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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
Open accessAbstract
Background Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.Objective The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.Design Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.Results Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.Conclusions Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake.
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Metadata
- Authors
- Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., & Jaakko, T.
- Affiliations
- Deutsches Diabetes-Zentrum e.V. (DE)
- Heinrich Heine University Düsseldorf (DE)
- Finnish Institute for Health and Welfare (FI)
- University of Helsinki (FI)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 91
- Issue
- 4
- Pages
- 950-957
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2139329734
- Cited by
- 364
- References
- 40
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 21 · 2021: 28 · 2020: 29 · 2019: 13 · 2018: 28 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 37 · 2013: 38 · 2012: 28
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- coffee consumption, type 2 diabetes, subclinical inflammation, oxidative stress, caffeine, chlorogenic acid, methylxanthines, IL-18, 8-isoprostane, adiponectin, HDL cholesterol, apolipoprotein A-I, lipid metabolism, glucose metabolism, dietary intervention
- MeSH terms
- Adult, Anti-Inflammatory Agents, Apolipoproteins, Blood Glucose, Caffeic Acids, Caffeine, Chlorogenic Acid, Cholesterol, Coffee, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Lipids, Male, Middle Aged, Risk Factors, Dinoprost, Biomarkers, Single-Blind Method, Interleukin-18, Plant Preparations, Adiponectin
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