sources [588] without significant alterations in hemodynamics or clinical boundaries of hepatorenal and muscle enzyme status [478, 589].”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [587]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“possibly due to greater responsiveness resulting from baseline NO deficiency [112,155,245].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [112]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“clinical studies suggest that older individuals may experience substantial improvements in blood pressure and endothelial function after consuming nitrates”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [112]
Experimental — accuracy not yet measuredIn the citing paper
“recent research has suggested that the beneficial effects of the DASH diet on BP are related to the high inorganic nitrate content of some of the food products included in the DASH dietary plan (e.g., green leafy and root vegetables) (9).”
From Inorganic Nitrate and Beetroot Juice Supplementation Reduces Blood Pressure in Adults: A Systematic Review and Meta-Analysis (2013) · cites this paper as [9]
In the citing paper
“Inorganic nitrate is present in numerous foodstuffs and is abundant in green leafy vegetables and beetroot.”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [7]
In the citing paper
“In addition to its generation by means of the NOS system, body stores of nitrate and nitrite may also be increased exogenously through the diet, particularly through the consumption of green leafy vegetables such as lettuce, spinach, rocket, celery, cress, and beetroot”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [7]
In the citing paper
“Green leafy vegetables as well as root vegetables such as beets are known to contain the highest amounts of inorganic nitrate[36,161,370].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [161]
In the citing paper
“Unsurprisingly, estimates of average daily nitrate consumption in the U.S. and Europe, regions with high rates of CVD and vascular disease, reach only 40–100mg and 30–180mg, respectively[157,161,372].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [161]
In the citing paper
“with a typical DASH-compliant diet estimated to contain a range of nitrate from 174–1222mg/day[161].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [161]
In the citing paper
“Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [28]
In the citing paper
“according to a report by Hord [28], in which the daily nitrate and nitrite intakes were calculated based on the variations using the vegetable and fruit components of the DASH (Dietary Approaches to Stop Hypertension) dietary pattern [46], the level easily exceeds 1,200 mg/day nitrate.”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [28]
In the citing paper
“dietary nitrate/nitrite improves the features of lifestyle-related diseases by enhancing NO availability, and thus provides potential options for prevention and therapy for these patients [28].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [28]
In the citing paper
“This is more than five-fold higher than the WHO’s ADI of 3.7 mg nitrate/kg body weight/day, and more than two-fold the US Environmental Protection Agency’s level of 7.0 mg nitrate/kg body weight/day for a 60 kg individual [28].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [28]
In the citing paper
“Although it may be difficult to isolate the specific effects of these dietary nutrients, as discussed above, the nitrate and nitrite derived from vegetables and fruits are reduced to NO, which is followed by the formation of S-nitrosothiols [123], rather than the formation of nitrosamines especially in the presence of reducing agents such as vitamin C and E in the stomach [28,124].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [28]
In the citing paper
“Webb et al. (81) showed that beetroot juice (500 ml; 23 mmol nitrate) completely reduced endothelial dysfunction induced by ischaemicreperfusion injury to the forearm and preserved the FMD response, whereas the FMD response was reduced by 60 % in the control subjects.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [81]
In the citing paper
“The peak effect in BP occurred at 3 h after ingestion and in association with an increase in plasma nitrite concentration, supporting the hypothesis that the delayed appearance of nitrite is due to the sequential bioconversion of nitrate to nitrite and further to NO in vivo.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [81]
In the citing paper
“In most of the studies examined, peak reduction in BP compared with baseline occurred at 2-3 h after the consumption of dietary nitrate, which is the same time at which peak plasma nitrite concentrations have been observed (81,82,86,87,89,92) ,”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [81]
In the citing paper
“In 2008, Webb et al. (81) showed that ingestion of a single dose of beetroot juice (500 ml; 23 mmol nitrate) by fourteen healthy subjects reduced systolic BP (SBP) and DBP by 10 and 8 mmHg, respectively.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [81]
In the citing paper
“A few studies have found inhibitory effects of dietary nitrate on platelet aggregation, suggesting that inhibition of abnormal platelet aggregation may be partly responsible for the cardiovascular benefits of nitrate supplementation.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [81]
In the citing paper
“In a study by Webb et al. (81) supplementation of healthy individuals with beetroot juice (550 ml; 23 mmol nitrate) also had an inhibitory effect on ex vivo platelet aggregation in response to collagen and adenosine diphosphate.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [81]
In the citing paper
“A recent systematic review found the pooled effect for inorganic nitrate and beetroot juice supplementation to be a significant reduction of SBP of ~4-5 mmHg (6) .”
From High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women (2015) · cites this paper as [6]
In the citing paper
“However, most of the study populations have consisted of healthy, young men and may not be representative of the whole population (6) .”
