Cited by 364Coffee research and impactsNutritional Studies and DietAlcohol Consumption and Health Effects

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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial

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Kempf, Kerstin, Herder, Christian, Erlund, Iris, Kolb, Hubert, Martin, Stephan, Carstensen, Maren, Koenig, Wolfgang, Sundvall, Jouko, Bidel, Siamak, Kuha, Suvi, Jaakko, Tuomilehto·2010·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.2009.28548

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Abstract

Background Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.Objective The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.Design Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.Results Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.Conclusions Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake.

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“However, a clinical trial and an epidemiological study reported that regular coffee consumption appears to have beneficial effects on subclinical inflammation, HDLc, and TG levels [12, 13].”
Background
Coffee consumption and its interaction with the genetic variant AhR rs2066853 in colorectal cancer risk: a case–control study in Korea
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“…the first study by Kempf et al., 47 volunteers with an elevated risk of type 2 diabetes were sequentially given two different doses of coffee (four and eight cups/day) for four weeks each, leading to a significant decrease in the serum concentration of isoprostanes for the eight cups/day dose [87].”
Coffee consumption is associated with a reduced risk of venous thrombosis that is mediated through hemostatic factor levels
Roach, R. E. J., Siegerink, B., le Cessie, S., Rosendaal, F. R., Cannegieter, S. C., & Lijfering, W. M. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12034 · Cited by 13
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“…Campinas, SP, Brazil 2 Institute of Chemistry, State University of Campinas, Campinas, SP, Brazil inflammatory capacity (Huxley et al. 2009; Kempf et al. 2010), and can prevent the development of Alzheimer’s disease and assist in the control of intracellular calcium content (Fu et al.…”
Background
Effect of Coffee and Cocoa-Based Confectionery Containing Coffee on Markers of DNA Damage and Lipid Peroxidation Products: Results from a Human Intervention Study
Martini, D., Domínguez‐Perles, R., Rosi, A., Tassotti, M., Angelino, D., Medina, S., Ricci, C., Guy, A., Oger, C., Gigliotti, L., et al. (2021) · Nutrients · doi:10.3390/nu13072399 · Cited by 13
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BackgroundResultInfluential
Coffee and Its Major Polyphenols in the Prevention and Management of Type 2 Diabetes: A Comprehensive Review
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“Prevention of impairment of lung function by antioxidant actitivy (Alfaro et al. 2018) may be potential mechanism given that coffee drinking may reduce oxidative stress (Kempf et al. 2010; Jokura et al. 2015).”
Background
Efficacy of Hydroxytyrosol-Rich Food Supplements on Reducing Lipid Oxidation in Humans
Bender, C., Candi, I., & Rogel, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065521 · Cited by 12
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“Also, coffee consumption has been associated with increased levels of adiponectin, a hormone thought to have insulinsensitizing properties [20–22].”
Background
Effects of caffeine on brain antioxidant status and mitochondrial respiration in acetaminophen-intoxicated mice
Gonçalves, D. F., Tassi, C. L. C., Amaral, G. P., Stefanello, S. T., Corte, C. L. D., Soares, F. A. A., Posser, T., Franco, J. L., & de Carvalho, N. R. (2020) · Toxicology Research · doi:10.1093/toxres/tfaa075 · Cited by 12
“Beside that caffeine inhibits production of pro-inflammatory cytokines and promotes production of antiinflammatory cytokines [52, 53], this could improve survival in APAP intoxication.”
Background
Investigation of Optimum Roasting Conditions to Obtain Possible Health Benefit Supplement, Antioxidants from Coffee Beans
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“Many previous studies have reported that coffee consumption was associated with lower levels of inflammatory markers such as IL-8(35), fetuin-A(36) and 8-isoprostane levels(35), which were risk factors of incident mobility limitation(37) and ADL disability(38).”
Background
Moderate coffee consumption is associated with lower risk of mortality in prior Acute Coronary Syndrome patients: a prospective analysis in the ERICO cohort
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“Moreover, epidemiologic studies suggest that intake of coffee is inversely associated with specific markers of inflammation (Kempf et al. 2010) which are responsible for progression of atherosclerosis (Libby et al.”
BackgroundInfluential
Coffee and Caffeine Intake among Students of the Brazilian Northeast
Penafort, A. M., Pereira, I. B., Carioca, A. A. F., Sabry, M. O. D., Pinto, F. J. M., & Sampaio, H. A. D. C. (2016) · Food and Nutrition Sciences · doi:10.4236/fns.2016.71004 · Cited by 11
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Background
Coffee Consumption and Cardiovascular Diseases – Has the Time Come to Change Dietary Advice? A Mini Review
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“One study found that drinking 8 cups of coffee per day decreased the concentrations of proinfl ammatory interleukin-18 [Kempf et al., 2010], whereas another reported an inverse correlation between the consumption of 1 cups of coffee per day and the level of C-reactive protein [Kotani et al., 2008].”
Background
Impact of Caffeine on Weight Changes Due to Ketotifen Administration
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Background
The Examination of the Influence of Caffeinated Coffee Consumption on the Concentrations of Serum Prolactin and Selected Parameters of the Oxidative‐Antioxidant Balance in Young Adults: A Preliminary Report
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Ist Kaffeetrinken gesund?
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Plant extracts of spices and coffee synergistically dampen nuclear factor–κB in U937 cells
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“Coffee consumption has also been associated with a lower risk of inflammation-related diseases [31–36].”
Background
Caffeine Increases Apolipoprotein A-1 and Paraoxonase-1 but not Paraoxonase-3 Protein Levels in Human-Derived Liver (HepG2) Cells
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“It has been shown that ApoA1, PON1 and PON3 are antioxidant, anti-inflammatory and anti-atherosclerotic proteins, and they play important roles in the atheroprotective activities of HDL (4,5).”
BackgroundResultInfluential
Coffee Intake and obesity
Pimentel, G. D., Micheletti, T. O., Fernandes, R. C., & Nehlig, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816093-0.00024-0 · Cited by 8
Association Between Coffee Consumption and Metabolic Syndrome Components Among Saudi Adults
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“A different study on the relationship between coffee and lipid metabolism showed that consistent filtered coffee consumption over three months had a favorable impact on high-density lipoprotein cholesterol (HDL-C) levels [10].”
Habitual Tea and Coffee Consumption and Mean Reaction Time Among Qatari Adults
Heggy, A. J., Masoumi, A. A., Alyafei, M. S., Albader, F. S., Al-Abdi, T., & Shi, Z. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215130 · Cited by 7
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Coffee and Colorectal Cancer: Grounds for Prevention?
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Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation
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Targeted proteomic response to coffee consumption
Kuang, A., Erlund, I., Herder, C., Westerhuis, J. A., Tuomilehto, J. O., & Cornelis, M. C. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02009-1 · Cited by 6
“Results of correlation analysis of changes among previously identified clinical [5], metabolite [6] and lipid [7] markers of coffee response and the nominal to significant proteins identified here (Table 1) are presented in Online Resource 1, Fig.”
Background
Association of coffee consumption with type 2 diabetes and glycemic traits: a Mendelian randomization study
Cho, H. J., Okekunle, A. P., Yie, G.-E., Youn, J., Kang, M.-I., Jin, T., Sung, J., & Lee, J. E. (2023) · Nutrition Research and Practice · doi:10.4162/nrp.2023.17.4.789 · Cited by 6
“Several prospective studies [22,36,37], reviews [5,38-41], and randomized trials [11,12] have studied the coffee consumption-T2D relationship without genetic evidence to support causal relationships.”
Background
Kaffee und Diabetes
Kempf, K., & Martin, S. (2010) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-010-1156-x · Cited by 7
“rostan – einem Marker für oxidativen Stress (Abbildung 3), Interleukin-18 und Adiponektin signifikant beeinflusst [56].”
BackgroundInfluential
Caffeine
Roberts, A. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00030-9 · Cited by 6
Reducing sugar use in coffee while maintaining enjoyment: A randomized controlled trial
Lenne, R. L., & Mann, T. L. (2017) · Journal of Health Psychology · doi:10.1177/1359105317723452 · Cited by 7
“In addition, correlational studies show an inverse relationship between coffee consumption and type 2 diabetes (Kempf et al., 2010; Salazar-Martinez, 2004; Van Dam and Hu, 2005), although confounding variables (e.”