From High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women (2015) · cites this paper as [6]
In the citing paper
“Intake of nitrite from environmental sources also occurs through contaminated ground water, commonly due to fertilizers, livestock and human excreta, which pose a potential hazard to health [59, 65].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [59]
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Citations
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Sacks, F. M., Svetkey, L. P., Vollmer, W. M., Appel, L. J., Bray, G. A., Harsha, D., Obarzanek, E., Conlin, P. R., Miller, E. R., Simons-Morton, D. G., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440101 · Cited by 5,638
Food, nutrition, physical activity, and the prevention of cancer: a global perspective
Marmot, M. G., Atinmo, T., Byers, T., Chen, J., Hirohata, T., Jackson, A., James, W., Kolonel, L. N., Kumanyika, S., Leitzmann, C., et al. (2008) · Choice Reviews Online · doi:10.5860/choice.45-5024 · Cited by 5,368
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 2×
“These enzymes synthesize nitric oxide from the amino acid L-arginine and molecular oxygen to accomplish vasodilation, blood pressure regulation, inhibition of endothelial inflammatory cell recruitment, and platelet aggregation (21).”
BackgroundBjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease
Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396
Appel, L. J., Brands, M. W., Daniels, S. R., Karanja, N., Elmer, P. J., & Sacks, F. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000202568.01167.b6 · Cited by 1,304
Shepard, T. H. (1981) · Teratology · doi:10.1002/tera.1420230118 · Cited by 1,298
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.21.1550 · Cited by 1,255
Research works printed but not linked: 1
- WangZHTX,WeiYS,LiSX.Nitrate accumulation and its regulation by nutrient management in vegetables. In:.Balanceable fertilization and high quality vegetables.Beijing, China:China Agricultural University Press,2000.
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Ding, Z., Johanningsmeier, S. D., Price, R., Reynolds, R., Truong, V., Payton, S. C., & Breidt, F. (2018) · Food Control · doi:10.1016/j.foodcont.2018.03.005 · Cited by 141
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Christensen, P. M., Nyberg, M., & Bangsbo, J. (2013) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12005 · Cited by 138
Woessner, M., Smoliga, J. M., Tarzia, B., Stabler, T., Van Bruggen, M., & Allen, J. D. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.01.002 · Cited by 139
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Espejo‐Herrera, N., Gràcia‐Lavedan, E., Boldo, E., Aragonés, N., Pérez‐Gómez, B., Pollán, M., Molina, A. J., Fernández‐Villa, T., Martín, V., Vecchia, C. L., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30083 · Cited by 136
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Senefeld, J. W., Wiggins, C. C., Regimbal, R. J., Dominelli, P. B., Baker, S. E., & Joyner, M. J. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002363 · Cited by 146
Trivedi, M. K., & Branton, A. (2015) · Journal of Chromatography & Separation Techniques · doi:10.4172/2157-7064.1000282 · Cited by 132
Nitrate and Nitrites in Foods: Worldwide Regional Distribution in View of Their Risks and Benefits
Kalaycıoğlu, Z., & Erim, F. B. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01194 · Cited by 140
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Self-citationResearch gaps in evaluating the relationship of meat and health
Klurfeld, D. M. (2015) · Meat Science · doi:10.1016/j.meatsci.2015.05.022 · Cited by 135
Cen, T., Zhang, X., Xie, S., & Li, D. (2020) · Environment International · doi:10.1016/j.envint.2020.105544 · Cited by 127
Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health
Kapil, V., Weitzberg, E., Lundberg, J. O., & Ahluwalia, A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.03.162 · Cited by 130
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Murphy, M., Eliot, K., Heuertz, R. M., & Weiss, E. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2011.12.002 · Cited by 124
Milkowski, A., Garg, H. K., Coughlin, J. R., & Bryan, N. S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.08.004 · Cited by 123
Self-citationHobbs, D. A., Goulding, M. G., Nguyen, A., Malaver, T., Walker, C. F., George, T. W., Methven, L., & Lovegrove, J. A. (2013) · Journal of Nutrition · doi:10.3945/jn.113.175778 · Cited by 126
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Self-citationNadtochiy, S. M., & Redman, E. (2011) · Nutrition · doi:10.1016/j.nut.2010.12.006 · Cited by 125
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Gorenjak, A. H., & Čenčič, A. (2013) · Acta Alimentaria · doi:10.1556/aalim.42.2013.2.4 · Cited by 122
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Kamm, A., Przychodzen, P., Kuban-Jankowska, A., Jacewicz, D., Dabrowska, A. M., Nussberger, S., Wozniak, M., & Gorska-Ponikowska, M. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.09.005 · Cited by 120
Hoon, M. W., Jones, A. M., Johnson, N. A., Blackwell, J. R., Broad, E. M., Lundy, B., Rice, A. J., & Burke, L. M. (2014) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2013-0207 · Cited by 119
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Nossaman, V. E., Nossaman, B. D., & Kadowitz, P. J. (2010) · Cardiology in Review · doi:10.1097/crd.0b013e3181c8e14a · Cited by 120
Bahra, M., Kapil, V., Pearl, V., Ghosh, S., & Ahluwalia, A. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.01.004 · Cited by 116
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Kang, J. H., Willett, W. C., ROSNER, B. A., Buys, E. S., Wiggs, J. L., & Pasquale, L. R. (2016) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2015.5601 · Cited by 116
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113
“Intake of nitrite from environmental sources also occurs through contaminated ground water, commonly due to fertilizers, livestock and human excreta, which pose a potential hazard to health [59, 65].”