Background
An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
Karusheva, Y., Kunstein, L., Bierwagen, A., Nowotny, B., Kabisch, S., Groener, J. B., Fleitmann, A. K., Herder, C., Pacini, G., Straßburger, K., et al. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0324-5 · Cited by 6
“One single cup of coffee aggravated postprandial glucose excursion in healthy individuals and in patients with T2D [12], whereas regular coffee intake did not influence glucose homeostasis despite its anti-inflammatory effects [13].”
Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation
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Coffee and Type 2 Diabetes Risk
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Coffee: Fuel for Your Day or Foe for Your Arteries
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A Cross-Sectional Study on the Combined Effect of Body Weight and Coffee Consumption on Serum Levels of Leptin, Vitamin B12, and Folic Acid in Healthy Young Adult Males
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Different Preparations of Coffee Have Varied Effects on Body Weight and Blood Lipids in Experimental Rats
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“…antioxidants (Damat et al., 2019; Halvorsen et al., 2002; Moriera et al., 2013; Natella et al., 2007; Suryono et al., 2020) and anti– inflammation (Cardenas; Quesada; Medina, 2011; Dewanti et al., 2019; Kempf et al., 2010; Moriera et al., 2013) that might counteract the adverse effect of caffeine.”
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Nutrition and Type 2 Diabetes
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BackgroundInfluential
Effects of Coffee Supplementation on Homocysteine and Leptin Levels: A Systematic Review and Meta-analysis of Clinical Trials
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Kafein ve Obezite
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“The prerequisites for organizing a Focus Group Discussion (FGD) include the requirement that the size of panelists consist of 8-12 individuals partake in the session (Djekic et al., 2021; Kempf et al., 2010).”
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Pinandito, Y. K. A., Shidqi, A., & Retnowati, W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13868-3.00018-1 · Cited by 2
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“Coffee consumption may reduce levels of proinflammatory cytokines, considered a risk factor for diabetes [42], and chlorogenic acid may inhibit hydrolysis of glucose-6-phosphate to glucose and reduce glucose absorption in the gastrointestinal tract [30, 43].”
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Comparative Compositional Analysis of Regular and Decaf Coffees by LC/MS and HPLC and Potential Effects on Inflammatory Cytokines Produced during Bacterial Infections
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“Moreover, owing to the absence of speci ﬁ c demographic information and clinical records for the studied patients, we were unable to conduct subgroup analyses.”
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Authors: Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., & Jaakko, T.
Affiliations: Deutsches Diabetes-Zentrum e.V. (DE)
Heinrich Heine University Düsseldorf (DE)
Finnish Institute for Health and Welfare (FI)
University of Helsinki (FI)
ORCID: Kempf, Kerstin
Herder, Christian
Erlund, Iris
Kolb, Hubert
Kuha, Suvi
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2010-04
Volume: 91
Issue: 4
Pages: 950-957
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.2009.28548
OpenAlex: W2139329734
Cited by: 364
References: 40
Citations by year: 2026: 8 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 21 · 2021: 28 · 2020: 29 · 2019: 13 · 2018: 28 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 37 · 2013: 38 · 2012: 28
FWCI: 22.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4706 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: coffee consumption, type 2 diabetes, subclinical inflammation, oxidative stress, caffeine, chlorogenic acid, methylxanthines, IL-18, 8-isoprostane, adiponectin, HDL cholesterol, apolipoprotein A-I, lipid metabolism, glucose metabolism, dietary intervention
MeSH terms: Adult, Anti-Inflammatory Agents, Apolipoproteins, Blood Glucose, Caffeic Acids, Caffeine, Chlorogenic Acid, Cholesterol, Coffee, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Lipids, Male, Middle Aged, Risk Factors, Dinoprost, Biomarkers, Single-Blind Method, Interleukin-18, Plant Preparations, Adiponectin

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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial

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