BackgroundHuman skeletal muscle nitrate store: Influence of dietary nitrate supplementation and exercise
Wylie, L. J., Park, J. W., Vanhatalo, A., Kadach, S., Black, M. I., Stoyanov, Z., Schechter, A. N., Jones, A. M., & Piknova, B. (2019) · The Journal of Physiology · doi:10.1113/jp278076 · Cited by 116
Joris, P. J., & Mensink, R. P. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.09.001 · Cited by 114
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Salehzadeh, H., Maleki, A., Rezaee, R., Shahmoradi, B., & Ponnet, K. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227551 · Cited by 114
Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114
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Clements, W., Lee, S.-R., & Bloomer, R. J. (2014) · Nutrients · doi:10.3390/nu6115224 · Cited by 118
Sindelar, J. J., & Milkowski, A. L. (2011) · Cited by 111
Baliga, R. S., Milsom, A. B., Ghosh, S. M., Trinder, S. L., MacAllister, R. J., Ahluwalia, A., & Hobbs, A. J. (2012) · Circulation · doi:10.1161/circulationaha.112.100586 · Cited by 110
Bondonno, C. P., Liu, A. H., Croft, K. D., Ward, N. C., Shinde, S., Moodley, Y. P., Lundberg, J. O., Puddey, I. B., Woodman, R. J., & Hodgson, J. M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.101188 · Cited by 114
Ashworth, A., Mitchell, K., Blackwell, J. R., Vanhatalo, A., & Jones, A. M. (2015) · Public Health Nutrition · doi:10.1017/s1368980015000038 · Cited by 109
López, A., García-Alonso, J., Fenoll, J., Hellín, P., & Flores, P. (2013) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2013.10.001 · Cited by 109
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Omar, S. A., Artime, E., & Webb, A. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.008 · Cited by 106
Taku, K., Lin, N., Cai, D., Hu, J., Zhao, X., Zhang, Y., Wang, P., Melby, M. K., Hooper, L., Kurzer, M. S., et al. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833c6edb · Cited by 105
Varadharaj, S., Kelly, O. J., Khayat, R. N., Kumar, P. S., Ahmed, N., & Zweier, J. L. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00064 · Cited by 101
Strasser, B., Sperner‐Unterweger, B., Fuchs, D., & Gostner, J. M. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_23 · Cited by 102
Sadler, R., Maetam, B., Edokpolo, B., Connell, D., Yu, Q., Stewart, D., Park, M., Gray, D. J., & Laksono, B. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.06.041 · Cited by 104
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Brkić, D., Bošnir, J., Bevardi, M., Bošković, A. G., Miloš, S., Lasić, D., Krivohlavek, A., Racz, A., Ćuić, A. M., & Uršulin-Trstenjak, N. (2017) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v14i3.4 · Cited by 103
Peña-Jorquera, H., Cid-Jofré, V., Landaeta-Díaz, L., Petermann-Rocha, F., Martorell, M., Zbinden-Foncea, H., Ferrari, G., Jorquera-Aguilera, C., & Cristi-Montero, C. (2023) · Nutrients · doi:10.3390/nu15143244 · Cited by 103
Zand, J., Lanza, F., Garg, H. K., & Bryan, N. S. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.03.008 · Cited by 101
Self-citationVegetable-derived bioactive nitrate and cardiovascular health
Bondonno, C. P., Blekkenhorst, L. C., Liu, A. H., Bondonno, N. P., Ward, N. C., Croft, K. D., & Hodgson, J. M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.08.001 · Cited by 101
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Blekkenhorst, L. C., Prince, R. L., Ward, N. C., Croft, K. D., Lewis, J. R., Devine, A., Shinde, S., Woodman, R. J., Hodgson, J. M., & Bondonno, C. P. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600982 · Cited by 99
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Metadata
- Authors
- Hord, N. G., Tang, Y., & Bryan, N. S.
- Affiliations
- Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
- Corresponding author
- Bryan, Nathan S
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 90
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2114325309
- Cited by
- 1,069
- References
- 105
- Citations by year
- 2026: 53 · 2025: 66 · 2024: 47 · 2023: 77 · 2022: 79 · 2021: 80 · 2020: 66 · 2019: 74 · 2018: 70 · 2017: 87 · 2016: 66 · 2015: 73 · 2014: 48 · 2013: 51 · 2012: 42
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- dietary nitrate, dietary nitrite, vegetable consumption, fruit consumption, processed meat, DASH diet, blood pressure reduction, nitric oxide, commensal bacteria, methemoglobinemia, gastrointestinal cancer risk, acceptable daily intake, dietary habits
- MeSH terms
- Animals, Diet, Food Analysis, Food Handling, Fruit, Health, Humans, Meat, Nitrates, Nitric Oxide, Nitrites, Vegetables
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